1. Aoki A, Mizutani K, Taniguchi Y, Lin T, Ohsugi Y, Mikami R, Katagiri S, Meinzer W, Iwata T: Current status of Er:YAG laser in periodontal surgery. The Japanese dental science review. 2024.12; 60 1-14. ( PubMed , DOI )

  2. Lisa Yagasaki, Tomoki Chiba, Ryota Kurimoto, Mitsuyo Nakajima, Takanori Iwata, Hiroshi Asahara: in periodontal ligament on the metabolism of alveolar bone and cementum. Regen Ther. 2024.03; 25 186-193. ( PubMed , DOI )

  3. Yamaki D, Fukuba S, Okada M, Takeuchi S, Hoshi S, Matsuura T, Iwata T: Octacalcium phosphate collagen composite for periodontal regeneration in a canine one-wall intrabony defect. Journal of periodontal research. 2024.02; ( PubMed , DOI )

  4. Lin T, Ng MY, Mizutani K, Aoki A: Er:YAG laser-assisted periodontal regeneration with modified minimally invasive surgical technique (M-MIST) under microscope in an advanced periodontitis case with severe attachment loss beyond the root apex. Journal of dental sciences. 2024.01; 19 (1): 707-709. ( PubMed , DOI )

  5. Shiba T, Komatsu K, Takeuchi Y, Koyanagi T, Taniguchi Y, Takagi T, Maekawa S, Nagai T, Kobayashi R, Matsumura S, Katagiri S, Izumi Y, Aoki A, Iwata T: Novel flowchart guiding the non-surgical and surgical management of peri-implant complications: a narrative review Bioenginnering. 2024.01; 11 (2): 118.

  1. Lin P, Liu A, Tsuchiya Y, Noritake K, Ohsugi Y, Toyoshima K, Tsukahara Y, Shiba T, Nitta H, Aoki A, Iwata T, Katagiri S: Association between periodontal disease and chronic obstructive pulmonary disease Japanese Dental Science Review. 2023.12; 59 389-402. ( PubMed , DOI )

  2. Takeuchi Y, Aoki A, Hiratsuka K, Chui C, Ichinose A, Aung N, Kitanaka Y, Hayashi S, Toyoshima K, Iwata T, Arakawa S: Application of different wavelengths of LED lights in antimicrobial photodynamic therapy for the treatment of periodontal disease. Antibiotics (Basel, Switzerland). 2023.11; 12 (12): ( PubMed , DOI )

  3. Lin P, Niimi H, Hirota T, Ohsugi Y, Shimohira T, Toyoshima K, Katagiri S, Iwata T, Aoki A: Effects of low-level Er:YAG laser irradiation on proliferation and gene expression in primary gingival fibroblasts isolated from mouse maxilla Journal of biophotonics. 2023.11; e202300166. ( PubMed , DOI )

  4. Takemura S, Mizutani K, Mikami R, Nakagawa K, Hakariya M, Sakaniwa E, Saito N, Kominato H, Kido D, Takeda K, Aoki A, Iwata T: Enhanced periodontal tissue healing via vascular endothelial growth factor expression following low-level erbium-doped: yttrium, aluminum, and garnet laser irradiation: In vitro and in vivo studies. Journal of periodontology. 2023.11; ( PubMed , DOI )

  5. Hirasawa I, Odagiri H, Park G, Sanghavi R, Oshita T, Togi A, Yoshikawa K, Mizutani K, Takeuchi Y, Kobayashi H, Katagiri S, Iwata T, Aoki A: Anti-inflammatory effects of cold atmospheric plasma irradiation on the THP-1 human acute monocytic leukemia cell line. PloS one. 2023.10; 18 (10): e0292267. ( PubMed , DOI )

  6. Toyoshima K, Ohsugi Y, Lin P, Komatsu K, Shiba T, Takeuchi Y, Hirota T, Shimohira T, Tsuchiya Y, Katagiri S, Iwata T, Aoki A: Blue LED irradiation without a photosensitizer alters oral microbiome composition of ligature-induced periodontitis in mice Photobiomodulation, Photomedicine, and Laser Surgery. 2023.10;

  7. Aoki A, Mizutani K, Mikami R, Ohsugi Y, Kobayashi H, Akizuki T, Taniguchi Y, Takeuchi Y, Katagiri S, Sasaki Y, Komaki M, Meinzer W, Izumi Y, Iwata T: Er:YAG laser-assisted comprehensive periodontal pocket therapy for residual periodontal pocket treatment: A randomized controlled clinical trial Journal of Periodontology. 2023.10; 94 (10): 1187-1199. ( DOI )

  8. Hayashi S, Takeuchi Y, Hiratsuka K, Kitanaka Y, Toyoshima K, Nemoto T, Aung N, Hakariya M, Ikeda Y, Iwata T, Aoki A: Effects of various light-emitting diode wavelengths on periodontopathic bacteria and gingival fibroblasts: An in vitro study. Photodiagnosis and Photodynamic Therapy. 2023.10; 44 103860. ( PubMed , DOI )

  9. Buranasin P, Kominato H, Mizutani K, Mikami R, Saito N, Takeda K, Iwata T: Influence of Reactive Oxygen Species on Wound Healing and Tissue Regeneration in Periodontal and Peri-Implant Tissues in Diabetic Patients. Antioxidants (Basel). 2023.09; 12 (9): 1787. ( PubMed , DOI )

  10. Mikami R, Komagamine Y, Aoyama N, Mizutani K, Sasaki Y, Iwata T, Minakuchi S, Kanazawa M: Association between occlusal supports and nutritional status in older adults: A systematic review Journal of Dental Sciences. 2023.09;

  11. Takeuchi Y, Nemoto T, Kitanaka Y, Aoki A, Izumi Y, Iwata T, Arakawa S: Antibacterial activity of lysozyme-chitosan oligosaccharide conjugates on two periodontal bacteria Oral diseases. 2023.08; ( PubMed , DOI )

  12. Katagiri S, Ohsugi Y, Shiba T, Yoshimi K, Nakagawa K, Nagasawa Y, Uchida A, Liu A, Lin P, Tsukahara Y, Iwata T, Tohara H: Homemade blenderized tube feeding improves gut microbiome communities in children with enteral nutrition Frontiers in Microbiology. 2023.08; 14 1215236.

  13. Takeda K, Mizutani K, Mikami R, Fujino A, Ito Y, Takeuchi S, Saito N, Iwata T: Morphological analysis of the impact of diabetes on gingival capillaries with non-invasive blood flow scope - A preliminary study. Journal of dental sciences. 2023.07; 18 (3): 1134-1140. ( PubMed , DOI )

  14. Mikami R, Mizutani K, Gohda T, Matsuyama Y, Gotoh H, Nakagawa K, Takemura S, Aoyama N, Matsuura T, Kido D, Takeda K, Saito N, Izumi Y, Iwata T: Malnutrition- inflammation- atherosclerosis (MIA) syndrome associates with periodontitis in end-stage renal disease patients undergoing hemodialysis: a cross-sectional study. Scientific reports. 2023.07; 13 (1): 11805. ( PubMed , DOI )

  15. Yuichi Ikeda, Otofumi Chigasaki, Koji Mizutani, Yoshiyuki Sasaki, Norio Aoyama, Risako Mikami, Misa Gokyu, Makoto Umeda, Yuichi Izumi, Akira Aoki, Yasuo Takeuchi: The Potential of a Saliva Test for Screening of Alveolar Bone Resorption healthcare. 2023.06; 11 (13): 1822. ( PubMed , DOI )

  16. Shiba T, Komatsu K, Watanabe T, Takeuchi Y, Nemoto T, Ohsugi Y, Katagiri S, Shimogishi M, Marukawa E, Iwata T: Peri-implantitis management by resective surgery combined with implantoplasty and Er:YAG laser irradiation, accompanied by free gingival graft: a case report. Therapeutic advances in chronic disease. 2023.06; 14 20406223231174816. ( PubMed , DOI )

  17. Lin, TC; Ng, MY; Aoki, A; Yu, CH: Er:YAG laser-assisted comprehensive periodontal pocket therapy (Er-LCPT) under microscope in a severe periodontitis with type 2 diabetes mellitus patient: A case report JOURNAL OF DENTAL SCIENCES. 2023.04; 18 (2): 924-926. ( PubMed , DOI )

  18. Kataoka A, Shiba T, Katagiri S, Koyama S, Kito K, Ota T, Katayama T, Ohsugi Y, Nagai T, Kobayashi R, Komatsu K, Urata M, Imazuru T, Iwata T, Kozuma K: Novel and efficient method for diagnosing infective endocarditis using 16S ribosomal RNA gene amplicon sequence JACC Case Reports. 2023.04; 11 101793. ( PubMed , DOI )

  19. Nashimoto Y, Hori T, Ostrovidov S, Katagiri S, Kaji H: Engineering oral microenvironments using microphysiological systems Sensors and Materials. 2023.04; 35 (4): 1293-1299.

  20. Masuda H, Arisaka Y, Hakariya M, Iwata T, Yoda T, Yui N: Molecular mobility of polyrotaxane surfaces alleviates oxidative stress-induced senescence in mesenchymal stem cells. Macromolecular bioscience. 2023.03; e2300053. ( PubMed , DOI )

  21. Takeuchi S, Fukuba S, Okada M, Nohara K, Sato R, Yamaki D, Matsuura T, Hoshi S, Aoki K, Iwata T: Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model. Regenerative Therapy. 2023.03; 22 128-135. ( PubMed , DOI )

  22. Tashiro A, Yonetsu T, Aoyama N, Shiheido-Watanabe Y, Niida T, Miyazaki S, Maejima Y, Goya M, Isobe M, Iwata T, Sasano T: Periodontitis was associated with worse clinical outcomes after catheter ablation for paroxysmal atrial fibrillation Frontiers in Cardiovascular Medicine. 2023.01; 9 1061243. ( DOI )

  1. Ohsugi Y, Hatasa M, Katagiri S, Hirota T, Shimohira T, Shiba T, Komatsu K, Tsuchiya Y, Fukuba S, Lin P, Toyoshima K, Maekawa S, Niimi H, Iwata T, Aoki A: High-frequency pulsed diode laser irradiation inhibits bone resorption in mice with ligature-induced periodontitis Journal of Clinical Periodontology. 2022.12; 49 (12): 1275-1288. ( PubMed , DOI )

  2. Taichen L, Min N, Aoki A, Chuan-Hang Y: Er:YAG laser-assisted comprehensive periodontal pocket therapy (Er-LCPT) under microscope in a severe periodontitis with type 2 diabetes mellitus patient: A case report Journal of Dental Science. 2022.12; 18 (2): 924-926. ( DOI )

  3. Hakariya M, Arisaka Y, Masuda H, Yoda T, Iwata T, Yui N: Suppressed migration and enhanced cisplatin chemosensitivity in human cancer cell lines by tuning the molecular mobility of supramolecular biomaterials. Macromolecular Bioscience. 2022.12; 23 (2): 2200438. ( PubMed , DOI )

  4. Morita K, Nakamura A, Machida M, Kawasaki T, Nakanishi R, Ichida J, Iwata T, Umezawa A, Akutsu H: Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions Regeneration Therapy. 2022.12; 21 389-397. ( PubMed , DOI )

  5. Nagasawa Y, Katagiri S, Nakagawa K, Hirota T, Yoshimi K, Uchida A, Hatasa M, Komatsu K, Shiba T, Ohsugi Y, Uesaka N, Iwata T, Tohara H: Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome Journal of Functional Foods. 2022.11; e-pub

  6. Tamura A, Kang TW, Tonegawa A, Arisaka Y, Masuda H, Mikami R, Iwata T, Yoda T, Yui N: Supramolecular Surface Coatings with Acetylated Polyrotaxane-Based Triblock Copolymers for Thermal Regulation of Cell Adhesion and Fabrication of Cell Sheets. Biomacromolecules. 2022.11; 23 (11): 4860-4871.

  7. Tamura A, Kang TW, Tonegawa A, Arisaka Y, Masuda H, Mikami R, Iwata T, Yoda T, Yui N: Supramolecular Surface Coatings with Acetylated Polyrotaxane-Based Triblock Copolymers for Thermal Regulation of Cell Adhesion and Fabrication of Cell Sheets. Biomacromolecules. 2022.10; 23 (11): 4860-4871. ( PubMed , DOI )

  8. Tanaka-Takemura Y, Arisaka Y, Hakariya M, Masuda H, Mikami R, Sekiya-Aoyama R, Iwata T, Yoda T, Ono T, Yui N: Independent roles of molecular mobility and zeta potential on supramolecular surfaces in the sequence of RAW264.7 macrophage responses. Macromolecular bioscience. 2022.09; 22 (11): 2200282.

  9. Chiniforush N, Coluzzi D, Aoki A: Antimicrobial photodynamic therapy for periodontal and peri-implant disease Clinical Dentistry Reviewed. 2022.08; 6 (9): epub. ( DOI )

  10. Park K, Li Q, Lynes MD, Yokomizo H, Maddaloni E, Shinjo T, St-Louis R, Li Q, Katagiri S, Fu J, Clermont A, Park H, Wu IH, Yu MG, Shah H, Tseng YH, King GL: Endothelial cells induced progenitors into brown fat to reduce atherosclerosis Circulation Research. 2022.07; 131 (2): 168-183. ( PubMed , DOI )

  11. Coluzzi D.J., Mizutani K, Yukna R, Al-Falaki R, Lin T, Aoki A: Surgical laser therapy for periodontal and peri-implant disease Clinical Dental Review. 2022.06; 6 (7): epub.

  12. Lin T, Taniguchi Y, Aoki A, Chen CC: Management of furcation-involved molar using Er:YAG laser-assisted bone regenerative therapy: A case report Journal of Dental Science. 2022.06; 17 (4): 1836-1838. ( DOI )

  13. Fujii Y, Liu L, Yagasaki L, Inotsume M, Chiba T, Asahara H: Cartilage Homeostasis and Osteoarthritis International Journal of Molecular Sciences. 2022.06; 23 (11): 6316. ( PubMed , DOI )

  14. Koji Mizutani, Risako Mikami, Natsumi Saito, Eri Sakaniwa, Takanori Iwata: Periodontal Disease and Chronic Kidney Disease: the Impact of Oral Health on Inflammation and Nutrition in Patients Undergoing Hemodialysis Current Oral Health Reports. 2022.05; 9 81-88. ( DOI )

  15. Coluzzi DJ, Aoki A, Chiniforush N: Non-surgical laser therapy for periodontal and peri‐implant disease Clinical Dentistry Reviewed. 2022.05; 6 (6): epub.

