1. Meiko Oki, Mirai Nakayama, Yumi Tsuchida, Shingo Kamijo, Kazuhiro Aoki: Objective evaluation of tooth carving using homologous models Journal of Dental Education. 2024.03; 88 (3): 314-321. ( PubMed , DOI )

  1. Cangyou Xie, Fatma Rashed, Yosuke Sasaki, Masud Khan, Jia Qi, Yuri Kubo, Yoshiro Matsumoto, Shinichi Sawada, Yoshihiro Sasaki, Takashi Ono, Tohru Ikeda, Kazunari Akiyoshi and Kazuhiro Aoki: Comparison of Osteoconductive Ability of Two Types of Cholesterol-Bearing Pullulan (CHP) Nanogel-Hydrogels Impregnated with BMP-2 and RANKL-Binding Peptide: Bone Histomorphometric Study in a Murine Calvarial Defect Model 2023.06; 24 (11): ( DOI )

  2. Takeuchi S, Fukuba S, Okada M, Nohara K, Sato R, Yamaki D, Matsuura T, Hoshi S, Aoki K, Iwata T: Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model. Regenerative Therapy. 2023.03; 22 128-135. ( PubMed , DOI )

  3. Matsuno H, Li B, Okawara H, Toyoshima Y, Xie C, Khan M, Murakami N, Aoki K, Wakabayashi N: Effect of tension and compression on dynamic alveolar histomorphometry. Journal of the mechanical behavior of biomedical materials. 2023.02; 138 105666. ( PubMed , DOI )

  4. Takahashi K, Amano H, Urano T, Li M, Oki M, Aoki K, Amizuka N, Nakayama KI, Nakayama K, Udagawa N, Higashi N: p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms PLOS ONE. 2023.02; 18 (2): e0276838. ( PubMed , DOI )

  1. Xie Cangyou, Satake-Ozawa Michiko, Rashed Fatma, Khan Masud, Ikeda Masaomi, Hayashi Shunya, Sawada Shinichi, Sasaki Yoshihiro, Ikeda Tohru, Mori Yoshiyuki, Akiyoshi Kazunari, Aoki Kazuhiro: Perforated Hydrogels Consisting of Cholesterol-Bearing Pullulan (CHP) Nanogels: A Newly Designed Scaffold for Bone Regeneration Induced by RANKL-Binding Peptides and BMP-2 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022.07; 23 (14): 7768 (1)-7768 (15). ( PubMed , DOI )

  1. Gao Jing, Muroya Ryusuke, Huang Fei, Nagata Kengo, Shin Masashi, Nagano Ryoko, Tajiri Yudai, Fujii Shinsuke, Yamaza Takayoshi, Aoki Kazuhiro, Tamura Yukihiko, Inoue Mayuko, Chishaki Sakura, Kukita Toshio, Okabe Koji, Matsuda Miho, Mori Yoshihide, Kiyoshima Tamotsu, Jimi Eijiro: Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway LABORATORY INVESTIGATION. 2021.09; 101 (11): 1475-1483. ( PubMed , DOI )

  2. Yuna Hirohashi, Shingo Kamijo, Masud Khan, Masaomi Ikeda, Meiko Oki, Khairul Matin, Fatma Rashed, Kazuhiro Aoki: Tetracycline, an appropriate reagent for measuring bone-formation activity in the murine model of the Streptococcus mutans-induced bone loss Frontiers in Cellular and Infection Microbiology Microbiome in Health and Disease. 2021.09; 11 714366. ( PubMed , DOI )

  3. Rashed Fatma, Kamijyo Shingo, Shimizu Yuri, Hirohashi Yuna, Khan Masud, Sugamori Yasutaka, Murali Ramachandran, Aoki Kazuhiro: The Effects of Receptor Activator of NF-kappa B Ligand-Binding Peptides on Bone Resorption and Bone Formation FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021.07; 9 648084. ( PubMed , DOI )

  4. Okawara H, Arai Y, Matsuno H, Marcián P, Borák L, Aoki K, Wakabayashi N: Effect of load-induced local mechanical strain on peri-implant bone cell activity related to bone resorption and formation in mice: An analysis of histology and strain distributions. Journal of the mechanical behavior of biomedical materials. 2021.01; 116 104370. ( PubMed , DOI )

  1. Keo P, Matsumoto Y, Shimizu Y, Nagahiro S, Ikeda M, Aoki K, Ono T: A pilot study to investigate the histomorphometric changes of murine maxillary bone around the site of mini-screw insertion in regenerated bone induced by anabolic reagents. European journal of orthodontics. 2020.03; ( PubMed , DOI )

  2. Takakura N, Matsuda M, Khan M, Hiura F, Aoki K, Hirohashi Y, Mori K, Yasuda H, Hirata M, Kitamura C, Jimi E: A novel inhibitor of NF-κB-inducing kinase prevents bone loss by inhibiting osteoclastic bone resorption in ovariectomized mice. Bone. 2020.03; 135 115316. ( PubMed , DOI )

