1) The biological and chemical approach to study the Hippo pathway that controls cell proliferation, cell differentiation, and cell death.
2) Versatile roles of the tumor suppressor RASSF proteins
3) Discovery and development of chemical compounds that suppress cancer stemness and metastasis
4) Discovery and development of chemical compounds that facilitate myogenesis and prevent muscle atrophy
5) Development of mouse models mimicking human progeria syndromes
6) Study of health life span in Caenorhabditis elegans
We organaized the course of Biochemmistry for the undergraduate students.
We organized the course of Biochemmistry for the master students.
We gave a lecture about metabolism of cancer cells.
We gave a lecture entitled "How is the life of human maintained?" for the students of Tokyo University of Foreign Studies.
Lectures & Courses
We organize the course, “Medical Biochemistry”. The students are requested through these courses to obtain a comprehensive integrated knowledge of human biochemistry, which is important to understand how health is maintained and which molecular and biochemical events cause human diseases and underlie the rational treatments.
2) Graduate and others
We are studying the signaling pathway that regulates cell proliferation, cell differentiation, cell polarity, and cell death. This pathway is well conserved from fly to human. The mutations of the components lead to oncogenesis and organ malformation. Several recent studies suggest that this pathway is implicated in inflammation and cell differentiation such as adipogenesis, osteogenesis, and keratinocyte differentiation. The pathway plays an important role in various human diseases and could be a new therapeutic target. We give lectures about our current studies to graduate students and others, and provide graduate students with the opportunity to participate in them.