  16. Mikami R, Mizutani K, Matsuyama Y, Gohda T, Gotoh H, Aoyama N, Matsuura T, Kido D, Takeda K, Saito N, Fujiwara T, Izumi Y, Iwata T: Association of type 2 diabetes with periodontitis and tooth loss in patients undergoing hemodialysis. PLoS One. 2022.05; 17 (5): e0267494. ( PubMed , DOI )

  17. Mizutani K, Mikami R, Tsukui A, Nagai S, Pavlic V, Komada W, Iwata T, Aoki A: Novel flapless esthetic procedure for the elimination of extended gingival metal tattoos adjacent to prosthetic teeth: Er:YAG laser micro-keyhole surgery. Journal of prosthodontic research. 2022.04; 66 (2): 346-352. ( PubMed , DOI )

  18. Taku Fukushima, Taishi Yonetsu, Norio Aoyama, Akira Tashiro, Takayuki Niida, Yuka Shiheido-Watanabe, Yasuhiro Maejima, Mitsuaki Isobe, Takanori Iwata, Tetsuo Sasano: Effect of Periodontal Disease on Long-Term Outcomes After Percutaneous Coronary Intervention for De Novo Coronary Lesions in Non-Smokers. Circ J. 2022.04; 86 (5): 811-818. ( PubMed , DOI )

  19. Takada K, Chiba T, Miyazaki T, Yagasaki L, Nakamichi R, Iwata T, Moriyama K, Harada H, Asahara H: Single cell RNA sequencing reveals critical functions of Mkx in periodontal ligament homeostasis Frontiers in cell and developmental biology. 2022.02; 10 795441. ( PubMed , DOI )

  20. Yoshida S, Hatasa M, Ohsugi Y, Tsuchiya Y, Liu A, Niimi H, Morita K, Shimohira T, Sasaki N, Maekawa S, Shiba T, Hirota T, Okano T, Hirose A, Ibi R, Noritake K, Tomiga Y, Nitta H, Suzuki T, Takahashi H, Miyasaka N, Iwata T, Katagiri S: Porphyromonas gingivalis administration induces gestational obesity, alters gene expression in the liver and brown adipose tissue in pregnant mice, and causes underweight in fetuses Frontiers in Cellular and Infection Microbiology. 2022.01; 11 745117. ( PubMed , DOI )

  21. Shiba T, Katagiri S, Komatsu K, Nemoto T, Takeuchi Y, Chen B, Zhou YS, Iwata T: Treatment of peri-implantitis caused by malpositioning and an extra implant: a case report International Journal of Periodontics & Restorative Dentistry. 2022.01; 42 (1): e15-e20. ( PubMed , DOI )

  22. Saito N, Mikami R, Mizutani K, Takeda K, Kominato H, Kido D, Ikeda Y, Buranasin P, Nakagawa K, Takemura S, Ueno T, Hosaka K, Hanawa T, Shinomura T, Iwata T: Impaired dental implant osseointegration in rat with streptozotocin-induced diabetes. Journal of periodontal research. 2022.01; 57 (2): 412-424. ( PubMed , DOI )

  23. Kaibuchi N, Iwata T, Koga YK, Okamoto T.: Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw. Frontiers in Bioengineering and Biotechnology. 2022; 10 902349. ( PubMed , DOI )

  1. Takeda K, Mizutani K, Matsuura T, Kido D, Mikami R, Buranasin P, Saito N, Kominato H, Takemura S, Nakagawa K, Iwata T: Antioxidant effect of enamel matrix derivative for early phase of periodontal tissue regeneration in diabetes. Journal of periodontology. 2021.11; 93 (8): 1206-1217. ( PubMed , DOI )

  2. Shimogishi M, Watanabe T, Shibasaki M, Shiba T, Komatsu K, Nemoto T, Ishihara K, Nakano Y, Iwata T, Kasugai S, Nakagawa I: Patient-specific establishment of bacterial composition within the peri-implant microbiota during the earliest weeks after implant uncovering. Journal of Periodontal Research. 2021.10; 56 (5): 964-971. ( PubMed , DOI )

  3. Lin T, Taniguchi Y, Aoki A, Chen CC: The “Er:YAG laser-assisted periimplantitis total therapy (Er:LPTT)” - a novel procedure to perform periimplantitis treatment with bone regeneration therapy Journal of Dental Sciences. 2021.10; 16 (4): 1302-1304. ( PubMed , DOI )

  4. Nemoto T, Shiba T, Komatsu K, Watanabe T, Shimogishi M, Shibasaki M, Koyanagi T, Nagai T, Katagiri S, Takeuchi Y, Iwata T: Discrimination of bacterial community structures among healthy, gingivitis, and periodontitis statuses through integrated metatranscriptomic and network analyses. mSystems. 2021.10; 6 (6): e0088621. ( PubMed , DOI )

  5. Hakariya M, Arisaka Y, Masuda H, Yoda T, Tamura A, Iwata T, Yui N: Tissue Adhesion-Anisotropic Polyrotaxane Hydrogels Bilayered with Collagen Gels. 2021.10; 7 (4): 168. ( PubMed , DOI )

  6. Tanaka D, Ikeda Y, Ikeda E, Yokose M, Ganss B, Iwata T: Effect of Amelotin on Bone Growth in the Murine Calvarial Defect Model. Annals of Biomedical Engineering. 2021.10; ( PubMed , DOI )

  7. Mikami R, Arisaka Y, Hakariya M, Iwata T, Yui N: Improved epithelial cell-cell adhesion using molecular mobility of supramolecular surfaces Biomaterials science. 2021.10; 9 (21): 7151-7158. ( DOI )

  8. Shiba T, Komatsu K, Sudo T, Sawafuji R, Saso A, Ueda S, Watanabe T, Nemoto T, Kano C, Nagai T, Ohsugi Y, Katagiri S, Takeuchi Y, Kobayashi H, Iwata T: Comparison of periodontal bacteria of Edo and modern periods using novel diagnostic approach for periodontitis with micro-CT. Frontiers in cellular and infection microbiology. 2021.09; 11 723821. ( PubMed , DOI )

  9. Saida H, Fukuba S, Shiba T, Komatsu K, Iwata T, Nitta H: Two-stage approach for class II mandibular furcation defect with insufficient keratinized mucosa: a case report with 3 years' follow-up. The Journal of international medical research. 2021.09; 49 (9): 3000605211044595. ( PubMed , DOI )

  10. Mikami R, Mizutani K, Shioyama H, Matsuura T, Aoyama N, Suda T, Kusunoki Y, Takeda K, Izumi Y, Aida J, Aoki A, Iwata T: Influence of aging on periodontal regenerative therapy using enamel matrix derivative: A 3-year prospective cohort study. Journal of clinical periodontology. 2021.09; 49 (2): 123-133. ( PubMed , DOI )

  11. Kominato H, Takeda K, Mizutani K, Mikami R, Kido D, Buranasin P, Saito N, Takemura S, Nakagawa K, Nagasawa T, Iwata T.: Metformin accelerate wound healing by Akt phosphorylation of gingival fibroblast in insulin-resistant prediabetes mice. Journal of Periodontology. 2021.08; 93 (2): 256-268. ( PubMed , DOI )

  12. Mizutani K, Buranasin P, Mikami R, Takeda K, Kido D, Watanabe K, Takemura S, Nakagawa K, Kominato H, Saito N, Hattori A, Iwata T.: Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis ANTIOXIDANTS. 2021.08; 10 (8): ( PubMed , DOI )

  13. Shimohira T, Niimi H, Ohsugi Y, Tsuchiya Y, Morita K, Yoshida S, Hatasa M, Shiba T, Kadokura H, Yokose S, Katagiri S, Iwata T, Aoki A: Low-level erbium-doped yttrium aluminum garnet laser irradiation induced alteration of gene expression in osteogenic cells from rat calvariae Photobiomodulation, Photobiomedicine, and Laser Surgery. 2021.08; 39 (8): 566-577. ( DOI )

  14. Lin P, Niimi H, Ohsugi Y, Tsuchiya Y, Shimohira T, Komatsu K, Liu A, Shiba T, Aoki A, Iwata T, Katagiri S: Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease International Journal of Molecular Sciences. 2021.08; 22 (16): 8900. ( PubMed , DOI )

  15. Kataoka A, Katagiri S, Kawashima H, Nagura F, Nara Y, Hioki H, Nakashima M, Sasaki N, Hatasa M, Maekawa S, Ohsugi Y, Shiba T, Watanabe Y, Shimokawa T, Iwata T, Kozuma K: Association between Periodontal Bacteria and Degenerative Aortic Stenosis: A Pilot Study Journal of Periodontal and Implant Science. 2021.08; 51 (4): 226-238.

  16. Shiba T, Watanabe T, Komatsu K, Koyanagi T, Nemoto T, Ohsugi Y, Michi Y, Katagiri S, Takeuchi Y, Ishihara K, Iwata T: Non-surgical treatment for periodontitis and peri-implantitis: longitudinal clinical and bacteriological findings-A case report with a 7-year follow-up evaluation. SAGE open medical case reports. 2021.07; 9 2050313X211029154. ( PubMed , DOI )

  17. Tanabe G, Hasunuma T, Inai Y, Takeuchi Y, Kobayashi H, Hayashi K, Shimizu S, Kamiya N, Churei H, Sumita Y, Suzuki K, Moriya N, Ueno T: Potential assessment of dehydration during high-intensity training using a capacitance sensor for oral mucosal moisture: evaluation of elite athletes in a field-based survey. Chemosensors. 2021.07; 9 (8): 196. ( DOI )

  18. Mikami R, Mizutani K, Matsuyama Y, Matsuura T, Kido D, Takeda K, Takemura S, Nakagawa K, Mukaiyama Y, Suda T, Yasuda T, Ohta S, Takaya N, Fujiwara T, Izumi Y, Iwata T: Association between periodontal inflammation and serum lipid profile in a healthy population: A cross-sectional study. Journal of periodontal research. 2021.07; 56 (6): 1037-1045. ( PubMed , DOI )

  19. Aoki A, Mizutani K, Mikami R, Taniguchi Y, Ohsugi Y, M Walter, Izumi Y, Iwata T.: Residual periodontal pocket treatment with Er:YAG laser-assisted comprehensive periodontal pocket therapy: a retrospective study CLINICAL ORAL INVESTIGATIONS. 2021.07; 26 (1): 761-771. ( PubMed , DOI )

  20. Taniguchi Y, Sawada K, Yamada A, Mizutani K, Meinzer W, Iwata T, Izumi Y, Aoki A: Er:YAG laser-assisted bone regenerative therapy for implant placement: A case series. The International journal of periodontics & restorative dentistry. 2021.07; 41 (4): e137-e175. ( PubMed , DOI )

  21. Masuda H, Arisaka Y, Hakariya M, Iwata T, Yoda T, Yui N: Synergy of molecularly mobile polyrotaxane surfaces with endothelial cell co-culture for mesenchymal stem cell mineralization. RSC Advances. 2021.06; 11 (30): 18685-18692. ( DOI )

  22. Yamaguchi Y, Saito A, Horie M, Aoki A, Micke P, Ohshima M, Kappert K: Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis Odontology. 2021.06; 109 (4): 912-920. ( PubMed , DOI )

  23. Yang J, Liu Q, Shiba T, Ji C, Iwata T, Jiang T: Application of digital prosthodontics and connective tissue grafting in the management of peri-implant mucosal recession around a malpositioned 1-piece implant: A clinical report. The Journal of prosthetic dentistry. 2021.05; 128 (6): 1145-1151. ( PubMed , DOI )

  24. Arisaka Y, Hakariya M, Iwata T, Masuda H, Yoda T, Tamura A, Yui N: Surface-tethering of methylated polyrotaxanes with 4-vinylbenzyl groups onto poly(ether ether ketone) substrates for improving osteoblast compatibility. Dental materials journal. 2021.05; 40 (3): 813-819. ( PubMed , DOI )

  25. Miyazaki T, Kurimoto R, Chiba T, Matsushima T, Nakamichi R, Tsutsumi H, Takada K, Yagasaki L, Kato T, Shishido K, Kobayashi Y, Matsumoto T, Moriyama K, Asahara H: Mkx regulates the orthodontic tooth movement via osteoclast induction Journal of Bone and Mineral Metabolism. 2021.05; 39 (5): 780-786. ( PubMed , DOI )

  26. Fukuba Shunsuke, Akizuki Tatsuya, Matsuura Takanori, Okada Munehiro, Nohara Kohei, Hoshi Shu, Addin Ammar Shujaa, Iwata Takanori, Izumi Yuichi: Effects of combined use of recombinant human fibroblast growth factor-2 and beta-tricalcium phosphate on ridge preservation in dehiscence bone defects after tooth extraction: A split-mouth study in dogs JOURNAL OF PERIODONTAL RESEARCH. 2021.04; 56 (2): 298-305. ( PubMed , DOI )

  27. Terasawa K, Kato Y, Ikami Y, Sakamoto K, Ohtake K, Kusano S, Tomabechi Y, Kukimoto-Niino M, Shirouzu M, Guan JL, Kobayashi T, Iwata T, Watabe T, Yokoyama S, Hara-Yokoyama M: Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells. Autophagy. 2021.04; 1-19. ( PubMed , DOI )

  28. Chigasaki O, Aoyama N, Sasaki Y, Takeuchi Y, Mizutani K, Ikeda Y, Gokyu M, Umeda M, Izumi Y, Iwata T, Aoki A: #IPorphyromonas gingivalis#IR, the most influential pathogen in red-complex bacteria: A cross-sectional study on the relationship between bacterial count and clinical periodontal status in Japan J Periodontol. 2021.04; 92 (12): 1719-1729. ( PubMed , DOI )

  29. Hatasa M, Yoshida S, Takahashi H, Tanaka K, Kubotsu Y, Ohsugi Y, Katagiri T, Iwata T, Katagiri S: Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response International Journal of Molecular Sciences. 2021.04; 22 (7): 3728.

  30. Takeda K, Mizutani K, Minami I, Kido D, Mikami R, Konuma K, Saito N, Kominato H, Takemura S, Nakagawa K, Izumi Y, Ogawa Y, Iwata T: Association of periodontal pocket area with type 2 diabetes and obesity: a cross-sectional study. BMJ open diabetes research & care. 2021.04; 9 (1): ( PubMed , DOI )

  31. Fukuba Shunsuke, Okada Munehiro, Nohara Kohei, Iwata Takanori: Alloplastic Bone Substitutes for Periodontal and Bone Regeneration in Dentistry: Current Status and Prospects MATERIALS. 2021.03; 14 (5): ( DOI )

  32. Nomura Y, Morozumi T, Saito A, Yoshimura A, Kakuta E, Suzuki F, Nishimura F, Takai H, Kobayashi H, Noguchi K, Takahashi K, Tabeta K, Umeda M, Minabe M, Fukuda M, Sugano N, Hanada N, Yoshinari N, Sekino S, Takashiba S, Sato S, Nakamura T, Sugaya T, Nakayama Y, Ogata Y, Numabe Y, Nakagawa T: Prospective Longitudinal Changes in the Periodontal Inflamed Surface Area Following Active Periodontal Treatment for Chronic Periodontitis Journal of Clinical Medicine. 2021.03; 10 (6): 1165. ( DOI )

  33. Shimohira T, Katagiri S, Ohsugi Y, Hirota T, Hatasa M, Mizutani K, Watanabe K, Niimi H, Iwata T, Aoki A: Comprehensive and Sequential Gene Expression Analysis of Bone Healing Process Following Er:YAG Laser Ablation Photobiomodulation, Photobiomedicine, and Laser Surgery. 2021.02; 39 (2): 100-112. ( PubMed , DOI )

  34. Mikami R, Mizutani K, Nagai S, Pavlic V, Iwata T, Aoki A: A novel minimally-invasive approach for metal tattoo removal with Er:YAG laser. Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]. 2021.02; 33 (4): 550-559. ( PubMed , DOI )

  35. Sekiya-Aoyama R, Arisaka Y, Hakariya M, Masuda H, Iwata T, Yod T, Yui N: Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells Biomaterials Science. 2021.02; 9 (3): 675-684. ( PubMed , DOI )

  36. Nomura Y, Morozumi T, Numabe Y, Ogata Y, Nakayama Y, Sugaya T, Nakamura T, Sato S, Takashiba S, Sekino S, Yoshinari N, Hanada N, Sugano N, Fukuda M, Minabe M, Umeda M, Tabeta K, Takahashi K, Noguchi K, Kobayashi H, Takai H, Nishimura F, Suzuki F, Kakuta E, Yoshimura A, Saito A, Nakagawa T: Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination Journal of Clinical Medicine. 2021.02; 10 (4): ( PubMed , DOI )

  37. Watanabe K, Katagiri S, Takahashi H, Sasaki N, Maekawa S, Komazaki R, Hatasa M, Kitajima Y, Maruyama Y, Shiba T, Komatsu K, Ohsugi Y, Tanaka K, Matsuzawa A, Hirota T, Tohara H, Eguchi Y, Anzai K, Hattori A, Iwata T: Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota FASEB JOURNAL. 2021.02; 35 (2): e21171. ( PubMed , DOI )

  38. Iwakawa Hidehiro, Takigawa Masateru, Goya Masahiko, Iwata Toyoto, Martin Claire A., Anzai Tatsuhiko, Takahashi Kunihiko, Amemiya Miki, Yamamoto Tasuku, Sekigawa Masahiro, Shirai Yasuhiro, Tao Susumu, Hayashi Tatsuya, Takahashi Yoshihide, Watanabe Hiroyuki, Sasano Tetsuo: Clinical implications of local impedance measurement using the IntellaNav MiFi OI ablation catheter: an ex vivo study JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY. 2021.02; ( DOI )

  39. Harada Y, Sunaga M, Takeuchi Y, Mizutani K, Katagiri S, Ikeda Y, Aoki A, Iwata T, Kinoshita A: Standardization of examiners using a dental model for pocket probe training: Adequacy of evaluation with model and standard accuracy rate of skilled examiners Journal of medical and dental sciences. 2021.02; 68 49-54.

  40. Nakayama Y, Mizutani K, Tsumanuma Y, Yoshino H, Aoyama N, Inagaki K, Morita M, Izumi Y, Murakami S, Yoshimura H, Matsuura T, Murakami T, Yamamoto M, Yoshinari N, Mezawa M, Ogata Y, Yoshimura A, Kono K, Maruyama K, Sato S, Sakagami R, Ito H, Numabe Y, Nikaido M, Hanioka T, Seto K, Fukuda J, Warnakulasuriya S, Nagao T: A multicenter prospective cohort study on the effect of smoking cessation on periodontal therapies in Japan Journal of Oral Science. 2021.01; 63 (1): 114-118. ( PubMed , DOI )

  41. Inagaki K, Kikuchi T, Noguchi T, Mitani A, Naruse K, Matsubara T, Kawanami M, Negishi J, Furuichi Y, Nemoto E, Yamada S, Yoshie H, Tabeta K, Tomita S, Saito A, Katagiri S, Izumi Y, Nitta H, Iwata T, Numabe Y, Yamamoto M, Yoshinari N, Fujita T, Kurihara H, Nishimura F, Nagata T, Yumoto H, Naito T, Noguchi K, Ito K, Murakami S, Nishimura R, Tajima N: A large-scale observational study to investigate the current status of diabetic complications and their prevention in Japan (JDCP study 6): baseline dental and oral findings. Diabetology international. 2021.01; 12 (1): 52-61. ( PubMed , DOI )

  42. Hatasa M, Ohsugi Y, Katagiri S, Yoshida S, Niimi H, Morita K, Tsuchiya Y, Shimohira T, Sasaki N, Maekawa S, Shiba T, Hirota T, Tohara H, Takahashi H, Nitta H, Iwata T: Endotoxemia by Porphyromonas gingivalis alters endocrine functions in brown adipose tissue Frontiers in Cellular and Infection Microbiology. 2021.01; 19 (10): 580577.

