神経病理学

170  件  
※ 登録方法の違いにより重複して表示されている場合があります。

  1. Homma H, Yoshioka Y, Fujita K, Shirai S, Hama Y, Komano H, Saito Y, Yabe I, Okano H, Sasaki H, Tanaka H, Okazawa H: Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Commun Biol. 2024.04; 7 (1): 413. ( PubMed , DOI )

  2. Homma H, Tanaka H, Fujita K, Okazawa H: Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease. Int J Mol Sci. 2024.03; 25 (7): 3636. ( PubMed , DOI )

  1. Yoshioka Y, Taniguchi JB, Homma H, Tamura T, Fujita K, Inotsume M, Tagawa K, Misawa K, Matsumoto N, Nakagawa M, Inoue H, Tanaka H, Okazawa H: AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells. Commun Med (Lond). 2023.11; 3 (1): 170. ( PubMed , DOI )

  2. Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, Khan M, Razzaghi M, Prasolava T, Lanni S, Sato N, Caron MC, Panigrahi GB, Wang P, Lau R, Castel AL, Masson JY, Tippett L, Turner C, Spies M, La Spada AR, Campos EI, Curtis MA, Boisvert FM, Faull RLM, Davidson BL, Nakamori M, Okazawa H, Wold MS, Pearson CE: Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability. Cell. 2023.10; 186 (22): 4898-4919.e25. ( PubMed , DOI )

  3. Fujita K, Homma H, Jin M, Yoshioka Y, Jin X, Saito Y, Tanaka H, Okazawa H: Mutant α-synuclein propagates via the lymphatic system of the brain in the monomeric state. Cell Rep. 2023.08; 42 (8): 112962. ( PubMed , DOI )

  4. Shiwaku H, Katayama S, Gao M, Kondo K, Nakano Y, Motokawa Y, Toyoda S, Yoshida F, Hori H, Kubota T, Ishikawa K, Kunugi H, Ikegaya Y, Okazawa H, Takahashi H: Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1α in schizophrenia. Brain Behav Immun. 2023.07; 111 32-45. ( PubMed , DOI )

  5. Jin X, Tanaka H, Jin M, Fujita K, Homma H, Inotsume M, Yong H, Umeda K, Kodera N, Ando T, Okazawa H: PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. Nat Commun. 2023.01; 14 (1): 9. ( PubMed , DOI )

  1. Tanaka H, Okazawa H: PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity. Int J Mol Sci. 2022.06; 23 (11): 6227. ( PubMed , DOI )

  2. Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, Fujita K, Tamaki H, Takebayashi H, Terasaki O, Nagase Y, Nagase T, Kubota T, Ishikawa K, Okazawa H, Takahashi H: Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell Rep Med. 2022.04; 3 (4): 100597. ( PubMed , DOI )

  1. Okazawa H, Tanaka H: Molecular Dissection and Therapeutic Application of SCA1 Pathologies Revealed by Comprehensive Approaches. Cerebellum as a CNS Hub. 2021.11; 479-486.

  2. Jin M, Shiwaku H, Tanaka H, Obita T, Ohuchi S, Yoshioka Y, Jin X, Kondo K, Fujita K, Homma H, Nakajima K, Mizuguchi M, Okazawa H: Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nat Commun. 2021.11; 12 (1): 6565. ( PubMed , DOI )

  3. Tanaka H, Kondo K, Fujita K, Homma H, Tagawa K, Jin X, Jin M, Yoshioka Y, Takayama S, Masuda H, Tokuyama R, Nakazaki Y, Saito T, Saido T, Murayama S, Ikura T, Ito N, Yamamori Y, Tomii K, Bianchi ME, Okazawa H: HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology. Commun Biol. 2021.10; 4 (1): 1175. ( PubMed , DOI )

  4. Jin M, Jin X, Homma H, Fujita K, Tanaka H, Murayama S, Akatsu H, Tagawa K, Okazawa H: Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis. Commun Biol. 2021.08; 4 (1): 961. ( PubMed , DOI )

  5. Kondo K, Ikura T, Tanaka H, Fujita K, Takayama S, Yoshioka Y, Tagawa K, Homma H, Liu S, Kawasaki R, Huang Y, Ito N, Tate SI, Okazawa H: Hepta-Histidine Inhibits Tau Aggregation. ACS Chem Neurosci. 2021.08; 12 (16): 3015-3027. ( PubMed , DOI )

  6. Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, Bertens CJ, Tsumaki K, Kondo K, Shiwaku H, Tagawa K, Akatsu H, Atsuta N, Katsuno M, Furukawa K, Ishiki A, Waragai M, Ohtomo G, Iwata A, Yokota T, Inoue H, Arai H, Sobue G, Sone M, Fujita K, Okazawa H: DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life Sci Alliance. 2021.06; 4 (7): e202101022. ( PubMed , DOI )

