Personnel Information

写真a

HAYASHI Yohei


Job title

Associate Professor
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Campus Career 【 display / non-display 】

  • 2025.04
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Oral Health Sciences， Department of Oral Biology， Associate Professor
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Research Areas 【 display / non-display 】

  • Developmental biology

  • Animal life science

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Research Theme 【 display / non-display 】

  • Metabolic regulation of reproductive lifespan, 2023.04 - 2028.03

  • Dynamic reproductive lifespan: Life-long changes and fluctuations in germ cell function and risk for next generation, 2023.04 - 2028.03

  • Role of metabolic regulation in primordial germ cell formation and differentiation, 2019.04 - 2023.03

  • Investigation of the Induction Method for Temperature-Controlled Repeated Thermal Stimulation, 2019.04 - 2022.03

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Published Papers & Misc 【 display / non-display 】

  1. Frequency-Regulated Repeated Micro-Vibration Promotes Osteoblast Differentiation Through BMP Signaling in MC3T3-E1 Cells. 2025.04; 15 (4): 588. ( PubMed, DOI )

  2. Physical Stimulation Methods Developed for In Vitro Neuronal Differentiation Studies of PC12 Cells: A Comprehensive Review 2024.01; 25 (2): 772. ( PubMed, DOI )

  3. LARP7 is required for sex chromosome silencing during meiosis in mice. 2024; 19 (12): e0314329. ( PubMed, DOI )

  4. Nutritional and metabolic control of germ cell fate through O-GlcNAc regulation 2023; 24 (11): e56845. ( PubMed, DOI )

  5. SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells 2022.12; 23 (24): 15602. ( PubMed, DOI )

  6. 林陽平, 生田佳穂, 伊藤(松岡)由美, 丹藤由希子, 竹原雅子花, 森野勝太郎, 前川聡, 松居靖久. 始原生殖細胞形成におけるO-GlcNAc修飾を介した代謝-エピゲノム制御の役割 日本生化学会大会(Web). 2022.11; 95回 2S14m-02. ( ichushi )

  7. Matsui Yasuhisa, Hayashi Yohei. 生殖細胞の非遺伝的遺伝形質および発生を制御する代謝経路(Metabolic pathways regulating the development and non-genomic heritable traits of germ cells) The Journal of Reproduction and Development. 2022.04; 68 (2): 96-103. ( ichushi )

  8. Effect of Beta 2-Adrenergic Receptor Gly16Arg Polymorphism on Taste Preferences in Healthy Young Japanese Adults 2022.03; 14 (7): 1430. ( PubMed, DOI )

  9. Metabolic Control of Germline Formation and Differentiation in Mammals 2022.01; 16 (5-6): 1-16. ( PubMed, DOI )

  10. Metabolic pathways regulating the development and non-genomic heritable traits of germ cells 2022; 68 (2): 96-103. ( PubMed, DOI )

  11. Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes† 2021.04; 105 (1): 64-75. ( PubMed, DOI )

  12. Characterization of PC12 Cell Subclones with Different Sensitivities to Programmed Thermal Stimulation 2020.11; 21 (21): 8356. ( PubMed, DOI )

  13. Proteomic and metabolomic analyses uncover sex-specific regulatory pathways in mouse fetal germline differentiation† 2020.10; 103 (4): 717-735. ( PubMed, DOI )

  14. Watanabe Kei, Hong Guang, Tominami Kanako, Izumi Satoshi, Hayashi Yohei, Kudo Tada-aki. 健康な日本人若年女性におけるβ3-アドレナリン受容体Trp64Arg多型と脂質嗜好性の関連(Association between Beta3-Adrenergic Receptor Trp64Arg Polymorphism and Fat Preference in Healthy Young Japanese Women) The Tohoku Journal of Experimental Medicine. 2019.07; 248 (3): 181-192. ( ichushi )

  15. Mochizuki K, Tando Y, Sekinaka T, Otsuka K, Hayashi Y, Kobayashi H, Kamio A, Ito-Matsuoka Y, Takehara A, Kono T, Osumi N, Matsui Y. SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling. Development (Cambridge, England). 2018.12; 145 (23): ( PubMed, DOI )

  16. Mochizuki K, Hayashi Y, Sekinaka T, Otsuka K, Ito-Matsuoka Y, Kobayashi H, Oki S, Takehara A, Kono T, Osumi N, Matsui Y. Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination. Cell reports. 2018.09; 24 (10): 2682-2693.e6. ( PubMed, DOI )

