Graduating School 【 display / non-display 】
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Kyoto University, Faculty of Agriculture, Graduated
Graduate School 【 display / non-display 】
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Kyoto University, Graduate School, Division of Agriculture, Doctor's Course, Completed
Campus Career 【 display / non-display 】
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2025.10-NowInstitute of Science Tokyo, -, Institute of Integrated Research, Advanced Pathophysiological Science, Cellular Dynamics, Associate Professor
External Career 【 display / non-display 】
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SIU School of Medicine, Project Researcher
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, Senior Staff
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Massachusetts Institute of Technology, Project Researcher
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2021.07-2025.09Harvard Medical School, Dana-Farber Cancer Institute, Medical Oncology, Junior Associate Professor
Academic Society Affiliations 【 display / non-display 】
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American Association for Cancer Research
Research Theme 【 display / non-display 】
Published Papers & Misc 【 display / non-display 】
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Saleh Mohamed Fathi, Nita Akihiro, Ohta Yudai, Kobayashi Aya, Li Hao, Sakamoto Yasuhisa, Moroishi Toshiro. Hippo Pathway Drives Durable Non-Cell-Autonomous Ferroptosis Resistance in Lung Cancer(タイトル和訳中) Cancer Science. 2026.03; 117 (3): 683-694. ( ichushi )
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Saleh MF, Nita A, Ohta Y, Kobayashi A, Li H, Sakamoto Y, Moroishi T. Hippo Pathway Drives Durable Non-Cell-Autonomous Ferroptosis Resistance in Lung Cancer. Cancer science. 2025.12; 117 (3): 683-694. ( PubMed, DOI )
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Light-Controllable Binary Switch Activation of CAR T Cells 2022.06; 17 (12): ( DOI )
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Systematic discovery of immune regulatory mechanisms in tumor cells 2019.02; 7 (2): ( DOI )
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A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing 2018.02; 359 (6377): 770-+. ( DOI )
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ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production 2016.05; 11 (5): ( DOI )
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SPARC in tumor microenvironment induces dormancy of prostate cancer in bone 2015.08; 75 ( DOI )
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ABCA1, ABCG1, and ABCG4 Are Distributed to Distinct Membrane Meso-Domains and Disturb Detergent-Resistant Domains on the Plasma Membrane 2014.10; 9 (10): ( DOI )
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HAS2 promotes tumor progression by stimulating interaction of cancer stem-like cells with tumor associated macrophage and stromal cells through a paracrine loop of growth factors in the bone 2013.04; 73 (8): ( DOI )
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Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain 2013.03; 5 (3): 384-396. ( DOI )
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Interleukin-1β promotes brain metastasis of breast cancer by activating Notch signaling through reactive astrocytes 2013.02; 73 ( DOI )
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miR-7 suppresses brain metastasis of cancer stem-like cells by modulating Kruppel-like factor 4 in breast cancer 2013.02; 73 ( DOI )
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Hyaluronan synthase 2 promotes breast cancer bone metastasis by stimulating interaction of cancer stem-like cells with tumor-associated macrophage 2012.04; 72 ( DOI )
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Roles of lipogenesis in cancer stem-like cells at early stage of breast cancer 2012.04; 72 ( DOI )
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Reactive astrocytes promote the growth of cancer stem-like cells of metastatic breast tumor by activating Notch signaling in brain 2012.04; 72 ( DOI )
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N-myc downstream regulated gene 1, NDRG1, modulates Wnt-β-catenin signaling and pleiotropically suppresses metastasis 2012.04; 72 ( DOI )
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Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone (vol 19, pg 2641, 2011) 2012.03; 209 (3): 639. ( DOI )
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N-myc downstream regulated gene 1 modulates Wnt-ß-catenin signalling and pleiotropically suppresses metastasis 2012.02; 4 (2): 93-108. ( DOI )
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Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem-Like Cells with Macrophages and Stromal Cells 2012.01; 72 (2): 537-547. ( DOI )
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Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone 2011.12; 208 (13): 2641-2655. ( DOI )
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Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase 2011.11; 130 (2): 387-398. ( DOI )
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Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway 2011.07; 128 (1): 57-68. ( DOI )
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<i>KAI1</i> Gene Is Engaged in <i>NDRG1</i> Gene-mediated Metastasis Suppression through the ATF3-NFκB Complex in Human Prostate Cancer 2011.05; 286 (21): 18949-18959. ( DOI )
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Hyaluronan synthase 2 promotes tumor progression by stimulating interaction of cancer stem -like cells with tumor associated macrophage and stromal cells in the bone 2011.04; 71 ( DOI )
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Upregulation of lipogenic genes, SREBP-1, ACLY, ACC-1 and FAS, confer proliferation and survival advantages to cancer stem-like cells in ductal carcinoma in situ 2011.04; 71 ( DOI )
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Hypoxia induces Notch signaling and promotes breast cancer metastasis by stimulating growth and self renewal of cancer stem-like cells 2011.04; 71 ( DOI )
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NDRG1 pleiotropically suppresses tumor metastasis through modulation of Wnt-βcatenin pathway 2011.02; 28 (2): 188-189.
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Metabolic genes in cancer: Their roles in tumor progression and clinical implications 2010.04; 1805 (2): 141-152. ( DOI )
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Inhibition of fatty acid synthase and induction of apoptosis in human breast cancer cells by <i>Cacalia deliphiniifolia</i> 2009.05; 69
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The expression of metastasis suppressor gene, KAI1/CD82, is down-regulated by OCT4, SOX2 and NANOG in tumor stem cells of breast cancer 2009.05; 69
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Resveratrol induces apoptosis by blocking enzymatic activity and destabilizing the protein of fatty acid synthase in breast tumor cells 2009.05; 69
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Notch pathway is stimulated by hypoxia and promotes metastasis through activation of EMT and metalloproteinase 2009.05; 69
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Molecular Mechanisms of Subcellular Localization of ABCG5 and ABCG8 2009.03; 73 (3): 619-626. ( DOI )
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RhoC promotes metastasis via activation of the Pyk2 pathway, in prostate cancer 2008.09; 68 (18): 7613-7620. ( DOI )
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Critical role of ADAM15 in tumor progression; targeting multiple factors for metastasis promotion 2008.06; 4 (3): 351-354. ( DOI )
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Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1 2007.11; 48 (11): 2377-2384. ( DOI )
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Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4 2007.07; 46 (1): 188-199. ( DOI )
Conference Activities & Talks 【 display / non-display 】
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低分子駆動性キメラサイトカイン受容体を用いたCAR T・CAR NK細胞療法の機能亢進. 2026.09.25
Awards & Honors 【 display / non-display 】
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Breast Cancer Concept Award,Department of Defense (DOD),2010
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Prostate Cancer Training Award,Department of Defense (DOD),2010