1. Lihong Cheng, Caiyue Shi, Xixi Li, Toshiro Matsui: Impact of Peptide Transport and Memory Function in the Brain Nutrients. 2024.09; ( DOI )

  2. Cryo-electron tomography of the actin cytoskeleton and membrane organization during lamellipodia formation using optogenetics 2024.08; ( DOI )

  3. Cheng L, Shi C, Nakamura S, Esaki N, Ichiba Y, Tanaka M, Sakai K, Matsui T: Adiponectin-Receptor Agonistic Dipeptide Tyr-Pro Stimulates the Acetylcholine Nervous System in NE-4C Cells. Journal of agricultural and food chemistry. 2024.04; 72 (13): 7121-7129. ( PubMed , DOI )

  4. Toshifumi Asano, Philipp Sasse, Takao Nakata: Development of a Cre-recombination-based color-switching reporter system for cell fusion detection. Biochem Biophys Res Commun. 2024.01; 690 149231. ( PubMed , DOI )

  5. Aiko Takada, Toshifumi Asano, Ken-Ichi Nakahama, Takashi Ono, Takao Nakata, Tomohiro Ishii: Development of an optogenetics tool, Opto-RANK, for control of osteoclast differentiation using blue light. Sci Rep. 2024.01; 14 (1): 1749. ( PubMed , DOI )

  1. Cheng L, Tanaka M, Yoshino A, Nagasato Y, Takata F, Dohgu S, Matsui T: A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration. Scientific reports. 2023.10; 13 (1): 16908. ( PubMed , DOI )

  1. Tomoya Uchimura, Toshifumi Asano, Takao Nakata, Akitsu Hotta, Hidetoshi Sakurai: A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs. Cell Reports Medicine. 2021.06; 2 (6): 100298. ( PubMed , DOI )

  2. Shogo Yoshihara , Xuguang Jiang , Momo Morikawa , Tadayuki Ogawa , Sotaro Ichinose , Hirooki Yabe , Akiyoshi Kakita , Manabu Toyoshima , Yasuto Kunii , Takeo Yoshikawa , Yosuke Tanaka , Nobutaka Hirokawa : Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport Cell Reports. 2021.04; 35 (2): 108971. ( PubMed , DOI )

  3. Hironori Inaba, Qianqian Miao, Takao Nakata: Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling. J Biol Chem. 2021.01; 100290. ( PubMed , DOI )

  1. Takanobu Shimizu, Takeshi Nakamura, Hironori Inaba, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Takao Nakata, Hiroshi Nishina, Yutaka Hata: The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation. J. Biol. Chem.. 2020.08; 295 (32): 11214-11230. ( PubMed , DOI )

  1. Xiang, L; Wu, QB; Cheng, LH; Sun, KY; Li, J; Yoshida, M; Qi, JH: Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2019.10; 2019 1-14. ( PubMed , DOI )

  2. Manabu Toyoshima,Xuguang Jiang, Tadayuki Ogawa, Tetsuo Ohnishi, Shogo Yoshihara, Shabeesh Balan, Takeo Yoshikawa, Nobutaka Hirokawa: Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis Life Science Alliance. 2019.10; 2 (5): lsa.201900478. ( PubMed , DOI )

  1. Moe Sato, Toshifumi Asano, Jun Hosomichi, Takashi Ono, Takao Nakata: Optogenetic manipulation of intracellular calcium by BACCS promotes differentiation of MC3T3-E1 cells. Biochemical and Biophysical Research Communications. 2018.11; 506 (3): 716-722. ( PubMed , DOI )

  2. Bian, LL; Cao, SN; Cheng, LH; Nakazaki, A; Nishikawa, T; Qi, JH: Semi-synthesis and Structure-Activity Relationship of Neuritogenic Oleanene Derivatives CHEMMEDCHEM. 2018.09; 13 (18): 1972-1977. ( PubMed , DOI )

  3. Qi, JH; Cheng, LH; Sun, YJ; Hirata, Y; Ushida, N; Ma, ZH; Osada, H; Nishikawa, T; Xiang, L: Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2018.07; 57 (27): 8100-8104. ( PubMed , DOI )

