1. Ota Y, Yasunaga K, Mahazu S, Prah I, Nagai S, Hayashi T, Suzuki M, Yoshida M, Hoshino Y, Akeda Y, Suzuki T, Gu Y, Saito R: Comparative evaluation of analytical pipelines for illumina short- and nanopore long-read 16S rRNA gene amplicon sequencing with mock microbial communities. Journal of microbiological methods. 2024.04; 221 106929. ( PubMed , DOI )

  2. Ali T, Nguyen HM, Abbas N, Takeuchi O, Akira S, Suzuki T, Matsuzaki G, Takaesu G: TAK1-binding proteins (TAB)2 and TAB3 are redundantly required for TLR-induced cytokine production in macrophages. International immunology. 2024.04; ( PubMed , DOI )

  1. Doan YH, Dennis FE, Takemae N, Haga K, Shimizu H, Appiah MG, Lartey BL, Damanka SA, Hayashi T, Suzuki T, Kageyama T, Armah GE, Katayama K: Emergence of Intergenogroup Reassortant G9P[4] Strains Following Rotavirus Vaccine Introduction in Ghana. Viruses. 2023.12; 15 (12): ( PubMed , DOI )

  2. Suzuki, T; Boonyaleka, K; Okano, T; Iida, T; Yoshida, M; Fukano, H; Hoshino, Y; Iwakura, Y; Ablordey, AS; Ashida, H: Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer PLOS Pathogens. 2023.11; 19 (11): e1011747. ( PubMed , DOI )

  3. Miyamoto K, Sujino T, Harada Y, Ashida H, Yoshimatsu Y, Yonemoto Y, Nemoto Y, Tomura M, Melhem H, Niess JH, Suzuki T, Suzuki T, Suzuki S, Koda Y, Okamoto R, Mikami Y, Teratani T, Tanaka K, Yoshimura A, Sato T, Kanai T: The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis. Cell reports. 2023.08; 42 (8): 113005. ( PubMed , DOI )

  4. Umeda S, Sujino T, Miyamoto K, Yoshimatsu Y, Harada Y, Nishiyama K, Aoto Y, Adachi K, Hayashi N, Amafuji K, Moritoki N, Shibata S, Sasaki N, Mita M, Tanemoto S, Ono K, Mikami Y, Sasabe J, Takabayashi K, Hosoe N, Suzuki T, Sato T, Atarashi K, Teratani T, Ogata H, Nakamoto N, Shiomi D, Ashida H, Kanai T: D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease. Cellular and molecular gastroenterology and hepatology. 2023.08; 16 1011-1031. ( PubMed , DOI )

  5. Boonyaleka K, Okano T, Iida T, Leewananthawet A, Sasai M, Yamamoto M, Ashida H, Suzuki T: Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS-induced colitis. European journal of immunology. 2023.07; e2350455. ( PubMed , DOI )

  6. Boonyaleka K, Okano T, Iida T, Leewananthawer A, Sasai M, Yamamoto M, Ashida H, Suzuki T: Fusobacterium nucleatum infection activates the noncanonical inflammasome to exacerbate inflammatory response in acute colitis mice Eur. J. Immunol. 2023.07; e2350455

  1. Samiratu Mahazu, Isaac Prah, Yusuke Ota, Takaya Hayashi, Yoko Nukui, Masato Suzuki, Yoshihiko Hoshino, Yukihiro Akeda, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito: Klebsiella species and Enterobacter cloacae isolates harboring blaOXA-181 and blaOXA-48: resistome, fitness cost, and plasmid stability. Microbiol Spectr. 2022.12; e0332022. ( PubMed , DOI )

  2. Samiratu Mahazu, Wakana Sato, Alafate Ayibieke, Isaac Prah, Takaya Hayashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito: Insights and genetic features of extended-spectrum beta-lactamase producing Escherichia coli isolates from two hospitals in Ghana. Sci Rep. 2022.02; 12 (1): 1843. ( PubMed , DOI )

  3. Sumiko Yoshida Masahiro Hatasa Yujin Ohsugi Yosuke Tsuchiya Anhao Liu Hiromi Niimi Kazuki Morita Tsuyoshi Shimohira Naoki Sasaki Shogo Maekawa Takahiko Shiba Tomomitsu Hirota Tokuju Okano Asuka Hirose Rinko Ibi Kanako Noritake Yuki Tomiga Hiroshi Nitta Toshihiko Suzuki Hirokazu Takahashi Naoyuki Miyasaka Takanori Iwata Sayaka Katagiri: Porphyromonas gingivalis Administration Induces Gestational Obesity, Alters Gene Expression in the Liver and Brown Adipose Tissue in Pregnant Mice, and Causes Underweight in Fetuses Frontiers in Cellular and Infection Microbiology. 2022.01;

  1. Samiratu Mahazu, Isaac Prah, Alafate Ayibieke, Wakana Sato, Takaya Hayashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito: Possible Dissemination of Escherichia coli Sequence Type 410 Closely Related to B4/H24RxC in Ghana. Front Microbiol. 2021.12; 12 770130. ( PubMed , DOI )

  2. Isaac Prah, Alafate Ayibieke, Samiratu Mahazu, Chihiro Tani Sassa, Takaya Hayashi, Shoji Yamaoka, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito: Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic Escherichia coli in Ghana. Emerg Microbes Infect. 2021.12; 10 (1): 865-873. ( PubMed , DOI )