  7. Hitoshi Okazawa: Intracellular amyloid hypothesis for ultra-early phase pathology of Alzheimer's disease. Neuropathology. 2021.04; 41 (2): 93-98. ( PubMed , DOI )

  8. Saito M, Nakayama M, Fujita K, Uchida A, Yano H, Goto S, Okazawa H, Sone M: Role of the Drosophila YATA protein in the proper subcellular localization of COPI revealed by in vivo analysis. Genes Genet Syst. 2021.03; 95 (6): 303-314. ( PubMed , DOI )

  9. Daniel J Klionsky, etc.: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021.02; 1-382. ( PubMed , DOI )

  1. Yang SS, Ishida T, Fujita K, Nakai Y, Ono T, Okazawa H: PQBP1, an intellectual disability causative gene, affects bone development and growth. Biochem Biophys Res Commun. 2020.03; 523 (4): 894-899. ( PubMed , DOI )

  2. Yang SS, Ishida T, Fujita K, Nakai Y, Ono T, Okazawa H. : PQBP1, an intellectual disability causative gene, affects bone development and growth. Biochemical and Biophysical Research Communications.. 2020.03; 523 894-899. ( DOI )

  3. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H: YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nat Commun . 2020.01; 11 (1): 507. ( PubMed , DOI )

  4. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H.: YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nature Communications. 2020.01; 11 507. ( DOI )

  1. Rahmn SK, Okazawa H, Chen YW: Frameshift PQBP-1 mutants K192Sfs*7 and R153Sfs*41 implicated in X-linked intellectual disability form stable dimers. Journal of Structural Biology. 2019.06; 206 (3): 305-313. ( PubMed , DOI )

  2. Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A: Chronic cerebral hypoperfusion shifts the equilibrium of amyloid beta oligomers to aggregation-prone species with higher molecular weight. Scientific Reports. 2019.02; 9 (1): 2827. ( PubMed , DOI )

  3. Chen X, Kondo K, Okazawa H: Methods to Image Macroautophagy in the Brain In Vivo. Methods Mol Biol. 2019.01; 1880 529-534. ( PubMed , DOI )

  4. Inoue S, Hayashi K, Fujita K, Tagawa K, Okazawa H, Kubo K, Nakajima K: Drebrin-like (Dbnl) controls neuronal migration via regulating N-cadherin expression in the developing cerebral cortex. Journal of Neuroscience. 2019.01; 39 (4): 678-691. ( PubMed , DOI )

  1. Hitoshi Okazawa: PQBP1, an intrinsically disordered/denatured protein at the crossroad of intellectual disability and neurodegenerative diseases. Neurochem Int. 2018.10; 119 17-25. ( PubMed , DOI )

  2. Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S, Saito T, Saido T, Muramatsu S, Fujita K, Okazawa H: The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Mol psychiatry. 2018.10; 23 (10): 2090-2110. ( PubMed , DOI )

  3. Fujita K, Homma H, Kondo K, Ikuno M, Yamakado H, Tagawa K, Murayama S, Takahashi R, Okazawa H.: Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. eNeuro. 2018.10; 5 (4): ENEURO.0217-18.2018.. ( DOI )

  4. Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S, Saito T, Saido T, Muramatsu SI, Fujita K, Okazawa H. : The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Molecular Psychiatry. 2018.10; 23 2090-2110. ( DOI )

  5. Tamura T, Okazawa H: TRIAD(Transcriptional Repression-Induced Atypical Death) Apoptosis and Beyond. 2018.09; 2 411-426.

  6. Furotani K, Kamimura K, Yajima T, Nakayama M, Enomoto R, Tamura T, Okazawa H, Sone M: Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model. PLoS ONE. 2018.09; 13 (9): e0204048. ( PubMed , DOI )

  7. Fujita K, Homma H, Kondo K, Ikuno M, Yamakado H, Tagawa K, Murayama S, Takahashi R, Okazawa H: Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. eNeuro. 2018.07; 5 (4): ( PubMed , DOI )

  8. Hitoshi Okazawa: Bridging Multiple Dementias. ACS Chem Neurosci. 2018.04; 9 (4): 636-638. ( PubMed , DOI )

  9. Irie R, Kamagata K, Kerever A, Ueda R, Yokosawa S, Otake Y, Ochi H, Yoshizawa H, Hayashi A, Tagawa K, Okazawa H, Takahashi K, Sato K, Hori M, Arikawa-Hirasawa E, Aoki S: The Relationship between Neurite Density Measured with Confocal Microscopy in a Cleared Mouse Brain and Metrics Obtained from Diffusion Tensor and Diffusion Kurtosis Imaging. Magn Reson Med Sci. 2018.04; 17 (2): 138-144. ( PubMed , DOI )

