1. Moeka Nomura, Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura: Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study. Biochem Biophys Res Commun. 2023.12; 695 149438. ( PubMed , DOI )

  2. Kana Unuma, Shuheng Wen, Toshihiko Aki, Koichi Uemura: Ectopic myogenesis and fibrosis accompany adipogenesis during thymic involution induced by repeated cocaine administration. Biochem Biophys Res Commun. 2023.12; 686 149201. ( PubMed , DOI )

  3. Shuheng Wen, Kana Unuma, Ryoichi Hanazawa, Shutaro Nagano, Ryo Watanabe, Akihiro Hirakawa, Koichi Uemura: Alcohol and toxicological factors influencing fatal falls from height in the Greater Tokyo Area: a retrospective study. Int J Legal Med. 2023.11; ( PubMed , DOI )

  4. Shuheng Wen, Kana Unuma, Motoki Inaji, Yohsuke Makino, Shutaro Nagano, Kazuki Harada, Nobutaka Arai, Koichi Uemura: Case report: Fatal ischemic stroke induced by unruptured traumatic intracranial vertebral artery dissection. Front Neurol. 2023.09; 14 1202698. ( PubMed , DOI )

  5. Toshihiko Aki, Hiroki Tanaka, Takeshi Funakoshi, Kana Unuma, Koichi Uemura: Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells. Biochem Biophys Res Commun. 2023.07; 676 66-72. ( PubMed , DOI )

  6. Shuheng Wen, Kana Unuma, Koichi Uemura, Kazuki Harada: Revisiting the canonical definition of heat hematoma: A rare case of postmortem subdural heat hematoma. J Forensic Leg Med. 2023.07; 98 102563. ( PubMed , DOI )

  7. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura: Cocaine induces vascular smooth muscle cells proliferation via DRP1-mediated mitochondrial fission and PI3K/HIF-1α signaling. Biochem Biophys Res Commun. 2023.07; 676 30-35. ( PubMed , DOI )

  8. Kana Unuma, Hiroyuki Sato, Shuheng Wen, Yohsuke Makino, Akihiro Hirakawa, Koichi Uemura: The proportion of false-positives in positive Seratec® prostate-specific antigen SemiQuant test results in postmortem screening for seminal fluid. Leg Med (Tokyo). 2023.05; 62 102243. ( PubMed , DOI )

  9. Toshihiko Aki, Mitsuki Kukita, Mao Takata, Takeshi Funakoshi, Kana Unuma, Koichi Uemura: Induction of filamin-C and its involvement in the regulation of cellular senescence and apoptosis in Huh-7 hepatoma cells during arsenic trioxide exposure. Biochem Biophys Res Commun. 2023.04; 651 92-97. ( PubMed , DOI )

  10. Miyu Komatsu, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura: Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2023.03; 378 39-50. ( PubMed , DOI )

  11. Unuma K, Tomomasa D, Noma K, Yamamoto K, Matsuyama TA, Makino Y, Hijikata A, Wen S, Ogata T, Okamoto N, Okada S, Ohashi K, Uemura K, Kanegane H: Case Report: Molecular autopsy underlie COVID-19-associated sudden, unexplained child mortality. Frontiers in immunology. 2023; 14 1121059. ( PubMed , DOI )

  1. Wen Shuheng, Unuma Kana, Watanabe Ryo, Uemura Koichi, Harada Kazuki: 見逃された外傷性頭蓋外椎骨動脈仮性動脈瘤による致死的なくも膜下出血　診断困難な高度外傷症例における法医学的評価(Fatal Subarachnoid Hemorrhage Due to Neglected Traumatic Extracranial Vertebral Artery Pseudoaneurysm: Forensic Assessment in a Difficult to Diagnosed Highly Decomposed Case) 法医学の実際と研究. 2022.11; (65): 161-166. ( ichushi )

  2. Maiko Toya, Saki Minegishi, Hajime Utsuno, Jun Ohta, Shuuji Namiki, Kana Unuma, Koichi Uemura, Koichi Sakurada: Forensic Characteristics of Physical Elder Abuse and Current Status and Issues of Collaboration between Forensic Medicine Departments and Related Institutions in Japan. Int J Environ Res Public Health. 2022.11; 19 (22): ( PubMed , DOI )

  3. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura: Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration. Int J Mol Sci. 2022.10; 23 (19): ( PubMed , DOI )

  4. Makino Yohsuke, Unuma Kana, Nolte Kurt B., Adolphi Natalie L.: Accuracy of forensic pathologists in incorporating post-mortem CT (PMCT) in forensic death investigation JOURNAL OF FORENSIC SCIENCES. 2022.09; 67 (6): 2351-2359. ( PubMed , DOI )

  5. Wen Shuheng, Unuma Kana, Makino Yohsuke, Mori Hiroki, Uemura Koichi: Fatal consequence after MiraDry treatment: Necrotizing fasciitis complicated with streptococcal toxic shock syndrome(和訳中) Legal Medicine. 2022.09; 58 1-4. ( ichushi )