  3. Abass A, Okano T, Boonyaleka K, Kinoshita-Daitoku R, Yamaoka S, Ashida H, Suzuki T: Effect of low oxygen concentration on activation of inflammation by Helicobacter pylori Biochem Biophys Res Commun. 2021.06; 560 179-185. ( DOI )

  4. Kinoshita-Daitoku R, Kiga K, Miyakoshi M, Otsubo R, Ogura Y, Sanada T, Bo Z, Phuoc TV, Okano T, Iida T, Yokomori R, Kuroda E, Hirukawa S, Tanaka M, Sood A, Subsomwong P, Ashida H, Binh TT, Nguyen LT, Van KV, Ho DQD, Nakai K, Suzuki T, Yamaoka Y, Hayashi T, Mimuro H: A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment Nat Commun. 2021.04; 12 (1): 2085. ( DOI )

  5. Prah Isaac, Ayibieke Alafate, Nguyen Thi Thu Huong, Iguchi Atsushi, Mahazu Samiratu, Sato Wakana, Hayashi Takaya, Yamaoka Shoji, Suzuki Toshihiko, Iwanaga Shiroh, Ablordey Anthony, Saito Ryoichi: Virulence Profiles of Diarrheagenic Escherichia coli Isolated from the Western Region of Ghana(和訳中) Japanese Journal of Infectious Diseases. 2021.03; 74 (2): 115-121. ( 医中誌 )

  6. Okano Tokuju, Suzuki Toshihiko: Inflammasome activation inducer produced by Aggregatibacter actinomycetemcomitans causes arthritis(和訳中) 口腔病学会雑誌. 2021.03; 88 (1): 70-71. ( 医中誌 )

  7. Kurashima Y, Kigoshi T, Murasaki S, Arai F, Shimada K, Seki N, Kim YG, Hase K, Ohno H, Kawano K, Ashida H, Suzuki T, Morimoto M, Saito Y, Sasou A, Goda Y, Yuki Y, Inagaki Y, Iijima H, Suda W, Hattori M, Kiyono H: Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation. Nature communications. 2021.02; 12 (1): 1067. ( PubMed , DOI )

  8. 岡野 徳壽, 鈴木 敏彦: 低酸素環境と疾患(がん、感染症)の分子論　低酸素環境下においてTRIF-HIF-1α経路はP.gingivalisによるインフラマソーム活性化亢進を制御している(TRIF-HIF-1α signaling under hypoxia drives enhancement of inflammasome activation by P. gingivalis) 日本細菌学雑誌. 2021.02; 76 (1): 57. ( 医中誌 )

  9. Abass Adiza, 鈴木 敏彦: ピロリ菌によって誘導されるインフラマソーム活性化における低酸素環境下での影響(The effect of hypoxia on Helicobacter pylori induced inflammasome activation) 日本細菌学雑誌. 2021.02; 76 (1): 107. ( 医中誌 )

  10. Ashida H, Suzuki T, Sasakawa C: Shigella infection and host cell death: A double-edged sword for the host and pathogen survival Current Opinion in Microbiology. 2021.02; 59 1-7. ( DOI )

  11. Yoshida S, Hatasa M, Ohsugi Y, Tsuchiya Y, Liu A, Niimi H, Morita K, Shimohira T, Sasaki N, Maekawa S, Shiba T, Hirota T, Okano T, Hirose A, Ibi R, Noritake K, Tomiga Y, Nitta H, Suzuki T, Takahashi H, Miyasaka N, Iwata T, Katagiri S: Porphyromonas gingivalis Administration Induces Gestational Obesity, Alters Gene Expression in the Liver and Brown Adipose Tissue in Pregnant Mice, and Causes Underweight in Fetuses. Frontiers in cellular and infection microbiology. 2021; 11 745117. ( PubMed , DOI )

  1. Prah Isaac, Ayibieke Alafate, Mahazu Samiratu, 佐々 千尋, 林 隆也, 鈴木 敏彦, 岩永 史朗, 山岡 昇司, Ablordey Anthony, 齋藤 良一: ガーナから来た下痢患者由来のOXA-181型カルバペネマーゼ産生大腸菌に関する全ゲノム性状分析(Whole-genome characterization of OXA-181 carbapenemase producing Escherichia coli from diarrheic patients in Ghana) 日本臨床微生物学会雑誌. 2020.12; 31 (Suppl.1): 205. ( 医中誌 )

  2. Alafate Ayibieke, Ayumi Kobayashi, Masato Suzuki, Wakana Sato, Samiratu Mahazu, Isaac Prah, Miyuki Mizoguchi, Kyoji Moriya, Takaya Hayashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito: Prevalence and characterization of carbapenem-hydrolyzing class D β-lactamase-producing Acinetobacter isolates from Ghana. Front Microbiol. 2020.11; 11 587398. ( PubMed , DOI )

  3. Prah I, Ayibieke A, Huong NTT, Iguchi A, Mahazu S, Sato W, Hayashi T, Yamaoka S, Suzuki T, Iwanaga S, Ablordey A, Saito R: Virulence profile of diarrhoeagenic Escherichia coli from the Western region of Ghana. Japanese journal of infectious diseases. 2020.08; ( PubMed , DOI )

  4. Ashida H, Sasakawa C, Suzuki T: A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8. The EMBO journal. 2020.07; 39 (17): e104469. ( PubMed , DOI )

  5. Saeki A, Tsuchiya K, Suda T, Into T, Hasebe A, Suzuki T, Shibata KI: Gasdermin D-independent release of interleukin-1b by living macrophages in response to mycoplasmal lipoproteins and lipopeptides. Immunology. 2020.06; ( PubMed , DOI )