  10. Kawahori K, Hashimoto K, Yuan X, Tsujimoto K, Hanzawa N, Hamaguchi M, Kase S, Fujita K, Tagawa K, Okazawa H, Nakajima Y, Shibusawa N, Yamada M, Ogawa Y: Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring. Thyroid. 2018.03; 28 (3): 395-406. ( PubMed , DOI )

  11. Kawahori K, Hashimoto K, Yuan X, Tsujimoto K, Hanzawa N, Hamaguchi M, Kase S, Fujita K, Tagawa K, Okazawa H, Nakajima Y, Shibusawa N, Yamada M, Ogawa Y. : Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring. Thyroid. 2018.03; 28 (3): 395-406. ( DOI )

  12. Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Mutsuki Amano, Ayumu Saito, Seiya Imoto, Hiroyasu Akatsu, Yoshio Hashizume, Kozo Kaibuchi, Satoru Miyano, Hitoshi Okazawa: Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nat Commun. 2018.01; 9 (1): 433. ( PubMed , DOI )

  13. Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, Imoto S, Akatsu H, Hashizume Y, Kaibuchi K, Miyano S, Okazawa H. : Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nature Communications. 2018.01; 9 433. ( DOI )

  1. Fujita K, Mao Y, Uchida S, Chen X, Shiwaku H, Tamura T, Ito H, Watase K, Homma H, Tagawa K, Sudol M, Okazawa H: Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1. Nat Commun. 2017.11; 8 (1): 1864. ( PubMed , DOI )

  2. Hitoshi Okazawa: Ultra-Early Phase pathologies of Alzheimer's disease and other neurodegenerative diseases. Proc Jpn Acad Ser B Phys Biol Sci. 2017.06; 93 (6): 361-377. ( PubMed , DOI )

  3. Sato K, Kerever A, Kamagata K, Tsuruta K, Irie R, Tagawa K, Okazawa H, Arikawa-Hirasawa E, Nitta N, Aoki I, Aoki S: Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain. Acta Radiol Open. 2017.04; 6 (4): 2058460117703816. ( PubMed , DOI )

  4. Yamanishi E, Hasegawa K, Fujita K, Ichinose S, Yagishita S, Murata M, Tagawa K, Akashi T, Eishi Y, Okazawa H: A novel form of necrosis, TRIAD, occurs in human Huntington's disease. Acta Neuropathol Commun. 2017.03; 5 (1): 19. ( PubMed , DOI )

  1. Mao Y, Chen X, Xu M, Fujita K, Sasabe K, Homma H, Murata M, Tagawa K, Tamura T, Kaye J, Finkbeiner S, Blandino G, Sudol M, Okazawa H : Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. Hum Mol Genet. 2016.11; 25 (21): 4749-4770. ( PubMed , DOI )

  2. Kamagata K, Kerever A, Yokosawa S, Otake Y, Ochi H, Hori M, Kamiya K, Tsuruta K, Tagawa K, Okazawa H, Aoki S, Arikawa-Hirasawa E: Quantitative Histological Validation of Diffusion Tensor MRI with Two-Photon Microscopy of Cleared Mouse Brain. Magn Reson Med Sci. 2016.10; 15 (4): 416-421. ( PubMed , DOI )

  3. Taniguchi JB, Kondo K, Fujita K, Chen X, Homma H, Sudo T, Mao Y, Watase K, Tanaka T, Tagawa K, Tamura T, Muramatsu SI, Okazawa H: RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. Hum Mol Genet. 2016.10; 25 (20): 4432-4447. ( PubMed , DOI )

  4. Mao, Y., Chen, X., Xu, M.,Fujita, K., Sasabe, K.,Homma, H., Murata, M., Tagawa, K., Tamura, T., Kaye, J., Finkbeiner, S., Blandino, G., Sudol, M., Okazawa, H. : Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology. Hum Mol Genet.. 2016.09;

  5. Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H: Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016.09; 6 33861. ( PubMed , DOI )

  6. Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, Homma H, Tamura T, Watanabe H, Katsuno M, Matsumi C, Kajikawa M, Saito T, Saido T, Sobue G, Miyawaki A, Okazawa H: HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2016.08; 6 31895. ( PubMed , DOI )

  7. Mizuguchi M, Obita T, Kajiyama A, Kozakai Y, Nakai T, Nabeshima Y, Okazawa H: Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD. FEBS Lett. 2016.07; 590 (14): 2221-2231. ( PubMed , DOI )

  8. Mao Y, Tamura T, Yuki Y, Abe D, Tamada Y, Imoto S, Tanaka H, Homma H, Tagawa K, Miyano S, Okazawa H: The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. Cell Death Dis. 2016.04; 7 (4): e2207. ( PubMed , DOI )