  6. Wen Shuheng, Unuma Kana, Uemura Koichi: Two fatal cases due to inadvertent discharge of carbon dioxide fire suppressant: Intoxication or asphyxiation? JOURNAL OF FORENSIC AND LEGAL MEDICINE. 2022.08; 90 102390. ( PubMed , DOI )

  7. Shuheng Wen, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura: Role of Mitochondrial Dynamics in Cocaine's Neurotoxicity. Int J Mol Sci. 2022.05; 23 (10): ( PubMed , DOI )

  8. Shuheng Wen, Kana Unuma, Yohsuke Makino, Hiroki Mori, Koichi Uemura: Fatal consequence after MiraDry® treatment: Necrotizing fasciitis complicated with streptococcal toxic shock syndrome. Leg Med (Tokyo). 2022.05; 58 102095. ( PubMed , DOI )

  9. Saki Minegishi, Hajime Utsuno, Jun Ohta, Shuuji Namiki, Maiko Toya, Nozomi Sumi, Kana Unuma, Hisako Saitoh, Hirotaro Iwase, Koichi Uemura, Koichi Sakurada: Sixty-eight cases of postmortem pink teeth observed in dental autopsies of unidentified cadavers Journal of Forensic Sciences. 2022.02; ( DOI )

  10. Toshihiko Aki, Kana Unuma, Koichi Uemura: The Role of Peroxiredoxins in the Regulation of Sepsis. Antioxidants (Basel). 2022.01; 11 (1): ( PubMed , DOI )

  11. Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura: Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells. Apoptosis. 2022.01; ( PubMed , DOI )

  12. Unuma K, Kaga H, Funakoshi T, Nomura M, Aki T, Uemura K: Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis. PloS one. 2022; 17 (11): e0277032. ( PubMed , DOI )

  13. Sho Aoki, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura: Aggregation-prone A53T mutant of α-synuclein exaggerates methamphetamine neurotoxicity in SH-SY5Y cells: Protective role of cellular cholesterol. Toxicol Rep. 2022; 9 2020-2029. ( PubMed , DOI )

  1. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura: Altered cardiac mitochondrial dynamics and biogenesis in rat after short-term cocaine administration. Sci Rep. 2021.12; 11 (1): 24129. ( PubMed , DOI )

  2. Zhaoyang Tang, Shuheng Wen, Taoming Liu, Aijiao Yu, Yuanhong Li: Comparative study of treatment for striae alba stage striae gravidarum: 1565-nm non-ablative fractional laser versus fractional microneedle radiofrequency. Lasers Med Sci. 2021.12; 36 (9): 1823-1830. ( PubMed , DOI )

  3. Shuheng Wen, Kana Unuma, Ryo Watanabe, Yohsuke Makino, Koichi Uemura: Forensic evaluation of fatal-suffocating retropharyngeal haematoma secondary to cervical fractures: Report of two cases. J Forensic Leg Med. 2021.11; 85 102274. ( PubMed , DOI )

  4. Toshihiko Aki, Koichi Uemura: Cell Death and Survival Pathways Involving ATM Protein Kinase. Genes (Basel). 2021.10; 12 (10): ( PubMed , DOI )

  5. Wen Shuheng, Unuma Kana, Chinuki Yuko, Hikino Hajime, Uemura Koichi: Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report (vol 51, 101878, 2021) LEGAL MEDICINE. 2021.09; 52 101936. ( PubMed , DOI )

  6. Wen Shuheng, Unuma Kana, Chinuki Yuko, Hikino Hajime, Uemura Koichi: セツキシマブ初回投与後のα-Gal症候群による致死的アナフィラキシー　法医学的事例の初報告例(Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report) Legal Medicine. 2021.07; 51 1-4. ( ichushi )

  7. Momoka Ota, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura: Oxcarbazepine induces mitotic catastrophe and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2021.07; 350 240-248. ( PubMed , DOI )

  8. Wen Shuheng, Unuma Kana, Chinuki Yuko, Hikino Hajime, Uemura Koichi: Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report LEGAL MEDICINE. 2021.07; 51 101878. ( PubMed , DOI )

  9. Kana Unuma, Yohsuke Makino, Kouhei Yamamoto, Shinya Hattori, Nobutaka Arai, Kentaro Sakai, Masanobu Kitagawa, Koichi Uemura, Hirokazu Kanegane: Fatal intracranial hemorrhage due to infantile acute lymphoblastic leukemia mimicking abusive head trauma. J Forensic Sci. 2021.07; 66 (6): 2504-2510. ( PubMed , DOI )

  10. Atsushi Yamada, Kana Unuma, Nobutaka Arai, Osamu Kitamura, Koichi Uemura: Inappropriate diet and fatal malnutrition in a 10-year-old child fed only infant formula throughout life: Novel pathological diagnostic criterion for starvation via lipophagy. Forensic Sci Int. 2021.07; 325 110896. ( PubMed , DOI )