  43. Kaibuchi N, Iwata T, Okamoto T, Kawase-Koga Y, Yamato M: Cell therapy for medication-related osteonecrosis of the jaw: update on treatment strategies European Cells & Materials. 2021; 41 31-39. ( DOI )

  1. Komatsu K, Shiba T, Takeuchi Y, Watanabe T, Koyanagi T, Nemoto T, Shimogishi M, Shibasaki M, Katagiri S, Kasugai S, Iwata T: Discriminating Microbial Community Structure Between Peri-Implantitis and Periodontitis With Integrated Metagenomic, Metatranscriptomic, and Network Analysis Frontiers in Cellular and Infection Microbiology, Tokyo Medical and Dental University. 2020.12; 10 596490. ( DOI )

  2. Lin T, Taniguchi Y, Aoki A, Chang YC: Clinical evaluation of ridge preservation and augmentation with buccal bone deficiency by Er:YAG laser-assisted bone regenerative therapy Journal of Dental Science. 2020.12; 15 (4): 560-561.

  3. Koji Mizutani, Risako Mikami, Tomohito Gohda, Hiromichi Gotoh, Norio Aoyama, Takanori Matsuura, Daisuke Kido, Kohei Takeda, Yuichi Izumi, Yoshiyuki Sasaki, Takanori Iwata: Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study. Sci Rep. 2020.12; 10 (1): 21872. ( PubMed , DOI )

  4. Ohsugi Yujin, Niimi Hiromi, Shimohira Tsuyoshi, Hatasa Masahiro, Katagiri Sayaka, Aoki Akira, Iwata Takanori: In Vitro Cytological Responses against Laser Photobiomodulation for Periodontal Regeneration INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020.12; 21 (23): ( PubMed , DOI )

  5. Lin Taichen, Taniguchi Yoichi, Aoki Akira, Chang Yu-Chao: Clinical evaluation of ridge preservation and augmentation with buccal bone deficiency by Er:YAG laser-assisted bone regenerative therapy JOURNAL OF DENTAL SCIENCES. 2020.12; 15 (4): 560-561. ( PubMed , DOI )

  6. Ikeda Yuichi, Kawada Ayako, Tanaka Daiki, Ikeda Eri, Kobayashi Hiroaki, Iwata Takanori: A comparative questionnaire study of patient complaint levels between magnetostrictive ultrasonic scaler (Cavitron(R)) and piezoelectric ultrasonic scalers INTERNATIONAL JOURNAL OF DENTAL HYGIENE. 2020.12; ( PubMed , DOI )

  7. Kitanaka Y, Takeuchi Y, Hiratsuka K, Aung N, Sakamaki Y, Nemoto T, Meinzer W, Izumi Y, Iwata T, Aoki A: The effect of antimicrobial photodynamic therapy using yellow-green LED and rose bengal on #IPorphyromonas gingivalis#IR. Photodiagnosis and photodynamic therapy, Tokyo Medical and Dental University. 2020.12; 32 102033. ( PubMed , DOI )

  8. Sato T, Iwata T, Usui M, Kokabu S, Sugamori Y, Takaku Y, Kobayashi T, Ito K, Matsumoto M, Takeda S, Xu R, Chida D: Bone phenotype in melanocortin 2 receptor-deficient mice. Bone reports. 2020.12; 13 100713. ( PubMed , DOI )

  9. Mizutani K, Shioyama H, Matsuura T, Mikami R, Takeda K, Izumi Y, Aoki A, Iwata T: Periodontal regenerative therapy in type 2 diabetes patients using minimally invasive surgical technique with enamel matrix derivative under 3-year observation: A prospective cohort study. Journal of periodontology. 2020.12; e-pub (9): 1262-1273. ( PubMed , DOI )

  10. Nomura Y, Morozumi T, Fukuda M, Hanada N, Kakuta E, Kobayashi H, Minabe M, Nakamura T, Nakayama Y, Nishimura F, Noguchi K, Numabe Y, Ogata Y, Saito A, Sato S, Sekino S, Sugano N, Sugaya T, Suzuki F, Takahashi K, Takai H, Takashiba S, Umeda M, Yoshie H, Yoshimura A, Yoshinari N, Nakagawa T: Optimal Examination Sites for Periodontal Disease Evaluation: Applying the Item Response Theory Graded Response Model Journal of Clinical Medicine. 2020.11; 9 (11): ( PubMed , DOI )

  11. Ikawa Takahiro, Mizutani Koji, Sudo Takeaki, Kano Chihiro, Ikeda Yuichi, Akizuki Tatsuya, Kobayashi Hiroaki, Izumi Yuichi, Iwata Takanori: Clinical comparison of an electric-powered ionic toothbrush and a manual toothbrush in plaque reduction: A randomized clinical trial INTERNATIONAL JOURNAL OF DENTAL HYGIENE. 2020.11; ( DOI )

  12. Ohsugi Y, Niimi H, Shimohira T, Hatasa M, Katagiri S, Aoki A, Iwata T: In vitro cytological responses against laser photobiomodulation for periodontal regeneration International Journal of Molecular Sciences. 2020.11; 21 (23): 9002.

  13. Inagaki K, Kikuchi T, Noguchi T, Mitani A, Naruse K, Matsubara T, Kawanami M, Negishi J, Furuichi Y, Nemoto E, Yamada S, Yoshie H, Tabeta K, Tomita S, Saito A, Katagiri S, Izumi Y, Nitta H, Iwata T, Numabe Y, Yamamoto M, Yoshinari N, Fujita T, Kurihara H, Nishimura F, Nagata T, Yumoto H, Naito T, Noguchi K, Ito K, Murakami S, Nishimura R, Tajima N: A large-scale observational study to investigate the current status of diabetic complications and their prevention in Japan (JDCP study 6): baseline dental and oral findings Diabetology International. 2020.10; e-pub

  14. Ye C, Xia Z, Tang J, Khemwong T, Kapila Y, Kuraji R, Huang P, Wu Y, Kobayashi H: Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery. Scientific Reports. 2020.09; 10 (1): 15807. ( PubMed , DOI )

  15. Ohsugi Y, Katagiri S, Hirota T, Niimi H, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kitazawa M, Matsuzawa A, Kadokura H, Yokose S, Iwata T, Aoki A: Laser irradiation decreases sclerostin expression in bone and osteogenic cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020.09; 34 (9): 12877-12893. ( PubMed , DOI )

  16. Tsuchiya Y, Hayashi M, Nagamatsu K, Ono T, Kamakura M, Iwata T, Nakashima T: The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-kappa B signaling downstream of FFAR4 Journal of biological chemistry, Tokyo Medical and Dental University. 2020.08; 295 (34): 12224-12232. ( DOI )

  17. Onizuka S, Yamazaki Y, Park SJ, Sugimoto T, Sone Y, Sjöqvist S, Usui M, Takeda A, Nakai K, Nakashima K, Iwata T: Correction to: RNA-sequencing reveals positional memory of multipotent mesenchymal stromal cells from oral and maxillofacial tissue transcriptomes. BMC genomics. 2020.08; 21 (1): 551. ( PubMed , DOI )

  18. Ikawa T, Akizuki T, Ono W, Maruyama K, Okada M, Stavropoulos A, Izumi Y, Iwata T: Ridge reconstruction in damaged extraction sockets using tunnel beta-tricalcium phosphate blocks: A 6-month histological study in beagle dogs Journal of Periodontal Research. 2020.08; 55 (4): 496-502. ( DOI )

  19. Ohsugi Y, Katagiri S, Hirota T, Niimi H, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kitazawa M, Matsuzawa A, Kadokura H, Yokose S, Iwata T, Aoki A: Laser irradiation decreases sclerostin expression in bone and osteogenic cells. The FASEB Journal. 2020.08; 34 (9): 12877-12893. ( PubMed , DOI )

  20. Mikami R, Mizutani K, Gohda T, Gotoh H, Matsuyama Y, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Fujiwara T, Iwata T: Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study. Clinical and experimental nephrology. 2020.08; e-pub (1): 58-65. ( PubMed , DOI )

  21. Kobayashi T, Torii D, Iwata T, Izumi Y, Nasu M, Tsutsui TW: Characterization of proliferation, differentiation potential, and gene expression among clonal cultures of human dental pulp cells. Human cell. 2020.07; 33 (3): 490-501. ( PubMed , DOI )

  22. Suzuki S, Aoki A, Katagiri S, Maekawa S, Ejiri K, Kong S, Nagata M, Yamaguchi Y, Ohshima M, Izumi Y: Detection of hepatocyte growth factor in oral rinses using water for possible periodontal diagnosis. Journal of Oral Science. 2020.06; 62 (3): 250-255. ( PubMed , DOI )

  23. Niimi H, Ohsugi Y, Katagiri S, Watanabe K, Hatasa M, Shimohira T, Tsuchiya Y, Maekawa S, Hirota T, Kadokura H, Yokose S, Iwata T, Aoki A: Effects of low-level Er:YAG laser irradiation on proliferation and calcification of primary osteoblast-like cells Isolated from rat calvaria Frontiers in cell and developmental biology, Tokyo Medical and Dental University. 2020.06; 6 459.

  24. Sano K, Usui M, Moritani Y, Nakazawa K, Hanatani T, Kondo H, Nakatomi M, Onizuka S, Iwata T, Sato T, Togari A, Ariyoshi W, Nishihara T, Nakashima K: Co-cultured spheroids of human periodontal ligament mesenchymal stem cells and vascular endothelial cells enhance periodontal tissue regeneration Regenerative Therapy. 2020.06; 14 59-71. ( DOI )

  25. Onizuka S, Yamazaki Y, Park SJ, Sugimoto T, Sone Y, Sjöqvist S, Usui M, Takeda A, Nakai K, Nakashima K, Iwata T: RNA-sequencing reveals positional memory of multipotent mesenchymal stromal cells from oral and maxillofacial tissue transcriptomes BMC GENOMICS. 2020.06; 21 (1): 417. ( DOI )

  26. Park JY, Park CH, Yi T, Kim SN, Iwata T, Yun JH: rhBMP-2 Pre-Treated Human Periodontal Ligament Stem Cell Sheets Regenerate a Mineralized Layer Mimicking Dental Cementum International Journal of Molecular Sciences. 2020.06; 21 (11): 3637. ( DOI )

  27. Iwata T: PCR detection and new therapies for COVID-19 Journal of periodontal and implant science. 2020.06; 50 (3): 133-134. ( DOI )

  28. Ogawa M, Katagiri S, Koyanagi T, Maekawa S, Shiba T, Ohsugi Y, Takeuchi Y, Ikawa T, Takeuchi S, Sekiuchi T, Arai Y, Kazama R, Wakabayashi N, Izumi Y, Iwata T: Accuracy of cone beam computed tomography in evaluation of palatal mucosa thickness Journal of Clinical Periodontology, Tokyo Medical and Dental University. 2020.04; 47 (4): 479-488. ( PubMed , DOI )

  29. Ye C, Katagiri S, Miyasaka N, Kobayashi H, Khemwong T, Nagasawa T, Izumi Y: The periodontopathic bacteria in placenta, saliva and subgingival plaque of threatened preterm labor and preterm low birth weight cases: a longitudinal study in Japanese pregnant women Clinical Oral Investigations. 2020.04; 24 (12): 4261-4270. ( PubMed , DOI )

  30. Tanaka K, Takahashi H, Katagiri S, Sasaki K, Ohsugi Y, Watanabe K, Rasadul IMD, Mine K, Nagafuchi S, Iwata T, Eguchi Y, Anzai K: Combined effect of canagliflozin and exercise training on high-fat diet-fed mice. American journal of physiology. Endocrinology and metabolism. 2020.04; 318 (4): E492-E503. ( PubMed , DOI )

  31. Kohei Nohara, Soichiro Itoh, Tatsuya Akizuki, Miho Nakamura, Shunsuke Fukuba, Takanori Matsuura, Munehiro Okada, Yuichi Izumi, Takanori Iwata, Kimihiro Yamashita: Enhanced new bone formation in canine maxilla by a graft of electrically polarized β-tricalcium phosphate. J. Biomed. Mater. Res. Part B Appl. Biomater.. 2020.04; ( PubMed , DOI )

  32. Kawamura R, Mizutani K, Lin T, Kakizaki S, Mimata A, Watanabe K, Saito N, Meinzer W, Iwata T, Izumi Y, Aoki A: Ex Vivo Evaluation of Gingival Ablation with Various Laser Systems and Electroscalpel Photobiomodulation Photomedicine and Laser Surgery, Tokyo Medical and Dental University. 2020.03; 38 (6): 364-373. ( PubMed , DOI )

  33. Kasai S, Onizuka S, Katagiri S, Nakamura T, Hanatani T, Kudo T, Sugata Y, Ishimatsu M, Usui M, Nakashima K: Associations of cytokine levels in gingival crevicular fluid of mobile teeth with clinical improvement after initial periodontal treatment Journal of oral science. 2020.03; 62 (2): 189-196. ( PubMed , DOI )

  34. Ye C, Kobayashi H, Katagiri S, Miyasaka N, Takeuchi Y, Kuraji R, Izumi Y: The relationship between the anti-#IPorphyromonas gingivalis#IR immunoglobulin G subclass antibody and small for gestational age delivery: a longitudinal study in pregnant Japanese women. International dental journal. 2020.03; 70 (4): 296-302. ( PubMed , DOI )

  35. Techatanawat S, Surarit R, Chairatvit K, Khovidhunkit W, Roytrakul S, Thanakun S, Kobayashi H, Khovidhunkit SP, Izumi Y: Salivary and serum interleukin-17A and interleukin-18 levels in patients with type 2 diabetes mellitus with and without periodontitis PLoS One. 2020.02; 15 (2): e0228921. ( PubMed , DOI )

  36. Hatasa M, Ohsugi Y, Katagiri S, Yoshida S, Niimi H, Morita K, Tsuchiya Y, Shimohira T, Sasaki N, Maekawa S, Shiba T, Hirota T, Tohara H, Takahashi H, Nitta H, Iwata T.: Endotoxemia by Porphyromonas gingivalis alters endocrine functions in brown adipose tissue Frontiers in Cellular and Infection Microbiology. 2020; 10 580577. ( PubMed , DOI )

  37. Niimi H, Ohsugi Y, Katagiri S, Watanabe K, Hatasa M, Shimohira T, Tsuchiya Y, Maekawa S, Hirota T, Kadokura H, Yokose S, Iwata T, Aoki A: Effects of Low-Level Er:YAG Laser Irradiation on Proliferation and Calcification of Primary Osteoblast-Like Cells Isolated From Rat Calvaria. Frontiers in cell and developmental biology. 2020; 8 459. ( PubMed , DOI )

  38. Mikami R, Mizutani K, Sasaki Y, Iwata T, Aoki A: Patient-reported outcomes of laser-assisted pain control following non-surgical and surgical periodontal therapy: A systematic review and meta-analysis. PloS one. 2020; 15 (9): e0238659. ( PubMed , DOI )

  1. Lin Taichen, Taniguchi Yoichi, Aoki Akira, Chang Yu-Chao: Clinical evaluation of multiple peri-implant bony defect management by Er:YAG laser-assisted bone regenerative therapy JOURNAL OF DENTAL SCIENCES. 2019.12; 14 (4): 430-432. ( PubMed , DOI )

  2. Katagiri S, Shiba T, Tohara H, Yamaguchi K, Hara K, Nakagawa K, Komatsu K, Watanabe K, Ohsugi Y, Maekawa S, Iwata T: Re-initiation of Oral Food Intake Following Enteral Nutrition Alters Oral and Gut Microbiota Communities FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2019.12; 9 434. ( PubMed , DOI )

  3. Kato Y, Arakawa S, Terasawa K, Inokuchi JI, Iwata T, Shimizu S, Watabe T, Hara-Yokoyama M: The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Bioorganic & medicinal chemistry letters. 2019.12; 30 (3): 126891. ( PubMed , DOI )

  4. Gholami L, Asefi S, Hooshyarfard A, Sculean A, Romanos GE, Aoki A, Fekrazad R: Photobiomodulation in Periodontology and Implant Dentistry: Part I Photobiomodulation, photomedicine, and laser surgery. 2019.11; 37 (12): 739-765. ( PubMed , DOI )

  5. Gholami L, Asefi S, Hooshyarfard A, Sculean A, Romanos GE, Aoki A, Fekrazad R: Photobiomodulation in Periodontology and Implant Dentistry: Part II. Photobiomodulation, photomedicine, and laser surgery. 2019.11; 37 (12): 766-783. ( PubMed , DOI )

  6. Maekawa S, Onizuka S, Katagiri S, Hatasa M, Ohsugi Y, Sasaki N, Watanabe K, Ohtsu A, Komazaki R, Ogura K, Miyoshi-Akiyama T, Iwata T, Nitta H, Izumi Y: RNA sequencing for ligature induced periodontitis in mice revealed important role of S100A8 and S100A9 for periodontal destruction Scientific Reports. 2019.10; 9 (1): 14663. ( PubMed , DOI )

  7. Park Sung-Joon, Onizuka Satoru, Seki Masahide, Suzuki Yutaka, Iwata Takanori, Nakai Kenta: A systematic sequencing-based approach for microbial contaminant detection and functional inference BMC BIOLOGY. 2019.09; 17 (1): 72. ( PubMed , DOI )

  8. Watanabe K, Ohsugi Y, Maekawa S, Sasaki N, Shiba T, Katagiri S, Arakawa S: Ozone Ultrafine Bubble Water improves wound healing via modification of inflammation Journal of the Stomatological Society. 2019.07; 86 (2): 25-34.