  4. Zhang, H; Farooq, U; Cheng, LH; Ye, Y; Wang, YC; Kawagishi, H; Ojika, M; Qi, JH: Specific Inhibitors of Sporangium Formation of Phytophthora capsici from Kalimeris indica CHEMISTRY OF NATURAL COMPOUNDS. 2018.05; 54 (3): 567-569. ( DOI )

  1. Tomohiro Ishii, Koji Sato, Toshiyuki Kakumoto, Shigenori Miura, Kazushige Touhara, Shoji Takeuchi, Takao Nakata: Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS. Nat Commun. 2015; 6 8021. ( PubMed , DOI )

  1. Toshiyuki Kakumoto, Takao Nakata: Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis. PLoS ONE. 2013; 8 (8): e70861. ( PubMed , DOI )

  1. Takao Nakata, Shinsuke Niwa, Yasushi Okada, Franck Perez, Nobutaka Hirokawa: Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport. J. Cell Biol.. 2011.07; 194 (2): 245-255. ( PubMed , DOI )

  1. Takao Nakata, Nobutaka Hirokawa: Neuronal polarity and the kinesin superfamily proteins. Sci. STKE. 2007.02; 2007 (372): pe6. ( PubMed , DOI )

  1. Junlin Teng, Tatemitsu Rai, Yosuke Tanaka, Yosuke Takei, Takao Nakata, Motoyuki Hirasawa, Ashok B Kulkarni, Nobutaka Hirokawa: The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat. Cell Biol.. 2005.05; 7 (5): 474-482. ( PubMed , DOI )

  1. Takao Nakata, Nobutaka Hirokawa: Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head. J. Cell Biol.. 2003.09; 162 (6): 1045-1055. ( PubMed , DOI )

  2. Homma N, Takei Y, Tanaka Y, Nakata T, Terada S, Kikkawa M, Noda Y, Hirokawa N.: Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension Cell. 2003.07; 114 (2): 229-239. ( PubMed , DOI )

  1. Ying Xu, Sen Takeda, Takao Nakata, Yasuko Noda, Yosuke Tanaka, Nobutaka Hirokawa: Role of KIFC3 motor protein in Golgi positioning and integration. J. Cell Biol.. 2002.07; 158 (2): 293-303. ( PubMed , DOI )

  2. Kazuo Nakajima, Yosuke Takei, Yosuke Tanaka, Terunaga Nakagawa, Takao Nakata, Yasuko Noda, Mitsutoshi Setou, Nobutaka Hirokawa: Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport. Mol. Cell. Biol.. 2002.02; 22 (3): 866-873. ( PubMed )

  1. J Teng, Y Takei, A Harada, T Nakata, J Chen, N Hirokawa: Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J. Cell Biol.. 2001.10; 155 (1): 65-76. ( PubMed , DOI )

  2. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N.: Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta Cell. 2001.06; 105 (5): 587-597. ( PubMed , DOI )

  1. J Chen, T Nakata, Z Zhang, N Hirokawa: The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation. J. Cell. Sci.. 2000.11; 113 Pt 21 3861-3869. ( PubMed )

  1. Nakata T, Terada S, Hirokawa N.: Visualization of the dynamics of synaptic vesicle and plasma membrane proteins in living axons Journal of Cell Biology. 1998.02; 140 (3): 659-674. ( PubMed , DOI )

  2. K i Nagata, A Puls, C Futter, P Aspenstrom, E Schaefer, T Nakata, N Hirokawa, A Hall: The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J.. 1998.01; 17 (1): 149-158. ( PubMed , DOI )

  1. H Yamazaki, T Nakata, Y Okada, N Hirokawa: Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proc. Natl. Acad. Sci. U.S.A.. 1996.08; 93 (16): 8443-8448. ( PubMed )

  2. Terada S, Nakata T, Peterson AC, Hirokawa N.: Visualization of slow axonal transport in vivo Science. 1996.08; 273 (5276): 784-788. ( PubMed , DOI )