  6. Kinoshita-Daitoku R, Kiga K, Sanada T, Ogura Y, Bo Z, Iida T, Yokomori R, Kuroda E, Tanaka M, Sood A, Suzuki T, Nakai K, Hayashi T, Mimuro H: Mutational diversity in mutY deficient Helicobacter pylori and its effect on adaptation to the gastric environment. Biochemical and biophysical research communications. 2020.05; 525 (3): 806-811. ( PubMed , DOI )

  7. Mototsugu Tanaka, Ryo Kinoshita-Daitoku, Kotaro Kiga, Takahito Sanada , Bo Zhu, Tokuju Okano, Chihiro Aikawa, Tamako Iida, Yoshitoshi Ogura, Tetsuya Hayashi, Koshu Okubo, Miho Kurosawa, Junichi Hirahashi, Toshihiko Suzuki, Ichiro Nakagawa, Masaomi Nangaku, Hitomi Mimuro : Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps Scientific Reports. 2020.02; 24 (1): ( DOI )

  8. Tanaka M, Kinoshita-Daitoku R, Kiga K, Sanada T, Zhu B, Okano T, Aikawa C, Iida T, Ogura Y, Hayashi T, Okubo K, Kurosawa M, Hirahashi J, Suzuki T, Nakagawa I, Nangaku M, Mimuro H: Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps. Scientific reports. 2020.02; 10 (1): 3251. ( PubMed , DOI )

  9. Prah Isaac, Ayibieke Alafate, 井口 純, Mahazu Samiratu, 佐藤 和佳菜, 鈴木 敏彦, 山岡 昇司, 岩永 史朗, Ablordey Anthony, 齋藤 良一: Virulence Profile of Diarrheagenic E. coli from the Western region of Ghana(和訳中) 日本細菌学雑誌. 2020.01; 75 (1): 118. ( 医中誌 )

  10. 岡野 徳壽, 鈴木 敏彦: A. actinomycetemcomitans induces inflammasome activation via lysosomal degradation(和訳中) 日本細菌学雑誌. 2020.01; 75 (1): 90. ( 医中誌 )

  11. Toma C, Suzuki T: Evaluation of Intracellular Trafficking in Macrophages. Methods in molecular biology (Clifton, N.J.). 2020; 2134 199-206. ( PubMed , DOI )

  1. Okano Tokuju, Sasai Miwa, Yamamoto Masahiro, Suzuki Toshihiko: Immunology of infection-2　Aggregatibacter actinomycetemcomitans induces activation of noncanonical inflammasome via lysosomal degradation(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 3-C. ( 医中誌 )

  2. Kiyonobu Yamamura, Hiroshi Ashida , Tokuju Okano , Ryo Kinoshita-Daitoku, Shiho Suzuki, Kaori Ohtani, Miwako Hamagaki , Tohru Ikeda , Toshihiko Suzuki 1: Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene Frontiers in Microbiology. 2019.10;

  3. Yamamura Kiyonobu, Ashida Hiroshi, Okano Tokuju, Kinoshita-Daitoku Ryo, Suzuki Shiho, Ohtani Kaori, Hamagaki Miwako, Ikeda Tohru, Suzuki Toshihiko: Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene FRONTIERS IN MICROBIOLOGY. 2019.10; 10 2406. ( PubMed , DOI )

  4. Leewananthawet Anongwee, Arakawa Shinichi, Okano Tokuju, Kinoshita Ryo Daitoku, Ashida Hiroshi, Izumi Yuichi, Suzuki Toshihiko: Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS. 2019.06; 20 (1): 589-598. ( PubMed , DOI )

  5. Ryota Otsubo, Hitomi Mimuro, Hiroshi Ashida, Jun Hamazaki, Shigeo Murata, Chihiro Sasakawa: Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation. Cell. Microbiol.. 2019.03; 21 (3): e12974. ( PubMed , DOI )

  6. Nakamoto Nobuhiro, Sasaki Nobuo, Aoki Ryo, Miyamoto Kentaro, Suda Wataru, Teratani Toshiaki, Suzuki Takahiro, Koda Yuzo, Chu Po-Sung, Taniki Nobuhito, Yamaguchi Akihiro, Kanamori Mitsuhiro, Kamada Nobuhiko, Hattori Masahira, Ashida Hiroshi, Sakamoto Michiie, Atarashi Koji, Narushima Seiko, Yoshimura Akihiko, Honda Kenya, Sato Toshiro, Kanai Takanori: Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis NATURE MICROBIOLOGY. 2019.03; 4 (3): 492-503. ( DOI )

  1. Suzuki Shiho, Suzuki Toshihiko: Cellular inhibitor of apoptosis protein 1 and 2 are important for the Inflammasome activation) Proceedings of The Japanese Society for Immunology . 2018.12; 47 (Proceedings): 1-E. ( 医中誌 )

  2. Ashida Hiroshi, Suzuki Toshihiko: Bacterial / mycofungal / parasite infection　Analysis of novel Shigella effector mechanism that regulate host cell death Proceedings of The Japanese Society for Immunology . 2018.12; 47 (Proceedings): 3-H. ( 医中誌 )

  3. Okano T, Ashida H, Suzuki S, Shoji M, Nakayama K, Suzuki T: Porphyromonas gingivalis triggers NLRP3-mediated inflammasome activation in macrophages in a bacterial gingipains-independent manner. European journal of immunology. 2018.12; 48 (12): 1965-1974. ( PubMed , DOI )