  11. Shuheng Wen, Kana Unuma, Ryo Watanabe, Koichi Uemura: Diagnosis by forensic autopsy of cannula malposition resulting in fatal tension pneumothorax after attempted percutaneous tracheostomy: A short communication. J Forensic Leg Med. 2021.05; 81 102177. ( PubMed , DOI )

  12. Tatsuya Norii, Yohsuke Makino, Kana Unuma, Natalie L Adolphi, Danielle Albright, David P Sklar, Cameron Crandall, Darren Braude: CT imaging of extraglottic airway device-pictorial review. Emerg Radiol. 2021.02; 28 (3): 665-673. ( PubMed , DOI )

  13. Tatsuya Norii, Yohsuke Makino, Kana Unuma, Gary M Hatch, Natalie L Adolphi, Sarah Dallo, Danielle Albright, David P Sklar, Darren Braude: Extraglottic Airway Device Misplacement: A Novel Classification System and Findings in Postmortem Computed Tomography. Ann Emerg Med. 2021.01; 77 (3): 285-295. ( PubMed , DOI )

  14. Moeka Nomura, Kana Unuma, Toshihiko Aki, Koichi Uemura: Sustained splenic contraction after daily cocaine administration in rats. PLoS One. 2021; 16 (6): e0252853. ( PubMed , DOI )

  15. Tatsuhiko Murata, Kanako Noritake, Toshihiko Aki, Koichi Uemura: Possible roles of AMPK and macropinocytosis in the defense responses against Δ 9-THC toxicity on HL-1 cardiomyocytes Toxicol Rep. 2021; 8 980-987. ( PubMed , DOI )

  1. Nagai M, Sakurada K, Imaizumi K, Ogawa Y, Uo M, Funakoshi T, Uemura K: Evaluation of Parameters for Estimating the Postmortem Interval of Skeletal Remains Using Bovine Femurs: A Pilot Study. Diagnostics. 2020.12; 10 (12): ( PubMed , DOI )

  2. Kitayama Tetsushi, Fukagawa Takashi, Watahiki Haruhiko, Mita Yusuke, Fujii Koji, Unuma Kana, Sakurada Koichi, Uemura Koichi, Sekiguchi Kazumasa, Mizuno Natsuko: 口腔粘膜細胞スワブと被災者の身元確認試料に対するRapid DNAシステムの評価(Evaluation of Rapid DNA system for buccal swab and disaster victim identification samples) Legal Medicine. 2020.09; 46 1-8. ( ichushi )

  3. Kana Unuma, Ryo Watanabe, Naho Hirayama, Koichi Uemura: Autopsy Identification of Viable Mycobacterium Tuberculosis in the Lungs of a Markedly Decomposed Body. J. Forensic Sci.. 2020.08; 65 (6): 2194-2197. ( PubMed , DOI )

  4. Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura: Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells. Sci Rep. 2020.06; 10 (1): 10581. ( PubMed , DOI )

  5. Kitayama T, Fukagawa T, Watahiki H, Mita Y, Fujii K, Unuma K, Sakurada K, Uemura K, Sekiguchi K, Mizuno N: Evaluation of Rapid DNA system for buccal swab and disaster victim identification samples. Legal medicine (Tokyo, Japan). 2020.05; 46 101713. ( PubMed , DOI )

  6. Joji Kunihiro, Hiroaki Nabeka, Hiroyuki Wakisaka, Kana Unuma, Md Sakirul Islam Khan, Tetsuya Shimokawa, Farzana Islam, Takuya Doihara, Kimiko Yamamiya, Shouichiro Saito, Fumihiko Hamada, Seiji Matsuda: Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection. PLoS One. 2020; 15 (12): e0241315. ( PubMed , DOI )

  7. Shuheng Wen, Toshihiko Aki, Kana Unuma, Koichi Uemura: Chemically Induced Models of Parkinson's Disease: History and Perspectives for the Involvement of Ferroptosis. Front Cell Neurosci. 2020; 14 581191. ( PubMed , DOI )

  1. Kana Unuma, Ayaka Yoshikawa, Toshihiko Aki, Koichi Uemura: Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137. J Toxicol Pathol. 2019.10; 32 (4): 305-310. ( PubMed , DOI )

  2. Unuma Kana, Yoshikawa Ayaka, Aki Toshihiko, Uemura Koichi: 敗血症モデルラットにおける血中ペルオキシレドキシン4の上昇は肝細胞からの分泌と関連し、GYY4137によって軽減する(Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137) Journal of Toxicologic Pathology. 2019.10; 32 (4): 305-310. ( ichushi )

  3. Miao Zhang, Meng-Zhou Zhang, Shu-Heng Wen, Ying-Fu Sun, Peng-Hao Jiang, Lin-Lin Wang, Rui Zhao, Chang-Liang Wang, Shu-Kun Jiang, Da-Wei Guan: The distribution and time-dependent expression of HIPK2 during the repair of contused skeletal muscle in mice. Histol Histopathol. 2019.07; 34 (7): 745-753. ( PubMed , DOI )

