Pharmacokinetics and Pharmacodynamics

36  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Miuzno S., Noda T., Mogushi K., Hase T., Iida Y., Takeuchi K., Ishiwata Y., Uchida S., Nagata M.: Prediction of vancomycin-associated nephrotoxicity based on the area under the concentration-time curve of vancomycin: a machine learning analysis Biological and Pharmaceutical Bulletin. 2024.11; 47 (11): 1946-1952. ( DOI )

  2. Noda T, Mizuno S, Mogushi K, Hase T, Iida Y, Takeuchi K, Ishiwata Y, Nagata M: Development of a predictive model for nephrotoxicity during tacrolimus treatment using machine learning methods. British journal of clinical pharmacology. 2024.03; 90 (3): 675-683. ( PubMed , DOI )

  1. Yokoyama K, Yakuo T, Mamada M, Nagata M: Olanzapine Overdose in a Two-Year-Old Girl Resulting in Both High Serum and Plasma Levels. Cureus. 2023.08; 15 (8): e43002. ( PubMed , DOI )

  2. Kaneko S, Asahina Y, Nakagawa M, Murakawa M, Miyazaki Y, Asakage T, Fukuda S, Namiki T, Kano Y, Nagata M, Tsuchiya J, Miyoshi M, Kitahata-Kawai F, Nitta S, Itsui Y, Kakinuma S, Okamoto R: Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors. Hepatology research : the official journal of the Japan Society of Hepatology. 2023.01; 53 (5): 450-459. ( PubMed , DOI )

  1. Xue B, Ishiwata Y, Kawano Y, Takahashi H, Negishi K, Aoyama T, Nagata M: Paliperidone-Induced Acute Hyperglycemia Is Caused by Adrenaline Secretion via the Activation of Hypothalamic AMP-Activated Protein Kinase. Biological & pharmaceutical bulletin. 2022.11; 45 (11): 1669-1677. ( PubMed , DOI )

  2. Takagi M, Ogawa C, Iehara T, Aoki-Nogami Y, Ishibashi E, Imai M, Kimura T, Nagata M, Yasuhara M, Masutani M, Yoshimura K, Tomizawa D, Ogawa A, Yonemori K, Morishita A, Miyamoto S, Takita J, Kihara T, Nobori K, Hasebe K, Miya F, Ikeda S, Shioda Y, Matsumoto K, Fujimura J, Mizutani S, Morio T, Hosoi H, Koike R: First phase 1 clinical study of olaparib in pediatric patients with refractory solid tumors. Cancer. 2022.05; 128 (15): 2949-2957. ( PubMed , DOI )

  3. Kawano Y, Obana M, Nagata M, Mano Y, Katsuyama M, Yamamoto Y, Maeda-Minami A, Negishi K, Takagi M, Shimada S, Aoyama T: The antiplatelet effect of mirtazapine is mediated by co-blocking 5-HT#D2A#DR and α#D2#DR-adrenergic receptors on platelets: An in vitro human plasma-based study. European journal of pharmacology. 2022.02; 917 174640. ( PubMed , DOI )

  1. Kawasumi K, Kawano Y, Kujirai A, Mano Y, Matsui R, Maeda-Minami A, Yamamoto Y, Negishi K, Shimada S, Yamaguchi M, Nagata M, Aoyama T: Risk Factors Associated With Unplanned Acute Care in Outpatient Chemotherapy With Oral Anticancer Drugs as Monotherapy or Combination Therapy With Injectable Anticancer Drugs. Anticancer research. 2021.11; 41 (11): 5827-5834. ( PubMed , DOI )

  2. Ishiwata Y, Nagata M, Kiuchi S, Ippongi C, Takeda H, Takahashi H: Intravenous Infusion of Fentanyl Has No Effect on Blood Concentration of Tacrolimus In Patients Receiving Hematopoietic Stem Cell Transplantation. Therapeutic drug monitoring. 2021.10; 43 (5): 688-691. ( PubMed , DOI )

  3. Enomoto A, Mano Y, Kawano Y, Nishikawa T, Aoyama T, Sasaki Y, Nagata M, Takahashi H: Comparison of the Safety and Effectiveness of Four Direct Oral Anticoagulants in Japanese Patients with Nonvalvular Atrial Fibrillation Using Real-World Data. Biological and Pharmaceutical Bulletin. 2021.09; 44 (9): 1294-1302. ( DOI )

  4. Kawano Y, Nagata M, Nakamura S, Akagi Y, Suzuki T, Tsukada E, Hoshiko M, Kujirai A, Nakamatsu S, Nishikawa T, Enomoto A, Negishi K, Shimada S, Aoyama T, Mano Y: Comprehensive Exploration of Medications That Affect the Bleeding Risk of Oral Anticoagulant Users. Biological & pharmaceutical bulletin. 2021.05; 44 (5): 611-619. ( PubMed , DOI )