  4. Okano T, Ashida H, Suzuki S, Shoji M, Nakayama K, Suzuki T: Porphyromonas gingivalis triggers NLRP3-mediated inflammasome activation in macrophages in a bacterial gingipains-independent manner. European Journal of Imunology. 2018.12; ( DOI )

  5. Alafate Ayibieke, Wakana Sato, Samiratu Mahazu, Isaac Prah, John Addow-Thompson, Mitsuko Ohashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito: Molecular characterisation of the NDM-1-encoding plasmid p2189-NDM in an Escherichia coli ST410 clinical isolate from Ghana. PLoS ONE. 2018.12; 13 (12): e0209623. ( PubMed , DOI )

  6. Nakasone Noboru, Ogura Yasunori, Higa Naomi, Toma Claudia, Koizumi Yukiko, Takaesu Giichi, Suzuki Toshihiko, Yamashiro Tetsu: Effects of Psidium guajava leaf extract on secretion systems of gram-negative enteropathogenic bacteria MICROBIOLOGY AND IMMUNOLOGY. 2018.07; 62 (7): 444-453. ( PubMed , DOI )

  7. Yamaguchi Takayoshi, Higa Naomi, Okura Nobuhiko, Matsumoto Arina, Hermawan Idam, Yamashiro Tetsu, Suzuki Toshihiko, Toma Claudia: Characterizing interactions of Leptospira interrogans with proximal renal tubule epithelial cells BMC MICROBIOLOGY. 2018.07; 18 (1): 64. ( PubMed , DOI )

  8. Ayumi Saeki, Masahiro Sugiyama, Akira Hasebe, Toshihiko Suzuki, Ken-Ichiro Shibata: Activation of NLRP3 inflammasome in macrophages by mycoplasmal lipoproteins and lipopeptides. Mol Oral Microbiol. 2018.04; ( PubMed , DOI )

  9. Yuhei Maruzuru, Takeshi Ichinohe, Ryota Sato, Kensuke Miyake, Tokuju Okano, Toshihiko Suzuki, Takumi Koshiba, Naoto Koyanagi, Shumpei Tsuda, Mizuki Watanabe, Jun Arii, Akihisa Kato, Yasushi Kawaguch: Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication Cell Host & Microbe. 2018.02; 23 (2): 254-265.

  10. Yuhei Maruzuru, Takeshi Ichinohe, Ryota Sato, Kensuke Miyake, Tokuju Okano, Toshihiko Suzuki, Takumi Koshiba, Naoto Koyanagi, Shumpei Tsuda, Mizuki Watanabe, Jun Arii, Akihisa Kato, Yasushi Kawaguchi: Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication. Cell Host Microbe. 2018.02; 23 (2): 254-265.e7. ( PubMed , DOI )

  11. Shiho Suzuki, Toshihiko Suzuki, Hitomi Mimuro, Tsunehiro Mizushima, Chihiro Sasakawa: Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation. EMBO Rep.. 2018.01; 19 (1): 89-101. ( PubMed , DOI )

  1. Suzuki Shiho, Suzuki Toshihiko: Immune response to bacteial infections The microbial-host interactions that drive the activation of the Nlrc4 inflammasome in Shigella-infected macrophages(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-E. ( 医中誌 )

  2. Suzuki Toshihiko, Kannagi Mari: Pathogen infection and host responses(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): OT4. ( 医中誌 )

  3. Noboru Nakasone, Naomi Higa, Claudia Toma, Yasunori Ogura, Toshihiko Suzuki, Tetsu Yamashiro: Epigallocatechin gallate inhibits the type III secretion system of Gram-negative enteropathogenic bacteria under model conditions. FEMS Microbiol. Lett.. 2017.07; 364 (13): ( PubMed , DOI )

  4. Ayumi Saeki, Toshihiko Suzuki, Akira Hasebe, Ryousuke Kamezaki, Mari Fujita, Futoshi Nakazawa, Ken-Ichiro Shibata: Activation of nucleotide-binding domain-like receptor containing protein 3 inflammasome in dendritic cells and macrophages by Streptococcus sanguinis. Cell. Microbiol.. 2017.03; 19 (3): ( PubMed , DOI )

  5. Hiroshi Ashida, Chihiro Sasakawa: Bacterial E3 ligase effectors exploit host ubiquitin systems. Curr. Opin. Microbiol.. 2017.02; 35 16-22. ( PubMed , DOI )

  6. Toma Claudia, 山口 孝治, 比嘉 直美, 松本 亜里奈, 大倉 信彦, 仲宗根 昇, 鈴木 敏彦, 山城 哲: 感染性のLeptospira interrogansと腎上皮細胞の相互作用(Interaction of virulent Leptospira interrogans with renal epithelial cells) 日本細菌学雑誌. 2017.02; 72 (1): 124. ( 医中誌 )

  7. Yohei Yamaguchi, Tomoko Kurita-Ochiai, Ryoki Kobayashi, Toshihiko Suzuki, Tomohiro Ando: Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease. Inflamm. Res.. 2017.01; 66 (1): 59-65. ( PubMed , DOI )

  8. Noboru Nakasone, Yasunori Ogura, Naomi Higa, Claudia Toma, Yukiko Koizumi, Toshihiko Suzuki, Tetsu Yamashiro: Hot-PBS extract of Vibrio vulnificus induces NF-kB activation Electronic J. Biol.. 2017;

  1. M Sugiyama, A Saeki, A Hasebe, R Kamesaki, Y Yoshida, Y Kitagawa, T Suzuki, K Shibata: Activation of inflammasomes in dendritic cells and macrophages by Mycoplasma salivarium. Mol Oral Microbiol. 2015.07; ( PubMed , DOI )