  4. Wenwen Dong, Yingfu Sun, Hao Cheng, Bei Yang, Linlin Wang, Zhenfei Jiang, Bingxuan Li, Shuheng Wen, Xiangshen Guo, Dawei Guan, Rui Zhao: Dynamic cell type-specific expression of Nrf2 after traumatic brain injury in mice. Eur J Neurosci. 2019.07; 50 (2): 1981-1993. ( PubMed , DOI )

  5. Kana Unuma, Yohsuke Makino, Yoshiyuki Sasaki, Hirotaro Iwase, Koichi Uemura.: Presepsin: A potential superior diagnostic biomarker for the postmortem differentiation of sepsis based on the Sepsis-3 criteria Forensic Science International. 2019.06; 299 17-20. ( PubMed , DOI )

  6. Kana Unuma, Toshihiko Aki, Ayaka Yamashita, Ayaka Yoshikawa, Koichi Uemura: Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats. J Toxicol Sci. 2019; 44 (2): 107-112. ( PubMed , DOI )

  7. Unuma Kana, Aki Toshihiko, Yamashita Ayaka, Yoshikawa Ayaka, Uemura Koichi: Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats JOURNAL OF TOXICOLOGICAL SCIENCES. 2019; 44 (1-3): 107-112.

  8. Takeshi Funakoshi, Mako Furukawa, Toshihiko Aki, Koichi Uemura: Repeated exposure of cocaine alters mitochondrial dynamics in mouse neuroblastoma Neuro2a. Neurotoxicology. 2019; 75 70-77. ( PubMed , DOI )

  9. Unuma Kana, Aki Toshihiko, Yamashita Ayaka, Yoshikawa Ayaka, Uemura Koichi: 硫化水素ドナーであるNaHSは、ラットの気道分泌物増加を伴う気管支炎を誘発する(Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats) The Journal of Toxicological Sciences. 2019; 44 (1-3): 107-112. ( ichushi )

  10. Toshihiko Aki, Kana Unuma, Kanako Noritake, Naho Hirayama, Takeshi Funakoshi, Koichi Uemura: Formation of high molecular weight p62 by CORM-3. PLoS ONE. 2019; 14 (1): e0210474. ( PubMed , DOI )

  1. Hirayama Naho, Aki Toshihiko, Funakoshi Takeshi, Noritake Kanako, Unuma Kana, Uemura Koichi: パラコートに曝露したヒト神経細胞の壊死(Necrosis in human neuronal cells exposed to paraquat) The Journal of Toxicological Sciences. 2018.03; 43 (1-3): 193-202. ( ichushi )

  2. Naho Hirayama, Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura: Necrosis in human neuronal cells exposed to paraquat. J Toxicol Sci. 2018.03; 43 (3): 193-202. ( PubMed , DOI )

  3. Toshihiko Aki, Kana Unuma, Kanako Noritake, Hatsumi Kurahashi, Takeshi Funakoshi, Koichi Uemura: Interaction of carbon monoxide-releasing ruthenium carbonyl CORM-3 with plasma fibronectin. Toxicol In Vitro. 2018.03; 50 201-209. ( PubMed , DOI )

  4. Kana Unuma, Toshihiko Aki, Suguru Nagano, Ryo Watanabe, Koichi Uemura: The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. Biochem. Biophys. Res. Commun.. 2018.01; 495 (2): 1668-1674. ( PubMed , DOI )

  1. Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura.: Modes of Chemically Induced Cell Death. Comprehensive Toxicology 3rd ed Volume 1 (General subjects). 2017.12;

  2. Toshihiko Aki, Kana Unuma, and Koichi Uemura: Emerging roles of mitochondria and autophagy in liver injury during sepsis. Cell Stress. 2017.11; 1 (2): 79-89.

  3. Watanabe Ryo, Unuma Kana, Noritake Kanako, Funakoshi Takeshi, Aki Toshihiko, Uemura Koichi: 三酸化ヒ素投与ラットの脳におけるDNA損傷反応の毛細血管拡張性運動失調症およびrad3関連(ATR)-前骨髄球性白血病蛋白質(PML)経路(Ataxia telangiectasia and rad3 related(ATR)-promyelocytic leukemia protein(PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide) Journal of Toxicologic Pathology. 2017.10; 30 (4): 333-337. ( ichushi )

  4. Kanako Noritake, Toshihiko Aki, Moe Kimura, Takeshi Funakoshi, Kana Unuma, Koichi Uemura: Restoration of YAP activation rescues HL-1 cardiomyocytes from apoptotic death by ethanol. J Toxicol Sci. 2017.10; 42 (5): 545-551. ( PubMed , DOI )

  5. Ryo Watanabe, Kana Unuma, Kanako Noritake, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura.: Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide. J. Toxicologic Pathology. 2017.07; 30 333-337.

