Outline Research Education
Home page URL http://www.tmd.ac.jp/med/mphm/eYakuri.HTM


Title Name Researcher information
Assistant Professor SAEGUSA Hironao
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Many intriguing mysteries left in the issue of brain function like (1) learning and memory, (2) cognition and behavior, (3) generation of consciousness, (4) personality and mentality. On the other hand, in the modern-day world with a complicated human relations and prolonged life span, necessity of deeper understanding and development of the means to cure the numerous neurological disorders and pain is enormously increased.

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1. Regulation of Microglial function in Neuroinflammation/Neurodegenerative diseases
2. Regulation of Macrophage function in Inflammatory bowel disease and Rheumatoid arthritis
3. Energy metabolic imaging at single cell level of cancer stem cell/cancer cell using Bioluminescence and FRET and Imaging
4. Energy metabolic imaging at single cell level of neuron, microglia and astrocyte in the degenerative area of the mouse model of various neurodegenerative diseases
5. Neural mechanisms of pleasure and motivation in feeding
6. Molecular basis of Calcium channelopathy
7. Alteration of Neuron-Glia interaction in Neurological disorders
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Undergraduate course: Pharmacology course provides the principle of pharmacological basis of therapeutics. Several representative therapeutic drugs in each disease will be picked up and systematic lectures -from basic pharmacology to mechanism of action, drug metabolism, clinical application and side effects- will be provided. Students are projected to acquire self-learning skills during the course and expected to be ready for handling clinical cases by pharmacological means.
We consider education through the pharmacology lab work is important. Students are given opportunity to dissect out several tissues (heart, skeletal muscle, ileum and vas deferens) from living animals by themselves and test the effect of a number of drugs including specific agonist, antagonist and non-selective drugs. Lab work course is divided into two parts. In the first part, students were given several known drugs for testing the known effect on these tissues. In the second part, students are given two unknown drugs and requested to identify the name and concentration of each drug using the tissues they prepare by themselves.

Graduate course: During the first couple of months, students are requested to acquire basic techniques of biochemistry, molecular biology, pharmacology and electrophysiology that are routinely used in our laboratory. Then students will be given a small project to do using the techniques they have learned during the initial training. Students are also required to read relevant scientific papers and conduct seminar style lectures to other lab members monthly. After completion of the initial phase, students start their own project under the supervision of the faculties in the lab.
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