  5. Asada M, Nagata M, Mizuno T, Uchida T, Takahashi H, Makita K, Arai H, Kijima S, Echizen H, Yasuhara M: Population pharmacokinetics of cefazolin before, during and after cardiopulmonary bypass in adult patients undergoing cardiac surgery. European journal of clinical pharmacology. 2021.04; 77 (5): 735-745. ( PubMed , DOI )

  6. Kawano Y, Katsuyama M, Nagata M, Obana M, Nakamatsu S, Mori A, Sakamoto N, Mano Y, Negishi K, Shimada S, Aoyama T: Antiplatelet Effect of Mirtazapine via Co-blocking of the 5-HT#D2A#DR and α#D2#DR-Adrenergic Receptors on Platelets. Biological & pharmaceutical bulletin. 2021.02; 44 (2): 238-244. ( PubMed , DOI )

  7. Yanagie H, Fujino T, Yanagawa M, Terao T, Imagawa T, Fujihara M, Morishita Y, Mizumachi R, Murata Y, Dewi N, Ono Y, Ikushima I, Seguchi K, Nagata M, Nonaka Y, Furuya Y, Hisa T, Nagasaki T, Arimori K, Nakashima T, Sugihara T, Kakimi K, Ono M, Nakajima J, Eriguchi M, Higashi S, Takahashi H: Tumor Growth Suppression With Novel Intra-arterial Chemotherapy Using Epirubicin-entrapped Water-in-oil-in-water Emulsion #IIn Vivo#IR. In vivo. 2021.01; 35 (1): 239-248. ( PubMed , DOI )

  1. Suzuki S, Naito S, Numasawa Y, Asada M, Shoji N, Zeniya M, Takahashi D, Sato H, Iimori S, Nomura N, Sohara E, Okado T, Ishiwata Y, Nagata M, Rai T, Yokota T, Uchida S: Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient. Internal medicine (Tokyo, Japan). 2019.02; ( PubMed , DOI )

  2. Masatoshi Takagi, Chitose Ogawa, Yuki Aoki-Nogami, Tomoko Iehara, Eri Ishibashi, Minoru Imai, Tetsuro Kihara, Kiyoshi Nobori, Kazuhisa Hasebe, Shuki Mizutani, Toshimi Kimura, Masashi Nagata, Masato Yasuhara, Kenichi Yoshimura, Pariko Yorozu, Hajime Hosoi, Ryuji Koike: Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: study protocol. BMC Pediatr. 2019.01; 19 (1): 31. ( PubMed , DOI )

  1. Asada M, Nagata M, Mizuno T, Uchida T, Kurashima N, Takahashi H, Makita K, Arai H, Echizen H, Yasuhara M: Effects of cardiopulmonary bypass on the disposition of cefazolin in patients undergoing cardiothoracic surgery. Pharmacology research & perspectives. 2018.12; 6 (6): e00440. ( PubMed , DOI )

  2. Masashi Nagata, Yuri Kimura, Yasuyoshi Ishiwata, Hiromitsu Takahashi, Masato Yasuhara: Clozapine-Induced Acute Hyperglycemia Is Accompanied with Elevated Serum Concentrations of Adrenaline and Glucagon in Rats. Biol. Pharm. Bull.. 2018.08; 41 (8): 1286-1290. ( PubMed , DOI )

  3. Yasuyoshi Ishiwata, Masashi Nagata, Kohta Tsuge, Hiromitsu Takahashi, Sayo Suzuki, Kohsuke Imai, Masatoshi Takagi, Hirokazu Kanegane, Tomohiro Morio, Masato Yasuhara: Population Pharmacokinetics of Intravenous Busulfan in Japanese Pediatric Patients With Primary Immunodeficiency Diseases. J Clin Pharmacol. 2018.03; 58 (3): 327-331. ( PubMed , DOI )

  1. Yasuyoshi Ishiwata, Masashi Nagata, Takafumi Arai, Misato Makiishi, Maho Yoshikawa, Hiromitsu Takahashi, Hitoshi Kohsaka, Masato Yasuhara: Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study. Ther Drug Monit. 2016.12; 38 (6): 717-721. ( PubMed , DOI )

  2. Masashi Nagata, Mayumi Nakajima, Yasuyoshi Ishiwata, Yutaka Takahashi, Hiromitsu Takahashi, Kenichi Negishi, Masato Yasuhara: Mechanism Underlying Induction of Hyperglycemia in Rats by Single Administration of Olanzapine. Biol. Pharm. Bull.. 2016.05; 39 (5): 754-761. ( PubMed , DOI )

