基本情報

写真a

藤生　克仁(フジウ　カツヒト)

FUJIU Katsuhito


職名

教授
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  • 2025年08月
    -
    現在
    東京科学大学 教育研究組織 総合研究院 難治研・未来科学研究部門 統合生理学分野 教授
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  1. Chen P, Hu G, Yang W, Nakashima Y, Xu Z, Yang Y, Kondo S, Chen X, Takasugi S, Kovács E, Fujiu K, Cabral H. Hide-and-seek molecular navigator targets tumor cell surface thiols by programmable disulfide exchange. Biomaterials. 2026.11; 334 124256. ( PubMed, DOI )

  2. Watanabe E, Nishii N, Maeda A, Sakai Y, Fujiu K, Suzuki M, Kato R, Abe H, Noda T, Tada H, Takagi M. Expert Consensus Statement: Committee on Implantable Devices and Committee on Social Issues, Japanese Heart Rhythm Society (JHRS) Statement on Remote Monitoring of Cardiac Implantable Electronic Devices. Journal of arrhythmia. 2026.10; 42 (5): e70437. ( PubMed, DOI )

  3. Goto K, Nakayama Y, Sugita J, Oshima T, Kani K, Kobayashi A, Setoguchi N, Liu Y, Yang Y, Ku J, Uchida R, Hasumi E, Nagasawa T, Komuro I, Takeda N, Manabe I, Fujiu K. Altered bone marrow niche forms central innate immune memory driving cardiac dysfunction. Nature communications. 2026.08; 17 (1): ( PubMed, DOI )

  4. Nishikawa Masachika, Suzuki Yuta, Kaneko Hidehiro, Okada Akira, Takeda Norifumi, Morita Hiroyuki, Fujiu Katsuhito, Azegami Tatsuhiko, Hayashi Kaori, Kitaoka Kaori, Miura Katsuyuki, Mizuno Atsushi, Nomura Akihiro, Kario Kazuomi, Node Koichi, Yasunaga Hideo, Nangaku Masaomi, Arima Hisatomi, Takeda Norihiko. In Response to "Quantifying the population burden of hypertension: methodological considerations on the PAF analysis of the DeSC cohort" Hypertension Research. 2026.08; 49 (8): 2477-2478. ( 医中誌 )

  5. Hu X, Sugita J, Fujiu K, Tixier-Mita A, Toshiyoshi H. Unsupervised machine learning-assisted multimodal characterization of cardiomyocytes on a thin-film-transistor microelectrode array (TFT-MEA). Biomedical physics & engineering express. 2026.07; 12 (4): ( PubMed, DOI )

  6. Azegami Tatsuhiko, Kaneko Hidehiro, Okada Akira, Suzuki Yuta, Aoyama Kazuki, Fujiu Katsuhito, Takeda Norifumi, Morita Hiroyuki, Yokoo Takashi, Nangaku Masaomi, Node Koichi, Takeda Norihiko, Yasunaga Hideo, Hayashi Kaori. In Response to "Is low lean body mass a risk factor for hypertension?" Hypertension Research. 2026.07; 49 (7): 2299-2300. ( 医中誌 )

  7. Fujiu K. Cardiac Conduction in Physiology and Disease　- Gap Junction Biology, Immune Modulation, and Computational Electrophysiology. Circulation journal : official journal of the Japanese Circulation Society. 2026.06; 90 (7): 755-766. ( PubMed, DOI )

  8. Nishikawa Masachika, Suzuki Yuta, Ko Toshiyuki, Kaneko Hidehiro, Okada Akira, Takeda Norifumi, Morita Hiroyuki, Fujiu Katsuhito, Azegami Tatsuhiko, Hayashi Kaori, Kitaoka Kaori, Miura Katsuyuki, Furui Yuji, Node Koichi, Yasunaga Hideo, Nangaku Masaomi, Takeda Norihiko. Association of Weight Loss With Improvement in Metabolic Status Among People Eligible for the Specific Health Guidance Program Circulation Reports. 2026.06; 8 (6): 909-914. ( 医中誌 )

  9. Kuroyanagi D, Kaneko H, Suzuki Y, Okada A, Morita H, Takeda N, Fujiu K, Komuro K, Ko T, Mitsuno R, Nakayama T, Azegami T, Hayashi K, Yasunaga H, Takeda N, Kawamura A. Relationship of Depression With Incident Cardiovascular Disease in Individuals With Chronic Kidney Disease. Circulation reports. 2026.05; 8 (5): 730-737. ( PubMed, DOI )