  2. Yohei Yamaguchi, Tomoko Kurita-Ochiai, Ryoki Kobayashi, Toshihiko Suzuki, Tomohiro Ando: Activation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated atherosclerosis. Pathog Dis. 2015.06; 73 (4): ( PubMed , DOI )

  3. Hiroshi Ashida, Chihiro Sasakawa: Shigella IpaH Family Effectors as a Versatile Model for Studying Pathogenic Bacteria. Front Cell Infect Microbiol. 2015; 5 100. ( PubMed , DOI )

  4. Hiroshi Ashida, Hitomi Mimuro, Chihiro Sasakawa: Shigella manipulates host immune responses by delivering effector proteins with specific roles. Front Immunol. 2015; 6 219. ( PubMed , DOI )

  5. Kazuhito Satou, Makiko Shimoji, Hinako Tamotsu, Ayaka Juan, Noriko Ashimine, Misuzu Shinzato, Claudia Toma, Toshitsugu Nohara, Akino Shiroma, Kazuma Nakano, Kuniko Teruya, Yasunobu Terabayashi, Shun Ohki, Nobuo Koizumi, Shou Okano, Toshihiko Suzuki, Takashi Hirano: Complete Genome Sequences of Low-Passage Virulent and High-Passage Avirulent Variants of Pathogenic Leptospira interrogans Serovar Manilae Strain UP-MMC-NIID, Originally Isolated from a Patient with Severe Leptospirosis, Determined Using PacBio Single-Molecule Real-Time Technology. Genome Announc. 2015; 3 (4): ( PubMed , DOI )

  1. Hiroshi Ashida, Minsoo Kim, Chihiro Sasakawa: Manipulation of the host cell death pathway by Shigella. Cell. Microbiol.. 2014.12; 16 (12): 1757-1766. ( PubMed , DOI )

  2. Hiroshi Ashida, Chihiro Sasakawa: Shigella hacks host immune responses by reprogramming the host epigenome. EMBO J.. 2014.11; 33 (22): 2598-2600. ( PubMed , DOI )

  3. Shiho Suzuki, Hitomi Mimuro, Minsoo Kim, Michinaga Ogawa, Hiroshi Ashida, Takahito Toyotome, Luigi Franchi, Masato Suzuki, Takahito Sanada, Toshihiko Suzuki, Hiroko Tsutsui, Gabriel Núñez, Chihiro Sasakawa: Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc. Natl. Acad. Sci. U.S.A.. 2014.10; 111 (40): E4254-E4263. ( PubMed , DOI )

  4. Ryota Itoh, Issaku Murakami, Bin Chou, Kazunari Ishii, Toshinori Soejima, Toshihiko Suzuki, Kenji Hiromatsu: Chlamydia pneumoniae harness host NLRP3 inflammasome-mediated caspase-1 activation for optimal intracellular growth in murine macrophages. Biochem. Biophys. Res. Commun.. 2014.09; 452 (3): 689-694. ( PubMed , DOI )

  5. Claudia Toma, Gerald L Murray, Toshitsugu Nohara, Masaru Mizuyama, Nobuo Koizumi, Ben Adler, Toshihiko Suzuki: Leptospiral outer membrane protein LMB216 is involved in enhancement of phagocytic uptake by macrophages. Cell. Microbiol.. 2014.09; 16 (9): 1366-1377. ( PubMed , DOI )

  6. Ting Liu, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Koichi Shikada, Mai Yamagishi, Katsuaki Hoshino, Tsuneyasu Kaisho, Kiwamu Takemoto, Toshihiko Suzuki, Erina Kuranaga, Osamu Ohara, Masayuki Miura: Single-cell imaging of caspase-1 dynamics reveals an all-or-none inflammasome signaling response. Cell Rep. 2014.08; 8 (4): 974-982. ( PubMed , DOI )

  7. Hiroshi Ashida, Minsoo Kim, Chihiro Sasakawa: Exploitation of the host ubiquitin system by human bacterial pathogens. Nat. Rev. Microbiol.. 2014.06; 12 (6): 399-413. ( PubMed , DOI )

  8. Amy M King, Gabriela Pretre, Thanatchaporn Bartpho, Rasana W Sermswan, Claudia Toma, Toshihiko Suzuki, Azad Eshghi, Mathieu Picardeau, Ben Adler, Gerald L Murray: High-temperature protein G is an essential virulence factor of Leptospira interrogans. Infect. Immun.. 2014.03; 82 (3): 1123-1131. ( PubMed , DOI )

  9. Shiho Suzuki, Luigi Franchi, Yuan He, Raul Muñoz-Planillo, Hitomi Mimuro, Toshihiko Suzuki, Chihiro Sasakawa, Gabriel Núñez: Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ. PLoS Pathog.. 2014.02; 10 (2): e1003926. ( PubMed , DOI )

  1. Naomi Higa, Claudia Toma, Toshitsugu Nohara, Noboru Nakasone, Giichi Takaesu, Toshihiko Suzuki: Lose the battle to win the war: bacterial strategies for evading host inflammasome activation. Trends Microbiol.. 2013.07; 21 (7): 342-349. ( PubMed , DOI )

  2. Taira Kobayashi, Michinaga Ogawa, Takahito Sanada, Hitomi Mimuro, Minsoo Kim, Hiroshi Ashida, Reiko Akakura, Mitsutaka Yoshida, Magdalena Kawalec, Jean-Marc Reichhart, Tsunehiro Mizushima, Chihiro Sasakawa: The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe. 2013.05; 13 (5): 570-583. ( PubMed , DOI )