  1. Chen X, Kondo K, Motoki K, Homma H, Okazawa H: Fasting activates macroautophagy in neurons of Alzheimer's disease mouse model but is insufficient to degrade amyloid-beta. Scientific Reports. 2015.07; 5 12115. ( PubMed , DOI )

  2. Shiwaku H, Okazawa H: Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders. Current Molecular Medicine. 2015.02; 15 (2): 119-128. ( PubMed , DOI )

  3. Hikaru Ito, Kyota Fujita, Kazuhiko Tagawa, Xigui Chen, Hidenori Homma, Toshikazu Sasabe, Jun Shimizu, Shigeomi Shimizu, Takuya Tamura, Shin-ichi Muramatsu, Hitoshi Okazawa: HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO Mol Med. 2015.01; 7 (1): 78-101. ( PubMed , DOI )

  4. Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, Oka T, Ito H, Motoki K, Yoshida C, Hatsuta H, Murayama S, Iwatsubo T, Miyano S, Okazawa H. : Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. Human Molecular Genetics.. 2015.01; 24 540-558. ( DOI )

  1. Shiraishi R, Tamura T, Sone M, Okazawa H: Systematic analysis of fly models with multiple drivers reveals different effects of ataxin-1 and huntingtin in neuron subtype-specific expression. PLoS ONE. 2014.12; 9 (12): e116567. ( PubMed , DOI )

  2. Nabeshima Y, Mizuguchi M, Kajiyama A, Okazawa H: Segmental isotope-labeling of the intrinsically disordered protein PQBP1. FEBS Letters. 2014.12; 588 (24): 4583-4589. ( PubMed , DOI )

  3. Tagawa, K., Homma, H., Saito, A., Fujita, K., Chen, X., Imoto, S., Oka, T., Ito, H., Motoki, K., Yoshida, C., Hatsuta, H., Murayama, S., Iwatsubo, T., Miyano, S., Okazawa, H.: Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. Hum Mol Genet. 2014.09; ( PubMed , DOI )

  4. Ito, H., Shiwaku, H., Yoshida, C., Homma, H., Luo, H., Chen, X., Fujita, K., Musante, L., Fischer, U., Frints, S G M., Romano, C., Ikeuchi, Y., Shimamura, T., Imoto, S., Miyano, S., Muramatsu, S-I., Kawauchi, T., Hoshino, M., Sudol, M., Arumughan, A., Wanker, E E., Rich, T., Schwartz, C., Matsuzaki, F., Bonni, A., Kalscheuer, V M., Okazawa, H.: In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Mol Psychiatry. 2014.07; 20 (4): 459-71. ( PubMed , DOI )

  5. Mizuguchi M, Obita T, Serita T, Kojima R, Nabeshima Y, Okazawa H: Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD. Nat Commun. 2014.04; 5 3822. ( PubMed , DOI )

  6. Barclay SS, Tamura T, Ito H, Fujita K, Tagawa K, Shimamura T, Katsuta A, Shiwaku H, Sone M, Imoto S, Miyano S, Okazawa H: Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. Hum Mol Genet. 2014.03; 23 (5): 1345-1364. ( PubMed , DOI )

  1. Ikeuchi Y, de la Torre-Ubieta L, Matsuda T, Steen H, Okazawa H, Bonni A: The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Cell Rep. 2013.09; 4 (5): 879-889. ( PubMed , DOI )

  2. Shiwaku H, Yagishita S, Eishi Y, Okazawa H: Bergmann glia are reduced in spinocerebellar ataxia type 1. Neuroreport. 2013.08; 24 (11): 620-625. ( PubMed , DOI )

  3. Li C, Ito H, Fujita K, Shiwaku H, Qi Y, Tagawa K, Tamura T, Okazawa H: Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells. PLoS ONE. 2013.07; 8 (7): e68627. ( PubMed , DOI )

  4. Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H: A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases. Nat Commun. 2013.05; 4 1816. ( PubMed , DOI )

  5. Tamura T, Sone M, Nakamura Y, Shimamura T, Imoto S, Miyano S, Okazawa H: A restricted level of PQBP1 is needed for the best longevity of Drosophila. Neurobiol Aging. 2013.01; 34 (1): 356.e11-356.e20. ( PubMed , DOI )

  1. Martin Rees, Christian Gorba, Cesira de Chiara, Tam T T Bui, Mitla Garcia-Maya, Alex F Drake, Hitoshi Okazawa, Annalisa Pastore, Dmitri Svergun, Yu Wai Chen: Solution model of the intrinsically disordered polyglutamine tract-binding protein-1. Biophys J. 2012.04; 102 (7): 1608-1616. ( PubMed , DOI )