  3. Shigeki Nagahiro, Tomoki Uehara, Mariko Yamamoto Kawai, Preksa Keo, Hiroki Ochi, Shingo Sato, Shinji Kuroda, Takashi Ono, Michiyo Miyashin, Kazuhiro Aoki: RANKL-binding peptide promotes ectopic bone formation induced by BMP-2 gene transfer in murine gastrocnemius muscle Dental, Oral and Maxillofacial Research. 2020.01; 6 (1): ( DOI )

  1. Amano Hitoshi, Iwaki Futoshi, Oki Meiko, Aoki Kazuhiro, Ohba Shinsuke: An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts REGENERATIVE THERAPY. 2019.12; 11 290-296. ( PubMed , DOI )

  2. Touyama K, Khan M, Aoki K, Matsuda M, Hiura F, Takakura N, Matsubara T, Harada Y, Hirohashi Y, Tamura Y, Gao J, Mori K, Kokabu S, Yasuda H, Fujita Y, Watanabe K, Takahashi Y, Maki K, Jimi E: Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis. Journal of cellular biochemistry. 2019.06; ( PubMed , DOI )

  3. Sone E, Noshiro D, Ikebuchi Y, Nakagawa M, Khan M, Tamura Y, Ikeda M, Oki M, Murali R, Fujimori T, Yoda T, Honma M, Suzuki H, Ando T, Aoki K: The induction of RANKL molecule clustering could stimulate early osteoblast differentiation. Biochemical and biophysical research communications. 2019.02; 509 (2): 435-440. ( PubMed , DOI )

  1. Urata Mariko, Kokabu Shoichiro, Matsubara Takuma, Sugiyama Goro, Nakatomi Chihiro, Takeuchi Hiroshi, Hirata-Tsuchiya Shizu, Aoki Kazuhiro, Tamura Yukihiko, Moriyama Yasuko, Ayukawa Yasunori, Matsuda Miho, Zhang Min, Koyano Kiyoshi, Kitamura Chiaki, Jimi Eijiro: A peptide that blocks the interaction of NF-B p65 subunit with Smad4 enhances BMP2-induced osteogenesis JOURNAL OF CELLULAR PHYSIOLOGY. 2018.09; 233 (9): 7356-7366. ( PubMed , DOI )

  2. Ikebuchi Yuki, Aoki Shigeki, Honma Masashi, Hayashi Madoka, Sugamori Yasutaka, Khan Masud, Kariya Yoshiaki, Kato Genki, Tabata Yasuhiko, Penninger Josef M., Udagawa Nobuyuki, Aoki Kazuhiro, Suzuki Hiroshi: Coupling of bone resorption and formation by RANKL reverse signalling NATURE. 2018.09; 561 (7722): 195-200. ( PubMed , DOI )

  3. Cui Xinnan, Murakami Tatsuya, Tamura Yukihiko, Aoki Kazuhiro, Hoshino Yu, Miura Yoshiko: Bacterial Inhibition and Osteoblast Adhesion on Ti Alloy Surfaces Modified by Poly(PEGMA-r-Phosmer) Coating ACS APPLIED MATERIALS & INTERFACES. 2018.07; 10 (28): 23674-23681. ( PubMed , DOI )

  4. Mikami R, Mizutani K, Aoki A, Tamura Y, Aoki K, Izumi Y: Low-level ultrahigh-frequency and ultrashort-pulse blue laser irradiation enhances osteoblast extracellular calcification by upregulating proliferation and differentiation via transient receptor potential vanilloid 1. Lasers Surg Med. 2018.04; 50 (4): 340-352. ( PubMed , DOI )

  5. Hideaki Inagawa, Natsuki Suzuki, Kazuhiro Aoki, Noriyuki Wakabayashi: Potential for estimation of Young's modulus based on computed tomography numbers in bone: A validation study using a nano-indentation test on murine maxilla Dental, Oral and Craniofacial Research. 2018.01; 4 (4): 1-7. ( DOI )

  6. Yasuhiro Shimizu, Masud Khan, Genki Kato, Kazuhiro Aoki & Takashi Ono: Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice. Scientific Reports. 2018.01; 8 (173): 1-9. ( DOI )

  7. Lin Ding, Peng Zhang, Xin Wang, Jia Hao, Kazuhiro Aoki, Shinji Kuroda, Shohei Kasugai: Effect of doxycycline-treated hydroxyapatite surface on bone apposition: A histomophometric study in murine maxillae. Dent Mater J. 2018.01; 37 (1): 130-138. ( PubMed , DOI )

  1. Toru Takemoto, Yuji Kabasawa, Yusuke Higuchi, Yasuhiko Tabata, Kazuhiro Aoki, Yukihiko Tamura, Hiroyuki Harada: Combination of the RANKL-binding peptide W9 and bFGF induces bone regeneration in the rat calvarial defect model. Dent Oral Craniofac Res. 2017.12; 4 (3): 1-7. ( DOI )

  2. Aierken MULATI, Songtao WU, Kazuhiro AOKI, Shohei KASUGAI: Effects of Osteotomy with Drilling on Osteocytes Journal of Oral Tissue Engineering. 2017.12; 15 (2): 95-101. ( DOI )

  3. Boosana KABOOSAYA, Lia Kartika WULANSARI, Trang Nguyen V.N., Kazuhiro AOKI, Shohei KASUGAI: Ligation Period Required to Induce Periodontitis in Mice: Analysis with Micro-computed Tomography Journal of Oral Tissue Engineering. 2017.10; 15 (1): 25-34. ( DOI )