  3. Naomi Higa, Claudia Toma, Yukiko Koizumi, Noboru Nakasone, Toshitsugu Nohara, Junya Masumoto, Toshio Kodama, Tetsuya Iida, Toshihiko Suzuki: Vibrio parahaemolyticus effector proteins suppress inflammasome activation by interfering with host autophagy signaling. PLoS Pathog.. 2013.01; 9 (1): e1003142. ( PubMed , DOI )

  4. Hiroshi Ashida, Hiroyasu Nakano, Chihiro Sasakawa: Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells. PLoS Pathog.. 2013; 9 (6): e1003409. ( PubMed , DOI )

  1. Takahito Sanada, Minsoo Kim, Hitomi Mimuro, Hiroshi Ashida, Michinaga Ogawa, Tsunehiro Mizushima, Chihiro Sasakawa: A bacterial effector targets the TRAF6-NFκB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells. Virulence. 2012.10; 3 (6): 518-521. ( PubMed , DOI )

  2. Takahito Sanada, Minsoo Kim, Hitomi Mimuro, Masato Suzuki, Michinaga Ogawa, Akiho Oyama, Hiroshi Ashida, Taira Kobayashi, Tomohiro Koyama, Shinya Nagai, Yuri Shibata, Jin Gohda, Jun-ichiro Inoue, Tsunehiro Mizushima, Chihiro Sasakawa: The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Nature. 2012.03; 483 (7391): 623-626. ( PubMed , DOI )

  3. Yukiko Koizumi, Claudia Toma, Naomi Higa, Toshitsugu Nohara, Noboru Nakasone, Toshihiko Suzuki: Inflammasome activation via intracellular NLRs triggered by bacterial infection. Cell. Microbiol.. 2012.02; 14 (2): 149-154. ( PubMed , DOI )

  1. Hiroshi Ashida, Michinaga Ogawa, Minsoo Kim, Hitomi Mimuro, Chihiro Sasakawa: Bacteria and host interactions in the gut epithelial barrier. Nat. Chem. Biol.. 2011.12; 8 (1): 36-45. ( PubMed , DOI )

  2. Hiroshi Ashida, Hitomi Mimuro, Michinaga Ogawa, Taira Kobayashi, Takahito Sanada, Minsoo Kim, Chihiro Sasakawa: Cell death and infection: a double-edged sword for host and pathogen survival. J. Cell Biol.. 2011.12; 195 (6): 931-942. ( PubMed , DOI )

  3. Hiroshi Ashida, Michinaga Ogawa, Hitomi Mimuro, Taira Kobayashi, Takahito Sanada, Chihiro Sasakawa: Shigella are versatile mucosal pathogens that circumvent the host innate immune system. Curr. Opin. Immunol.. 2011.08; 23 (4): 448-455. ( PubMed , DOI )

  4. Michinaga Ogawa, Hitomi Mimuro, Yuko Yoshikawa, Hiroshi Ashida, Chihiro Sasakawa: Manipulation of autophagy by bacteria for their own benefit. Microbiol. Immunol.. 2011.07; 55 (7): 459-471. ( PubMed , DOI )

  5. Nozomi Ishijima, Masato Suzuki, Hiroshi Ashida, Yusuke Ichikawa, Yumi Kanegae, Izumu Saito, Thomas Borén, Rainer Haas, Chihiro Sasakawa, Hitomi Mimuro: BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity. J. Biol. Chem.. 2011.07; 286 (28): 25256-25264. ( PubMed , DOI )

  6. Michinaga Ogawa, Yuko Yoshikawa, Taira Kobayashi, Hitomi Mimuro, Makoto Fukumatsu, Kotaro Kiga, Zhenzi Piao, Hiroshi Ashida, Mitsutaka Yoshida, Shigeru Kakuta, Tomohiro Koyama, Yoshiyuki Goto, Takahiro Nagatake, Shinya Nagai, Hiroshi Kiyono, Magdalena Kawalec, Jean-Marc Reichhart, Chihiro Sasakawa: A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 2011.05; 9 (5): 376-389. ( PubMed , DOI )

  7. Hiroshi Ashida, Michinaga Ogawa, Minsoo Kim, Shiho Suzuki, Takahito Sanada, Claire Punginelli, Hitomi Mimuro, Chihiro Sasakawa: Shigella deploy multiple countermeasures against host innate immune responses. Curr. Opin. Microbiol.. 2011.02; 14 (1): 16-23. ( PubMed , DOI )

  1. Andrea J McCoy, Yukiko Koizumi, Naomi Higa, Toshihiko Suzuki: Differential regulation of caspase-1 activation via NLRP3/NLRC4 inflammasomes mediated by aerolysin and type III secretion system during Aeromonas veronii infection. J. Immunol.. 2010.12; 185 (11): 7077-7084. ( PubMed , DOI )

  2. Andrea J McCoy, Yukiko Koizumi, Claudia Toma, Naomi Higa, Vishva Dixit, Shun'ichiro Taniguchi, Jürg Tschopp, Toshihiko Suzuki: Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages. Eur. J. Immunol.. 2010.10; 40 (10): 2797-2803. ( PubMed , DOI )

  3. Minsoo Kim, Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Chihiro Sasakawa: Bacterial interactions with the host epithelium. Cell Host Microbe. 2010.07; 8 (1): 20-35. ( PubMed , DOI )

  4. Hiroshi Ashida, Minsoo Kim, Marc Schmidt-Supprian, Averil Ma, Michinaga Ogawa, Chihiro Sasakawa: A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Nat. Cell Biol.. 2010.01; 12 (1): 66-73; sup pp 1. ( PubMed , DOI )