  2. Nakamura Y, Tagawa K, Oka T, Sasabe T, Ito H, Shiwaku H, La Spada AR, Okazawa H: Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network. Hum Mol Genet. 2012.03; 21 (5): 1099-1110. ( PubMed , DOI )

  1. Tamura T, Sone M, Iwatsubo T, Tagawa K, Wanker EE, Okazawa H: Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease. PLoS ONE. 2011.11; 6 (11): e27408. ( PubMed , DOI )

  2. Oka T, Tagawa K, Ito H, Okazawa H: Dynamic changes of the phosphoproteome in postmortem mouse brains. PLoS ONE. 2011.06; 6 (6): e21405. ( PubMed , DOI )

  1. Aoki Y, Nakamura A, Yokota T, Saito T, Okazawa H, Nagata T, Takeda SI: In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse. Mol Ther. 2010.11; 18 (11): 1995-2005. ( PubMed , DOI )

  2. Tamura T, Horiuchi D, Chen YC, Sone M, Miyashita T, Saitoe M, Yoshimura N, Chiang AS, Okazawa H: Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning. J. Neurosci. 2010.10; 30 (42): 14091-14101. ( PubMed , DOI )

  3. Konno M, Hamazaki TS, Fukuda S, Tokuhara M, Uchiyama H, Okazawa H, Okochi H, Asashima M: Efficiently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-free culture. Biochem Biophys Res Commun. 2010.10; 400 (4): 461-465. ( PubMed , DOI )

  4. Honda S, Hayashi S, Imoto I, Toyama J, Okazawa H, Nakagawa E, Goto Y, Inazawa J: Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis. J Hum Genet. 2010.09; 55 (9): 590-599. ( PubMed , DOI )

  5. Shiwaku H, Yoshimura N, Tamura T, Sone M, Ogishima S, Watase K, Tagawa K, Okazawa H: Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J. 2010.07; 29 (14): 2446-2460. ( PubMed , DOI )

  6. Takahashi M, Mizuguchi M, Shinoda H, Aizawa T, Demura M, Okazawa H, Kawano K: Polyglutamine tract-binding protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain. Biochim Biophys Acta. 2010.07; 1804 (7): 1500-1507. ( PubMed , DOI )

  7. Shiwaku Hiroki, Yoshimura Natsue, Tamura Takuya, Sone Masaki, Ogishima Soichi, Watase Kei, Tagawa Kazuhiko, Okazawa Hitoshi: Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity EMBO JOURNAL. 2010.07; 29 (14): 2446-2460. ( PubMed , DOI )

  8. Enokido Y, Tamura T, Ito H, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H: Mutant huntingtin impairs Ku70-mediated DNA repair. J Cell Biol. 2010.05; 189 (3): 425-443. ( PubMed , DOI )

  1. Ito H, Yoshimura N, Kurosawa M, Ishii S, Nukina N, Okazawa H: Knock-down of PQBP1 impairs anxiety-related cognition in mouse. Hum Mol Genet. 2009.11; 18 (22): 4239-4254. ( PubMed , DOI )

  2. Chin JH, Shiwaku H, Goda O, Komuro A, Okazawa H: Neural stem cells express Oct-3/4. Biochem Biophys Res Commun. 2009.10; 388 (2): 247-251. ( PubMed , DOI )

  3. Takahashi M, Mizuguchi M, Shinoda H, Tomoyasu AT, Demura M, Okazawa H, Kawano K: Polyglutamine tract binding protein-1 is an intrinsically unstructured protein Biochim. Biophys. Acta. 2009.06; 1794 (6): 936-943. ( PubMed , DOI )

  4. Morimoto N, Nagai M, Miyazaki K, Kurata T, Takehisa Y, Ikeda Y, Kamiya T, Okazawa H, Abe K: Progressive decrease in the level of YAPdeltaCs, pro-survival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene J Neurosci Res. 2009.03; 87 (4): 928-936. ( PubMed )

  5. Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, Okazawa H, Nabeshima Y: Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. PLoS ONE. 2009.02; 4 (2): e4466. ( PubMed , DOI )

  6. Takahashi Keiko, Yoshina Sawako, Masashi Maekawa, Ito Wakana, Inoue Takao, Shiwaku Hiroki, Arai Hiroyuki, Mitani Shohei, Okazawa Hitoshi: Nematode Homologue of PQBP1, a Mental Retardation Causative Gene, Is Involved in Lipid Metabolism PLOS ONE. 2009.01; 4 (1): e4104. ( PubMed , DOI )

  7. Tamura T, Sone M, Yamashita M, Wanker EE, Okazawa H: Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models. PLoS ONE. 2009.01; 4 (1): e4262. ( PubMed , DOI )