  1. Masashi Nagata, Yasuyoshi Ishiwata, Yutaka Takahashi, Hiromitsu Takahashi, Kazutaka Saito, Yasuhisa Fujii, Kazunori Kihara, Masato Yasuhara: Pharmacokinetic-pharmacodynamic analysis of sunitinib-induced thrombocytopenia in Japanese patients with renal cell carcinoma. Biol. Pharm. Bull.. 2015.03; 38 (3): 402-410. ( PubMed , DOI )

  1. 徳永 仁, 松尾 徳子, 高村 徳人, 杉本 龍星, 岡崎 愛, 永井 和正, 青木 傳, 緒方 賢次, 瀬戸口 奈央, 吉田 裕樹, 永田 将司, 岸本 修一, 福島 昭二, 池田 理, 西尾 豊隆, 川井 恵一, 有森 和彦: 蛋白結合阻害を利用したcisplatin肝動注療法に関する研究　ラットにおけるL-cysteine併用時におけるcisplatinの体内動態と抗腫瘍効果 九州保健福祉大学研究紀要. 2014.03; (15): 91-97. ( ichushi )

  1. Ishiwata Y, Takahashi Y, Nagata M, Yasuhara M: Effects of moxifloxacin on serum glucose concentrations in rats. Biol Pharm Bull. 2013; 36 (4): 686-690. ( PubMed )

  1. Arino T, Karakawa S, Ishiwata Y, Nagata M, Yasuhara M: Effect of cimetidine on pentamidine induced hyperglycemia in rats. Eur J Pharmacol. 2012.10; 693 (1-3): 72-79. ( PubMed , DOI )

  2. Kawano Y, Nagata M, Kohno T, Ichimiya A, Iwakiri T, Okumura M, Arimori K: Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells. Biol Pharm Bull. 2012; 35 (3): 400-407. ( PubMed )

  1. Nagata M, Hidaka Y, Hatakeyama K, Kawano Y, Iwakiri T, Okumura M, Arimori K: Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats. Biopharm Drug Dispos. 2011.03; 32 (2): 126-130. ( PubMed , DOI )

  1. Nagata M, Hidaka Y, Hidaka M, Kawano Y, Iwakiri T, Okumura M, Arimori K: Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats. J Pharm Pharmacol. 2010.05; 62 (5): 598-603. ( PubMed , DOI )

  2. Tokunaga J., Matsuo Y., Takamura N., Ogata K., Yoshida H., Nagata M., Kishimoto S., Fukushima S., Ikeda O., Nishio T., Kawai K., Arimori K.: Inhibition of cicplatin protein binding: a possible therapeutic advantage. J. Appl. Ther. Res.. 2010; 7 (4): 127-132.

  1. Nagata M, Matsuo Y, Hidaka M, Kawano Y, Okumura M, Tokunaga J, Takamura N, Arimori K: Effect of acute hepatic failure on epirubicin pharmacokinetics after intrahepatic arterial injection in rats. Biol Pharm Bull. 2008.03; 31 (3): 493-496. ( PubMed )

  2. Hidaka M, Nagata M, Kawano Y, Sekiya H, Kai H, Yamasaki K, Okumura M, Arimori K: Inhibitory effects of fruit juices on cytochrome P450 2C9 activity in vitro. Biosci Biotechnol Biochem. 2008.02; 72 (2): 406-411. ( PubMed )

  3. Iwakiri T, Okumura M, Matsunaga N, Ichihara E, Shiotsuki S, Nagata M, Kumagai Y, Kai H, Arimori K: Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes. Eur J Pharmacol. 2008.02; 580 (1-2): 19-26. ( PubMed , DOI )

  1. Nagata M, Hidaka M, Sekiya H, Kawano Y, Yamasaki K, Okumura M, Arimori K: Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos. 2007.02; 35 (2): 302-305. ( PubMed , DOI )

  1. Ishiwata Y, Nagata M, Yasuhara M: Effect of isoniazid on the pharmacodynamics of cefazolin-induced seizures in rats. Drug Metab Pharmacokinet. 2005.04; 20 (2): 117-120. ( PubMed )

  1. Nagata M, Fujichika T, Yasuhara M: Effect of experimental renal failure and hypotonic hyponatremia on the pharmacodynamics of cefazolin-induced seizures in rats. Pharm Res. 2003.06; 20 (6): 937-942. ( PubMed )

  1. Nagata M, Yasuhara M: Effect of experimental renal failure on the pharmacodynamics of cefoselis-induced seizures in rats. Biol Pharm Bull. 2001.09; 24 (9): 1049-1052. ( PubMed )

To the head of this page.▲