  1. Hiroshi Ashida, Michinaga Ogawa, Hitomi Mimuro, Chihiro Sasakawa: Shigella infection of intestinal epithelium and circumvention of the host innate defense system. Curr. Top. Microbiol. Immunol.. 2009; 337 231-255. ( PubMed , DOI )

  1. Michinaga Ogawa, Yutaka Handa, Hiroshi Ashida, Masato Suzuki, Chihiro Sasakawa: The versatility of Shigella effectors. Nat. Rev. Microbiol.. 2008.01; 6 (1): 11-16. ( PubMed , DOI )

  1. Hiroki Iwai, Minsoo Kim, Yuko Yoshikawa, Hiroshi Ashida, Michinaga Ogawa, Yukihiro Fujita, Daniel Muller, Teruo Kirikae, Peter K Jackson, Shuji Kotani, Chihiro Sasakawa: A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell. 2007.08; 130 (4): 611-623. ( PubMed , DOI )

  2. Toshihiko Suzuki, Luigi Franchi, Claudia Toma, Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Naohiro Inohara, Chihiro Sasakawa, Gabriel Nuñez: Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog.. 2007.08; 3 (8): e111. ( PubMed , DOI )

  3. Hiroshi Ashida, Takahito Toyotome, Takeshi Nagai, Chihiro Sasakawa: Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors. Mol. Microbiol.. 2007.02; 63 (3): 680-693. ( PubMed , DOI )

  1. Toshihiko Suzuki, Yuko Yoshikawa, Hiroshi Ashida, Hiroki Iwai, Takahito Toyotome, Hidenori Matsui, Chihiro Sasakawa: High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin. J. Immunol.. 2006.10; 177 (7): 4709-4717. ( PubMed , DOI )

  1. 芦田　浩,　鈴木　敏彦: 赤痢菌による宿主細胞死制御機構 月刊「細胞」. 2022.10; 54 (10): 4-7.

  2. 岩澤　茉莉絵,　芦田　浩,　鈴木　敏彦,　笹川　千尋: 赤痢菌によるインフラマソーム制御機構 炎症と免疫. 2022.02; 30 123-127.

  1. 芦田 浩, 笹川 千尋, 鈴木 敏彦: 細胞内センサーによる病原体認識の新機軸　腸管病原菌による宿主細胞死クロストーク制御機構の解明 日本細菌学雑誌. 2021.02; 76 (1): 33. ( 医中誌 )

  1. 木下 遼, 氣駕 恒太朗, 大坪 亮太, 小椋 義俊, 眞田 貴人, 岡野 徳壽, 鈴木 敏彦, 山岡 吉生, 林 哲也, 三室 仁美: RNAで細菌を制御する(Regulating with RNA in Bacteria　sRNA regulates pathogenicity during persistent infection of Helicobacter) 日本細菌学雑誌. 2020.01; 75 (1): 33. ( 医中誌 )

  1. 佐伯 歩, 引頭 毅, 長谷部 晃, 鈴木 敏彦, 柴田 健一郎: マイコプラズマ由来リポタンパク質/リポペプチドにより誘導される生きたマクロファージからのIL-1β細胞外分泌機構 Journal of Oral Biosciences Supplement. 2019.10; 2019 127. ( 医中誌 )

  2. 岡野 徳壽, 鈴木 敏彦: Porphyromonas ginvivalisによるTLR4-TRIF経路依存性インフラマソーム活性化機構の解明 Journal of Oral Biosciences Supplement. 2019.10; 2019 255. ( 医中誌 )

  3. 岡野 徳壽, 芦田 浩, 鈴木 志穂, 鈴木 敏彦: 最近の歯学　細菌感染制御　Porphyromonas gingivalisによる炎症誘導機構 口腔病学会雑誌. 2019.07; 86 (2): 47. ( 医中誌 )

  4. 芦田 浩, 笹川 千尋, 鈴木 敏彦: バクテリオロジーのフロントランナー〜AMED獲得者の革新的細菌学研究〜　腸内細菌叢と病原細菌の相互作用解析 日本細菌学雑誌. 2019.03; 74 (1): 24. ( 医中誌 )

  5. 木下 遼, 氣駕 恒太朗, 大坪 亮太, 小椋 義俊, 真田 貴人, 岡野 徳壽, 鈴木 敏彦, 林 哲也, 三室 仁美: ヘリコバクター・ピロリのsmall RNAによる持続感染機構の解析 日本細菌学雑誌. 2019.03; 74 (1): 95. ( 医中誌 )

  6. 佐伯 歩, 土屋 晃介, 須田 貴司, 引頭 毅, 長谷部 晃, 鈴木 敏彦, 柴田 健一郎: マイコプラズマのリポペプチドFSL-1はどのようにして生きたマクロファージからIL-1βの放出を誘発するのか 日本細菌学雑誌. 2019.03; 74 (1): 85. ( 医中誌 )

  7. 岡野 徳壽, 鈴木 志穂, 庄子 幹郎, 中山 浩次, 鈴木 敏彦: 低酸素状態はP.gingivalis感染によるインフラマソーム活性化を増強する 日本細菌学雑誌. 2019.03; 74 (1): 91. ( 医中誌 )

  8. 鈴木 志穂, 鈴木 敏彦, 笹川 千尋: GLMN-cIAP1/2は細菌感染に対するインフラマソーム活性をコントロールする 日本細菌学雑誌. 2019.03; 74 (1): 112. ( 医中誌 )