  3. R Takemura, T Nakata, Y Okada, H Yamazaki, Z Zhang, N Hirokawa: mRNA expression of KIF1A, KIF1B, KIF2, KIF3A, KIF3B, KIF4, KIF5, and cytoplasmic dynein during axonal regeneration. J. Neurosci.. 1996.01; 16 (1): 31-35. ( PubMed )

  1. T Nakata, N Hirokawa: Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport. J. Cell Biol.. 1995.11; 131 (4): 1039-1053. ( PubMed )

  2. H Yamazaki, T Nakata, Y Okada, N Hirokawa: KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. J. Cell Biol.. 1995.09; 130 (6): 1387-1399. ( PubMed )

  1. M Kikkawa, T Ishikawa, T Nakata, T Wakabayashi, N Hirokawa: Direct visualization of the microtubule lattice seam both in vitro and in vivo. J. Cell Biol.. 1994.12; 127 (6 Pt 2): 1965-1971. ( PubMed )

  2. T Hayashi, F Soulie, T Nakata, N Hirokawa: Redistribution of synapsin I and synaptophysin in response to electrical stimulation in the rat neurohypophysial nerve endings. Cell Struct. Funct.. 1994.08; 19 (4): 253-262. ( PubMed )

  3. A Ando, K Yonezawa, I Gout, T Nakata, H Ueda, K Hara, Y Kitamura, Y Noda, T Takenawa, N Hirokawa: A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment. EMBO J.. 1994.07; 13 (13): 3033-3038. ( PubMed )

  4. S Kondo, R Sato-Yoshitake, Y Noda, H Aizawa, T Nakata, Y Matsuura, N Hirokawa: KIF3A is a new microtubule-based anterograde motor in the nerve axon. J. Cell Biol.. 1994.06; 125 (5): 1095-1107. ( PubMed )

  5. H Miki, K Miura, K Matuoka, T Nakata, N Hirokawa, S Orita, K Kaibuchi, Y Takai, T Takenawa: Association of Ash/Grb-2 with dynamin through the Src homology 3 domain. J. Biol. Chem.. 1994.02; 269 (8): 5489-5492. ( PubMed )

  1. T Nakata, R Sato-Yoshitake, Y Okada, Y Noda, N Hirokawa: Thermal drift is enough to drive a single microtubule along its axis even in the absence of motor proteins. Biophys. J.. 1993.12; 65 (6): 2504-2510. ( PubMed , DOI )

  2. Z Zhang, Y Tanaka, S Nonaka, H Aizawa, H Kawasaki, T Nakata, N Hirokawa: The primary structure of rat brain (cytoplasmic) dynein heavy chain, a cytoplasmic motor enzyme. Proc. Natl. Acad. Sci. U.S.A.. 1993.09; 90 (17): 7928-7932. ( PubMed )

  3. Y Noda, T Nakata, N Hirokawa: Localization of dynamin: widespread distribution in mature neurons and association with membranous organelles. Neuroscience. 1993.07; 55 (1): 113-127. ( PubMed )

  4. T Nakata, R Takemura, N Hirokawa: A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis. J. Cell. Sci.. 1993.05; 105 ( Pt 1) 1-5. ( PubMed )

  5. T. Nakata and N. Hirokawa. : Is dynamin GTPase a microtubule based motor? Neuronal Cytoskeleton. 1993; 285-303.

  1. Y Tanaka, K Kawahata, T Nakata, N Hirokawa: Chronological expression of microtubule-associated proteins (MAPs) in EC cell P19 after neuronal induction by retinoic acid. Brain Res.. 1992.11; 596 (1-2): 269-278. ( PubMed )

  2. K Maeda, T Nakata, Y Noda, R Sato-Yoshitake, N Hirokawa: Interaction of dynamin with microtubules: its structure and GTPase activity investigated by using highly purified dynamin. Mol. Biol. Cell. 1992.10; 3 (10): 1181-1194. ( PubMed )

  3. T Nakata, N Hirokawa: Organization of cortical cytoskeleton of cultured chromaffin cells and involvement in secretion as revealed by quick-freeze, deep-etching, and double-label immunoelectron microscopy. J. Neurosci.. 1992.06; 12 (6): 2186-2197. ( PubMed )