  10. Masuda T, Ejiri K, Kaneko H, Suzuki Y, Miyoshi T, Taya S, Iwasaki K, Nakagawa K, Nishii N, Morita H, Okada A, Fujiu K, Takeda N, Morita H, Yasunaga H, Takeda N, Yuasa S. Insomnia and the Risk of Atrial Fibrillation: A Nationwide, Real-World Cohort Study. Journal of the American Heart Association. 2026.05; 15 (9): e045149. ( PubMed, DOI )

  11. Nishikawa Masachika, Suzuki Yuta, Kaneko Hidehiro, Okada Akira, Takeda Norifumi, Morita Hiroyuki, Fujiu Katsuhito, Azegami Tatsuhiko, Hayashi Kaori, Kitaoka Kaori, Miura Katsuyuki, Mizuno Atsushi, Nomura Akihiro, Kario Kazuomi, Node Koichi, Yasunaga Hideo, Nangaku Masaomi, Arima Hisatomi, Takeda Norihiko. Population attributable fraction of modifiable risk factors for incident hypertension: an analysis of large-scale epidemiological cohort Hypertension Research. 2026.05; 49 (5): 1726-1735. ( 医中誌 )

  12. Azegami Tatsuhiko, Kaneko Hidehiro, Okada Akira, Suzuki Yuta, Aoyama Kazuki, Fujiu Katsuhito, Takeda Norifumi, Morita Hiroyuki, Yokoo Takashi, Nangaku Masaomi, Node Koichi, Takeda Norihiko, Yasunaga Hideo, Hayashi Kaori. In response to lean body mass index and hypertension risk in men: a nationwide epidemiological cohort study Hypertension Research. 2026.04; 49 (4): 1565-1566. ( 医中誌 )

  13. Liu Y, Nakayama Y, Sugita J, Oshima T, Kani K, Kobayashi A, Setoguchi N, Iwai Y, Manabe I, Fujiu K. MALAT1 regulates human macrophage metabolism by interacting with HADHB. iScience. 2026.03; 29 (3): 115107. ( PubMed, DOI )

  14. Azegami Tatsuhiko, Kaneko Hidehiro, Okada Akira, Suzuki Yuta, Aoyama Kazuki, Fujiu Katsuhito, Takeda Norifumi, Morita Hiroyuki, Yokoo Takashi, Nangaku Masaomi, Node Koichi, Takeda Norihiko, Yasunaga Hideo, Hayashi Kaori. Lean body mass index and hypertension risk in men: a nationwide epidemiological cohort study Hypertension Research. 2026.03; 49 (3): 829-836. ( 医中誌 )

  15. Kitani Yuya, Suzuki Yuta, Kaneko Hidehiro, Okada Akira, Morita Hiroyuki, Fujiu Katsuhito, Node Koichi, Yasunaga Hideo, Takeda Norihiko, Nakagawa Naoki. Association of changes in body weight and waist circumference with a subsequent risk of developing hypertension in men requiring specific healthcare guidance Hypertension Research. 2026.02; 49 (2): 508-515. ( 医中誌 )

  16. Sugita Junichi, Chen Ziyu, Setoguchi Naoto, Goto Kohsaku, Kobayashi Atsushi, Kani Kunihiko, Yang Yiyi, Ku Jiaxin, Ueno Kensuke, Uchida Ryoko, Hasumi Eriko, Oshima Tsukasa, Nakayama Yukiteru, Fujiu Katsuhito. Cardiopulmonary neuro-immune reflex: From afferent stress signaling to peripheral myeloid memory Journal of Cardiology. 2026.01; 87 (1): 77-84. ( 医中誌 )

  17. Kitaoka Kaori, Kaneko Hidehiro, Suzuki Yuta, Okada Akira, Mizuno Atsushi, Fujiu Katsuhito, Takeda Norifumi, Morita Hiroyuki, Azegami Tatsuhiko, Hayashi Kaori, Node Koichi, Furui Yuji, Miura Katsuyuki, Yasunaga Hideo, Takeda Norihiko. Reply to Comment on "Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure" Hypertension Research. 2025.12; 48 (12): 3321-3323. ( 医中誌 )

  18. Seno Hiroshi, Wang Yilin, Kojima Toshiya, Oshima Tsukasa, Yamagata Kenichiro, Yamazaki Masatoshi, Sakuma Ichiro, Fujiu Katsuhito, Tomii Naoki. Phase Variance Analysis for Identifying Heterogeneous Conduction Regions in Persistent Atrial Fibrillation: Impact of Recording Duration Journal of Arrhythmia. 2025.12; 41 (6): joa3.70246. ( 医中誌 )

  19. Oshima Tsukasa, Akazawa Hiroshi, Ishida Junichi, Kadowaki Hiroshi, Shindo Akito, Ueda Tomomi, Amano Yosuke, Watanabe Kousuke, Fujiu Katsuhito, Kage Hidenori, Komuro Issei. Risk Factors and Prognostic Significance of Non-Perioperative Atrial Fibrillation in Lung Cancer Patients Circulation Reports. 2025.12; 7 (12): 1171-1180. ( 医中誌 )

