Personnel Information

写真a

YAHATA Yoshio


Job title

Professor
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Campus Career 【 display / non-display 】

  • 2025.05
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Oral Health Sciences， Department of Pulp Biology and Endodontics， Professor
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Research Areas 【 display / non-display 】

  • Conservative dentistry

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Research Theme 【 display / non-display 】

  • Development of standard setting technology which guarantee bone forming ability of jaw bone derived skeltal stem cells, 2025.04 - 2028.03

  • Development of a novel bone regeneration technique using endochondral ossification by skeletal stem cells., 2024.04 - 2027.03

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Published Papers & Misc 【 display / non-display 】

  1. Sinsareekul C, Phothichailert S, Suwittayarak R, Trachoo V, Kornsuthisopon C, Sukarawan W, Yahata Y, Osathanon T, Hiran-Us S. Cytotoxicity and Bioactivity of Five Hydraulic Silicate Cements in Human Dental Pulp Cells at Different Setting Stages. International dental journal. 2026.09; 76 (6): 111144. ( PubMed, DOI )

  2. Nakano, M; Tanaka, Y; Kyaw, MS; Shuai, W; Kamano, Y; Toyama, F; Noguchi, T; Harada, F; Suresh, VV; Handa, K; Mizuta, K; Yahata, Y; Saito, M. Novel Method to Target Apical Periodontitis Worsened by Inflammatory Bowel Disease JOURNAL OF DENTAL RESEARCH. 2026.09; 105 (10): 1317-1327. ( PubMed, DOI )

  3. Alghamdi, F; Ren, CM; Tazawa, K; Liu, SC; Zhou, CY; Takahashi, J; Ishidori, M; Ohshima, R; Kawashima, N; Okiji, T; Yahata, Y. Metformin suppresses periapical bone resorption in a mouse model of apical periodontitis <i>in vivo</i> and inhibits RANKL-induced osteoclastogenesis <i>in vitro</i> JOURNAL OF ORAL BIOSCIENCES. 2026.08; 68 (4): 100799. ( PubMed, DOI )

  4. 1. Alghamdi F, Ren C, Tazawa K, Liu S, Zhou C, Takahashi J, Ishidori M, Ohshima R, Kawashima N, Okiji T, Yahata Y.. Metformin suppresses periapical bone resorption in a mouse model of apical periodontitis in vivo and inhibits RANKL-induced osteoclastogenesis in vitro J Oral Biosci. 2026.07; 68 100799.

  5. 福林冬花，田澤建人，八幡祥生. ２型糖尿病が歯髄壊死を認める歯における根尖性歯周炎の大きさ, エンドトキシン濃度, および細菌数に及ぼす影響 ザ・クインテッセンス. 2026.02; 45 (2): 198-200.

  6. Ohshima, R; Quispe-Salcedo, A; Ohshima, H; Kawashima, N; Okiji, T; Yahata, Y. Osteopontin deficiency disturbs dentin bridge formation after direct pulp capping with mineral trioxide aggregate JOURNAL OF ORAL BIOSCIENCES. 2026.02; 68 (1): 100740. ( PubMed, DOI )

  7. Ohshima Risa, Quispe-Salcedo Angela, Ohshima Hayato, Kawashima Nobuyuki, Okiji Takashi, Yahata Yoshio. オステオポンチン欠損はmineral trioxide aggregateによる直接覆髄後のdentin bridge形成を抑制する(Osteopontin deficiency disturbs dentin bridge formation after direct pulp capping with mineral trioxide aggregate) Journal of Oral Biosciences. 2026.02; 68 (1): j.job.2026.100740. ( ichushi )

  8. Ohshima R, Quispe-Salcedo A, Ohshima H, Kawashima N, Okiji T, Yahata Y. Osteopontin deficiency disturbs dentin bridge formation after direct pulp capping with mineral trioxide aggregate Journal of Oral Biosciences. 2026.01; 1 (68):

  9. 石通昌治,牧圭一郎,八幡祥生,興地隆史. 根尖性歯周炎の治癒,歯根の伸長および根管内石灰化から評価した再生歯内療法の臨床成績 日本歯科評論. 2026.01; 126-127.