  1. T Nakata, A Iwamoto, Y Noda, R Takemura, H Yoshikura, N Hirokawa: Predominant and developmentally regulated expression of dynamin in neurons. Neuron. 1991.09; 7 (3): 461-469. ( PubMed )

  1. T Nakata, K Sobue, N Hirokawa: Conformational change and localization of calpactin I complex involved in exocytosis as revealed by quick-freeze, deep-etch electron microscopy and immunocytochemistry. J. Cell Biol.. 1990.01; 110 (1): 13-25. ( PubMed )

  1. T Nakata, N Hirokawa: Cytoskeletal reorganization of human platelets after stimulation revealed by the quick-freeze deep-etch technique. J. Cell Biol.. 1987.10; 105 (4): 1771-1780. ( PubMed )

  1. Optogenetic manipulations of small GTPases and observations of their intracellular functions 2021.08; 56 (2): 59-63. ( DOI )

  1. 豊島学, 蒋緒光, 小川覚之, 大西哲生, 吉原壯悟, SHABEESH Balan, 廣川信隆, 吉川武男: Analysis of protein molecular pathology of neurodevelopmental disorder by carbonyl stress 日本神経精神薬理学会プログラム・抄録集. 2020.08; 50回・42回・4回 190.

  1. Tomohiro Ishii, Takao Nakata: Light manipulation of intracellular Ca2+ signals by a genetically encoded protein Experimental Medicine. 2016.03; 34 (4): 601-606.

  1. Lihong Cheng, Yanhui Wang, Lan Xiang, Jianhua Qi: Heat Shock Cognate 70 kDa Protein Is the Target of Tetradecyl 2,3-Dihydroxybenzoate for Neuritogenic Effect in PC12 Cells Biomedicines. 2021.10; 9 (10): 1483. ( PubMed , DOI )

  2. Lihong Cheng, Hiroyuki Osada, Tianyan Xing, Minoru Yoshida, Lan Xiang, Jianhua Qi: The Insulin Receptor: A Potential Target of Amarogentin Isolated from Gentiana rigescens Franch That Induces Neurogenesis in PC12 Cells Biomedicines. 2021.05; 9 (5): ( PubMed , DOI )

  3. Yanjun Pan, Yanan Liu, Rui Fujii, Umer Farooq, Lihong Cheng, Akira Matsuura, Jianhua Qi, Lan Xiang: Ehretiquinone from Onosma bracteatum Wall Exhibits Antiaging Effect on Yeasts and Mammals through Antioxidative Stress and Autophagy Induction Oxidative Medicine and Cellular Longevity. 2021.01; 2021 1-15. ( PubMed , DOI )

  1. Dejene Disasa, Lihong Cheng, Majid Manzoor, Qian Liu, Ying Wang, Lan Xiang, Jianhua Qi: Amarogentin from Gentiana rigescens Franch Exhibits Antiaging and Neuroprotective Effects through Antioxidative Stress Oxidative Medicine and Cellular Longevity. 2020.08; 2020 1-15. ( PubMed , DOI )

  2. Qian Liu, Lihong Cheng, Akira Matsuura, Lan Xiang, Jianhua Qi: Gentiopicroside, a Secoiridoid Glycoside from Gentiana rigescens Franch, Extends the Lifespan of Yeast via Inducing Mitophagy and Antioxidative Stress Oxidative Medicine and Cellular Longevity. 2020.08; 2020 1-12. ( PubMed , DOI )

  1. Cheng L, Makoto MUROI, Cao S, Bian L, Osada H, Xiang L, Jianhua Qi: 3β,23,28-Trihydroxy-12-oleanene 3β-Caffeate from Desmodium sambuense-Induced Neurogenesis in PC12 Cells Mediated by ER Stress and BDNF-TrkB Signaling Pathways. Molecular pharmaceutics. 2019.04; 16 (4): 1423-1432. ( PubMed , DOI )

  1. Cheng L, Ye Y, Xiang L, Osada H, Qi J: Lindersin B from Lindernia crustacea induces neuritogenesis by activation of tyrosine kinase A/phosphatidylinositol 3 kinase/extracellular signal-regulated kinase signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017.01; 24 31-38. ( PubMed , DOI )

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