  4. Md Zahirul Haque Bhuyan, Yukihiko Tamura, Eri Sone, Yuki Yoshinari, Chizuko Maeda, Mariko Takahashi, Yasuhiko Tabata, Ramachandran Murali, Yoshihiro Waki, Kazuhiro Aoki: The intra-articular injection of RANKL-binding peptides inhibits cartilage degeneration in a murine model of osteoarthritis. J. Pharmacol. Sci.. 2017.06; 134 (2): 124-130. ( PubMed , DOI )

  1. Yasutaka Sugamori, Setsuko Mise-Omata, Chizuko Maeda, Shigeki Aoki, Yasuhiko Tabata, Ramachandran Murali, Hisataka Yasuda, Nobuyuki Udagawa, Hiroshi Suzuki, Masashi Honma, Kazuhiro Aoki: Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling. Bioessays. 2016.08; 38 (8): 717-725. ( PubMed , DOI )

  2. Yuki Arai, Kazuhiro Aoki, Yasuhiro Shimizu, Yasuhiko Tabata, Takashi Ono, Ramachandran Murali, Setsuko Mise-Omata, Noriyuki Wakabayashi: Peptide-induced de novo bone formation after tooth extraction prevents alveolar bone loss in a murine tooth extraction model. Eur. J. Pharmacol.. 2016.07; 782 89-97. ( PubMed , DOI )

  3. T Uehara, S Mise-Omata, M Matsui, Y Tabata, R Murali, M Miyashin, K Aoki: Delivery of RANKL-Binding Peptide OP3-4 Promotes BMP-2-Induced Maxillary Bone Regeneration. J. Dent. Res.. 2016.03; ( PubMed , DOI )

  4. Moe Htet, Marwa Madi, Ossama Zakaria, Takayuki Miyahara, Wang Xin, Zayar Lin, Kazuhiro Aoki, Shohei Kasugai: Decontamination of Anodized Implant Surface with Different Modalities for Peri-Implantitis Treatment: Lasers and Mechanical Debridement with Citric Acid. J. Periodontol.. 2016.03; 1-17. ( PubMed , DOI )

  5. Trang N Nguyen Vo, Jia Hao, Josh Chou, Masamitsu Oshima, Kazuhiro Aoki, Shinji Kuroda, Boosana Kaboosaya, Shohei Kasugai: Ligature induced peri-implantitis: tissue destruction and inflammatory progression in a murine model. Clin Oral Implants Res. 2016.01; ( PubMed , DOI )

  1. Natsuki Suzuki, Kazuhiro Aoki, Petr Marcián, Libor Borák, Noriyuki Wakabayashi: A threshold of mechanical strain intensity for the direct activation of osteoblast function exists in a murine maxilla loading model. Biomech Model Mechanobiol. 2015.11; 15 (5): 1091-1100. ( PubMed , DOI )

  2. Genki Kato, Yasuhiro Shimizu, Yuki Arai, Natsuki Suzuki, Yasutaka Sugamori, Miki Maeda, Mariko Takahashi, Yukihiko Tamura, Noriyuki Wakabayashi, Ramachandran Murali, Takashi Ono, Keiichi Ohya, Setsuko Mise-Omata, Kazuhiro Aoki: The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study. Arthritis Res. Ther. 2015; 17 (1): 251. ( PubMed , DOI )

  3. Masahiro Chatani, Akiko Mantoku, Kazuhiro Takeyama, Dawud Abduweli, Yasutaka Sugamori, Kazuhiro Aoki, Keiichi Ohya, Hiromi Suzuki, Satoko Uchida, Toru Sakimura, Yasushi Kono, Fumiaki Tanigaki, Masaki Shirakawa, Yoshiro Takano, Akira Kudo: Microgravity promotes osteoclast activity in medaka fish reared at the international space station. Sci Rep. 2015; 5 14172. ( PubMed , DOI )

  4. Toshimi Sato, Neil Alles, Masud Khan, Kenichi Nagano, Mariko Takahashi, Yukihiko Tamura, Asako Shimoda, Keiichi Ohya, Kazunari Akiyoshi, Kazuhiro Aoki: Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model. Int J Nanomedicine. 2015; 10 3459-3473. ( PubMed , DOI )

  1. Mise-Omata S. Alles N. Fukazawa T. Aoki K. Ohya K. Jimi E. Obata Y. Doi T: NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. Int. Immunol. 2014.11; 26 (11): 607-618. ( PubMed , DOI )

  2. Mohannad Nassar, Noriko Hiraishi, Yukihiko Tamura, Masayuki Otsuki, Kazuhiro Aoki, Junji Tagami: Phytic Acid: An Alternative Root Canal Chelating Agent. J Endod. 2014.11; ( PubMed , DOI )

  3. Kimura A. Kabasawa Y. Tabata Y. Aoki K. Ohya K. Omura K: Gelatin hydrogel as a carrier of recombinant human fibroblast growth factor-2 during rat mandibular distraction. J. Oral Maxillofac. Surg. 2014.10; 72 (10): 2015-2031. ( PubMed , DOI )