  1. Jiamei Hou, Takuya Tamura, Yoshiaki Kidokoro: Delayed synaptic transmission in Drosophila cacophonynull embryos. J. Neurophysiol.. 2008.11; 100 (5): 2833-2842. ( PubMed , DOI )

  2. Enokido Yasushi, Yoshitake Ayaka, Ito Hikaru, Okazawa Hitoshi: Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008.11; 376 (1): 128-133. ( PubMed , DOI )

  3. Inagaki R, Tagawa K, Qi ML, Enokido Y, Ito H, Tamura T, Shimizu S, Oyanagi K, Arai N, Kanazawa I, Wanker EE, Okazawa H: Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease. Eur. J. Neurosci. 2008.07; 28 (1): 30-40. ( PubMed , DOI )

  1. Qi ML, Tagawa K, Enokido Y, Yoshimura N, Wada Y, Watase K, Ishiura S, Kanazawa I, Botas J, Saitoe M, Wanker EE, Okazawa H: Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases. Nat Cell Biol. 2007.04; 9 (4): 402-414. ( PubMed , DOI )

  2. Daisuke Yamazaki, Junjiro Horiuchi, Yasuko Nakagami, Shintaro Nagano, Takuya Tamura, Minoru Saitoe: The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan. Nat. Neurosci.. 2007.04; 10 (4): 478-484. ( PubMed , DOI )

  3. Tagawa K, Marubuchi S, Qi ML, Enokido Y, Tamura T, Inagaki R, Murata M, Kanazawa I, Wanker EE, Okazawa H: The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes. J Neurosci. 2007.01; 27 (4): 868-880. ( PubMed , DOI )

  4. Takuya Tamura, Jiamei Hou, Noreen E Reist, Yoshiaki Kidokoro: Nerve-evoked synchronous release and high K+ -induced quantal events are regulated separately by synaptotagmin I at Drosophila neuromuscular junctions. J. Neurophysiol.. 2007.01; 97 (1): 540-549. ( PubMed , DOI )

  1. Marubuchi S, Okuda T, Tagawa K, Enokido Y, Horiuchi D, Shimokawa R, Tamura T, Qi ML, Eishi Y, Watabe K, Shibata M, Nakagawa M, Okazawa H: Hepatoma-derived growth factor, a new trophic factor for motor neurons, is up-regulated in the spinal cord of PQBP-1 transgenic mice before onset of degeneration. J Neurochem. 2006.10; 99 (1): 70-83. ( PubMed , DOI )

  2. Yoshimura N, Horiuchi D, Shibata M, Saitoe M, Qi ML, Okazawa H: Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship. FEBS Lett. 2006.04; 580 (9): 2335-2340. ( PubMed , DOI )

  3. Hoshino M, Qi ML, Yoshimura N, Miyashita T, Tagawa K, Wada Y, Enokido Y, Marubuchi S, Harjes P, Arai N, Oyanagi K, Blandino G, Sudol M, Rich T, Kanazawa I, Wanker EE, Saitoe M, Okazawa H: Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. J Cell Biol. 2006.02; 172 (4): 589-604. ( PubMed , DOI )

  1. Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, Kimura H: Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS FASEB J. 2005.11; 19 (13): 1854-1856. ( PubMed , DOI )

  2. Marubuchi S, Wada Y, Okuda T, Hara Y, Qi ML, Hoshino M, Nakagawa M, Kanazawa I, Okazawa H: PQBP -1 dysfunction induces cell death of neurons through mitochondrial stress. J Neurochem. 2005.11; 95 (3): 858-870. ( PubMed , DOI )

  3. Qi Y, Hoshino M, Wada Y, Marubuchi S, Yoshimura N, Kanazawa I, Shinomiya K, Okazawa H: PQBP-1 is expressed predominantly in the central nervous system during development. Eur J Neurosci. 2005.09; 22 (6): 1277-1286. ( PubMed , DOI )

  4. Tomonori Okamoto, Takuya Tamura, Kazuhiro Suzuki, Yoshiaki Kidokoro: External Ca2+ dependency of synaptic transmission in drosophila synaptotagmin I mutants. J. Neurophysiol.. 2005.08; 94 (2): 1574-1586. ( PubMed , DOI )

  5. Minoru Saitoe, Junjiro Horiuchi, Takuya Tamura, Naomi Ito: Drosophila as a novel animal model for studying the genetics of age-related memory impairment. Rev Neurosci. 2005; 16 (2): 137-149. ( PubMed )

  1. Okuda T, Tagawa K, Qi ML, Hoshio M, Ueda H, Kawano H, Kanazawa I, Muramatsu M, Okazawa H: Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo. Brain Res Mol Brain Res. 2004.12; 132 (1): 18-30. ( PubMed , DOI )