  10. Risako Yamamoto , Keiichiro Maki , Shunsuke Kimura , Satoshi Omori , Keiko Hirano , Arata Ebihara , Yoshio Yahata , Takashi Okiji. Impact of Downward Load and Rotational Kinematics on Root Canal Instrumentation with a Heat-Treated Nickel–Titanium Rotary Instrument materials. 2026.01; 19 (1): 108. ( PubMed, DOI )

  11. 1. Alghamdi F, Tazawa K, Ren C, Liu S, Zhou C, Takahashi J, Ohshima R, Ishidori M, Fukubayashi T, Kawashima N, Okiji T, Yahata Y. Temporal immunohistochemical analysis of macrophage, neutrophil, and osteoclast dynamics during metformin-mediated suppression of experimentally induced apical periodontitis in mice BMC Oral Health. 2026;

  12. Kyaw, MS; Yahata, Y; Nakano, M; Toyama, F; Ke, C; Shuai, W; Kamano, Y; Harada, F; Noguchi, T; Saito, M. Biocompatibility of a Novel Light-Curable Hydrogel-Based Root Canal Obturation Material: In Vivo and In Vitro Analyses JOURNAL OF ENDODONTICS. 2025.12; 51 (12): 1814-1822. ( PubMed, DOI )

  13. Takabayashi Masayuki, Yahata Yoshio, Handa Keisuke, Kyaw Moe Sandar, Suresh Venkata Venkataih, Saito Masahiro. L-乳酸-ε-カプロラクトン共重合体の膜が歯槽骨温存に及ぼす効果　開放治癒アプローチを用いた比較実験(The effect of L-lactide-ε-caprolactone copolymer membrane on alveolar bone preservation: A comparative study using the open healing approach) Regenerative Therapy. 2025.12; 30 20-30. ( ichushi )

  14. The effect of l-lactide-ε-caprolactone copolymer membrane on alveolar bone preservation: A comparative study using the open healing approach. 2025.12; 30 20-30. ( PubMed, DOI )

  15. Bai, XY; Kawashima, N; Wang, SH; Han, PF; Fujii, M; Sunada-Nara, K; Yu, Z; Okiji, T; Yahata, Y. MicroRNA-210 Suppresses NF-κB Signaling in Lipopolysaccharide-Stimulated Dental Pulp Cells Under Hypoxic Conditions INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025.11; 26 (22): ( PubMed, DOI )

  16. Endodontic Regeneration Therapy: Current Strategies and Tissue Engineering Solutions. 2025.03; 14 (6): ( PubMed, DOI )

  17. Yahata, Y; Handa, K; Ohkura, N; Okamoto, M; Ohshima, J; Itoh, S; Kawashima, N; Tanaka, T; Sato, N; Noiri, Y; Hayashi, M; Okiji, T; Saito, M. Autologous concentrated growth factor mediated accelerated bone healing in root-end microsurgery: A multicenter randomized clinical trial* REGENERATIVE THERAPY. 2023.12; 24 377-384. ( PubMed, DOI )

  18. Irrigation with reduced sodium hypochlorite solution concentration using laser-induced cavitation is effective and safe in rat intraradicular biofilm model. 2023.12; 49 (3): 544-553. ( PubMed, DOI )

  19. Yahata Yoshio, Handa Keisuke, Ohkura Naoto, Okamoto Motoki, Ohshima Jun, Itoh Shusaku, Kawashima Nobuyuki, Tanaka Toshinori, Sato Nobuya, Noiri Yuichiro, Hayashi Mikako, Okiji Takashi, Saito Masahiro. 自家成長因子濃縮物は根尖の顕微鏡下手術での骨治癒加速を媒介する　多施設共同無作為化比較試験(Autologous concentrated growth factor mediated accelerated bone healing in root-end microsurgery: A multicenter randomized clinical trial) Regenerative Therapy. 2023.12; 24 377-384. ( ichushi )

  20. Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease. 2023.03; 23 (1): 187. ( PubMed, DOI )