  4. Aoki K. Maeda M. Nakae T. Okada Y. Ohya K. Chiba K: A disulfide bond replacement strategy enables the efficient design of artificial therapeutic peptides. Tetrahedron. 2014.10; 70 7774-7779. ( DOI )

  5. Tada Y. Kokabu S. Sugiyama G. Nakatomi C. Aoki K. Fukushima H. Osawa K. Sugamori Y. Ohya K. Okamoto M. Fujikawa T. Itai A. Matsuo K. Watanabe S. Jimi E: The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014.10; ( PubMed )

  6. Hirata-Tsuchiya S. Fukushima H. Katagiri T. Ohte S. Shin M. Nagano K. Aoki K. Morotomi T. Sugiyama G. Nakatomi C. Kokabu S. Doi T. Takeuchi H. Ohya K. Terashita M. Hirata M. Kitamura C. Jimi E: Inhibition of BMP2-induced bone formation by the p65 subunit of NF-κB via an interaction with Smad4. Mol. Endocrinol. 2014.09; 28 (9): 1460-1470. ( PubMed , DOI )

  7. Negishi N. Suzuki D. Ito R. Irie N. Matsuo K. Yahata T. Nagano K. Aoki K. Ohya K. Hozumi K. Ando K. Tamaoki N. Ito M. Habu S: Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged1. Exp. Hematol. 2014.06; 42 (6): 487-94.e1. ( PubMed , DOI )

  8. Kaori Shoi, Kazuhiro Aoki, Keiichi Ohya, Yuzo Takagi, Hitoyata Shimokawa: Characterization of pulp and follicle stem cells from impacted supernumerary maxillary incisors. Pediatr Dent. 2014.05; 36 (3): 79-84. ( PubMed )

  1. Wannakorn Sriarj, Kazuhiro Aoki, Keiichi Ohya, Mariko Takahashi, Yuzo Takagi, Hitoyata Shimokawa: TGF-β in dentin matrix extract induces osteoclastogenesis in vitro. Odontology. 2013.12; ( PubMed , DOI )

  2. Yoshie Nagai, Kenji Osawa, Hidefumi Fukushima, Yukihiko Tamura, Kazuhiro Aoki, Keiichi Ohya, Hisataka Yasuda, Hisako Hikiji, Mariko Takahashi, Yuji Seta, Sachiko Seo, Mineo Kurokawa, Shigeaki Kato, Hiroaki Honda, Ichiro Nakamura, Kenshi Maki, Eijiro Jimi: p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption. J. Bone Miner. Res.. 2013.12; 28 (12): 2449-2462. ( PubMed , DOI )

  3. Hitomi Nakamura, Kazuhiro Aoki, Wataru Masuda, Neil Alles, Kenichi Nagano, Hidefumi Fukushima, Kenji Osawa, Hisataka Yasuda, Ichiro Nakamura, Yuko Mikuni-Takagaki, Keiichi Ohya, Kenshi Maki, Eijiro Jimi: Disruption of NF-κB1 prevents bone loss caused by mechanical unloading. J. Bone Miner. Res.. 2013.06; 28 (6): 1457-1467. ( PubMed , DOI )

  4. Khan, M. Alles, N. Soysa, N. Mamun, A. Nagano, K. Mikami, R. Furuya, Y. Yasuda, H. Ohya, K. Aoki, K: The local administration of TNF-a and RANKL antagonist peptide promotes BMP-2-induced bone formation. J Oral Biosciences . 2013; 55 47-54. ( DOI )

  5. Fujiki K. Aoki K. Marcian P. Borak L. Hudieb M. Ohya K. Igarashi Y. Wakabayashi N.: The influence of mechanical stimulation on osteoclast localization in the mouse maxilla: bone histomorphometry and finite element analysis. Biomechanics and Modeling in Mechanobiology . 2013; 12 (2): 325-333. ( DOI )

  6. Furuya,Y. Inagaki, A. Khan, M. Mori, K. Penninger, J.M. Nakamura, M. Udagawa, N. Aoki, K. Ohya, K. Uchida, K. Yasuda, H: Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity. J Biol Chem . 2013; 288 (8): 5562-5571. ( DOI )

  7. Mamun, A. Khan, M. Alles, N. Matsui, M. Tabata, Y. Ohya, K. Aoki, K: Gelatin hydrogel carrier with the W9-peptide elicits synergistic effects on BMP-2-induced bone regeneration. J Oral Biosciences . 2013; 55 217-223. ( DOI )

  1. Hiroyuki Furuta, Kenji Osawa, Masashi Shin, Ayataka Ishikawa, Kou Matsuo, Masud Khan, Kazuhiro Aoki, Keiichi Ohya, Masato Okamoto, Kazuhiro Tominaga, Tetsu Takahashi, Osamu Nakanishi, Eijiro Jimi: Selective inhibition of NF-κB suppresses bone invasion by oral squamous cell carcinoma in vivo. Int. J. Cancer. 2012.09; 131 (5): E625-E635. ( PubMed , DOI )

  2. Aoki Kazuhiro, Alles Neil, Soysa Niroshani, Ohya Keiichi: Peptide-based delivery to bone. Adv Drug Deliv Rev. 2012.09; 64 (12): 1220-1238. ( PubMed , DOI )