  2. Takaomi Sakai, Takuya Tamura, Toshihiro Kitamoto, Yoshiaki Kidokoro: A clock gene, period, plays a key role in long-term memory formation in Drosophila. Proc. Natl. Acad. Sci. U.S.A.. 2004.11; 101 (45): 16058-16063. ( PubMed , DOI )

  3. Tagawa K, Hoshino M, Okuda T, Ueda H, Hayashi H, Engemann S, Okado H, Ichikawa M, Wanker EE, Okazawa H: Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein. J Neurochem. 2004.05; 89 (4): 974-987. ( PubMed , DOI )

  4. Hoshino M, Tagawa K, Okuda T, Ueda H, Okazawa H : General transcriptional repression by polyglutamine disease proteins is not directly linked to the presence of inclusion bodies Biochem. Biophys. Res. Commun. 2004.01; 313 (1): 110-116. ( PubMed , DOI )

  1. Takuya Tamura, Ann-Shyn Chiang, Naomi Ito, Hsin-Ping Liu, Junjiro Horiuchi, Tim Tully, Minoru Saitoe: Aging specifically impairs amnesiac-dependent memory in Drosophila. Neuron. 2003.12; 40 (5): 1003-1011. ( PubMed )

  2. Hoshino M, Tagawa K, Okuda T, Murata M, Oyanagi K, Arai N, Mizutani T, Kanazawa I, Wanker EE, Okazawa H : Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein J. Neurochem. 2003.10; 87 (１): 257-267. ( PubMed , DOI )

  3. Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE: Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease. J Biol Chem. 2003.10; 278 (42): 41452-41461. ( PubMed , DOI )

  4. Okuda T, Hattori H, Takeuchi S, Shimizu J, Ueda H, Palvimo JJ, Kanazawa I, Kawano H, Nakagawa M, Okazawa H: PQBP-1 transgenic mice show a late-onset motor neuron disease-like phenotype. Hum Mol Genet. 2003.04; 12 (7): 711-725. ( PubMed , DOI )

  1. Enokido Y, Maruoka H, Hatanaka H, Kanazawa I, Okazawa H: PQBP-1 increases vulnerability to low potassium stress and represses transcription in primary cerebellar neurons Biochem. Biophys. Res. Commun. 2002.06; 294 (2): 268-271. ( PubMed , DOI )

  2. Okazawa H, Rich T, Chang A, Lin X, Waragai M, Kajikawa M, Enokido Y, Komuro A, Kato S, Shibata M, Hatanaka H, Mouradian MM, Sudol M, Kanazawa I: Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. Neuron. 2002.05; 34 (5): 701-713. ( PubMed , DOI )

  3. Ueda H, Goto J, Hashida H, Lin X, Oyanagi K, Kawano H, Zoghbi HY, Kanazawa I, Okazawa H: Enhanced SUMOylation in polyglutamine diseases. Biochem Biophys Res Commun. 2002.04; 293 (1): 307-313. ( PubMed , DOI )

  1. Shoji M, Iwakami N, Takeuchi S, Waragai M, Suzuki M, Kanazawa I, Lippa CF, Ono S, Okazawa H: JNK activation is associated with intracellular beta-amyloid accumulation. Brain Res Mol Brain Res. 2000.12; 85 (1-2): 221-233. ( PubMed , DOI )

  2. Waragai M, Junn E, Kajikawa M, Takeuchi S, Kanazawa I, Shibata M, Mouradian MM, Okazawa H: PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain. Biochem Biophys Res Commun. 2000.07; 273 (2): 592-595. ( PubMed , DOI )

  1. Takeuchi S, I mafuku I, Waragai M, Roth C, Kanazawa I, Buettner R, Mouradian MM, Okazawa H : AP-2beta represses D(1A) dopamine receptor gene transcription in neuro2a cells Molecular Brain Research. 1999.12; 74 (1-2): 208-216. ( PubMed , DOI )

  2. Imafuku I, Masaki T, Waragai M, Takeuchi S, Kawabata M, Hirai S, Ohno S, Nee LE, Lippa CF, Kanazawa I, Imagawa M, Okazawa H: Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J Cell Biol. 1999.10; 147 (1): 121-134. ( PubMed , DOI )

  3. Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H: PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival. Hum Mol Genet. 1999.06; 8 (6): 977-987. ( PubMed , DOI )

  1. Imafuku I, Waragai M, Takeuchi S, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H: Polar amino acid-rich sequences bind to polyglutamine tracts. Biochem Biophys Res Commun. 1998.12; 253 (1): 16-20. ( PubMed , DOI )

  2. Skala H, Porteu A, Thomas M, Szajnert MF, Okazawa H, Kahn A, Phan-Dinh-Tuy F: Upstream elements involved in vivo in activation of the brain-specific rat aldolase C gene. Role of binding sites for POU and winged helix proteins J Biol Chem. 1998.11; 273 (48): 31806-31814. ( PubMed , DOI )