  9. 山村 清展, 岡野 徳壽, 大谷 郁, 鈴木 敏彦: ウェルシュ菌によるインフラマゾーム活性化 日本細菌学雑誌. 2019.03; 74 (1): 94. ( 医中誌 )

  10. 芦田 浩, 鈴木 敏彦: 腸内細菌叢と病原細菌の相互作用解析に基づくマウス腸管感染モデルの構築と解析 日本小児科学会雑誌. 2019.02; 123 (2): 213. ( 医中誌 )

  1. 後藤 健太, 鈴木 志穂, 鈴木 敏彦, 山城 哲: CIAP1、CIAP2、XIAPの機能について 琉球医学会誌. 2018.12; 37 (1-4): 118. ( 医中誌 )

  2. 上野 理佐子, 芦田 浩, 鈴木 志穂, 鈴木 敏彦, 山城 哲: 赤痢菌が分泌するeffectorタンパクOspD3の解明 琉球医学会誌. 2018.12; 37 (1-4): 119. ( 医中誌 )

  3. 佐藤 和佳菜, Ayibieke Alafate, 小林 あゆみ, 谷 千尋, 齋藤 良一, 鈴木 敏彦, 大橋 光子, 岩永 史朗: ガーナ共和国の臨床分離株における薬剤感受性成績 首都圏支部・関甲信支部医学検査学会プログラム・講演抄録集. 2018.10; 55回 131. ( 医中誌 )

  4. 岡野 徳壽, 庄子 幹郎, 中山 浩次, 鈴木 敏彦: Porphyromonas gingivalis gingipainsによる炎症抑制機構 Journal of Oral Biosciences Supplement. 2018.09; 2018 163. ( 医中誌 )

  5. Leewananthawet Anongwee, Arakawa Shinichi, Okano Tokuju, Ashida Hiroshi, Izumi Yuichi, Suzuki Toshihiko: in vitroにおけるオゾン微細泡の生物学的影響の評価 日本歯周病学会会誌. 2018.05; 60 135. ( 医中誌 )

  6. 亀崎 良助, 阿部 亜美, 佐伯 歩, 長谷部 晃, 鈴木 敏彦, 北川 善政, 柴田 健一郎: Aggregatibacter actinomycetemcomitansのゲノムDNAはマクロファージに対してnucleotide-binding domain-like receptor containing protein 3インフラマソームを活性化してIL-1βを誘導する 北海道歯学雑誌. 2018.03; 38 (2): 177-184. ( 医中誌 )

  7. 芦田 浩, 鈴木 敏彦: 赤痢菌による新たな細胞死制御機構の解明 日本細菌学雑誌. 2018.02; 73 (1): 28. ( 医中誌 )

  8. 佐伯 歩, 長谷部 晃, 鈴木 敏彦, 柴田 健一郎: NLRP3 inflammasome活性化のためのマイコプラズマリポペプチドFSL-1の細胞質ゾルへの移行 日本細菌学雑誌. 2018.02; 73 (1): 40. ( 医中誌 )

  9. 鈴木 志穂, 鈴木 敏彦, 三室 仁美, 笹川 千尋: IAP familyは細菌感染によるinflammasome活性化に関与する 日本細菌学雑誌. 2018.02; 73 (1): 130. ( 医中誌 )

  1. 芦田 浩, 鈴木 敏彦, 笹川 千尋: いま、細菌学者は何をやっている?-バクテリアの病理と生理と分子生物学- ワクチンおよび抗生物質代替創薬開発の基盤となる腸管病原細菌感染マウスモデルの構築とその機能解析 生命科学系学会合同年次大会. 2017.12; 2017年度 [1PS04-5]. ( 医中誌 )

  2. 芦田 浩, 鈴木 志穂, 鈴木 敏彦: 【多様化する感染症研究】 病原細菌によるインフラマソーム制御戦略 細胞. 2017.12; 49 (14): 695-699. ( 医中誌 )

  3. 芦田　浩,　鈴木　志穂,　鈴木　敏彦: 病原細菌によるインフラマソーム制御戦略 月刊「細胞」. 2017.12; 49 (14): 695-699.

  4. 岡野 徳壽, 鈴木 敏彦: Porphyromonas gingivalisによる低酸素条件でのインフラマソーム活性化 Journal of Oral Biosciences Supplement. 2017.09; 2017 190. ( 医中誌 )

  5. 佐伯 歩, 長谷部 晃, 鈴木 敏彦, 柴田 健一郎: インフラマソーム活性化物質としてのマイコプラズマ由来リポタンパク質 Journal of Oral Biosciences Supplement. 2017.09; 2017 189. ( 医中誌 )

  6. 芦田　浩,　鈴木　敏彦,　笹川　千尋: 赤痢菌による自然免疫抑制戦略の解明 化学療法の領域. 2017.06; 33 1281-1288.

  7. 芦田 浩, 鈴木 敏彦, 笹川 千尋: 私達の研究 赤痢菌による自然免疫抑制戦略の解明 化学療法の領域. 2017.05; 33 (6): 1281-1288. ( 医中誌 )

  8. 鈴木 志穂, 鈴木 敏彦: 赤痢菌感染に伴う感染マクロファージ細胞死の解析 日本細菌学雑誌. 2017.02; 72 (1): 63. ( 医中誌 )

  9. 佐伯 歩, 長谷部 晃, 鈴木 敏彦, 柴田 健一郎: マイコプラズマのIL-1β産生誘導物質の一つはリポペプチド・リポタンパク質である 日本細菌学雑誌. 2017.02; 72 (1): 68. ( 医中誌 )

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