  3. Hiroyuki Nakachi, Kazuhiro Aoki, Nobuyoshi Tomomatsu, Neil Alles, Kenichi Nagano, Masashi Yamashiro, Hongtao Zhang, Ramachandran Murali, Mark I Greene, Keiichi Ohya, Teruo Amagasa: A structural modulator of tumor necrosis factor type 1 receptor promotes bone formation under lipopolysaccharide-induced inflammation in a murine tooth extraction model. Eur. J. Pharmacol.. 2012.03; 679 (1-3): 132-138. ( PubMed , DOI )

  4. Yoshinori Seo, Hidefumi Fukushima, Toshimasa Maruyama, Kayoko Nakao Kuroishi, Kenji Osawa, Kenichi Nagano, Kazuhiro Aoki, Falk Weih, Takahiro Doi, Min Zhang, Keiichi Ohya, Takenobu Katagiri, Ryuji Hosokawa, Eijiro Jimi: Accumulation of p100, a precursor of NF-κB2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice. Mol. Endocrinol.. 2012.03; 26 (3): 414-422. ( PubMed , DOI )

  5. 林 直毅, 田村 幸彦, 楠本 康香, 下川 仁彌太, 青木 和広, 大谷 啓一, 山崎 統資, 篠塚 修: フェニトインによる歯肉増殖について　ヒト歯肉組織およびクローン歯肉細胞に関する研究. 障害者歯科. 2012.02; 33 (1): 16-26. ( 医中誌 )

  6. Soysa Niroshani Surangika, Alles Neil, Aoki Kazuhiro, Ohya Keiichi: Osteoclast formation and differentiation: an overview. J Med Dent Sci. 2012; 59 (3): 65-74. ( PubMed )

  1. Kenichi Nagano, Neil Alles, Anower Hussain Mian, Asako Shimoda, Nobuyuki Morimoto, Yukihiko Tamura, Hitoyata Shimokawa, Kazunari Akiyoshi, Keiichi Ohya, Kazuhiro Aoki: The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae. J. Bone Miner. Metab.. 2011.11; 29 (6): 671-681. ( PubMed , DOI )

  2. Soysa N S, Alles N, Takahashi M, Aoki K, Ohya K: Defective nuclear factor-kappaB-inducing kinase in aly/aly mice prevents bone resorption induced by local injection of lipopolysaccharide. J Periodontal Res. 2011.04; 46 (2): 280-284. ( PubMed , DOI )

  1. Alles Neil, Soysa Niroshani S, Hayashi Juri, Khan Masud, Shimoda Asako, Shimokawa Hitoyata, Ritzeler Olaf, Akiyoshi Kazunari, Aoki Kazuhiro, Ohya Keiichi: Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice. Endocrinology. 2010.10; 151 (10): 4626-4634. ( PubMed , DOI )

  2. Takato Inokuchi, Tatsuo Kawamoto, Kazuhiro Aoki, Asato Aoki, Kouhei Nagahama, Yoshiyuki Baba, Syouichi Suzuki, Masaharu Shibayama, Yoshihiro Mano, Keiichi Ohya, Keiji Moriyama: The effects of hyperbaric oxygen on tooth movement into the regenerated area after distraction osteogenesis. Cleft Palate Craniofac. J.. 2010.07; 47 (4): 382-392. ( PubMed , DOI )

  3. Asato Aoki, Tatsuo Kawamoto, Kazuhiro Aoki, Takato Inokuchi, Atsuo Kudoh, Kouhei Nagahama, Yoshiyuki Baba, Syouichi Suzuki, Keiichi Ohya, Keiji Moriyama: Amount of bone lengthening affects blood flow recovery and bone mineralization after distraction osteogenesis in a canine cleft palate model. Cleft Palate Craniofac. J.. 2010.05; 47 (3): 303-313. ( PubMed , DOI )

  4. Okamoto K, Iwai Y, Oh-Hora M, Yamamoto M, Morio T, Aoki K, Ohya K, Jetten AM, Akira S, Muta T, Takayanagi H: IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature. 2010.04; 464 (7293): 1381-1385. ( PubMed , DOI )

  5. Soysa Niroshani S, Alles Neil, Weih Debra, Lovas Agnes, Mian Anower Hussain, Shimokawa Hitoyata, Yasuda Hisataka, Weih Falk, Jimi Eijiro, Ohya Keiichi, Aoki Kazuhiro: The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclastogenesis. J Bone Miner Res. 2010.04; 25 (4): 809-818. ( PubMed , DOI )

  6. Higuchi Y, Kabasawa Y, Sato M, Kikuchi T, Aoki K, Ohya K, Maruoka Y, Omura K: Effect of recombinant human fibroblast growth factor-2 on bone formation in rabbit mandibular distraction models using beta-tricalcium phosphate. Congenit Anom (Kyoto). 2010.02; ( PubMed , DOI )

  7. Nakalekha C, Yokoyama C, Miura H, Alles N, Aoki K, Ohya K, Morita I: Increased bone mass in adult prostacyclin-deficient mice. J Endocrinol. 2010.02; 204 (2): 125-133. ( PubMed , DOI )