  6. Kana Unuma, Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura: A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung. Biochem. Biophys. Res. Commun.. 2017.06; 487 (3): 748-754. ( PubMed , DOI )

  1. Takeshi Funakoshi, Toshihiko Aki, Masateru Tajiri, Kana Unuma, Koichi Uemura: Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation. J. Biol. Chem.. 2016.11; 291 (48): 25050-25065. ( PubMed , DOI )

  2. Watanabe M, Unuma K, Makino Y, Komatsu A, Yamada A, Nagai H, Uemura K: An Autopsy Case of Asphyxia Caused by Uncontrolled Hemorrhage Following Transbronchial Lung Biopsy J Clin Respir Dis Care. 2016.07; ( DOI )

  3. Haruka Kimura-Kojima, Kana Unuma, Takeshi Funakoshi, Chizuru Kato, Ayumi Komatsu, Toshihiko Aki, Koichi Uemura: Increased MFG-E8 expression and its implications in the vascular pathophysiology of cocaine abuse. J Toxicol Pathol. 2016.04; 29 (2): 131-138. ( PubMed , DOI )

  4. Yusuke Fujii, Takeshi Funakoshi, Kana Unuma, Kanako Noritake, Toshihiko Aki, Koichi Uemura: Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation. J Toxicol Sci. 2016; 41 (5): 645-654. ( PubMed , DOI )

  1. 則竹 香菜子, 秋 利彦, 上村 公一: アルコールによる心筋障害とオートファジーの役割 月刊「細胞」. 2015.12; 47 (14): 44-47.

  2. Kyoko Uchida, Kana Unuma, Koichi Uemura: A fatality in a child with severe fatty liver due to n-butane and isopentane poisoning resulting from long-term inhalation of an antiperspirant aerosol. Forensic Sci Med Pathol. 2015.12; 11 (4): 631-632. ( PubMed , DOI )

  3. Ryohei Kuroda, Kaori Shintani-Ishida, Kana Unuma, Ken-ichi Yoshida: Immobilization Stress With α2-Adrenergic Stimulation Induces Regional and Transient Reduction of Cardiac Contraction Through Gi Coupling in Rats. Int Heart J. 2015.09; 56 (5): 537-543. ( PubMed , DOI )

  4. Mayumi Watanabe, Kana Unuma, Yohsuke Makino, Kanako Noritake, Atsushi Yamada, Hirotaro Iwase, Koichi Uemura: An Autopsy Case of Acute Massive Hematochezia Caused by Superior Mesenteric Vein Thrombosis: A First Report in Forensic Medicine. J. Forensic Sci.. 2015.08; ( PubMed , DOI )

  5. Toshihiko Aki, Takeshi Funakoshi, Koichi Uemura: Regulated necrosis and its implications in toxicology. Toxicology. 2015.07; 333 118-126. ( PubMed , DOI )

  6. Mayumi Watanabe, Kana Unuma, Yusuke Fujii, Kanako Noritake, Koichi Uemura: An autopsy case of vagus nerve stimulation following acupuncture. Leg Med (Tokyo). 2015.03; 17 (2): 120-122. ( PubMed , DOI )

  7. Sayuri Okawa, Kana Unuma, Atsushi Yamada, Toshihiko Aki, Koichi Uemura: Lipopolysaccharide induces expression of collagen VI in the rat lung. J Toxicol Pathol. 2015.01; 28 (1): 37-41. ( PubMed , DOI )

  8. Kanako Noritake, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura: Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS ONE. 2015; 10 (8): e0136952. ( PubMed , DOI )

  9. Kana Unuma, Toshihiko Aki, Takeshi Funakoshi, Kyoko Hashimoto, Koichi Uemura: Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy. Autophagy. 2015; 11 (9): 1520-1536. ( PubMed , DOI )

  10. Atsushi Yamada, Toshihiko Aki, Kana Unuma, Takeshi Funakoshi, Koichi Uemura: Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells. PLoS ONE. 2015; 10 (3): e0120192. ( PubMed , DOI )

  1. Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K: Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis. Toxicology. 2014.08; 322 43-50. ( PubMed , DOI )

  2. Uchida K, Unuma K, Funakoshi T, Aki T, Uemura K: Activation of Master Autophagy Regulator TFEB During Systemic LPS Administration in the Cornea. J Toxicol Pathol. 2014.07; 27 (2): 153-158. ( PubMed , DOI )

  3. Kashima J, Shintani-Ishida K, Nakajima M, Maeda H, Unuma K, Uchiyama Y, Yoshida K.: Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers. Hepatol Res.. 2014.07; 44 (7): 779-787.

  4. Yamada A, Unuma K, Kojima H, Uemura K.: Subarachnoid hemorrhage caused by a traffic accident: de novo aneurysm ruptured 30 years after surgical neck clipping. J Forensic Leg Med. . 2014.02; 22 90-92.

