Our laboratory aims to innovate research and medicine in the fields of medical and biological sciences. We are conducting research on unique devices and systems by integrating microdevices based on top-down microfabrication techniques and bottom-up techniques that utilize molecular self-assembly.

(1) Mechano-biological ovarian follicle activation device
We devised a new method of ovarian stimulation using a microneedle array for premature ovarian failure (POF). We evaluated the invasiveness of microneedle arrays and demonstrated that the mechanical stimulation of mouse ovaries promotes follicle development in vivo. We also evaluated mechano-transduction of microneedle array stimulation by using in vitro systems to identify the mechanism of the promotion of follicle development.
(2) AR microscope system for sperm retrieval
To reduce the time required for embryologists to search for sperm, we have developed an AR microscope system. This system can detect, track, and analyze the velocity of sperm from microscope images acquired by a high-speed camera, and show the information on a microdisplay in the microscope field of view without perceptible delay. The AR microscopy system improves the speed and rate of sperm detection compared to conventional microscopy using the naked eye.
(3) Optically-controlled massively parallel cell sorter
Cell sorters are widely used in biological research to sort specific cells from cell population. However, conventional cell sorters are concerned about the effects of high-speed flow and staining on cells. Furthermore, cell sorting based on temporal observation is not possible. We have developed a novel cell sorter using photo-responsive shape memory polymer that enables parallel sorting by addressing with light irradiation.
(4) Development of a portable device for early detection of the viral infection using nucleic acid analysis
To develop a portable device that can test for viral infections at various sites, we have developed a new method for performing viral infection by using saliva by nucleic acid analysis, which requires only the addition of water to the device. We are developing a microdevice that enable minimum invasive and low-cost testing for viral infections by using this method.

Basic-Clinical Borderless Education