Personnel Information

写真a

SHINOHARA Ryota


Job title

Associate Professor
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Campus Career 【 display / non-display 】

  • 2025.09
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Cognitive and Behavioral Medicine， Department of Pharmacology， Associate Professor
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External Career 【 display / non-display 】

  • 2015.09
    -
    2016.09
    Kobe University, Graduate School of Medicine, Research Assistant Professor
  • 2016.10
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    2017.09
    Kobe University, Graduate School of Medicine, Assistant Professor
  • 2017.09
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    2019.08
    Yale University School of Medicine, Department of Psychiatry, Postdoctoral Fellow
  • 2019.09
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    2021.03
    Yale University School of Medicine, Department of Psychiatry, Associate Research Scientist
  • 2021.04
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    2021.06
    Kobe University, Graduate School of Medicine, Associate Professor
  • 2021.07
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    2024.03
    Kobe University, Graduate School of Medicine, Associate Professor
  • 2024.04
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    2025.08
    Kobe University, Institute for Advanced Research, Associate Professor
  • 2024.04
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    2025.08
    Kobe University, Graduate School of Medicine, Associate Professor
  • 2025.09
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    Now
    Kobe University, Graduate School of Medicine, Visiting Associate Professor

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Academic Society Affiliations 【 display / non-display 】

  • The Japanese Pharmacological Society

  • The Japanese Society of Neuropsychopharmacology

  • The Japan Neuroscience Society

  • Japanese Society of Osteoimmunology

  • Society for Neuroscience

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Academic Activity 【 display / non-display 】

  • 2024.09
    -
    Now
    Frontiers in Cellular Neuroscience Review Editor
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Research Areas 【 display / non-display 】

  • Function of nervous system

  • Pathophysiologic neuroscience

  • Pharmacology

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Research Theme 【 display / non-display 】

  • Elucidation of neural circuit mechanisms underlying diversity in behavioral changes induced by chronic stress, 2022.04 - 2025.03

  • Elucidation of the molecular and neural circuit basis of individual differences in stress resilience, 2021.10 - 2025.03

  • Elucidation of the neural basis underlying individual differences in brain dysfunction caused by chronic stress, 2021 - 2022

  • Molecular and neural circuit mechanisms underlying rapid antidepressant actions, 2017.09 - 2019.08

  • Identifying the molecular and neural circuit mechanisms of the action of rapid-acting antidepressants, 2017.09 - 2018.03

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Published Papers & Misc 【 display / non-display 】

  1. Yuki Okuda, Dongrui Li, Yuzuki Maruyama, Hirokazu Sonobe, Tomoyuki Mano, Kazuki Tainaka, Ryota Shinohara, Tomoyuki Furuyashiki. The activation of the piriform cortex to lateral septum pathway during chronic social defeat stress is crucial for the induction of behavioral disturbance in mice. Neuropsychopharmacology. 2025.04; 50 (5): 828-840. ( PubMed, DOI )

  2. Yumika Motooka, Ryota Shinohara, Shiho Kitaoka, Ai Uryu, Dongrui Li, Hiroyuki Neyama, Yilong Cui, Tatsuya Kida, Wakiko Arakaki, Hisashi Doi, Yasuyoshi Watanabe, Tomoyuki Furuyashiki. Alteration of COX-1 and TLR4 expression in the mouse brain during chronic social defeat stress revealed by Positron Emission Tomography study. Journal of Pharmacological Sciences. 2025.03; 157 (3): 156-166. ( PubMed, DOI )

  3. Ryota Shinohara, Tomoyuki Furuyashiki. Prefrontal contributions to mental resilience: Lessons from rodent studies of stress and antidepressant actions. Neurosci Res. 2025.02; 211 16-23. ( PubMed, DOI )

  4. Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki. Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice. Scientific Reports. 2022.07; 12 (1): 11385. ( PubMed, DOI )

  5. Santosh Pothula, Taro Kato, Rong-Jian Liu, Min Wu, Danielle Gerhard, Ryota Shinohara, Alexa-Nicole Sliby, Golam M I Chowdhury, Kevin L Behar, Gerard Sanacora, Pradeep Banerjee, Ronald S Duman. Cell-type specific modulation of NMDA receptors triggers antidepressant actions. Molecular Psychiatry. 2021.09; 26 (9): 5097-5111. ( PubMed, DOI )

  6. Ryota Shinohara, George K Aghajanian, Chadi G Abdallah. Neurobiology of the Rapid-Acting Antidepressant Effects of Ketamine: Impact and Opportunities. Biological Psychiatry. 2021.07; 90 (2): 85-95. ( PubMed, DOI )

  7. Ronald S Duman, Ryota Shinohara, Manoela V Fogaça, Brendan Hare. Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function. Molecular Psychiatry. 2019.12; 24 (12): 1816-1832. ( PubMed, DOI )

  8. Chisato Numa, Hirotaka Nagai, Masayuki Taniguchi, Midori Nagai, Ryota Shinohara, Tomoyuki Furuyashiki. Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex. Scientific Reports. 2019.11; 9 (1): 16670. ( PubMed, DOI )