  20. Yoshimura R, Nakamura N, Matsuura T, Toshima T, Fukuhara T, Aihara K, Fujiu K, Iwami S, Yoshizumi T. Prediction of graft loss in living donor liver transplantation during the early postoperative period. PLoS computational biology. 2025.11; 21 (11): e1013734. ( PubMed, DOI )

  21. Taya, S; Ejiri, K; Kaneko, H; Suzuki, Y; Miyoshi, T; Mizuno, A; Ko, T; Jimba, T; Azegami, T; Okada, A; Fujiu, K; Takeda, N; Morita, H; Hayashi, K; Node, K; Nangaku, M; Yasunaga, H; Takeda, N; Yuasa, S. Sex differences in the progression of cardiovascular-kidney-metabolic syndrome EUROPEAN HEART JOURNAL OPEN. 2025.11; 5 (6): oeaf162. ( PubMed, DOI )

  22. Kobayashi, A; Fujiu, K. Reply to Letter by Kim Regarding Article, "A Patient with Partial 17α-Hydroxylase Deficiency Initially Diagnosed with Asherman Syndrome and Pheochromocytoma" INTERNATIONAL HEART JOURNAL. 2025.11; 66 (6): 1038. ( PubMed, DOI )

  23. Kitaoka Kaori, Kaneko Hidehiro, Suzuki Yuta, Okada Akira, Mizuno Atsushi, Fujiu Katsuhito, Takeda Norifumi, Morita Hiroyuki, Azegami Tatsuhiko, Hayashi Kaori, Node Koichi, Furui Yuji, Miura Katsuyuki, Yasunaga Hideo, Takeda Norihiko. Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure Hypertension Research. 2025.10; 48 (10): 2537-2547. ( 医中誌 )

  24. Ishibashi Takuma, Kaneko Hidehiro, Suzuki Yuta, Ko Toshiyuki, Okada Akira, Fujiu Katsuhito, Takeda Norifumi, Morita Hiroyuki, Node Koichi, Yasunaga Hideo, Takeda Norihiko. Association of lean mass index with a risk of incident stroke: a nationwide epidemiological cohort study Journal of Cardiology. 2025.10; 86 (4): 411-413. ( 医中誌 )

  25. Sato Masataka, Kodera Satoshi, Hamano Shogo, Setoguchi Naoto, Tanabe Kengo, Kushida Shunichi, Saji Mike, Nanasato Mamoru, Maki Hisataka, Fujita Hideo, Kato Nahoko, Watanabe Hiroyuki, Takahashi Masao, Sawada Naoko, Ando Jiro, Sawano Shinnosuke, Kishikawa Risa, Shinohara Hiroki, Takeda Norifumi, Fujiu Katsuhito, Nakanishi Koki, Akazawa Hiroshi, Morita Hiroyuki, Takeda Norihiko. Enhancing Chest Radiography Artificial Intelligence Model with Electrocardiogram for Improved Detection of Low Ejection Fraction International Heart Journal. 2025.09; 66 (5): 771-779. ( 医中誌 )

  26. Ueno Kensuke, Ko Toshiyuki, Suzuki Yuta, Kaneko Hidehiro, Kamiya Kentaro, Okada Akira, Fujiu Katsuhito, Takeda Norifumi, Morita Hiroyuki, Node Koichi, Yasunaga Hideo, Takeda Norihiko. Frailty and its components and cardiovascular outcomes in older adults: A nationwide epidemiological study Geriatrics & Gerontology International. 2025.09; 25 (9): 1239-1246. ( 医中誌 )

  27. Aoyama Kazuki, Kaneko Hidehiro, Azegami Tatsuhiko, Okada Akira, Suzuki Yuta, Meguro Shu, Fujiu Katsuhito, Takeda Norifumi, Morita Hiroyuki, Takeda Norihiko, Yasunaga Hideo, Hayashi Kaori. Lean body mass index and the risk of diabetes onset: A nationwide epidemiological cohort study Journal of Diabetes Investigation. 2025.09; 16 (9): 1623-1630. ( 医中誌 )

  28. 藤生 克仁. 【臓器連関が解き明かす疾患の深層】臓器連関と心疾患　臓器連関が支える心臓の恒常性　心臓マクロファージと骨髄ニッチによる自然免疫記憶 医学のあゆみ. 2026.08; 298 (9): 688-692. ( 医中誌 )

  29. 藤生 克仁. 【感染症ワクチンによるオフターゲット効果の免疫学】心疾患における自然免疫記憶 炎症と免疫. 2026.06; 34 (4): 147-151. ( 医中誌 )