  9. Katagiri T, Yamazaki S, Fukui Y, Aoki K, Yagita H, Nishina T, Mikami T, Katagiri S, Shiraishi A, Kimura S, Tateda K, Sumimoto H, Endo S, Kameda H, Nakano H: JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling. Mucosal Immunol. 2019.07; ( PubMed , DOI )

  10. Yokomizo H, Maeda Y, Park K, Clermont AC, Hernandez SL, Fickweiler W, Li Q, Wang CH, Paniagua SM, Simao F, Ishikado A, Sun B, Wu IH, Katagiri S, Pober DM, Tinsley LJ, Avery RL, Feener EP, Kern TS, Keenan HA, Aiello LP, Sun JK, King GL: Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy. Sci Transl Med. 2019.07; 11 (499): ( PubMed , DOI )

  11. 渡辺数基, 大杉勇人, 前川祥吾, 佐々木直樹, 芝多佳彦, 片桐さやか, 荒川真一: 創傷治癒モデルマウスにおける炎症因子を介したオゾンウルトラファインバブル水の効果(Ozone Ultrafine Bubble Water Improves Wound Healing via Modification of Inflammation) 口腔病学会雑誌. 2019.07; 86 (2): 25-35. ( ichushi )

  12. Kaibuchi Nobuyuki, Iwata Takanori, Onizuka Satoru, Yano Kosei, Tsumanuma Yuka, Yamato Masayuki, Okano Teruo, Ando Tomohiro: Allogeneic multipotent mesenchymal stromal cell sheet transplantation promotes healthy healing of wounds caused by zoledronate and dexamethasone in canine mandibular bones REGENERATIVE THERAPY. 2019.06; 10 77-83. ( PubMed , DOI )

  13. Onizuka S, Iwata T: Application of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets for Periodontal Regeneration. Int J Mol Sci. 2019.06; 20 (11): ( PubMed , DOI )

  14. Sebastian S, Kasai Y, Shimura D, Ishikawa T, Ali N, Iwata T, Kanai N: Oral keratinocyte-derived exosomes regulate proliferation of fibroblasts and epithelial cells. Biochem. Biophys. Res. Commun.. 2019.06; 514 (3): 706-712. ( PubMed , DOI )

  15. Khemwong Thatawee, Kobayashi Hiroaki, Ikeda Yuichi, Matsuura Takanori, Sudo Takeaki, Kano Chihiro, Mikami Ryo, Izumi Yuichi: Fretibacterium sp. human oral taxon 360 is a novel biomarker for periodontitis screening in the Japanese population PLOS ONE. 2019.06; 14 (6): e0218266. ( PubMed , DOI )

  16. Aung N, Aoki A, Takeuchi Y, Hiratsuka K, Katagiri S, Kong S, Shujaa Addin A, Meinzer W, Sumi Y, Izumi Y: The effects of ultraviolet light-emitting diodes with different wavelengths on periodontopathic acteria #IIn Vitro#IR. Photobiomodulation, photomedicine, and laser surgery. 2019.05; 37 (5): 288-297. ( PubMed , DOI )

  17. Tanaka K, Takahashi H, Eguchi Y, Katagiri S, Ohsugi Y, Watanabe K, Iwata T, Anzai K: 肥満者と糖尿病患者の骨格筋に及ぼすcanagliflozinと運動の効果(The effects of canagliflozin and exercise training on skeletal muscle in obesity and diabetes) 糖尿病. 2019.04; 62 (Suppl.1): S-370. ( ichushi )

  18. Ohsugi Y, Aoki A, Mizutani K, Katagiri S, Komaki M, Noda M, Takagi T, Kakizaki S, Meinzer W, Izumi Y: Evaluation of bone healing following Er:YAG laser ablation in rat calvaria compared with bur drilling. Journal of Biophotonics. 2019.03; 12 (3): e201800245. ( PubMed , DOI )

  19. Ohtsu A, Takeuchi Y, Katagiri S, Suda W, Maekawa S, Shiba T, Komazaki R, Udagawa S, Sasaki N, Hattori M, Izumi Y: Influence of #IPorphyromonas gingivalis#IR in gut microbiota of streptozotocin-induced diabetic mice. Oral diseases. 2019.01; 25 (3): 868-880. ( PubMed , DOI )

  20. Sjöqvist S, Ishikawa T, Shimura D, Kasai Y, Imafuku A, Bou-Ghannam S, Iwata T, Kanai N: Exosomes derived from clinical-grade oral mucosal epithelial cell sheets promote wound healing. Journal of extracellular vesicles. 2019; 8 (1): 1565264. ( PubMed , DOI )

  1. Iwata Takanori, Yamato Masayuki, Washio Kaoru, Yoshida Toshiyuki, Tsumanuma Yuka, Yamada Azusa, Onizuka Satoru, Izumi Yuichi, Ando Tomohiro, Okano Teruo, Ishikawa Isao: Periodontal regeneration with autologous periodontal ligament-derived cell sheets - A safety and efficacy study in ten patients REGENERATIVE THERAPY. 2018.12; 9 38-44. ( PubMed , DOI )

  2. Maekawa Shogo, Suzuki Shinta, Aoki Akira, Katagiri Sayaka, Ikeda Yuichi, Ejiri Kenichiro, Kong Sophannary, Nagata Mizuki, Yamaguchi Yoko, Ohshima Mitsuhiro, Izumi Yuichi: 肝細胞増殖因子を用いた歯周炎の新規スクリーニングシステム(A new screening system for periodontitis using Hepatocyte growth factor) 日本歯周病学会会誌. 2018.12; 60 (4): 240. ( ichushi )

  3. Yumoto M, Saito N, Lin T, Kawamura R, Aoki A, Izumi Y, Wada S: High-energy, nanosecond pulsed Cr:CdSe laser with a 2.25-3.08 mu m tuning range for laser biomaterial processing. Biomedical Optics Express. 2018.11; 9 (11): 5645-5653. ( PubMed , DOI )

  4. Moritani Y, Usui M, Sano K, Nakazawa K, Hanatani T, Nakatomi M, Iwata T, Sato T, Ariyoshi W, Nishihara T, Nakashima K: Spheroid culture enhances osteogenic potential of periodontal ligament mesenchymal stem cells. Journal of periodontal research. 2018.10; 53 (5): 870-882. ( PubMed , DOI )

  5. Sasaki N, Katagiri S, Komazaki R, Watanabe K, Maekawa S, Shiba T, Udagawa S, Takeuchi Y, Ohtsu A, Kohda T, Tohara H, Miyasaka N, Hirota T, Tamari M, Izumi Y: Endotoxemia by #IPorphyromonas gingivalis#IR injection aggravates non-alcoholic fatty liver disease, disrupts glucose/lipid metabolism, and alters gut microbiota in mice. Frontiers in Microbiology. 2018.10; 9 2470. ( PubMed , DOI )

  6. Tsubokawa Masaki, Aoki Akira, Kakizaki Sho, Taniguchi Yoichi, Ejiri Kenichiro, Mizutani Koji, Koshy Geena, Akizuki Tatsuya, Oda Shigeru, Sumi Yasunori, Izumi Yuichi: 歯肉縁下歯石および歯根面セメント質を検出するための光干渉断層画像法に関するin vitro評価と臨床評価(In vitro and clinical evaluation of optical coherence tomography for the detection of subgingival calculus and root cementum) Journal of Oral Science. 2018.09; 60 (3): 418-427. ( ichushi )

  7. Khemwong Thatawee, 小林 宏明, 池田 裕一, 須藤 毅顕, 加納 千博, 松浦 孝典, 和泉 雄一: 歯周炎スクリーニングのための新規細菌バイオマーカー　Eubacterium saphenum(Eubacterium saphenum as a Novel Bacterial Biomarker for Periodontitis Screening) 口腔病学会雑誌. 2018.07; 85 (2): 62-68. ( ichushi )

  8. Khemwong T,　Kobayashi H Ikeda Y, Sudo T, Kano C, Matsuura T, Izumi Y : #IEubacterium Saphenum#IR as a Novel Bacterial Biomarker for Periodontitis Screening 口腔病学会雑誌. 2018.07; 85 (2): 62-67.

  9. Chigasaki O, Takeuchi Y, Aoki A, Sasaki Y, Mizutani K, Aoyama N, Ikeda Y, Gokyu M, Umeda M, Ishikawa I, Izumi Y: A cross-sectional study on the periodontal status and prevalence of red complex periodontal pathogens in a Japanese population. J Oral Sci. 2018.06; 60 (2): 293-303. ( PubMed , DOI )

  10. Chigasaki Otofumi, Takeuchi Yasuo, Aoki Akira, Sasaki Yoshiyuki, Mizutani Koji, Aoyama Norio, Ikeda Yuichi, Gokyu Misa, Umeda Makoto, Ishikawa Isao, Izumi Yuichi: 日本人集団を対象とした歯周状態およびレッドコンプレックス歯周病原細菌の陽性率に関する横断研究(A cross-sectional study on the periodontal status and prevalence of red complex periodontal pathogens in a Japanese population) Journal of Oral Science. 2018.06; 60 (2): 293-303. ( ichushi )

  11. Toru Takagi, Akira Aoki, Shizuko Ichinose, Yoichi Taniguchi, Noriko Tachikawa, Takeshi Shinoki, Walter Meinzer, Anton Sculean, Yuichi Izumi: Effective removal of calcified deposits on microstructured titanium fixture surfaces of dental implants with erbium lasers. J. Periodontol.. 2018.06; 89 (6): 680-690. ( PubMed , DOI )

  12. Tsubokawa M, Aoki A, Kakizaki S, Taniguchi Y, Ejiri K, Mizutani K, Koshy G, Akizuki T, Oda S, Sumi Y, Izumi Y: In vitro and clinical evaluation of optical coherence tomography for the detection of subgingival calculus and root cementum. Journal of oral science. 2018.05; ( PubMed , DOI )

  13. Pavlic V, Brkic Z, Marin S, Cicmil S, Gojkov-Vukelic M, Aoki A: Gingival melanin depigmentation by Er:YAG laser: a literature review. Journal of Cosmetic and Laser Therapy. 2018.04; 20 (2): 85-90. ( PubMed , DOI )

  14. Kakizaki S., Aoki A., Tsubokawa M., Lin T., Mizutani K., Koshy G., Sadr A., Oda S., Sumi Y., Izumi Y.: Observation and determination of periodontal tissue profile using optical coherence tomography JOURNAL OF PERIODONTAL RESEARCH. 2018.04; 53 (2): 188-199. ( DOI )

  15. Taniguchi Y, Sawada K, Aoki A, Miyazawa M, Yamada A, Nakahara K, Izumi Y.: Novel Prosthesis Technique for Fabricating a CAD/CAM Implant Superstructure Frame Using a 3D Printer. EC DENTAL SCIENCE. 2018.04; 17 (5): 459-468.

  16. Mikami R, Mizutani K, Aoki A, Tamura Y, Aoki K, Izumi Y: Low-level ultrahigh-frequency and ultrashort-pulse blue laser irradiation enhances osteoblast extracellular calcification by upregulating proliferation and differentiation via transient receptor potential vanilloid 1. Lasers Surg Med. 2018.04; 50 (4): 340-352. ( PubMed , DOI )

  17. Rina Komazaki, Sayaka Katagiri, Hirokazu Takahashi, Shogo Maekawa, Takahiko Shiba, Yasuo Takeuchi, Yoichiro Kitajima, Anri Ohtsu, Sayuri Udagawa, Naoki Sasaki, Kazuki Watanabe, Noriko Sato, Naoyuki Miyasaka, Yuichiro Eguchi, Keizo Anzai, Yuichi Izumi: Author Correction: Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism. Sci Rep. 2018.03; 8 (1): 4620. ( PubMed , DOI )

  18. Udagawa S, Katagiri S, Maekawa S, Takeuchi Y, Komazaki R, Ohtsu A, Sasaki N, Shiba T, Watanabe K, Ishihara K, Sato N, Miyasaka N, Izumi Y: Effect of #IPorphyromonas gingivalis#IR infection in the placenta and umbilical cord in pregnant mice with low birth weight. Acta Odontologica Scandinavica. 2018.01; 1-9. ( PubMed , DOI )

  19. Sineepat Talungchit, Waranun Buajeeb, Chotima Lerdtripop, Rudee Surarit, Kongthawat Chairatvit, Sittiruk Roytrakul, Hiroaki Kobayashi, Yuichi Izumi, Siribang-On Piboonniyom Khovidhunkit: Putative salivary protein biomarkers for the diagnosis of oral lichen planus: a case-control study. BMC Oral Health. 2018; 18 (1): 42. ( PubMed , DOI )

  1. Khemwong Thatawee, Kobayashi Hiroaki, Sudo Takeaki, Kano Chihiro, Izumi Yuichi: Beta-defensins inducing by interleukin-17s in oral epithelial cell CYTOKINE. 2017.12; 100 155.