  1. Kana Unuma, Kazuki Harada, Teruaki Oka, Koichi Uemura: Starch accumulation in the lungs of two infants following positive ventilation. Forensic Sci Med Pathol. 2013.12; 9 (4): 554-557. ( PubMed , DOI )

  2. Izumi Funakoshi-Hirose, Toshihiko Aki, Kana Unuma, Takeshi Funakoshi, Kanako Noritake, Koichi Uemura: Distinct effects of methamphetamine on autophagy-lysosome and ubiquitin-proteasome systems in HL-1 cultured mouse atrial cardiomyocytes. Toxicology. 2013.10; 312 74-82. ( PubMed , DOI )

  3. Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura: Impairment of autophagy: from hereditary disorder to drug intoxication. Toxicology. 2013.09; 311 (3): 205-215. ( PubMed , DOI )

  4. Marie Bessho, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Kanako Noritake, Chizuru Kato, Koichi Uemura: Rho-kinase inhibitor Y-27632 attenuates arsenic trioxide toxicity in H9c2 cardiomyoblastoma cells. Cardiovasc Toxicol. 2013.09; 13 (3): 267-277. ( PubMed , DOI )

  5. Kana Unuma, Toshihiko Aki, Seiji Matsuda, Takeshi Funakoshi, Ken-Ichi Yoshida, Koichi Uemura: Elimination and active extrusion of liver mitochondrial proteins during lipopolysaccharide administration in rat. Hepatol Res. 2013.05; 43 (5): 526-534. ( PubMed , DOI )

  6. Unuma K, Aki T, Funakoshi T, Yoshida K, Uemura K.: Cobalt Protoporphyrin Accelerates TFEB Activation and Lysosome Reformation during LPS-Induced Septic Insults in the Rat Heart. PLoS One.. 2013.02; 8 (2): e56526. ( DOI )

  7. Sugihara M, Odagiri F, Suzuki T, Murayama T, Nakazato Y, Unuma K, Yoshida K, Daida H, Sakurai T, Morimoto S, Kurebayashi N.: Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model. PLoS One.. 2013.01; 8 (1): e55514. ( DOI )

  8. Kana Unuma, Toshihiko Aki, Seiji Matsuda, Takeshi Funakoshi, Ken-Ichi Yoshida, Koichi Uemura: Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver. Hepatol Res. 2013.01; 43 (1): 91-96. ( PubMed , DOI )

  9. Funakoshi T, Aki T, Unuma K, Uemura K: Lysosome vacuolation disrupts the completion of autophagy during norephedrine exposure in SH-SY5Y human neuroblastoma cells. Brain Res. 2013.01; 1490 9-22. ( PubMed , DOI )

  1. Noritake K, Aki T, Funakoshi T, Unuma K, Nara A, Kato C, Uemura K: Critical roles of Rho-associated kinase in membrane blebbing and mitochondrial pathway of apoptosis caused by 1-butanol. Toxicol In Vitro. 2012.09; 26 (6): 849-855. ( PubMed , DOI )

  2. Bessho M, Unuma K, Nara A, Uemura K: A case in which a bone fragment caused by a bullet made a second channel in addition to the bullet channel. Leg Med (Tokyo). 2012.07; 14 (4): 188-190. ( PubMed , DOI )

  3. Nara A, Aki T, Funakoshi T, Unuma K, Uemura K: Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells. Brain Res. 2012.07; 1466 1-14. ( PubMed , DOI )

  4. Unuma K, Uozaki H, Kuroda R, Uemura K, Yoshida K: Death from axillary haemorrhage during haemodialysis in a patient with a history of microscopic polyangiitis. BMJ Case Rep. 2012.01; 2012 ( PubMed , DOI )

  1. Takeshi Funakoshi, Toshihiko Aki, Haruka Nakayama, Yumi Watanuki, Satoko Imori, Koichi Uemura: Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway by chelerythrine. Toxicol In Vitro. 2011.12; 25 (8): 1581-1587. ( PubMed , DOI )

  2. Ryohei Kuroda, Kazuki Harada, Takashi Kobayashi, Hisashi Nagai, Kana Unuma, Kanju Saka, Kaori Shintani-Ishida, Ken-ichi Yoshida: Sudden cardiac death caused by the administration of a β₂-agonist for asthma attack. Int J Cardiol. 2011.12; 153 (3): e56-e58. ( PubMed , DOI )

  3. Unuma K, Harada K, Funakoshi T, Uemura K.: Sudden death of an alcoholic elderly man with acute esophageal necrosis (black esophagus). Forensic Sci Int. 2011.11; 10 (212(1-3)): e15-7.