  1. Waragai M, Imafuku I, Takeuchi S, Kanazawa I, Oyama F, Udagawa Y, Kawabata M, Okazawa H: Presenilin 1 binds to amyloid precursor protein directly. Biochem Biophys Res Commun. 1997.10; 239 (2): 480-482. ( PubMed , DOI )

  1. Okazawa H, Imafuku I, Minowa MT, Kanazawa I, Hamada H, Mouradian MM: Regulation of striatal D1A dopamine receptor gene transcription by Brn-4. Proc Natl Acad Sci USA. 1996.10; 93 (21): 11933-11938. ( PubMed , DOI )

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  3. Okazawa H, Shimizu J, Kamei M, Imafuku I, Hamada H, Kanazawa I: Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells. J Cell Biol. 1996.03; 132 (5): 955-968. ( PubMed , DOI )

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  1. Shimazaki T, Okazawa H, Fujii H, Ikeda M, Tamai K, McKay RD, Muramatsu M, Hamada H: Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential. EMBO J. 1993.12; 12 (12): 4489-4498. ( PubMed , DOI )

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  3. Okazawa H, Kamei M and Kanazawa I : Molecular cloning and expression of a novel truncated form of chicken trkC FEBS letters. 1993.08; 329 (1-2): 171-177. ( PubMed , DOI )

  4. Okazawa H, Nishiyama K, Kamei M, Washizaki S, Murayama S, Kwak S and Kanazawa I: Trk immunoreactivity at neuronal dendrite and cell body Biochem. Biophys. Res. Commun. 1993.07; 194 (2): 683-690. ( PubMed , DOI )

  1. Okazawa H, Murata M, Watanabe M, Kamei M and Kanazawa I : Dopaminergic stimulation up-regulates the in vivo expression of brain derived neurotrophic factor (BDNF) in the striatum FEBS letters . 1992.11; 313 (2): 138-142. ( PubMed , DOI )

  1. Okazawa H, Okamoto K, Ishino F, Ishino-Kaneko T, Takeda S, Toyoda Y, Muramatsu M, Hamada H: The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer. EMBO J. 1991.10; 10 (10): 2997-3005. ( PubMed , DOI )

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  1. 岡澤 均, 藤田 慶大: 3塩基リピート病1(Huntington‘ｓDisease) メディカル・サイエンス・ダイジェスト. 2022.09; 48 (10): 3-5.

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  3. 望月 秀樹, 青木 正志, 池中 建介, 井上 治久, 岩坪 威, 宇川 義一, 岡澤 均, 小野 賢二郎, 小野寺 理, 北川 一夫, 齊藤 祐子, 下畑 享良, 髙橋 良輔, 戸田 達史, 中原 仁, 松本 理器, 水澤 英洋, 三井 純, 村山 繁雄, 勝野 雅央, 日本神経学会将来構想委員会, 青木 吉嗣, 石浦 浩之, 和泉 唯信, 小池 春樹, 島田 斉, 髙橋 祐二, 徳田 隆彦, 中嶋 秀人, 波田野 琢, 三澤 園子, 渡辺 宏久: 脳神経疾患克服に向けた研究推進の提言2020，各論I（方法論別) 臨床神経学. 2022.06; 62 (6): 429-442. ( PubMed , DOI )

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  3. 田中 ひかり, 岡澤 均: 脊髄小脳失調症 Clinical Neuroscience . 2020.03; 38 (3): 365-368.

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  3. 田中 ひかり, 岡澤 均: 発達障害原因遺伝子PQBP1はアルツハイマー病態を制御する ケミカルバイオロジー. 2019.06; 12 (1): 12.

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  2. 藤田 慶大, 岡澤 均: 変性疾患におけるシナプス異常の新知見 細胞. 2018.12; 50 (14): 25-28.

  3. 藤田 慶大, 岡澤 均: 凝集前病態の解明に基づくアルツハイマー病の新規DMT 開発 アルツハイマー病 . 2018.08; 157-164.

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  2. 岡澤 均, 本木 和美: 1990年以後の神経栄養因子臨床試験からの知見と教訓 生体の科学 . 2016.08; 67 (4): 291-295.

  3. 岡澤 均: 「認知症・神経変性疾患の克服への挑戦」によせて 生体の科学. 2016.08; 67 (4): 280.

  4. 藤田 慶大, 岡澤 均: 変性疾患の共通分子病態 生体の科学. 2016.08; 67 (4): 309-313.

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  1. 田村 拓也, 岡澤 均: 神経変性疾患の細胞死とHippo pathway —神経変性はHippo pathwayで制御されるか？— 医学のあゆみ. 2014.11; 251 (5): 449-454.

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