  9. Satoshi Okamura, Hirotaka Nagai, Chisato Numa, Midori Nagai, Ryota Shinohara, Tomoyuki Furuyashiki. Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice Neuropsychopharmacology Reports. 2019.06; 39 (2): 134-139. ( PubMed, DOI )

  10. Brendan D Hare, Ryota Shinohara, Rong Jian Liu, Santosh Pothula, Ralph J DiLeone, Ronald S Duman. Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects. Nature Communications. 2019.01; 10 (1): 223. ( PubMed, DOI )

  11. R Shinohara, M Taniguchi, A T Ehrlich, K Yokogawa, Y Deguchi, Y Cherasse, M Lazarus, Y Urade, A Ogawa, S Kitaoka, A Sawa, S Narumiya, T Furuyashiki. Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Molecular Psychiatry. 2018.08; 23 (8): 1717-1730. ( PubMed, DOI )

  12. Shu Higashida, Hirotaka Nagai, Kazuki Nakayama, Ryota Shinohara, Masayuki Taniguchi, Midori Nagai, Takatoshi Hikida, Satoshi Yawata, Yukio Ago, Shiho Kitaoka, Shuh Narumiya, Tomoyuki Furuyashiki. Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety. Scientific Reports. 2018.07; 8 (1): 10454. ( PubMed, DOI )

  13. Hisao Kojima, Ryota Shinohara, Saki Itonori, Masahiro Ito. Characterization of a novel rhamnose-containing acidic glycosphingolipid from the ascidian Halocynthia aurantium Journal of Oleo Science. 2017.03; 66 (3): 285-295. ( PubMed, DOI )

  14. Yuichi Deguchi, Masaya Harada, Ryota Shinohara, Michael Lazarus, Yoan Cherasse, Yoshihiro Urade, Daisuke Yamada, Masayuki Sekiguchi, Dai Watanabe, Tomoyuki Furuyashiki, Shuh Narumiya. mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety. Cell Reports. 2016.11; 17 (9): 2405-2417. ( PubMed, DOI )

  15. Tetsushi Hirano, Shogo Yanai, Takuya Omotehara, Rie Hashimoto, Yuria Umemura, Naoto Kubota, Kiichi Minami, Daichi Nagahara, Eiko Matsuo, Yoshiko Aihara, Ryota Shinohara, Tomoyuki Furuyashiki, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Nobuhiko Hoshi. The combined effect of clothianidin and environmental stress on the behavioral and reproductive function in male mice Journal of Veterinary Medical Science. 2015.10; 77 (10): 1207-1215.

  16. Yosuke Toyoda, Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Hiroshi Nishimaru, Hiroyuki Hioki, Takeshi Kaneko, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya. EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination. Genes to Cells. 2013.10; 18 (10): 873-885. ( PubMed, DOI )

  17. Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Naoko Kaneko, Kazunobu Sawamoto, Keisuke Watanabe, Hirohide Takebayashi, Hiroshi Kiyonari, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya. A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors. Nature Neuroscience. 2012.01; 15 (3): 373-80, S1. ( PubMed, DOI )

  18. Dean Thumkeo, Ryota Shinohara, Keisuke Watanabe, Hirohide Takebayashi, Yosuke Toyoda, Kiyoshi Tohyama, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya. Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia. PLoS One. 2011; 6 (9): e25465. ( PubMed, DOI )

  19. Masahiro Ito, Kazuhito Yokoi, Takashi Inoue, Shogo Asano, Rei Hatano, Ryota Shinohara, Saki Itonori, Mutsumi Sugita. Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava Journal of Oleo Science. 2009.08; 58 (9): 473-480.

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Conference Activities & Talks 【 display / non-display 】

  1. 篠原 亮太. レジリエンスと抗うつ作用の共通基盤：前頭前皮質ドパミン系の役割. 第99回日本薬理学会年会 2026.03.18 仙台

  2. 篠原 亮太. レジリエンスと抗うつ作用の共通基盤：前頭前皮質ドパミン系の役割. 第99回日本薬理学会 2026.03.18

  3. 篠原 亮太. ストレスによる前頭前皮質回路再編とその行動的意義. 第99回日本薬理学会年会 2026.03.16 仙台

  4. 篠原 亮太. ストレスによる前頭前皮質回路再編とその行動的意義. 第99回日本薬理学会 2026.03.16

  5. 奥田 裕己, 篠原 亮太, 園部 大和, 丸山 柚月, 李 東芮, 山本 真里奈, 山口 真広, 伊藤 慶, 佐藤 彰典, 小坂田 文隆, 古屋敷 智之. 慢性ストレスによる進行性神経回路再編と行動変容の持続における役割. 第68回日本神経化学会大会 2025.09.11 名古屋