  4. Kana Unuma, Kazuki Harada, Takeshi Funakoshi, Koichi Uemura: Sudden death of an alcoholic elderly man with acute esophageal necrosis (black esophagus). Forensic Sci. Int.. 2011.10; 212 (1-3): e15-e17. ( PubMed , DOI )

  5. Unuma K, Harada K, Furutani M, Furutani Y, Nakajima M, Nakanishi T, Matsuoka R, Yoshida KI: Multiple stenotic arteriopathy in a 72-year-old female with Williams syndrome. Journal of clinical pathology. 2011.01; ( PubMed , DOI )

  6. Noritake K, Unuma K, Nara A, Uchida K, Shiratori T, Watanuki Y, Funakoshi T, Uemura K: Autopsy findings of a patient with rapidly progressive massive ascites caused by alcoholic cirrhosis. Legal medicine (Tokyo, Japan). 2011.01; ( PubMed , DOI )

  1. Unuma K, Shintani-Ishida K, Yahagi N, Tsushima K, Shimosawa T, Ueyama T, Yoshida K: Restraint stress induces connexin-43 translocation via α-adrenoceptors in rat heart. Circ J. 2010.11; 74 (12): 2693-2701. ( PubMed )

  2. Nara A, Aki T, Funakoshi T, Uemura K: Methamphetamine induces macropinocytosis in differentiated SH-SY5Y human neuroblastoma cells. Brain Res. 2010.09; 1352 1-10. ( PubMed , DOI )

  3. Unuma K, Harada K, Nakajima M, Ito T, Okutsu K, Yoshida K: Unexpected death of a patient with rheumatoid arthritis complicated by a cervical deformity. Leg Med (Tokyo). 2010.09; 12 (5): 242-245. ( PubMed , DOI )

  4. Aki T, Nara A, Funakoshi T, Uemura K: Bifurcate effects of glucose on caspase-independent cell death during hypoxia. Biochem Biophys Res Commun. 2010.06; 396 (3): 614-618. ( PubMed , DOI )

  5. Nara A, Aki T, Funakoshi T, Uchida K, Nakayama H, Uemura K: Death due to blood transfusion-induced anaphylactic shock: A case report. Leg Med (Tokyo). 2010.05; 12 (3): 148-150. ( PubMed , DOI )

  6. Unuma K, Shintani-Ishida K, Tsushima K, Shimosawa T, Ueyama T, Kuwahara M, Yoshida K: Connexin-43 redistribution and gap junction activation during forced restraint protects against sudden arrhythmic death in rats. Circ J. 2010.05; 74 (6): 1087-1095. ( PubMed )

  7. Tojo A, Unuma K, Harada K, Yoshida K, Fujita T: Localization and mechanism of nephrocalcinosis in pseudo-Bartter's syndrome. Kidney Int. 2010.05; 77 (9): 831; author reply 831. ( PubMed , DOI )

  8. Unuma K, Harada K, Nakajima M, Eguchi H, Tsushima K, Ito T, Shintani-Ishida K, Kojima H, Yoshida K: Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication. Forensic Sci Int. 2010.01; 194 (1-3): e5-8. ( PubMed , DOI )

  1. Nakajima M, Kojima H, Takazawa Y, Yahagi N, Harada K, Takahashi K, Unuma K, Yoshida K: An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan. J Clin Pathol. 2009.11; 62 (11): 1029-1033. ( PubMed , DOI )

  2. Saka K, Konuma K, Asai S, Unuma K, Nakajima M, Yoshida K: Identification of active ingredients in dietary supplements using non-destructive mass spectrometry and liquid chromatography-mass spectrometry. Forensic Sci Int. 2009.10; 191 (1-3): e5-10. ( PubMed , DOI )

  3. Shintani-Ishida K, Unuma K, Yoshida K: Ischemia enhances translocation of connexin43 and gap junction intercellular communication, thereby propagating contraction band necrosis after reperfusion. Circ J. 2009.09; 73 (9): 1661-1668. ( PubMed )

  4. Aki T, Yanagisawa S: Application of rice nuclear proteome analysis to the identification of evolutionarily conserved and glucose-responsive nuclear proteins. J Proteome Res. 2009.08; 8 (8): 3912-3924. ( PubMed , DOI )

  5. Unuma K, Tojo A, Harada K, Saka K, Nakajima M, Ishii T, Fujita T, Yoshida K: Autopsy report on pseudo-Bartter syndrome with renal calcification induced by diuretics and diet pills. BMJ Case Report. 2009.03; ( DOI )

  1. Aki T, Funakoshi T, Nishida-Kitayama J, Mizukami Y: TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14. J Cell Physiol. 2008.10; 217 (1): 194-206. ( PubMed , DOI )

  2. Mizukami Y, Ono K, Du CK, Aki T, Hatano N, Okamoto Y, Ikeda Y, Ito H, Hamano K, Morimoto S: Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion. Cardiovasc Res. 2008.09; 79 (4): 589-599. ( PubMed , DOI )

  3. Aki T, Shigyo M, Nakano R, Yoneyama T, Yanagisawa S: Nano scale proteomics revealed the presence of regulatory proteins including three FT-Like proteins in phloem and xylem saps from rice. Plant Cell Physiol. 2008.05; 49 (5): 767-790. ( PubMed , DOI )

  4. Uemura K, Ueyama T, Shintani-Ishida K, Unuma K, Yoshida K: An autopsy report on four sudden cardiac death cases by immobilization. Int Med J. 2008; 15 301-305.