  2. Yoshiaki Nomura, Toshiya Morozumi, Taneaki Nakagawa, Tsutomu Sugaya, Masamitsu Kawanami, Fumihiko Suzuki, Keiso Takahashi, Yuzo Abe, Soh Sato, Asako Makino-Oi, Atsushi Saito, Satomi Takano, Masato Minabe, Yohei Nakayama, Yorimasa Ogata, Hiroaki Kobayashi, Yuichi Izumi, Naoyuki Sugano, Koichi Ito, Satoshi Sekino, Yukihiro Numabe, Chie Fukaya, Nobuo Yoshinari, Mitsuo Fukuda, Toshihide Noguchi, Tomoo Kono, Makoto Umeda, Osamu Fujise, Fusanori Nishimura, Atsutoshi Yoshimura, Yoshitaka Hara, Toshiaki Nakamura, Kazuyuki Noguchi, Erika Kakuta, Nobuhiro Hanada, Shogo Takashiba, Yasuharu Amitani, Hiromasa Yoshie: Site-level progression of periodontal disease during a follow-up period. PLoS ONE. 2017.12; 12 (12): e0188670. ( PubMed , DOI )

  3. Kong S, Aoki A, Iwasaki K, Mizutani K, Katagiri S, Suda T, Ichinose S, Ogita M, Pavlic V, Izumi Y: Biological effects of Er:YAG laser irradiation on the proliferation of primary human gingival fibroblasts. J Biophotonics. 2017.10; epub ( PubMed , DOI )

  4. Rina Komazaki, Sayaka Katagiri, Hirokazu Takahashi, Shogo Maekawa, Takahiko Shiba, Yasuo Takeuchi, Yoichiro Kitajima, Anri Ohtsu, Sayuri Udagawa, Naoki Sasaki, Kazuki Watanabe, Noriko Sato, Naoyuki Miyasaka, Yuichiro Eguchi, Keizo Anzai, Yuichi Izumi: Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism Scientific Reports. 2017.10;

  5. Enoki Y, Sato T, Kokabu S, Hayashi N, Iwata T, Yamato M, Usui M, Matsumoto M, Tomoda T, Ariyoshi W, Nishihara T, Yoda T: Netrin-4 Promotes Differentiation and Migration of Osteoblasts. In vivo (Athens, Greece). 2017.09; 31 (5): 793-799. ( PubMed )

  6. Nitta Hiroshi, Katagiri Sayaka, Nagasawa Toshiyuki, Izumi Yuichi, Ishikawa Isao, Izumiyama Hajime, Uchimura Isao, Kanazawa Masao, Chiba Hiroshige, Matsuo Akira, Utsunomiya Kazunori, Tanabe Haruyasu, Takei Izumi, Asanami Soichiro, Kajio Hiroshi, Ono Toaki, Hayashi Yoichi, Ueki Kiichi, Tsuji Masatomi, Kurachi Yoichi, Yamanouchi Toshikazu, Ichinokawa Yoshimi, Inokuchi Toshiki, Fukui Akiko, Miyazaki Shigeru, Miyauchi Takashi, Kawahara Reiko, Ogiuchi Hideki, Yoshioka Narihito, Negishi Jun, Mori Masatomo, Mogi Kenji, Saito Yasushi, Tanzawa Hideki, Nishikawa Tetsuo, Takada Norihiko, Nanjo Kishio, Morita Nobuo, Nakamura Naoto, Kanamura Narisato, Makino Hirofumi, Nishimura Fusanori, Kobayashi Kunihisa, Higuchi Yoshinori, Sakata Toshiie, Yanagisawa Shigetaka, Tei Chuwa, Ando Yuichi, Hanada Nobuhiro, Inoue Shuji: 2型糖尿病患者における細小血管合併症数は歯周炎重症度のリスクの上昇と関連する　多施設共同病院ベース横断研究の結果(The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study) Journal of Diabetes Investigation. 2017.09; 8 (5): 677-686. ( ichushi )

  7. Kato Y, Iwata T, Washio K, Yoshida T, Kuroda H, Morikawa S, Hamada M, Ikura K, Kaibuchi N, Yamato M, Okano T, Uchigata Y: Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model. Journal of visualized experiments : JoVE. 2017.08; (126): ( PubMed , DOI )

  8. Hua N, Takahashi H, Yee GM, Kitajima Y, Katagiri S, Kojima M, Anzai K, Eguchi Y, Hamilton JA: Influence of muscle fiber type composition on early fat accumulation under high-fat diet challenge. PLoS ONE. 2017.08; 12 (8): e0182430. ( PubMed , DOI )

  9. Saito Akira, Horie Masafumi, Ejiri Kenichiro, Aoki Akira, Katagiri Sayaka, Maekawa Shogo, Suzuki Shinta, Kong Sophannary, Yamauchi Tsuneto, Yamaguchi Yoko, Izumi Yuichi, Ohshima Mitsuhiro: MicroRNA profiling in gingival crevicular fluid of periodontitis-a pilot study FEBS OPEN BIO. 2017.07; 7 (7): 981-994. ( PubMed , DOI )

  10. Hamada M, Iwata T, Kato Y, Washio K, Morikawa S, Sakurai H, Yamato M, Okano T, Uchigata Y: Xenogeneic transplantation of human adipose-derived stem cell sheets accelerate angiogenesis and the healing of skin wounds in a Zucker Diabetic Fatty rat model of obese diabetes. Regenerative therapy. 2017.06; 6 65-73. ( PubMed , DOI )

  11. Kaibuchi N, Iwata T, Onizuka S, Yano K, Yamato M, Okano T, Ando T: Cytological character of mini pig mesenchymal stromal cells from various tissues and the attempt of cell sheet formation. Regenerative therapy. 2017.06; 6 83-89. ( PubMed , DOI )

  12. T Sudo, Y Okada, K Ozaki, K Urayama, M Kanai, H Kobayashi, M Gokyu, Y Izumi, T Tanaka: Association of NOD2 Mutations with Aggressive Periodontitis. J. Dent. Res.. 2017.06; 22034517715432. ( PubMed , DOI )

  13. Saito A, Horie M, Ejiri K, Aoki A, Katagiri S, Maekawa S, Suzuki S, Kong S, Yamauchi T, Yamaguchi Y, Izumi Y, Ohshima M: MicroRNA profiling in gingival crevicular fluid of periodontitis—a pilot study FEBS Openbio. 2017.06; e-pub

  14. Nitta H, Katagiri S, Nagasawa T, Izumi Y, Ishikawa I, Izumiyama H et al.: The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study. J Diabetes Investig. 2017.05; 8 677-686. ( PubMed , DOI )

  15. Nagase K, Sakurada Y, Onizuka S, Iwata T, Yamato M, Takeda N, Okano T: Thermoresponsive polymer-modified microfibers for cell separations. Acta biomaterialia. 2017.04; 53 81-92. ( PubMed , DOI )

  16. Kong Sophannary, Aoki Akira, Iwasaki Kengo, Mizutani Koji, Suda Tomonari, Katagiri Sayaka, Ogita Mayumi, Ando Yoshinori, Izumi Yuichi: ヒト歯肉線維芽細胞の増殖に及ぼすEr:YAGレーザー照射の効果(Effects of Er:YAG laser irradiation on proliferation of human gingival fibroblasts) 日本歯周病学会会誌. 2017.04; 59 (春季特別): 118. ( ichushi )

  17. Maekawa S, Katagiri S, Takeuchi Y, Komazaki R, Ohtsu A, Udagawa S, Izumi Y: Bone metabolic microarray analysis of ligature-induced periodontitis in streptozotocin-induced diabetic mice. J. Periodont. Res.. 2017.04; 52 (2): 233-245. ( PubMed , DOI )

  18. Eick S, Meier I, Spoerlé F, Bender P, Aoki A, Izumi Y, Salvi GE, Sculean A: In Vitro-Activity of Er:YAG Laser in Comparison with other Treatment Modalities on Biofilm Ablation from Implant and Tooth Surfaces PLoS ONE. 2017.01; 12 (1): e0171086. ( PubMed , DOI )

  19. Kakuta E, Nomura Y, Morozumi T, Nakagawa T, Nakamura T, Noguchi K, Yoshimura A, Hara Y, Fujise O, Nishimura F, Kono T, Umeda M, Fukuda M, Noguchi T, Yoshinari N, Fukaya C, Sekino S, Numabe Y, Sugano N, Ito K, Kobayashi H, Izumi Y, Takai H, Ogata Y, Takano S, Minabe M, Makino-Oi A, Saito A, Abe Y, Sato S, Suzuki F, Takahashi K, Sugaya T, Kawanami M, Hanada N, Takashiba S, Yoshie H: Assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study. BMC Oral Health. 2017.01; 17 (1): 46. ( PubMed , DOI )

  1. T Morozumi, T Nakagawa, Y Nomura, T Sugaya, M Kawanami, F Suzuki, K Takahashi, Y Abe, S Sato, A Makino-Oi, A Saito, S Takano, M Minabe, Y Nakayama, Y Ogata, H Kobayashi, Y Izumi, N Sugano, K Ito, S Sekino, Y Numabe, C Fukaya, N Yoshinari, M Fukuda, T Noguchi, T Kono, M Umeda, O Fujise, F Nishimura, A Yoshimura, Y Hara, T Nakamura, K Noguchi, E Kakuta, N Hanada, S Takashiba, H Yoshie: Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study. J. Periodont. Res.. 2016.12; 51 (6): 768-778. ( PubMed , DOI )

  2. Uekubo A, Hiratsuka K, Aoki A, Takeuchi Y, Abiko Y, Izumi Y: Effect of antimicrobial photodynamic therapy using rose bengal and blue light-emitting diode on Porphyromonas gingivalis in vitro: Influence of oxygen during treatment Laser Therapy. 2016.12; 25 (4): 299-308. ( PubMed )

  3. Lin T, Aoki A, Saito N, Yumoto M, Nakajima S, Nagasaka K, Ichinose S, Mizutani K, Wada S, Izumi Y: Dental hard tissue ablation using mid-infrared tunable nanosecond pulsed Cr:CdSe laser. Lasers Surg Med. 2016.12; 48 (10): 965-977. ( PubMed , DOI )

  4. Maekawa Shogo, Katagiri Sayaka, Takeuchi Yasuo, Komazaki Rina, Ohtsu Anri, Udagawa Sayuri, Izumi Yuichi: ストレプトゾトシン誘発性糖尿病マウスにおける結紮誘発性歯周炎の骨代謝マイクロアレイ分析(Bone Metabolic Microarray Analysis of Ligature-Induced-Periodontitis in Streptozotocin-Induced Diabetic Mice) 日本歯周病学会会誌. 2016.11; 58 (3): 168. ( ichushi )

  5. Onizuka S, Iwata T, Park SJ, Nakai K, Yamato M, Okano T, Izumi Y: ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells. Journal of cellular biochemistry. 2016.10; 117 (10): 2423-34. ( PubMed , DOI )

  6. Kaibuchi N, Iwata T, Yamato M, Okano T, Ando T: Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model. Acta biomaterialia. 2016.09; 42 400-410. ( PubMed , DOI )

  7. Katagiri S, Park K, Maeda Y, Rao TN, Khamaisi M, Li Q, Yokomizo H, Mima A, Lancerotto L, Wagers A, Orgill DP, King GL: Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance. Diabetes. 2016.09; 65 (9): 2760-2771. ( PubMed , DOI )

  8. Noda M, Aoki A, Mizutani K, Lin T, Komaki M, Shibata S, Izumi Y: High-frequency pulsed low-level diode laser therapy accelerates wound healing of tooth extraction socket: An in vivo study. Lasers Surg. Med. 2016.07; e-pub ( PubMed , DOI )

  9. Taniguchi Y, Aoki A, Sakai K, Mizutani K, Meinzer W, Izumi Y: A Novel Surgical Procedure for Er:YAG Laser-Assisted Periodontal Regenerative Therapy: Case Series. Int J Periodontics Restorative Dent. 2016.07; 36 (4): 507-515.

  10. Mizutani K, Aoki A, Coluzzi D, Yukna R, Wang C, Pavlic V, Izumi Y: Lasers in minimally invasive periodontal and peri-implant therapy. Periodontol. 2000. 2016.06; 71 (1): 185-212. ( PubMed , DOI )

  11. Park K, Mima A, Li Q, Rask-Madsen C, He P, Mizutani K, Katagiri S, Maeda Y, Wu IH, Khamaisi M, Preil SR, Maddaloni E, Sørensen D, Rasmussen LM, Huang PL, King GL: Insulin decreases atherosclerosis by inducing endothelin receptor B expression. JCI Insight. 2016.05; 1 (6): e86574. ( PubMed , DOI )

  12. Ye Changchang, Kobayashi Hiroaki, Katagiri Sayaka, Komazaki Rina, Yuichi Izumi: 緊急早産と早産の症例におけるPorphyromonas gingivalisに対する免疫グロブリンGサブクラス抗体の役割(The role of immunoglobulin G subclass antibodies against Porphyromonas. gingivalis in threatened preterm labor and preterm birth cases) 日本歯周病学会会誌. 2016.04; 58 (春季特別): 113. ( ichushi )

  13. Khamaisi M, Katagiri S, Keenan H, Park K, Maeda Y, Li Q, Qi W, Thomou T, Eschuk D, Tellechea A, Veves A, Huang C, Orgill DP, Wagers A, King GL: PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. J. Clin. Invest.. 2016.03; 126 (3): 837-853. ( PubMed , DOI )

  14. Lin T, Kawamura R, Aoki A, Ichinose S, Mizutani K, Taniguchi Y, Eguro T, Saito N, Izumi Y: Energy output reduction and surface alteration of quartz tips following Er:YAG laser contact irradiation on soft and hard tissues in vitro. Dental Materials Journal. 2016.02; 35 (1): 51-62. ( PubMed , DOI )

  15. Yuka Tsumanuma, Takanori Iwata, Atsuhiro Kinoshita, Kaoru Washio, Toshiyuki Yoshida, Azusa Yamada, Ryo Takagi, Masayuki Yamato, Teruo Okano, Yuichi Izumi: Allogeneic Transplantation of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets in Canine Critical-Size Supra-Alveolar Periodontal Defect Model. BioResearch Open Access. 2016.01; 5 (1): 22-36. ( PubMed , DOI )

  16. Supanee Thanakun, Suchaya Pornprasertsuk-Damrongsri, Misa Gokyu, Hiroaki Kobayashi, Yuichi Izumi: Inverse Association of Plasma IgG Antibody to Aggregatibacter actinomycetemcomitans and High C-Reactive Protein Levels in Patients with Metabolic Syndrome and Periodontitis. PLoS ONE. 2016; 11 (2): e0148638. ( PubMed , DOI )

  1. Komabayashi T, Ebihara A, Aoki A: The use of lasers for direct pulp capping. Journal of Oral Science. 2015.12; 57 (4): 277-286. ( DOI )

  2. Sculean A, Aoki A, Romanos G, Schwarz F, Miron RJ, Cosgarea R: Is Photodynamic Therapy an Effective Treatment for Periodontal and Peri-Implant Infections? Dental Clinics of North America. 2015.10; 59 (4): 831-858. ( PubMed , DOI )

  3. Tomonari Suda, Hiroaki Kobayashi, Toshiharu Akiyama, Takuya Takano, Misa Gokyu, Takeaki Sudo, Thatawee Khemwong, Yuichi Izumi: Desensitizing Agent Reduces Dentin Hypersensitivity During Ultrasonic Scaling: A Pilot Study. J Clin Diagn Res. 2015.09; 9 (9): ZC46-ZC49. ( PubMed , DOI )

  4. Ogita M, Tsuchida S, Aoki A, Satoh M, Kado S, Sawabe M, Nanbara H, Kobayashi H, Takeuchi Y, Mizutani K, Sasaki Y, Nomura F, Izumi Y: Increased cell proliferation and differential protein expression induced by low-level Er:YAG laser irradiation in human gingival fibroblasts: proteomic analysis. Lasers in Medical Science. 2015.09; 30 (7): 1855-1866.

  5. Pavlić V, vujić-Aleksić V, Aoki A, Nežić L: Treatment of recurrent aphthous stomatitis by laser therapy: A systematic review of the literature. Vojnosanit Pregl. 2015.08; 72 (8): 722-728. ( PubMed )

  6. Kato Y, Iwata T, Morikawa S, Yamato M, Okano T, Uchigata Y: Allogeneic Transplantation of an Adipose-Derived Stem Cell Sheet Combined With Artificial Skin Accelerates Wound Healing in a Rat Wound Model of Type 2 Diabetes and Obesity. Diabetes. 2015.08; 64 (8): 2723-34. ( PubMed , DOI )

  7. Aoki A, Mizutani K, Schwarz F, Sculean A, Yukna RA, Takasaki AA, Romanos GE, Taniguchi Y, Ssaki KM, Zeredo JL, Koshy G, Coluzzi DJ, White JM, Abiko Y, Ishikawa I, Izumi Y: Periodontal and peri-implant wound healing following laser therapy. Periodontol 2000. 2015.04; 68 (1): 217-69.

  8. Iwata T, Washio K, Yoshida T, Ishikawa I, Ando T, Yamato M, Okano T: Cell sheet engineering and its application for periodontal regeneration. Journal of tissue engineering and regenerative medicine. 2015.04; 9 (4): 343-56. ( PubMed , DOI )

  9. Shimizu R, Kamei N, Adachi N, Hamanishi M, Kamei G, Mahmoud EE, Nakano T, Iwata T, Yamato M, Okano T, Ochi M: Repair mechanism of osteochondral defect promoted by bioengineered chondrocyte sheet. Tissue engineering. Part A. 2015.03; 21 (5-6): 1131-41. ( PubMed , DOI )

  10. S. Shimizu, Y. Momozawa, A. Takahashi, T. Nagasawa, K. Ashikawa, Y. Terada, Y. Izumi, H. Kobayashi, M. Tsuji, M. Kubo, and Y. Furuichi2: A Genome-wide Association Study of Periodontitis in a Japanese Population Journal of Dental Research. 2015.02; 11

  11. Sawabe M, Aoki A, Komaki M, Iwasaki K, Ogita M, Izumi Y: Gingival tissue healing following Er:YAG laser ablation compared to electrosurgery in rats. Lasers in Medical Science. 2015.02; 30 (2): 875-883. ( PubMed , DOI )

  1. Asahi K, Imazeki N, Takahashi T, Takeuchi M, Kimura N, Sasaki E, Uchino H, Murasugi K, Hayakawa A, Katagiri S, Ishizuka N, Suzuki Y, Sekiya K, Takahashi M, Sato E, Kawakubo K, Uehara Y, Ikemoto S, Inoue S: High prevalence of general and abdominal obesity and relationship of obesity with diabetes mellitus in patients with psychiatric disorders Journal of Diabetes and Obesity. 2014.12; 1 (2): 1-6. ( DOI )

  2. Ogita M, Tsuchida S, Aoki A, Satoh M, Kado S, Sawabe M, Nanbara H, Kobayashi H, Takeuchi Y, Mizutani K, Sasaki Y, Nomura F, Izumi Y: Increased cell proliferation and differential protein expression induced by low-level Er:YAG laser irradiation in human gingival fibroblasts: proteomic analysis. Lasers Med Sci.. 2014.12; 28

  3. Ichinose-Tsuno A, Aoki A, Takeuchi Y, Kirikae T, Shimbo T, Lee MC, Yoshino F, Maruoka Y, Itoh T, Ishikawa I, Izumi Y: Antimicrobial photodynamic therapy suppresses dental plaque formation in healthy adults: a randomized controlled clinical trial. BMC Oral Health. 2014.12; 14 152. ( PubMed , DOI )

  4. Tsuchida S, Satoh M, Sogawa K, Ishige T, Segawa S, Kado S, Rahmutulla B, Ogita M, Sawai S, Beppu M, Nishimura M, Aoki A, Kodera Y, Matsushita K, Izumi Y, Nomura F: Application of proteomic technologies to discover and identify biomarkers for periodontal diseases: moesin is a potential mediator and biomarker for periodontal disease. Journal of Proteomics & Bioinformmatics. 2014.12; 7 (12): 379-384.