  1. Tomomatsu Nobuyoshi, Aoki Kazuhiro, Alles Neil, Soysa Niroshani S, Hussain Anower, Nakachi Hiroyuki, Kita Souma, Shimokawa Hitoyata, Ohya Keiichi, Amagasa Teruo: LPS-induced inhibition of osteogenesis is TNF-alpha dependent in a murine tooth extraction model. J Bone Miner Res. 2009.10; 24 (10): 1770-1781. ( PubMed , DOI )

  2. Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, Doi T, Aoki K, Alles N, Ohya K, Hosokawa R, Jimi E: Processing of the NF-kappaB2 Precursor, p100, to p52 is Critical for RANKL-Induced Osteoclast Differentiation. J Bone Miner Res. 2009.10; ( PubMed , DOI )

  3. Soysa Niroshani Surangika, Alles Neil, Aoki Kazuhiro, Ohya Keiichi: Three-dimensional characterization of osteoclast bone-resorbing activity in the resorption lacunae. J Med Dent Sci. 2009.09; 56 (3): 107-112. ( PubMed )

  4. Aoki K: Applications and the Future of Peptide Drugs for Inflammatory Bone Resorption. J Oral Biosci. 2009.06; 51 119-133.

  5. Alles Neil, Soysa Niroshani S, Hussain M D Anower, Tomomatsu Nobuyoshi, Saito Hiroaki, Baron Roland, Morimoto Nobuyuki, Aoki Kazuhiro, Akiyoshi Kazunari, Ohya Keiichi: Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss. Eur J Pharm Sci. 2009.05; 37 (2): 83-88. ( PubMed , DOI )

  6. Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M: Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2009.04; 296 (4): G850-9. ( PubMed , DOI )

  7. Sriarj W, Aoki K, Ohya K, Takagi Y, Shimokawa H: Bovine dentine organic matrix down-regulates osteoclast activity. J Bone Miner Metab. 2009; 27 (3): 315-323. ( PubMed , DOI )

  8. Soysa Niroshani S, Alles Neil, Shimokawa Hitoyata, Jimi Eijiro, Aoki Kazuhiro, Ohya Keiichi: Inhibition of the classical NF-kappaB pathway prevents osteoclast bone-resorbing activity. J Bone Miner Metab. 2009; 27 (2): 131-139. ( PubMed , DOI )

  1. Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H: Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science. 2008.02; 319 (5863): 624-627. ( PubMed , DOI )

  2. Hussain Mian A, Saito H, Alles N, Shimokawa H, Aoki K, Ohya K: Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo. (Corresponding author). J Bone Miner Metab. 2008; 26 (5): 469-477. ( PubMed , DOI )

  1. Gil-Henn H, Destaing O, Sims NA, Aoki K, Alles N, Neff L, Sanjay A, Bruzzaniti A, De Camilli P, Baron R, Schlessinger J: Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol. 2007.09; 178 (6): 1053-1064. ( PubMed , DOI )

  2. Saito H, Kojima T, Takahashi M, Horne WC, Baron R, Amagasa T, Ohya K, Aoki K: A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis. (Corresponding author). Arthritis Rheum. 2007.04; 56 (4): 1164-1174. ( PubMed , DOI )

  3. Kubota T, Hoshino M, Aoki K, Ohya K, Komano Y, Nanki T, Miyasaka N, Umezawa K: NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor. Arthritis Res Ther. 2007; 9 (5): R97. ( PubMed , DOI )

  1. Kojiro Sato, Ayako Suematsu, Tomoki Nakashima, Sayaka Takemoto-Kimura, Kazuhiro Aoki, Yasuyuki Morishita, Hiroshi Asahara, Keiichi Ohya, Akira Yamaguchi, Toshiyuki Takai, Tatsuhiko Kodama, Talal A Chatila, Haruhiko Bito, Hiroshi Takayanagi: Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat. Med.. 2006.12; 12 (12): 1410-1416. ( PubMed , DOI )

  2. Kamijo S, Nakajima A, Ikeda K, Aoki K, Ohya K, Akiba H, Yagita H, Okumura K: Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun. 2006.08; 347 (1): 124-132. ( PubMed , DOI )

  3. Aoki K, Saito H, Itzstein C, Ishiguro M, Shibata T, Blanque R, Mian AH, Takahashi M, Suzuki Y, Yoshimatsu M, Yamaguchi A, Deprez P, Mollat P, Murali R, Ohya K, Horne WC, Baron R: A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest. 2006.06; 116 (6): 1525-1534. ( PubMed , DOI )

  4. Suzuki Y, Aoki K, Saito H, Umeda M, Nitta H, Baron R, Ohya K: A tumor necrosis factor-alpha antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice. (Corresponding author). J Periodontal Res. 2006.04; 41 (2): 81-91. ( PubMed , DOI )

  5. Nonaka K, Fukuda S, Aoki K, Yoshida T, Ohya K: Regional distinctions in cortical bone mineral density measured by pQCT can predict alterations in material property at the tibial diaphysis of the Cynomolgus monkey. Bone. 2006.02; 38 (2): 265-272. ( PubMed , DOI )

  6. Varghese BJ, Aoki K, Shimokawa H, Ohya K, Takagi Y: Bovine deciduous dentine is more susceptible to osteoclastic resorption than permanent dentine: results of quantitative analyses. J Bone Miner Metab. 2006; 24 (3): 248-254. ( PubMed , DOI )

  7. Saito H, Soysa N, Alles N, Aoki K, Ohya K: Three-Dimensional Measurements of Bone Resorption Lacunae Reveal Inhibition of Osteoclast Activity by TNF-α Antagonist In Vitro. Dentistry in Japan. 2006; 42 35-37.