  30. 藤生 克仁. 【臓器連関のメカニズムと臨床的意義】臓器間コミュニケーションと心機能 Medical Science Digest. 2026.06; 52 (6): 332-335. ( 医中誌 )

  31. 藤生 克仁. 【心脳連関～脳と心臓・身体の不思議な関係～】識る　心脳連関における分子・生理機序 Heart View. 2026.05; 30 (5): 477-482. ( 医中誌 )

  32. 竹内 真樹, 御宿 義勝, 荷見 映理子, 藤生 克仁, 森 祐貴. 12誘導心電図から心房細動発症を予測するAIの臨床的有効性についての検討 総合健診. 2026.03; 53 (2): 330-339. ( 医中誌 )

  33. 藤生 克仁. 【心不全診療の未来戦略-ゲノム,AI,多臓器連関が拓く新時代】AIを活かした未来の心不全診療　デジタルツイン技術が切り拓く心不全の個別化医療 医学のあゆみ. 2025.11; 295 (9): 863-867. ( 医中誌 )

  34. 藤生 克仁. 【生体システムのレジリエンス-神経-免疫-内分泌連関から探る適応と修復のメカニズム】神経-免疫連関による循環・呼吸系恒常性の維持とその破綻　心肺-骨髄軸の再構築 医学のあゆみ. 2025.10; 295 (1): 53-60. ( 医中誌 )

  35. 藤生 克仁. 【心不全におけるサルコペニア・カヘキシアの複合的アプローチ】心不全に伴うサルコペニア　免疫細胞と自然免疫記憶がつなぐ新しい病態概念 日本サルコペニア・フレイル学会雑誌. 2025.08; 9 (1): 31-34. ( 医中誌 )

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  1. Kobayashi Atsushi, Nakayama Yukiteru, Takeda Norihiko, Fujiu Katsuhito. 内皮のPlvapは心不全における肺水腫に対する重要な防御因子である(Endothelial Plvap as a Key Defense against Pulmonary Edema in Heart Failure). 日本循環器学会学術集会抄録集 2026.03.01

  2. 内田 亮子, 藤生 克仁. 顔面血流における動脈相分布の変化を用いた高血圧および糖尿病の非侵襲的識別(Non-Invasive Identification of Hypertension and Diabetes via Altered Arterial Phase Distribution in Facial Blood Flow). 日本循環器学会学術集会抄録集 2026.03.01

  3. Konoma Satoshi, Nakanishi Koki, Daimon Masao, Hirose Kazutoshi, Iwama Kentaro, Mukai Yasuhiro, Yamamoto Yuko, Seki Hikari, Yoshida Yuriko, Hirokawa Megumi, Nakao Tomoko, Oshima Tsukasa, Matsubara Takumi, Shimizu Yu, Oguri Gaku, Kojima Toshiya, Hasumi Eriko, Fujiu Katsuhito, Morita Hiroyuki, Takeda Norihiko. 心房細動患者におけるHFA-PEFFスコアと左房力学、左房圧および逆リモデリングとの関連(Association of HFA-PEFF Score with Left Atrial Mechanics, Pressure and Reverse Remodeling in Patients with Atrial Fibrillation). 日本循環器学会学術集会抄録集 2026.03.01

  4. Kobayashi Tetsuro, Mochizuki Miho, Hagiwara Naho, Iseki Hachiro, Fujiu Katsuhito, Asanuma Daisuke, Moro Kazuyo. ILC1由来アンフィレグリンは皮膚の機械的ストレスに応答する上皮ターンオーバーを制御する(ILC1-Derived Amphiregulin Regulates Epithelial Turnover in Response to Mechanical Stress in the Skin). 日本免疫学会総会・学術集会記録 2025.11.01

  5. Liu Yuxiang, Nakayama Yukiteru, Fujiu Katsuhito. MALAT1はヒトマクロファージ代謝を制御するHADHB相互作用長鎖ノンコーディングRNAである(MALAT1 as a HADHB-Interacting LncRNA Regulating Human Macrophage Metabolism). 日本免疫学会総会・学術集会記録 2025.11.01

  6. 藤生 克仁. 生体内システム連関から病態を把握する　心不全による骨髄ニッチ変容と中枢性ストレスメモリによる多病性進展の神経免疫基盤. 日本内分泌学会雑誌 2026.05.01

  7. 藤生 克仁. 集団・社会形成への自律神経系の拡張　心不全ストレスによる交感神経ニューロパチーを介した中央免疫記憶形成. 日本自律神経学会総会プログラム・抄録集 2025.10.01

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  • 心不全を悪化させる骨髄の異変を発見，2026年08月

    Nature Communications

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