  1. Takao Hirata, Ying Jun Cui, Takeshi Funakoshi, Yoichi Mizukami, Yu-Ichiro Ishikawa, Futoshi Shibasaki, Mishiya Matsumoto, Takefumi Sakabe: The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen. Brain Res.. 2007.01; 1130 (1): 214-222. ( PubMed , DOI )

  2. Aki T, Konishi M, Kikuchi T, Fujimori T, Yoneyama T, Yanagisawa S: Distinct modulations of the hexokinase1-mediated glucose response and hexokinase1-independent processes by HYS1/CPR5 in Arabidopsis. J Exp Bot. 2007; 58 (12): 3239-3248. ( PubMed , DOI )

  1. Takeshi Funakoshi, Akie Yanai, Koh Shinoda, Michio M Kawano, Yoichi Mizukami: G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane. Biochem. Biophys. Res. Commun.. 2006.08; 346 (3): 904-910. ( PubMed , DOI )

  1. Hara K, Okamoto M, Aki T, Yagita H, Tanaka H, Mizukami Y, Nakamura H, Tomoda A, Hamasaki N, Kang D: Synergistic enhancement of TRAIL- and tumor necrosis factor alpha-induced cell death by a phenoxazine derivative. Mol Cancer Ther. 2005.07; 4 (7): 1121-1127. ( PubMed , DOI )

  2. Unuma K, Chen J, Saito S, Kobayashi N, Sato K, Saito K, Wakisaka H, Mominoki K, Sano A, Matsuda S: Changes in expression of prosaposin in the rat facial nerve nucleus after facial nerve transection. Neurosci Res. 2005.07; 52 (3): 220-227. ( PubMed , DOI )

  1. Mizukami Y, Iwamatsu A, Aki T, Kimura M, Nakamura K, Nao T, Okusa T, Matsuzaki M, Yoshida K, Kobayashi S: ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J Biol Chem. 2004.11; 279 (48): 50120-50131. ( PubMed , DOI )

  2. Toshihiko Utsumi, Kengo Nakano, Takeshi Funakoshi, Yoshiyuki Kayano, Sayaka Nakao, Nagisa Sakurai, Hiroyuki Iwata, Rumi Ishisaka: Vertical-scanning mutagenesis of amino acids in a model N-myristoylation motif reveals the major amino-terminal sequence requirements for protein N-myristoylation. Eur. J. Biochem.. 2004.02; 271 (4): 863-874. ( PubMed )

  1. Aki T, Yamaguchi K, Fujimiya T, Mizukami Y: Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene. 2003.11; 22 (52): 8529-8535. ( PubMed , DOI )

  2. Claeyssens S, Gangneux C, Brasse-Lagnel C, Ruminy P, Aki T, Lavoinne A, Salier JP: Amino acid control of the human glyceraldehyde 3-phosphate dehydrogenase gene transcription in hepatocyte. Am J Physiol Gastrointest Liver Physiol. 2003.11; 285 (5): G840-9. ( PubMed , DOI )

  3. Aki T, Yoshida K, Mizukami Y: The mechanism of alphaB-crystallin gene expression by proteasome inhibition. Biochem Biophys Res Commun. 2003.11; 311 (1): 162-167. ( PubMed )

  4. Fujimiya T, Shinagawa H, Ohbora Y, Aki T: Pharmacokinetic study of ethanol and its metabolites in culture cells. Leg Med (Tokyo). 2003.03; 5 Suppl 1 S123-5. ( PubMed )

  5. Fujimiya T, Ohbora Y, Shinagawa H, Aki T: Pharmacokinetic study of ethanol and its metabolites during ethanol infusion. Leg Med (Tokyo). 2003.03; 5 Suppl 1 S126-8. ( PubMed )

  6. Uemura K, Aki T, Yamaguchi K, Yoshida K: Protein kinase C-epsilon protects PC12 cells against methamphetamine-induced death: possible involvement of suppression of glutamate receptor. Life Sci. 2003.02; 72 (14): 1595-1607. ( PubMed )

  1. Aki T, Yoshida K, Fujimiya T: Phosphoinositide 3-kinase accelerates calpain-dependent proteolysis of fodrin during hypoxic cell death. J Biochem. 2002.12; 132 (6): 921-926. ( PubMed )

  2. Fujimiya T, Yamaoka K, Ohbora Y, Aki T, Shinagawa H: Michaelis-Menten elimination kinetics of acetaldehyde during ethanol oxidation. Alcohol Clin Exp Res. 2002.08; 26 (8 Suppl): 49S-54S. ( PubMed , DOI )

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