  1. Aoki K, Ohya K: [RANKL/RANK signaling-inhibitor] Nippon Rinsho. 2005.09; 63 (9): 1620-1626. ( PubMed )

  2. Takatsuna H, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C, Saito H, Aoki K, Ohya K, Takayanagi H, Umezawa K: Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1. J Bone Miner Res. 2005.04; 20 (4): 653-662. ( PubMed , DOI )

  3. Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese BJ, Yoshimasu H, Baron R, Ohya K, Amagasa T: Subcutaneous injections of a TNF-alpha antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis. J Med Dent Sci. 2005.03; 52 (1): 91-99. ( PubMed )

  4. Tint K, Kondo H, Kuroda S, Fujimori T, Aoki K, Ohya K, Kasugai S: Effectiveness of Extracted-teeth as Bone Substitute: Application to Parietal Bone Defects in Rabbits. J Oral Tissue Engin. 2005; 3 (1): 7-16.

  1. Nagahama K, Aoki K, Nonaka K, Saito H, Takahashi M, Varghese BJ, Shimokawa H, Azuma M, Ohya K, Ohyama K: The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis. Bone. 2004.11; 35 (5): 1059-1068. ( PubMed , DOI )

  2. Damrongrungruang T, Kuroda S, Kondo H, Aoki K, Ohya K, Kasugai S: A simple murine model for immobilization osteopenia. Clin Orthop Relat Res. 2004.08; (425): 244-251. ( PubMed )

  3. Jimi E, Aoki K, Saito H, D'Acquisto F, May MJ, Nakamura I, Sudo T, Kojima T, Okamoto F, Fukushima H, Okabe K, Ohya K, Ghosh S: Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med. 2004.06; 10 (6): 617-624. ( PubMed , DOI )

  4. Asawa Y, Aoki K, Ohya K, Ohshima H, Takano Y: Appearance of electron-dense segments: indication of possible conformation changes of pre-mineralizing collagen fibrils in the osteoid rat bones. J Electron Microsc. 2004; 53 423-433.

  1. Aoki K, Ohya K: [The mechanism of osteoprosis revealed by the animal studies: the involvement of alveolar bone resorption induced by the periodontal disease] Clin Calcium. 2003.05; 13 (5): 587-593. ( PubMed )

  2. Kitasako Y, Nakajima M, Foxton RM, Aoki K, Pereira PN, Tagami J: Physiological remineralization of artificially demineralized dentin beneath glass ionomer cements with and without bacterial contamination in vivo. Oper Dent. 2003.05; 28 (3): 274-280. ( PubMed )

  3. Horie D, Takahashi M, Aoki K, Ohya K: Clodronate stimulates bone formation as well as inhibits bone resorption and increases bone mineral density in rats fed a low-calcium diet. J Med Dent Sci. 2003.03; 50 (1): 121-132. ( PubMed )

  4. Kuroda S, Mukohyama H, Kondo H, Aoki K, Ohya K, Ohyama T, Kasugai S: Bone mineral density of the mandible in ovariectomized rats: analyses using dual energy X-ray absorptiometry and peripheral quantitative computed tomography. Oral Dis. 2003.01; 9 (1): 24-28. ( PubMed )

  1. Takahashi E, Mukohyama H, Aoki K, Duarte WR, Lerner UH, Ohya K, Omura K, Kasugai S: High extracellular calcium affects osteoclastogenesis in mouse bone marrow cell culture. J Med Dent Sci. 2002.12; 49 (4): 109-120. ( PubMed )

  2. Aoki K, Ohya K: [The drug treatment for bone resorption in the oral area] Clin Calcium. 2002.07; 12 (7): 997-1003. ( PubMed )

  3. Yamazoe T, Aoki K, Simokawa H, Ohya K, Takagi Y: Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. J Med Dent Sci. 2002.03; 49 (1): 57-66. ( PubMed )

  4. Juji T, Hertz M, Aoki K, Horie D, Ohya K, Gautam A, Mouritsen S, Oda H, Nakamura K, Tanaka S: A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders. J Bone Miner Metab. 2002; 20 (5): 266-268. ( PubMed , DOI )

  1. Nakamura H, Morita S, Kumei Y, Aoki K, Shimokawa H, Ohya K, Shinomiya KI: Effects of neurectomy and tenotomy on the bone mineral density and strength of tibiae. Acta Astronaut. 2001.08; 49 (3-10): 179-190. ( PubMed )

  1. Noji H, Yoshimasu H, Aoki K, Ohya K, Amagasa T: Non-invasive densitometric and histomorphometric study of the regenerated bone in the distraction gap in rabbits. J Med Dent Sci. 2000.09; 47 (3): 197-207. ( PubMed )

  2. Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R: Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med. 2000.09; 6 (9): 985-990. ( PubMed , DOI )