  6. 篠原 亮太, 祝 晴, 久末 敏博, 山口 勇太, 谷口 将之, 藤本 哲太, 氏原 大, 亀谷 直孝, 石井 慎一, 片山 義雄, 古屋敷 智之. ホスホエタノールアミンはマウスの慢性社会挫折ストレスによる好中球動員、血管障害、および行動変化を抑制する. 第48回日本神経科学大会 2025.07.24 新潟

  7. 篠原 亮太, 祝 晴, 久末 敏博, 山口 勇太, 谷口 将之, 藤本 哲太, 氏原 大, 亀谷 直孝, 石井慎一, 片山 義雄, 古屋敷 智之. ホスホエタノールアミンはマウスの慢性社会挫折ストレスによる好中球動員、血管障害、および行動変化を抑制する. 第48回日本神経科学大会 2025.07.24

  8. 篠原 亮太. 前頭前皮質ドパミン系によるストレス抵抗性とケタミンの抗うつ効果. APPW2025(第130回日本解剖学会/第102回日本生理学会/第98回日本薬理学会合同大会) 2025.03.19

  9. Shinohara Ryota. ストレス関連疾患の新規治療標的の探索　前頭前皮質ドパミン系によるストレス抵抗性とケタミンの抗うつ効果(Discovery of novel therapeutic targets for stress-related disorders　The prefrontal dopaminergic system underlies stress resilience and antidepressant effects of ketamine). The Journal of Physiological Sciences 2025.03.01

  10. Okuda Yuki, Li Dongrui, Maruyama Yuzuki, Sonobe Hirokazu, Mano Tomoyuki, Tainaka Kazuki, Shinohara Ryota, Furuyashiki Tomoyki. 慢性社会挫折ストレスにおける梨状皮質から外側中隔への経路の活性化はマウスの行動変容の誘導に重要である(The activation of the piriform cortex to lateral septum pathway during chronic social defeat stress is crucial for the induction of behavioral disturbance in mice). The Journal of Physiological Sciences 2025.03.01

  11. 篠原 亮太. Elucidating neural circuit mechanisms of stress, resilience, and antidepressant actions. 2024台日神経科学若手研究者交流会（NEURO2024サテライト企画） 2024.07.23

  12. 篠原 亮太. ストレス抵抗性とケタミンの抗うつ作用における前頭前皮質ドパミンD1受容体の役割. 「次世代脳」プロジェクト 冬のシンポジウム2022 新学術領域「マルチスケール脳」企画シンポジウム 2022.12.14

  13. 篠原 亮太, Brendan D. Hare, Rong-Jian Liu, Jin Hua Li, Xiao-Yuan Li, Catharine H. Duman, Ralph J. DiLeone, Ronald, S. Duman. Distinct downstream targets of the medial prefrontal cortex underlie discrete antidepressant responses to ketamine. 14th Asia Pacific Federation of Pharmacologists (APFP2021) 2021.11.27

  14. 篠原 亮太, Brendan D Hare, Rong-Jian Liu, Jin Hua Li, Xiao-Yuan Li, Catharine H Duman, Ralph J DiLeone, Ronald S Duman. ケタミンの即効性抗うつ作用を担う神経回路メカニズム. 第44回日本神経科学大会／第1回CJK国際会議 2021.07.29

  15. 篠原 亮太. Roles of the prefrontal dopaminergic system in stress resilience and rapid antidepressant responses. IBS Center for Cognition and Sociality Seminar 2021.03.10

  16. Shinohara, R., Hare, B.D., Liu, R.J., Duman, R.S.. Distinct projections of the medial prefrontal cortex underlie the rapid antidepressant actions of ketamine. Neuroscience 2019 2019.10.22 Chicago, IL

  17. 篠原 亮太. Dissecting neural circuits underlying stress and rapid antidepressant actions in animal models. Biological Sciences Training Program (BSTP) Seminar Series 2019.09.23

  18. Shinohara, R., Hare, B.D., Pothula, S., Duman, R.S.. Projection-specific optogenetic stimulation of medial prefrontal cortex neurons expressing dopamine D1 receptors produces rapid antidepressant effects. Neuroscience 2018 2018.11.05 San Diego, CA

  19. 篠原 亮太, 谷口 将之, エーリック アリザ, 横川 賢多朗, 出口 雄一, 小川 淳史, 北岡 志保, 澤 明, 成宮 周, 古屋敷 智之. 内側前頭前皮質のドパミンD1受容体による社会挫折ストレスへの感受性抑制と神経回路リモデリング. 第40回日本神経科学大会 2017.07.20

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Awards & Honors 【 display / non-display 】

  • The 11th Young Investigator Award，The Japanese Society of Neuropsychopharmacology，2022.11

  • Kobe University Excellent Young Researcher Award，Kobe University，2022.10

  • The 37th Encouragement of Young Investigator Award，The Japanese Pharmacological Society，2022.03

  • 29th Inoue Research Award for Young Scientists，Inoue Foundation for Science，2013.02

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External class subject 【 display / non-display 】

  • ，Kobe University

  • ，Kobe University

  • General Basic Subjects (Core Lectures)，Kobe University

  • Basic and clinical pharmacology，Kobe University

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