  21. Correction of large jawbone defect in the mouse using immature osteoblast-like cells and a 3D polylactic acid scaffold. 2022.09; 1 (4): pgac151. ( PubMed, DOI )

  22. A case series describing the risk of periodontal disease in Marfan syndrome patients harboring a possible aortic aneurysm or dissection. 2022.08; 22 (1): 336. ( PubMed, DOI )

  23. Er:YAG laser-induced cavitation can activate irrigation for the removal of intraradicular biofilm. 2022.03; 12 (1): 4897. ( PubMed, DOI )

  24. Clinical Applications of Cell-Scaffold Constructs for Bone Regeneration Therapy. 2021.10; 10 (10): ( PubMed, DOI )

  25. An experimental intraradicular biofilm model in the pig for evaluating irrigation techniques. 2021.04; 21 (1): 177. ( PubMed, DOI )

  26. Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation. 2021.01; 11 (1): 2613. ( PubMed, DOI )

  27. Sato Nobuya, Handa Keisuke, Venkataiah Venkata Suresh, Hasegawa Tatsuya, Njuguna Mary M., Yahata Yoshio, Saito Masahiro. 垂直性骨欠損に対し炭酸アパタイト、βリン酸三カルシウム、ハイドロキシアパタイト、ウシ由来異種骨が示す治癒能の比較(Comparison of the vertical bone defect healing abilities of carbonate apatite, β-tricalcium phosphate, hydroxyapatite and bovine-derived heterogeneous bone) Dental Materials Journal. 2020.04; 39 (2): 309-318. ( ichushi )

  28. Comparison of the vertical bone defect healing abilities of carbonate apatite, β-tricalcium phosphate, hydroxyapatite and bovine-derived heterogeneous bone. 2020.03; 39 (2): 309-318. ( PubMed, DOI )

  29. Effect of antiseptic agents on the surface micro hardness of calcium silicate-based materials. 2020.02; 28 (2): 21350-21356.

  30. Comparison of apical centring ability between incisal-shifted access and traditional lingual access for maxillary anterior teeth. 2017.12; 43 (3): 123-128. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Ricardo Shalina, Kamano Yuya, Harada Futaba, Yahata Yoshio, Margono Anggraini, Saito Masahiro. Whartonゼリー状間葉系間質細胞由来エクソソームの骨再生能(Bone Regenerative Potential of Exosomes Derived from Wharton's Jelly Mesenchymal Stromal Cells). 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集 2025.10.01

  2. Luo Yanshan, 牧 圭一郎, 山本 里沙子, 豊田 康氣, 平野 恵子, 大森 智史, 木村 俊介, 海老原 新, 八幡 祥生. 熱処理加工ニッケルチタン製ロータリーファイルの挿入角度の違いが動的回転疲労抵抗性に与える影響の解析(Effect of different insertion angles on the dynamic cyclic fatigue resistance of heat-treated NiTi rotary instruments). 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集 2025.10.01

  3. Ren C, Tazawa K, Kawashima N, Okiji T, Yahata Y. Metformin Reduces Inflammation and Bone Loss in Apical Periodontitis. Interface Summer Seminar 2025 2025.08.01 仙台

  4. Moe Sandar Kyaw , Yahata Yoshio, Saito Masahiro. 新規歯内充填材の根尖周囲組織反応の評価(Evaluation of periapical tissue reaction of the novel endodontic filling material). 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集 2024.11.01

  5. Venkataiah Venkata Suresh, Suzuki Shigeto, Yahata Yoshio, Saito Masahiro, Kitagawa Akira, Inagaki Masahiko, Handa Keisuke. 未分化骨芽細胞と三次元高分子足場を用いた再生医療等製品の開発(Development of bone regeneration product using immature osteoblasts and three dimensional polymer scaffold). 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集 2022.10.01

  6. Venkat Suresh V., Harada Futaba, Suzuki Shigeto, Kakiuchi Yusuke, Kitagawa Akira, Inagaki Masahiko, Yahata Yoshio, Saito Masahiro. 骨芽細胞を用いた骨再生治療法の開発(Development of osteoblast based bone regeneration therapy). 日本再生歯科医学会誌 2022.03.01

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