  5. Yoshida T, Iwata T, Takai Y, Birchmeier W, Yamato M, Okano T: Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice. Genes to cells : devoted to molecular & cellular mechanisms. 2014.11; 19 (11): 842-52. ( PubMed , DOI )

  6. Ejiri K, Aoki A, Yamaguchi Y, Ohshima M, Izumi Y: High-frequency low-level diode laser irradiation promotes proliferation and migration of primary cultured human gingival epithelial cells. Lasers Med Sci. 2014.07; 29 (4): 1339-1347.

  7. Enoki Y, Sato T, Tanaka S, Iwata T, Usui M, Takeda S, Kokabu S, Matsumoto M, Okubo M, Nakashima K, Yamato M, Okano T, Fukuda T, Chida D, Imai Y, Yasuda H, Nishihara T, Akita M, Oda H, Okazaki Y, Suda T, Yoda T: Netrin-4 derived from murine vascular endothelial cells inhibits osteoclast differentiation in vitro and prevents bone loss in vivo. FEBS letters. 2014.06; 588 (14): 2262-9. ( PubMed , DOI )

  8. Pirraco RP, Iwata T, Yoshida T, Marques AP, Yamato M, Reis RL, Okano T: Endothelial cells enhance the in vivo bone-forming ability of osteogenic cell sheets. Laboratory investigation; a journal of technical methods and pathology. 2014.06; 94 (6): 663-73. ( PubMed , DOI )

  9. Suphanantachat S, Iwata T, Ishihara J, Yamato M, Okano T, Izumi Y: A role for c-Kit in the maintenance of undifferentiated human mesenchymal stromal cells. Biomaterials. 2014.04; 35 (11): 3618-26. ( PubMed , DOI )

  10. K Mizutani, K Park, A Mima, S Katagiri, G L King: Obesity-associated Gingival Vascular Inflammation and Insulin Resistance. J. Dent. Res.. 2014.04; 93 (6): 596-601. ( PubMed , DOI )

  11. Okamoto T, Ishikawa I, Kumasaka A, Morita S, Katagiri S, Okano T, Ando T: Blue-violet light-emitting diode irradiation in combination with hemostatic gelatin sponge (Spongel) application ameliorates immediate socket bleeding in patients taking warfarin. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014.02; 117 (2): 170-177. ( PubMed , DOI )

  12. Iwata T, Yamato M, Ishikawa I, Ando T, Okano T: Tissue engineering in periodontal tissue. Anatomical record (Hoboken, N.J. : 2007). 2014.01; 297 (1): 16-25. ( PubMed , DOI )

  13. Washio K, Kuroda H, Iwata T, Yoshida T, Yamato M, Okano T: Improved enzymatic treatment for accurate cell counting from extracellular matrix-rich periodontal ligament cell sheets. The International journal of oral & maxillofacial implants. 2014.01; 29 (1): e117-21. ( PubMed , DOI )

  14. Misa Gokyu, Hiroaki Kobayashi, Hiromi Nanbara, Takeaki Sudo, Yuichi Ikeda, Tomonari Suda, Yuichi Izumi: Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells. PLoS ONE. 2014; 9 (12): e115107. ( PubMed , DOI )

  1. Chui C, Aoki A, Takeuchi Y, Sasaki Y, Hiratsuka K, Abiko Y, Izumi Y: Antimicrobial effect of photodynamic therapy using high-power blue light-emitting diode and red-dye agent on Porphyromonas gingivalis. J Periodont Res. 2013.12; 48 (6): 696-705. ( PubMed , DOI )

  2. Etemadi A, Sadeghi M, Abbas FM, Razavi F, Aoki A, Azad RF, Chiniforush N: Comparing efficiency and root surface morphology after scaling with Er:YAG and Er,Cr:YSGG lasers. Int J Periodontics Restorative Dent. 2013.12; 33 (6): e140-4. ( PubMed )

  3. 11. Yoshida T, Iwata T, Umemoto T, Shiratsuchi Y, Kawashima N, Sugiyama T, Yamato M and Okano T: Promotion of mouse ameloblast proliferation by Lgr5 mediated integrin signaling Journal of Cellular Biochemistry. 2013.09; 114 (9): 2138-2147. ( DOI )

  4. Tsuchida S, Satoh M, Kawashima Y, Sogawa K, Kado S, Sawai S, Nishimura M, Ogita M, Takeuchi Y, Kobyashi H, Aoki A, Kodera Y, Matsushita K, Izumi Y, Nomura F: Application of quantitative proteomic analysis using tandem mass tags for discovery and identification of novel biomarkers in periodontal disease. Proteomics. 2013.08; 13 (15): 2339-2350. ( PubMed , DOI )

  5. Tsuchida S, Satoh M, Kawashima Y, Sogawa K, Kado S, Sawai S, Nishimura M, Ogita M, Takeuchi Y, Kobyashi H, Aoki A, Kodera Y, Matsushita K, Izumi Y, Nomura F.: Application of quantitative proteomic analysis using tandem mass tags for discovery and identification of novel biomarkers in periodontal disease. Proteomics. Proteomics. 2013.08;

  6. Changchang Ye, Sayaka Katagiri, Naoyuki Miyasaka, Pariksha Bharti, Hiroaki Kobayashi, Yasuo Takeuchi, Yoshihito Momohara, Masaki Sekiguchi, Satoko Takamine, Toshiyuki Nagasawa, Yuichi Izumi: The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth. Arch. Gynecol. Obstet.. 2013.07; 288 (1): 65-72. ( PubMed , DOI )

  7. Taniguchi Y, Aoki A, Mizutani K, Takeuchi Y, Ichinose S, Takasaki AA, Schwarz F, Izumi Y: Optimal Er:YAG laser irradiation parameters for debridement of microstructured fixture surfaces of titanium dental implants. Lasers Med Sci. 2013.07; 28 (4): 1057-1068. ( PubMed , DOI )

  8. Katagiri S, Nitta H, Nagasawa T, Izumi Y, Kanazawa M, Matsuo A, Chiba H, Fukui M, Nakamura N, Oseko F, Kanamura N, Inagaki K, Noguchi T, Naruse K, Matsubara T, Miyazaki S, Miyauchi T, Ando Y, Hanada N, Inoue S: Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease. J Diabetes Investig. 2013.05; ( PubMed , DOI )

  9. Yamada A, Iwata T, Yamato M, Okano T, Izumi Y: Diverse functions of secreted frizzled-related proteins in the osteoblastogenesis of human multipotent mesenchymal stromal cells. Biomaterials. 2013.04; 34 (13): 3270-8. ( PubMed , DOI )

  10. Bharti P, Katagiri S, Nitta H, Nagasawa T, Kobayashi H, Takeuchi Y, Izumiyama H, Uchimura I, Inoue S, Izumi Y: Periodontal treatment with topical antibiotics improves glycemic control in association with elevated serum adiponectin in patients with type 2 diabetes mellitus. Obes Res Clin Pract. 2013.03; 7 (2): e129-e138. ( PubMed , DOI )

  11. Tatsumi K, Ohashi K, Matsubara Y, Kohori A, Ohno T, Kakidachi H, Horii A, Kanegae K, Utoh R, Iwata T, Okano T: Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism. Biochemical and biophysical research communications. 2013.02; 431 (2): 203-9. ( PubMed , DOI )

  12. Almehdi A, Aoki A, Ichinose S, Taniguchi Y, Sasaki KM, Ejiri K, Sawabe M, Chui C, Katagiri S, Izumi Y: Histological and SEM analysis of root cementum following irradiation with Er:YAG and CO2 lasers. Lasers Med Sci. 2013.01; 28 (1): 203-213. ( PubMed , DOI )

  1. Yoshida T., Kumashiro Y., Iwata T., Ishihara J., Umemoto T., Shiratsuchi Y., Kawashima N., Sugiyama T., Yamato M., Okano T.: Requirement of integrin beta 3 for iron transportation during enamel formation Journal of Dental Research. 2012.12; 91 (12): 1154-1159. ( DOI )

  2. Chui C, Hiratsuka K, Aoki A, Takeuchi Y, Abiko Y, Izumi Y: Blue LED inhibits the growth of Porphyromonas gingivalis by suppressing the expression of genes associated with DNA replication and cell division. Lasers Surg Med. 2012.12; 44 (10): 856-864. ( PubMed , DOI )

  3. Katagiri S, Nagasawa T, Kobayashi H, Takamatsu H, Bharti P, Izumiyama H, Uchimura I, Tagami T, Suzuki T, Nanbara H, Taniguchi Y, Hayakumo S, Koyanagi T, Himeno-Ando A, Goto M, Kajio H, Takahashi Y, Izumi Y, Noda M: Improvement of glycemic control after periodontal treatment by resolving gingival inflammation in type 2 diabetic patients with periodontal disease. 2012.08; ( PubMed , DOI )

  4. Taniguchi Y, Aoki A, Koyanagi Y, Takeuchi Y, Izumi Y, Oda S: Current Status of Various Approaches for Treatment of Peri-implant disease (Short communication). WCOI Year Book 2001 -CD version- 1st Edition, Year Book Committee Publication, World Congress for Oral Implantology, Published in June 25th, Tokyo, Japan. 2012.07; 33-40.

  5. Takeuchi Y, Nagasawa T, Katagiri S, Kitagawara S, Kobayashi H, Koyanagi T, Izumi Y: Salivary levels of antibacterial peptide (LL-37/hCAP-18) and cotinine in patients with chronic periodontitis. J Periodontol. 2012.06; 83 (6): 766-772. ( PubMed , DOI )

  6. Hiromi Nanbara, Nawarat Wara-aswapati, Toshiyuki Nagasawa, Yasuhiro Yoshida, Reiko Yashiro, Yukiko Bando, Hiroaki Kobayashi, Janjura Khongcharoensuk, Doosadee Hormdee, Waranuch Pitiphat, Jason A Boch, Yuichi Izumi: Modulation of Wnt5a expression by periodontopathic bacteria. PLoS ONE. 2012; 7 (4): e34434. ( PubMed , DOI )

  7. Yoshida T, Washio K, Iwata T, Okano T, Ishikawa I: Current status and future development of cell transplantation therapy for periodontal tissue regeneration. International journal of dentistry. 2012; 2012 307024. ( PubMed , DOI )

  1. Katagiri S, Nitta H, Nagasawa T, Izumi Y, Kanazawa M, Matsuo A, Chiba H, Miyazaki S, Miyauchi T, Nakamura N, Oseko F, Kanamura N, Ando Y, Hanada N, Inoue S: Reduced masticatory function in non-elderly obese Japanese adults. Obes Res Clin Pract. 2011.10; ( PubMed , DOI )

  2. Uraiwan Chokechanachaisakul, Tomoatsu Kaneko, Yusuke Yamanaka, Reika Kaneko, Ken-ichi Katsube, Hiroaki Kobayashi, Jacques E Nör, Takashi Okiji, Hideaki Suda: Gene expression analysis of resident macrophages in lipopolysaccharide-stimulated rat molar pulps. J Endod. 2011.09; 37 (9): 1258-1263. ( PubMed , DOI )

  3. Yuka Tsumanuma, Takanori Iwata, Kaoru Washio, Toshiyuki Yoshida, Azusa Yamada, Ryo Takagi, Takahiro Ohno, Konghua Lin, Masayuki Yamato, Isao Ishikawa, Teruo Okano, Yuichi Izumi: Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model. Biomaterials. 2011.09; 32 (25): 5819-5825. ( PubMed , DOI )

  4. Pirraco RP, Obokata H, Iwata T, Marques AP, Tsuneda S, Yamato M, Reis RL, Okano T: Development of osteogenic cell sheets for bone tissue engineering applications. Tissue engineering. Part A. 2011.06; 17 (11-12): 1507-15. ( PubMed , DOI )

  5. Izumi Y, Aoki A, Yamada Y, Kobayashi H, Iwata T, Akizuki T, Suda T, Nakamura S, Wara-Aswapati N, Ueda M, Ishikawa I: Current and future periodontal tissue engineering. Periodontol 2000. 2011.06; 56 (1): 166-187. ( PubMed , DOI )

  6. Wang HG., Kawashima N., Iwata T., Xu J., Takahashi S., Sugiyama T., Suda H.: MEPE activated by furin promotes pulpal cell adhesion Journal of Dental Research. 2011.04; 90 (4): 529-534. ( DOI )

  7. Chie Kobayashi, Ken Yaegaki, Bogdan Calenic, Nikolay Ishkitiev, Toshio Imai, Hisataka Ii, Izumi Aoyama, Hiroaki Kobayashi, Yuichi Izumi, Markus Haapasalo: Hydrogen sulfide causes apoptosis in human pulp stem cells. J Endod. 2011.04; 37 (4): 479-484. ( PubMed , DOI )

  8. Almehdi Aslam, 青木 章, 谷口 陽一, 澤辺 正規, 江尻 健一郎, チュイ・チャントゥーン , 佐藤 郁文, 片桐 さやか, 和泉 雄一: Er:YAGレーザー照射後歯根セメント質の変化の分析(Analysis of Root Cementum Alteration following Er:YAG Laser Irradiation) 日本歯周病学会会誌. 2011.04; 53 (春季特別): 105. ( ichushi )

  9. Pang P, Andreana S, Aoki A, Coluzzi D, Obeidi A, Olivi G, Parker S, Rechmann P, Sulewski J, Sweeney C, Swick M, Yung F.: Laser energy in oral soft tissue applications. J Laser Dent. 2011.03; 18 (3): 123-131.

  10. Akiyama F, Aoki A, Miura-Uchiyama M, Sasaki KM, Ichinose S, Umeda M, Ishikawa I, Izumi Y: In vitro studies of the ablation mechanism of periodontopathic bacteria and decontamination effect on periodontally diseased root surfaces by erbium:yttrium-aluminum-garnet laser. (Erratum in: Lasers Med Sci 2011; 26(2):277.) Lasers Med Sci. 2011.03; 26 (2): 193-204. ( PubMed , DOI )

  11. Takahashi M, Chen Z, Watanabe K, Kobayashi H, Nakajima T, Kimura A, Izumi Y: Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese. Open Dent J. 2011; 5 190-194. ( PubMed , DOI )

  1. Iwata T, Yamato M, Zhang Z, Mukobata S, Washio K, Ando T, Feijen J, Okano T, Ishikawa I: Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use. Journal of clinical periodontology. 2010.12; 37 (12): 1088-99. ( PubMed , DOI )

  2. Sato T, Chida D, Iwata T, Usui M, Hatori K, Abe T, Takeda S, Yoda T: Non-neuronal regulation and repertoire of cholinergic receptors in organs. Biomolecular concepts. 2010.12; 1 (5-6): 357-66. ( PubMed , DOI )

  3. Katagiri S, Nitta H, Nagasawa T, Izumi Y, KanazawaM, Matsuo A, Chiba H, Miyazaki S, Miyauchi T, Nakamura N, Kanamura N, Ando Y, Hanada N, Inoue S: High prevalence of periodontitis in non-elderly obese Japanese adults. 2010.10; ( PubMed )

  4. Washio K, Iwata T, Mizutani M, Ando T, Yamato M, Okano T, Ishikawa I: Assessment of cell sheets derived from human periodontal ligament cells: a pre-clinical study. Cell and tissue research. 2010.09; 341 (3): 397-404. ( PubMed , DOI )

  5. Bharti Pariksha, Katagiri Sayaka, Nitta Hiroshi, Nagasawa Toshiyuki, Kobayashi Hiroaki, Izumi Yuichi: 2型糖尿病患者において歯周治療は血清アディポネクチン値を上昇する(Periodontal treatment increases serum adiponectin level in type2 diabetes patients) 日本歯周病学会会誌. 2010.09; 52 (3): 296. ( ichushi )

  6. Wang H, Kawashima N, Iwata T, Xu J, Takahashi S, Sugiyama T, Suda H: Differentiation of odontoblasts is negatively regulated by MEPE via its C-terminal fragment. Biochemical and Biophysical Research Communications. 2010.07; 398 (3): 406-412. ( PubMed , DOI )

  7. Aleksic V, Aoki A, Iwasaki K, Takasaki AA, Wang CY, Abiko Y, Ishikawa I, Izumi Y: Low-level Er:YAG laser irradiation enhances osteoblast proliferation through activation of MAPK/ERK. Lasers Med Sci. 2010.07; 25 (4): 559-569. ( PubMed , DOI )

  8. Nagasawa Toshiyuki, Noda Mitsuhiko, Katagiri Sayaka, Takaichi Maki, Takahashi Yoshihiko, Wara-Aswapati Nawarat, Kobayashi Hiroaki, Ohara Satoko, Kawaguchi Yoko, Tagami Tadashi, Furuichi Yasushi, Izumi Yuichi: 歯周炎と糖尿病の関連性　悪循環を証明するための臨床研究の重要性(Relationship between Periodontitis and Diabetes: Importance of a Clinical Study to Prove the Vicious Cycle) Internal Medicine. 2010.05; 49 (10): 881-885. ( ichushi )

  9. Sahm N, Schwarz F, Aoki A, Becker J.: Die antimikrobielle photodynamische Therapie – Anwendung in der Parodontitis und Periimplantitistherapie. Parodontologie. 2010.04; 21 (2): 121-134.