  3. Iwasa Y, Shimoyama K, Aoki K, Ohya K, Uematsu H: The effect of high salt intake on the mandibular bone loss in Dahl-Iwai salt-sensitive rat. J Med Dent Sci. 2000.09; 47 (3): 187-195. ( PubMed )

  1. Seto H, Aoki K, Kasugai S, Ohya K: Trabecular bone turnover, bone marrow cell development, and gene expression of bone matrix proteins after low calcium feeding in rats. Bone. 1999.12; 25 (6): 687-695. ( PubMed )

  2. Aoki K, Didomenico E, Sims NA, Mukhopadhyay K, Neff L, Houghton A, Amling M, Levy JB, Horne WC, Baron R: The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice. Bone. 1999.09; 25 (3): 261-267. ( PubMed )

  1. Suzuki K, Aoki K, Ohya K: Effects of surface roughness of titanium implants on bone remodeling activity of femur in rabbits. Bone. 1997.12; 21 (6): 507-514. ( PubMed )

  2. Ogawara M, Aoki K, Okiji T, Suda H: Effect of ascorbic acid deficiency on primary and reparative dentinogenesis in non-ascorbate-synthesizing ODS rats. Arch Oral Biol. 1997.10; 42 (10-11): 695-704. ( PubMed )

  1. Kaneko H, Koyama T, Asou T, Aoki K, Ohya K: The effect of HACHIMI-JIO-GAN, a kanpo metabolism of rats treated by GnRH agonist. (in Japanese). J Jpn Menopanse Soc. 1995; 3 225-232.

  1. Ohya K, Yausi M, Oda T, Aoki K, Ogura H: Morphological observations of the hard tissues with the confocal laser scanning microscope.(in Japanese). J Oral Biosci. 1992; 34 339-349.

  2. Aoki K: Differential Response in the Cortical and the Cancellous regions of Tibia to a low Calcium feeding in rats : A Histomorphometric Study.(First Author). J Oral Biosci. 1992; 34 (5): 595-611.

  1. 青木和広: 「骨形態計測学の現状と未来を考える」　歯科基礎医学からみた骨形態計測の役割　リモデリング活性計測から骨動態計測まで 日本骨形態計測学会雑誌. 2022.11; 32 (2): 58-59.

  1. 青木和広: 骨疾患治療薬としてのペプチド薬―骨吸収抑制ペプチドの骨形成促進作用― 薬事日報. 2014.10;

  1. 大谷 啓一, 青木 和広: 骨粗鬆症治療薬の最近の動向について. 日本歯科評論. 2011.12; 71 (12): 109-112. ( 医中誌 )

  1. 青木 和広, 大谷 啓一: 文献と臨床の橋わたし　腫瘍壊死因子中和療法の新しい展開　WP9QYペプチドによる治療の可能性 日本歯科評論. 2007.07; 67 (7): 170-172. ( 医中誌 )

  1. 青木 和広, 大谷 啓一: 【関節リウマチの最新動向　骨免疫学的視点からの病因論・治療学】　関節リウマチ治療学の最新動向　シグナル伝達系を標的とした薬剤の開発研究　RANKL/RANKシグナル伝達阻害剤 日本臨床. 2005.09; 63 (9): 1620-1626. ( 医中誌 )

  1. 青木 和広, 大谷 啓一, 長濱 浩平: 分子レベルからみた整形外科疾患　免疫系細胞の骨代謝への関与 整形・災害外科. 2004.05; 47 (6): 722-723. ( 医中誌 )

  2. 大谷 啓一, 栢森 高, 脇 能広, 青木 和広: 乳癌(Walker 256/s)細胞により生じるラット骨吸収モデルにおよぼすクロドロネートの効果 応用薬理. 2004.04; 66 (1～2): 115-116. ( 医中誌 )

  1. 青木 和広, 大谷 啓一: 【顎骨の骨粗鬆症と歯周病】　動物実験から明らかになった骨粗鬆症のメカニズム　歯周病により引き起こされる顎骨吸収との関連について Clinical Calcium. 2003.04; 13 (5): 587-593. ( 医中誌 )

  1. 青木 和広, 大谷 啓一: 【顎骨と骨粗鬆症】　口腔領域における骨吸収への薬物治療 Clinical Calcium. 2002.06; 12 (7): 997-1003. ( 医中誌 )

  1. 青木 和広: 【骨形成・骨吸収の最近のトピックス】　骨吸収のトピックス　TNF-αペプチドアンタゴニストによる破骨細胞形成抑制作用 THE BONE. 2001.07; 15 (4): 357-362. ( 医中誌 )

  1. 青木 和広, 大谷 啓一: 最近の歯学　硬組織薬理　新規骨吸収抑制薬の開発,構造生物学からのアプローチ 口腔病学会雑誌. 2000.09; 67 (3): 275. ( 医中誌 )

  1. 大谷啓一、青木和広: 骨粗鬆症と薬物による骨吸収制御メカニズム　. 歯科医療 (第1歯科出版). 1997; 11 29-42.

  1. 小山 嵩夫, 麻生 武志, 青木 和広: GnRH agonistによるラットの骨量減少に対する八味地黄丸の抑制効果 産婦人科漢方研究のあゆみ. 1995.04; (12): 29-36. ( 医中誌 )

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