  10. Sato T, Abe T, Chida D, Nakamoto N, Hori N, Kokabu S, Sakata Y, Tomaru Y, Iwata T, Usui M, Aiko K, Yoda T: Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts. FEBS letters. 2010.02; 584 (4): 817-24. ( PubMed , DOI )

  11. Nagasawa Toshiyuki, Noda Mitsuhiko, Katagiri Sayaka, Takaichi Maki, Takahashi Yoshihiko, Wara-Aswapati Nawarat, Kobayashi Hiroaki, Ohara Satoko, Kawaguchi Yoko, Tagami Tadashi, Furuichi Yasushi, Izumi Yuichi: Relationship between Periodontitis and Diabetes - Importance of a Clinical Study to Prove the Vicious Cycle INTERNAL MEDICINE. 2010; 49 (10): 881-885. ( PubMed , DOI )

  1. Chen YW, Nagasawa T, Wara-Aswapati N, Ushida Y, Wang D, Takeuchi Y, Kobayashi H, Umeda M, Inoue Y, Iwai T, Ishikawa I, Izumi Y: Association between periodontitis and anti-cardiolipin antibodies in Buerger disease. J Clin Periodontol. 2009.10; 36 (10): 830-835. ( PubMed , DOI )

  2. Suda T, Nagasawa T, Wara-Aswapati N, Kobayashi H, Iwasaki K, Yashiro R, Hormdee D, Nitta H, Ishikawa I, Izumi Y: Regulatory roles of beta-catenin and AP-1 on osteoprotegerin production in interleukin-1alpha-stimulated periodontal ligament cells. Oral Microbiol Immunol. 2009.10; 24 (5): 384-389. ( PubMed , DOI )

  3. Eguro T, Aoki A, Maeda T, Takasaki AA, Hasegawa M, Ogawa M, Suzuki T, Yonemoto K, Ishikawa I, Izumi Y, Katsuumi I: Energy output reduction and surface alteration of quartz and sapphire tips following Er:YAG laser contact irradiation for tooth enamel ablation. Lasers Surg Med. 2009.10; 41 (8): 595-604. ( PubMed , DOI )

  4. Schwarz F, Aoki A, Sculean A, Becker J: The impact of laser application on periodontal and peri-implant wound healing. Periodontol 2000. 2009.09; 51 79-108. ( PubMed , DOI )

  5. Takasaki AA, Aoki A, Mizutani K, Schwarz F, Sculean A, Wang CY, Koshy G, Romanos G, Ishikawa I, Izumi Y: Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases. Periodontol 2000. 2009.09; 51 109-140. ( PubMed , DOI )

  6. Y Bando, K Noguchi, H Kobayashi, N Yoshida, I Ishikawa, Y Izumi: Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells. J Periodontal Res. 2009.06; 44 (3): 395-401. ( PubMed , DOI )

  7. Iwata T, Yamato M, Tsuchioka H, Takagi R, Mukobata S, Washio K, Okano T, Ishikawa I: Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model. Biomaterials. 2009.05; 30 (14): 2716-23. ( PubMed , DOI )

  8. Ishikawa I, Aoki A, Takasaki AA, Mizutani K, Sasaki KM, Izumi Y: Application of lasers in periodontics: true innovation or myth? Periodontol 2000. 2009.04; 50 90-126. ( PubMed , DOI )

  9. Katagiri S, Nitta H, Nagasawa T, Uchimura I, Izumiyama H, Inagaki K, Kikuchi T, Noguchi T, Kanazawa M, Matsuo A, Chiba H, Nakamura N, Kanamura N, Inoue S, Ishikawa I, Izumi Y: Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease. Diabetes Res Clin Pract. 2009.03; 83 (3): 308-315. ( PubMed , DOI )

  10. Yoshino T, Aoki A, Oda S, Takasaki AA, Mizutani K, Sasaki KM, Kinoshita A, Watanabe H, Ishikawa I, Izumi Y: Long-term histologic analysis of bone tissue alteration and healing following Er:YAG laser irradiation compared to electrosurgery. J Periodontol. 2009.01; 80 (1): 82-92. ( PubMed , DOI )

  11. Yuichi Izumi, Toshiyuki Nagasawa, Makoto Umeda, Hiroaki kobayashi, Yasuo Takeuchi, Reiko Yashiro, Doosadee Hormdee, Tomonari Suda, Yuka Ushida, Nawarat Wara-aswapati. : 28. Periodontitis and cardiovascular diseases: The link and relevant mechanisms. Japanese Dental Sciense Review. 2009; 45 98-108.

  12. Ishikawa I, Iwata T, Washio K, Okano T, Nagasawa T, Iwasaki K, Ando T: Cell sheet engineering and other novel cell-based approaches to periodontal regeneration. Periodontology 2000. 2009; 51 220-38. ( PubMed , DOI )

  1. Aoki A, Mizutani K, Takasaki AA, Sasaki KM, Nagai S, Schwarz F, Yoshida I, Eguro T, Zeredo JL, Izumi Y: Current status of clinical laser applications in periodontal therapy. Gen Dent. 2008.11; 56 (7): 674-87; quiz 688-9, 767. ( PubMed )

  2. Wang D, Nagasawa T, Chen Y, Ushida Y, Kobayashi H, Takeuchi Y, Umeda M, Izumi Y: Molecular mimicry of Aggregatibacter actinomycetemcomitans with b2 glycoprotein I. Oral Microbiol Immunol. 2008.10; 23 (5): 401-405. ( PubMed , DOI )

  3. Schwarz F, Aoki A, Becker J, Sculean A: Laser application in non-surgical periodontal therapy: a systematic review. J Clin Periodontol. 2008.09; 35 (8 Suppl): 29-44. ( PubMed , DOI )

  4. Yamakoshi Y, Lu Y, Hu JC, Kim JW, Iwata T, Kobayashi K, Nagano T, Yamakoshi F, Hu Y, Fukae M, Simmer JP: Porcine dentin sialophosphoprotein: length polymorphisms, glycosylation, phosphorylation, and stability. The Journal of biological chemistry. 2008.05; 283 (21): 14835-44. ( PubMed , DOI )

  5. Maruyama H, Aoki A, Sasaki KM, Takasaki AA, Iwasaki K, Ichinose S, Oda S, Ishikawa I, Izumi Y: The effect of chemical and/or mechanical conditioning on the Er:YAG laser-treated root cementum: analysis of surface morphology and periodontal ligament fibroblast attachment. Lasers Surg Med. 2008.03; 40 (3): 211-222. ( PubMed , DOI )

  6. Ishikawa I, Aoki A, Takasaki AA: Clinical application of erbium:YAG laser in periodontology. J Int Acad Periodontol. 2008.01; 10 (1): 22-30. ( PubMed )

  1. Gunji T, Onouchi Y, Nagasawa T, Katagiri S, Watanabe H, Kobayashi H, Arakawa S, Noguchi K, Hata A, Izumi Y: Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese. Biochem Biophys Res Commun.. 2007.12; ( PubMed , DOI )

  2. Rosa DS, Aranha AC, Eduardo Cde P, Aoki A: Esthetic treatment of gingival melanin hyperpigmentation with Er:YAG laser: short-term clinical observations and patient follow-up. J Periodontol. 2007.10; 78 (10): 2018-2025. ( PubMed )

  3. Takasaki AA, Aoki A, Mizutani K, Kikuchi S, Oda S, Ishikawa I: Er:YAG laser therapy for peri-implant infection: a histological study. Lasers Med Sci. 2007.09; 22 (3): 143-157. ( PubMed , DOI )

  4. Kiji M, Nagasawa T, Hormdee D, Yashiro R, Kobayashi H, Noguchi K, Nitta H, Izumi Y, Ishikawa I: Internal prostaglandin synthesis augments osteoprotegerin production in human gingival fibroblasts stimulated by lipopolysaccharide. Clin Exp Immunol. 2007.08; 149 (2): 327-334. ( PubMed , DOI )

  5. Schwarz F, Jepsen S, Herten M, Aoki A, Sculean A, Becker J: Immunohistochemical characterization of periodontal wound healing following nonsurgical treatment with fluorescence controlled Er:YAG laser radiation in dogs. Lasers Surg Med. 2007.06; 39 (5): 428-440. ( PubMed , DOI )

  6. Tomoe Fukui, Hiroaki Kobayashi, Urara Hasegawa, Toshiyuki Nagasawa, Kazunari Akiyoshi, Isao Ishikawa: Intracellular delivery of nanogel-quantum dot hybrid nanoparticles into human periodontal ligament cells. Drug Metab Lett. 2007.04; 1 (2): 131-135. ( PubMed , DOI )

  7. T Iwata, Y Yamakoshi, J C-C Hu, I Ishikawa, J D Bartlett, P H Krebsbach, J P Simmer: Processing of ameloblastin by MMP-20. J Dent Res. 2007.02; 86 (2): 153-157. ( PubMed , DOI )

  8. Iwata T, Yamakoshi Y, Simmer JP, Ishikawa I, Hu JC: Establishment of porcine pulp-derived cell lines and expression of recombinant dentin sialoprotein and recombinant dentin matrix protein-1. European journal of oral sciences. 2007.02; 115 (1): 48-56. ( PubMed , DOI )

  9. Nagasawa T, Kiji M, Yashiro R, Hormdee D, Lu H, Kunze M, Suda T, Koshy G, Kobayashi H, Oda S, Nitta H, Ishikawa I: Roles of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in periodontal health and disease. Periodontol 2000. 2007; 43 65-84. ( PubMed , DOI )

  1. Yamakoshi Y, Hu JC, Iwata T, Kobayashi K, Fukae M, Simmer JP: Dentin sialophosphoprotein is processed by MMP-2 and MMP-20 in vitro and in vivo. The Journal of biological chemistry. 2006.12; 281 (50): 38235-43. ( PubMed , DOI )

  2. Nagano T, Oida S, Suzuki S, Iwata T, Yamakoshi Y, Ogata Y, Gomi K, Arai T, Fukae M: Porcine enamel protein fractions contain transforming growth factor-beta1. Journal of periodontology. 2006.10; 77 (10): 1688-94. ( PubMed , DOI )

  3. Yamakoshi Y, Hu JC, Zhang H, Iwata T, Yamakoshi F, Simmer JP: Proteomic analysis of enamel matrix using a two-dimensional protein fractionation system. European journal of oral sciences. 2006.05; 114 Suppl 1 266-71; discussion 285. ( PubMed , DOI )

  4. Chun YH, Yamakoshi Y, Kim JW, Iwata T, Hu JC, Simmer JP: Porcine SPARC: isolation from dentin, cDNA sequence, and computer model. European journal of oral sciences. 2006.05; 114 Suppl 1 78-85; discussion 93. ( PubMed , DOI )

  5. Mizutani K, Aoki A, Takasaki AA, Kinoshita A, Hayashi C, Oda S, Ishikawa I: Periodontal tissue healing following flap surgery using an Er:YAG laser in dogs. Lasers Surg Med. 2006.04; 38 (4): 314-324. ( PubMed , DOI )

  6. Yashiro R, Nagasawa T, Kiji M, Hormdee D, Kobayashi H, Koshy G, Nitta H, Ishikawa I: Transforming growth factor-beta stimulates interleukin-11 production by human periodontal ligament and gingival fibroblasts. J Clin Periodontol. 2006.03; 33 (3): 165-171. ( PubMed , DOI )

  7. Takasaki AA, Aoki A, Ishikawa I: Erbium:YAG laser in Periodontics. Dentistry in Japan. 2006.03; 42 200-206.

  8. Kim JW, Yamakoshi Y, Iwata T, Hu YY, Zhang H, Hu JC, Simmer JP: Porcine dentin matrix protein 1: gene structure, cDNA sequence, and expression in teeth. European journal of oral sciences. 2006.02; 114 (1): 33-41. ( PubMed , DOI )

  1. Hormdee D, Nagasawa T, Kiji M, Yashiro R, Kobayashi H, Koshy G, Noguchi K, Nitta H, Ishikawa I: Protein kinase-A-dependent osteoprotegerin production on interleukin-1 stimulation in human gingival fibroblasts is distinct from periodontal ligament fibroblasts. Clin Exp Immunol. 2005.12; 142 (3): 490-497. ( PubMed , DOI )

  2. Pourzarandian A, Watanabe H, Ruwanpura SM, Aoki A, Noguchi K, Ishikawa I: Er:YAG laser irradiation increases prostaglandin E production via the induction of cyclooxygenase-2 mRNA in human gingival fibroblasts. J Periodontal Res. 2005.04; 40 (2): 182-186. ( PubMed , DOI )

  3. Pourzarandian A, Watanabe H, Ruwanpura SM, Aoki A, Ishikawa I: Effect of low-level Er:YAG laser irradiation on cultured human gingival fibroblasts. J Periodontol. 2005.02; 76 (2): 187-193. ( PubMed , DOI )

  4. Yamakoshi Y, Hu JC, Fukae M, Iwata T, Kim JW, Zhang H, Simmer JP: Porcine dentin sialoprotein is a proteoglycan with glycosaminoglycan chains containing chondroitin 6-sulfate. The Journal of biological chemistry. 2005.01; 280 (2): 1552-60. ( PubMed , DOI )

  5. Schwarz F, Becker J, Sculean A, Aoki A, Folwaczny M, Jepsen S: Therapie der Parodontitis und Periimplantitis mit dem Er:YAG-Laser - Literaturubersicht und eigene Erfahrungen (Treatment of periodontitis and peri-implantitis with an Er:YAG laser. A review of the literature and own experiences.). Deutsche Zahnrztliche Zeitschrift. 2005; 60 (3): 135-147.

  1. Yuguang Gao, Andrew Jheon, Houman Nourkeyhani, Hiroaki Kobayashi, Bernhard Ganss: Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene. Gene. 2004.10; 341 101-110. ( PubMed , DOI )

  2. Aoki A, Sasaki KM, Watanabe H, Ishikawa I: Lasers in nonsurgical periodontal therapy. Periodontol 2000. 2004.09; 36 59-97. ( PubMed , DOI )

  3. Pourzarandian A, Watanabe H, Aoki A, Ichinose S, Sasaki KM, Nitta H, Ishikawa I: Histological and TEM examination of early stages of bone healing after Er:YAG laser irradiation. Photomed Laser Surg. 2004.08; 22 (4): 342-350. ( PubMed , DOI )

  4. Nagano T, Iwata T, Ogata Y, Tanabe T, Gomi K, Fukae M, Arai T, Oida S: Effect of heat treatment on bioactivities of enamel matrix derivatives in human periodontal ligament (HPDL) cells. Journal of periodontal research. 2004.08; 39 (4): 249-56. ( PubMed , DOI )

  5. Ishikawa I, Aoki A, Takasaki AA: Potential applications of Erbium:YAG laser in periodontics. J Periodontal Res. 2004.08; 39 (4): 275-285. ( PubMed , DOI )

  6. T Nagasawa, H Kobayashi, M Aramaki, M Kiji, S Oda, Y Izumi: Expression of CD14, CD16 and CD45RA on monocytes from periodontitis patients. J Periodontal Res. 2004.02; 39 (1): 72-78. ( PubMed , DOI )

  1. Y Gao, H Kobayashi, B Ganss: The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). J Dent Res. 2003.12; 82 (12): 1002-1007. ( PubMed , DOI )

  2. Schwarz F, Aoki A, Sculean A, Georg T, Scherbaum W, Becker J: In vivo effects of an Er:YAG laser, an ultrasonic system and scaling and root planing on the biocompatibility of periodontally diseased root surfaces in cultures of human PDL fibroblasts. Lasers Surg Med. 2003.08; 33 (2): 140-147. ( PubMed , DOI )

  3. Yuya Murakami, Takehisa Kojima, Toshiyuki Nagasawa, Hiroaki Kobayashi, Isao Ishikawa: Novel isolation of alkaline phosphatase-positive subpopulation from periodontal ligament fibroblasts. J Periodontol. 2003.06; 74 (6): 780-786. ( PubMed , DOI )

  4. Matsuyama T, Aoki A, Oda S, Yoneyama T, Ishikawa I: Effects of the Er:YAG laser irradiation on titanium implant materials and contaminated implant abutment surfaces. J Clin Laser Med Surg. 2003.02; 21 (1): 7-17. ( PubMed , DOI )

  5. Ishikawa I, Sasaki KM, Aoki A, Watanabe H: Effects of Er:YAG laser on periodontal therapy. J Int Acad Periodontol. 2003.01; 5 (1): 23-28. ( PubMed )

  6. Umeda M, Kobayashi H, Takeuchi Y, Hayashi J, Morotome-Hayashi Y, Yano K, Aoki A, Ohkusa T, Ishikawa I: High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients. J Periodontol. 2003.01; 74 (1): 129-134. ( PubMed , DOI )

  1. Bernhard Ganss, Hiroaki Kobayashi: The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation. J Bone Miner Res. 2002.12; 17 (12): 2151-2160. ( PubMed , DOI )

  2. T Nagasawa, H Kobayashi, M Kiji, M Aramaki, R Mahanonda, T Kojima, Y Murakami, M Saito, Y Morotome, I Ishikawa: LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin. Clin Exp Immunol. 2002.11; 130 (2): 338-344. ( PubMed , DOI )

  3. Ishikawa I, Kawashima Y, Oda S, Iwata T, Arakawa S: Three case reports of aggressive periodontitis associated with Porphyromonas gingivalis in younger patients. Journal of periodontal research. 2002.10; 37 (5): 324-32. ( PubMed )

  4. Iwata T, Morotome Y, Tanabe T, Fukae M, Ishikawa I, Oida S: Noggin blocks osteoinductive activity of porcine enamel extracts. Journal of dental research. 2002.06; 81 (6): 387-91. ( PubMed , DOI )

  5. Sasaki KM, Aoki A, Ichinose S, Yoshino T, Yamada S, Ishikawa I: Scanning electron microscopy and Fourier transformed infrared spectroscopy analysis of bone removal using Er:YAG and CO2 lasers. J Periodontol. 2002.06; 73 (6): 643-652. ( PubMed , DOI )

  6. Sasaki KM, Aoki A, Ichinose S, Ishikawa I: Morphological analysis of cementum and root dentin after Er:YAG laser irradiation. Lasers Surg Med. 2002.05; 31 (2): 79-85. ( PubMed , DOI )

  7. Sasaki KM, Aoki A, Ichinose S, Ishikawa I: Ultrastructural analysis of bone tissue irradiated by Er:YAG Laser. Lasers Surg Med. 2002.05; 31 (5): 322-332. ( PubMed , DOI )

  8. Sasaki KM, Aoki A, Masuno H, Ichinose S, Yamada S, Ishikawa I: Compositional analysis of root cementum and dentin after Er:YAG laser irradiation compared with CO2 lased and intact roots using Fourier transformed infrared spectroscopy. J Periodontal Res. 2002.02; 37 (1): 50-59. ( PubMed )

  9. Aoki A: SEM of the dentin surface in an Er:YAG laser cavity preparation. In: Featured wavelengths:Er, Cr:YSGG and Er:YAG; "The Erbium lasers in dentistry" part 1. Wavelengths. 2002; 10 (1): 22.

  1. H Kobayashi, T Nagasawa, M Aramaki, R Mahanonda, I Ishikawa: Individual diversities in interferon gamma production by human peripheral blood mononuclear cells stimulated with periodontopathic bacteria. J Periodontal Res. 2000.12; 35 (6): 319-328. ( PubMed , DOI )

  2. Aoki A, Miura M, Akiyama F, Nakagawa N, Tanaka J, Oda S, Watanabe H, Ishikawa I: In vitro evaluation of Er:YAG laser scaling of subgingival calculus in comparison with ultrasonic scaling. J Periodontal Res. 2000.10; 35 (5): 266-277. ( PubMed )

  1. Aoki A, Ishikawa I, Yamada T, Otsuki M, Watanabe H, Tagami J, Ando Y, Yamamoto H: Comparison between Er:YAG laser and conventional technique for root caries treatment in vitro. J Dent Res. 1998.06; 77 (6): 1404-1414. ( PubMed )

  2. Aoki A, Watanabe H, Ishikawa I: Er:YAG clinical experience in Japan: review of scientific investigations. SPIE. 1998; 3248 40-45.

  1. Ando Y, Aoki A, Watanabe H, Ishikawa I: Bactericidal effect of erbium YAG laser on periodontopathic bacteria. Lasers Surg Med. 1996.10; 19 (2): 190-200. ( PubMed , DOI )

  1. Aoki A, Ando Y, Watanabe H, Ishikawa I: In vitro studies on laser scaling of subgingival calculus with an erbium:YAG laser. J Periodontol. 1994.12; 65 (12): 1097-1106. ( PubMed )

  1. Tomoko TABATA, Hisaichi NAKAGAWA, Khairul MATIN Masayuki OTSUKI, Akira AOKI and Yasushi SHIMADA: Biofilm Studies Using Optical Coherence Tomography (OCT): Review Journal of Japanese Society for Laser Dentistry. 2023.09; 33 (1): 11-17.

  2. Go Inoue, Koji Mizutani, Risako Mikami, Yasushi Shimada, Akira Aoki: Long-term Outcomes of Er: YAG Laser Microsurgery for Melanin Removal in Gingiva: A Case Report The Japanese Journal of Conservative Dentistry. 2023.05; 66 (2): 147-153. ( DOI )

  3. Aoki A: Comprehensive periodontal pocket therapy using scaler and Er:YAG laser The japanese journal of conservative dentistry. 2023.04; 66 (2): 105-113.

  4. Ohsugi Y, Toyoshima K, Hatasa M, Shimohira T, Shiba T, Komatsu K, Tsuchiya Y, Fukuba S, Niimi H, Katagiri S, Iwata T, Aoki A: Cytological responses in periodontal tissue to photobiomodulation by low-level diode laser irradiation Journal of Japan Society for Laser Dentistry. 2023.02; 32 (3): 33-38.

  5. Risako Mikami, Koji Mizutani, Norio Aoyama, Takanori Matsuura, Tomonari Suda, Kohei Takeda, Natsumi Saito, Shinichi Arakawa, Yuichi Izumi, Takanori Iwata, Jun Aida: Income-related inequalities in the association of smoking with periodontitis: a cross-sectional analysis in Tokyo Metropolitan Districts Clinical Oral Investigations. 2023.02; 27 (2): 519-528. ( PubMed , DOI )

  1. Cen YW, Lin T, Mizutani K,Aoki A: "25th Annual Symposium of Er:YAG Laser Releasement", International exchanges connected by Er:YAG laser Dental Magazine. 2022.08; (1812): 10-14.

  2. Aoki A: For special features on "Lasers in field of teeth and dental pulp・Unique reseraches on application of LED" Journal of Japan Society for Laser Surgery and Medicine . 2022.07; 43 (2): 74.

  3. Aoki A, Yoshinari N: In memories of Hajime Yamamoto Journal of Japanese Society of Laser Dentistry. 2022.06; 32 (1):

  4. Aoki A, Shinoki T: Dental Talk, "25th Anniverasry Symposium of Er:YAG laser releasement", Variable applications and advancement of Er:YAG laser Dental MAgazine. 2022.06; (181): 10-14.

  5. Kitanaka Y, Takeuchi Y, Hiratsuka K, Nitta H, Iwata T, Aoki A: Application of antimicrobial photodynamic therapy in periodontal treatment 2022.06; 32 (1): 9-14.

  1. Okada M, Ikawa T, Mizutani K, Mikami R, Takeda K, Sudo T, Ochiai A, Kiuch Y, Ikeda Y, Iwata T, IZUMI Y: Clinical Comparison of a Newly Developed Ionic Toothbrush with Soft Rubber Filaments and a Manual Toothbrush in Plaque Reduction: A Crossover Clinical Trial The Japanese Journal of Conservative Dentistry. 2021.10; 64 (5): 339-347. ( DOI )

  1. Aoki A: Application of Er:YAG laser in minimally invasive flapless periodontal pocket surgery Journal of the Japanese Academy of Clinical Periodontology. 2020.12; 38 (2): 19-27.

  2. Aoki A: Periodontal pocket therapy using a laser Dental Hygien. 2020.12; 41 (1): 43-45.

  3. Aoki A: Development of a novel periodontal pocket therapy which employs the Er:YAG laser The Journal of the Stomatological Society. 2020.12; 87 (2,3): 31-39.

  4. Aoki A: Potential of laser dentistry: 4 types of lasers, the differences and their use Clinical library, web. 2020.12;

  5. Kano T, Kobayashi H, Nozaki K, Tsumanuma Y, Sudo T, Khemwong T, Mikami R, Izumi Y: Effective root planing for biologically acceptable root surfaces: an experimental study Journal of the Japanese Society of Periodontology. 2020.03; 62 (1): 1-15. ( ichushi )

  6. Aoki A, Takeuchi Y, Akizuki T, Mizutani K, Katagiri S, Ikeda Y, Maekawa S, Watanabe K, Ebihara A, Hideshima M, Nikaido N, Oda S, Araki K, Iwata T, Izumi Y: Current Status of Clinical Practice of Periodontal Therapy by Predoctoral Dental Students at Tokyo Medical and Dental University (TMDU) J Jpn Soc Periodontol. 2020.03; 62 (1): 38-46. ( ichushi )

  1. Takeuchi Y, Shiba T, Nemoto T, Komatsu K, Iwata T: Pathogenesis and prevention of peri-implantitis 2019.12; 9 (1): 15-20.

  2. Aoki A: Periodontitis and its prevention Health Union of Tokyo Medical Practice bulletin. 2019.09; 4-5.

  3. Taniguchi Y, Mizutani K, Takagi T, Iwata T, Izumi Y, Aoki A: A new approach in periodontal therapy using Er:YAG laser: Theory and practice of Er-LCPT & Er-LBRT - Application of Er-LBRT (Er:YAG laser-assisted bone regenerative therapy) on regenerative therapy in peri-implantitis The Nippon Dental Review. 2019.09; 79 (9): 101-111. ( ichushi )

  4. Taniguchi Y, Mizutani K, Iwata T, Izumi Y, Aoki A: A new approach in periodontal therapy using Er:YAG laser: Theory and practice of Er-LCPT & Er-LBRT - Application of Er-LBRT (Er:YAG laser-assisted bone regenerative therapy) on alveolar ridge augumentation in peri-implantitis The Nippon Dental Review. 2019.08; 79 (8): 99-106. ( ichushi )

  5. Taniguchi Y, Mizutani K, Iwata T, Izumi Y, Aoki A: A new approach in periodontal therapy using Er:YAG laser: Theory and practice of Er-LCPT & Er-LBRT - Application of Er-LBRT (Er:YAG laser-assisted bone regenerative therapy) on alveolar ridge preservation in peri-implantitis The Nippon Dental Review. 2019.07; 79 (7): 137-145. ( ichushi )

  6. Aoki A: Find the medical frontline desired by doctors - The latest periodontal therapy "Bio-regeneration method" Ken. 2019.06; 48 (3): 35-38.

  7. Aoki A, Mizutani K, Taniguchi Y, Komaki M, Iwata T, Izumi Y: A new approach in periodontal therapy using Er:YAG laser: Theory and practice of Er-LCPT & Er-LBRT - Practice of Er:LCPT technique: application in severe periodontal pockets and peri-implantitis The Nippon Dental Review. 2019.04; 79 (4): 117-130. ( ichushi )

  8. Tsubokawa M, Tsukui A, Kakizaki S, Aoki A: Easy and low-costing 3D print by Mac for everyone - Simulation of laser irradiation using 3D printer The Nippon Dental Review. 2019.04; 133 (4): 798-803. ( ichushi )

  9. Taniguchi Y, Mizutani K, Takagi T, Iwata T, Izumi Y, Aoki A: Current applications of lasers/LEDs in wound healing and tissue regeneration in oral region: Development of Er:YAG laser-assisted bone regenerative therapy (Er-LBRT) in periodontal and peri-implant therapy The Journal of Japan Society of Laser in Surgery and Medicine. 2019.04; 40 (1): 45-54. ( ichushi )

  10. Mizutani K, Taniguchi Y, Izumi Y, Aoki A: A new approach in periodontal therapy using Er:YAG laser: Theory and practice of Er-LCPT & Er-LBRT - Evidence of Er:YAG Laser therapy on periodontitis and peri-implantitis 2 The Nippon Dental Review. 2019.03; 79 (3): 115-125. ( ichushi )

  11. Mizutani K, Aoki A, Taniguchi Y, Izumi Y: A new approach in periodontal therapy using Er:YAG laser: Theory and practice of Er-LCPT & Er-LBRT - Evidence of Er:YAG Laser therapy on periodontitis and peri-implantitis 1 The Nippon Dental Review. 2019.02; 79 (2): 95-105. ( ichushi )

  12. Aoki A, Mizutani K, Taniguchi Y, Izumi Y: A new approach in periodontal therapy using Er:YAG laser: Theory and practice of Er-LCPT & Er-LBRT - Characteristics of Er:YAG laser and development of new therapy for periodontal pockets The Nippon Dental Review. 2019.01; 79 (1): 89-101. ( ichushi )

  13. Aoki A: Minimally invasive flapless periodontal surgery Tokyo Medical and Dental University Almni Meeting News. 2019; 194 46-47.

  1. Tsubokawa M, Aoki A, Kakizaki S, Mizutani K, Sumi Y, Izumi Y: Application of OCT for Periodontal Treatment 2018.04; 39 (1): 37-48. ( DOI )

  2. Takeuchi Y, Aoki A, Hiratsuka K, Chanthoeun C, Ichinose A, Uekubo A, Izumi Y: Application of antimicrobial photodynamic therapy in dental treatments The Journal of Japan Society for Laser Surgery and Medicine. 2018.04; 38 (4): 457-470. ( DOI )

  1. Aoki A, Mizutani K, Taniguchi Y, KOmaki M, Ejiri K, Mikami M, Izumi Y: Periodontal pocket therapy using Er:YAG laser: systematic review of literature and introduction of a new treatment procedure The Journal of Japan Society for Laser Surgery and Medicine. 2017.08; 38 (2): 167-178.

  2. Aoki A, Mizutani K, Noda M, Izumi Y: Application of Er:YAG laser in periodontal therapy OPTRONICS. 2017.07; (427): 81-87.

  1. Aoki A, Takeuchi Y, Hiratsuka K, Izumi Y: Antibacterial photodynamic therapy inperiodontal therapy - Current status of aPDT in clinical and Latest research on LED applications Journal of Clinical and Experimental Medicine. 2016.09; 258 (11): 1058-1062.

  2. Taniguchi Y, Aoki A, Mizutani K, Izumi Y: Periodontal therapy applying features of Er:YAG laser JSLSM. 2016.03; 37 (1): 43-51.

  3. Aoki A: Introdacution of laser institution JSLSM. 2016.03; 37 (1): 124-126.

  1. Aoki A, Tsubokawa M, Kakizaki S, Lin T, Mizutani K, Izumi Y: Application of dental OCT in periodontal therapy Dental Materials Journal. 2015.11; 34 (6): 433-436.

  2. Aoki A, Mizutani K, Izumi Y: A novel Comprehensive periodntal pocket therapy using the Er:YAG laser The Journal of the Stomatological Society. 2015; 82 (3): 14.

  1. Taniguchi Y, Aoki A, Sakai K, Mizutani K, Izumi Y: Er:YAG laser-assisted periodontal regenerative therapy: case series. The Quintessence. 2014; 33 (1): 213-221.

  2. Ohashi H, Takamori K, Aoki A, Kato J, Nagai S, Yoshida I, Oura K, Waga M, Ogushi K, Tsukui A, Amagai T, Tagami J, Shinoki T: Questionnaire study on the first educational seminar for safety education and training in clinical laser dentistry. J Jpn Soc Laser Dent. 2014; 25 (1): 14-25.

  3. Izumi Y, Aoki A: Periodontal therapy in 21st century - Establishment of periodontal Phototherapy. The Nipponn Dental Review. 2014; 74 (5): 9-11.

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