  17. Hayashi Y, Matsui Y. Metabolomic and Proteomic Analyses of Mouse Primordial Germ Cells. Methods in molecular biology (Clifton, N.J.). 2018.05; 2045 259-269. ( PubMed, DOI )

  18. DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells. 2018; 13 (11): e0205969. ( PubMed, DOI )

  19. Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells 2017.08; 114 (31): 8289-8294. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Comprehensive analysis of age-associated changes in germ cell states during spermatogenesis. 2025.07.12 東京

  2. Understanding the combined effects of aging and environment on murine spermatogenesis. 2025.07.09 札幌

  3. Matsushita Ayumu, Kudo Tada-aki, Hayashi Yohei, Tominami Kanako, Izumi Satoshi, Tanaka Takakuni, Luo You-Ran, Gengyo-Ando Keiko, Noguchi Takuya, Matsuzawa Atsushi, Hong Guang, Nakai Junichi. MC3T3-E1細胞における周波数制御式反復微細振動(FRMV)依存的骨芽細胞分化メカニズムの検討(Investigation of the frequency-regulated micro-vibration(FRMV)-mediated osteoblast differentiation mechanism in MC3T3-E1 Cells). The Journal of Physiological Sciences 2024.05.01

  4. 林 陽平, 金子 仁太郎, 伊藤 由美[松岡], 竹原 雅子花, 古屋 茂樹, 松居 靖久. 生殖細胞の品質の定量に向けて　セリン代謝によるエピゲノム調節を介したオス生殖細胞の分化制御. 日本生化学会大会プログラム・講演要旨集 2023.10.01

  5. Kudo Tada-aki, Hong Guang, Tominami Kanako, Luo You-Ran, Izumi Satoshi, Tanaka Takakuni, Hayashi Yohei, Noguchi Takuya, Matsuzawa Atsushi, Nakai Junichi. 周波数制御式反復微細振動がMC3T3-E1細胞の骨芽細胞分化に与える影響(The Effect of Frequency-Regulated Repeated Micro-Vibration on Osteoblast Differentiation in MC3T3-E1 Cells). The Journal of Physiological Sciences 2023.05.01

  6. Luo You-Ran, Kudo Tada-aki, Tominami Kanako, Izumi Satoshi, Hayashi Yohei, Noguchi Takuya, Matsuzawa Atsushi, Nakai Junichi, Hong Guang. SP600125はPC12-P1F1細胞における温度制御された反復熱刺激による神経突起伸長を促進する(SP600125 Enhanced Neurite Outgrowth induced by Temperature-Controlled Repeated Thermal Stimulation in PC12-P1F1 Cells). The Journal of Physiological Sciences 2022.12.01

  7. Tominami Kanako, Kudo Tada-aki, Hong Guang, Luo You-Ran, Izumi Satoshi, Hayashi Yohei, Noguchi Takuya, Matsuzawa Atsushi, Nakai Junichi. 温度制御された反復熱刺激がMC3T3-E1細胞の骨芽細胞分化に及ぼす影響(The effect of Temperature-Controlled Repeated Thermal Stimulation on osteoblast differentiation in MC3T3-E1 Cells). The Journal of Physiological Sciences 2022.12.01

  8. Narita Kohei, Kudo Tada-aki, Hong Guang, Tominami Kanako, Izumi Satoshi, Hayashi Yohei, Nakai Junichi. ヒトβ2アドレナリン受容体遺伝子のGly16Arg多型と食の嗜好との関連性(Association between the Gly16Arg polymorphism of human beta2-adrenergic receptor gene and food preferences). The Journal of Physiological Sciences 2022.12.01

  9. 林 陽平, 生田 佳穂, 伊藤 由美[松岡], 丹藤 由希子, 竹原 雅子花, 森野 勝太郎, 前川 聡, 松居 靖久. 若手研究者が切り拓く生化学の学際的フロンティア　始原生殖細胞形成におけるO-GlcNAc修飾を介した代謝　エピゲノム制御の役割. 日本生化学会大会プログラム・講演要旨集 2022.11.01

  10. Kudo Tada-aki, Tominami Kanako, Izumi Satoshi, Hayashi Yohei, Noguchi Takuya, Hong Guang. 温度調節式反復温熱刺激(TRTS)高感受性PC12細胞亜株および低感受性PC12細胞亜株の樹立およびその細胞的特徴の検討(Establishment and characterization of neuron-like PC12-derived cell lines with hypersensitivity or hyposensitivity to temperature-regulated repeated thermal stimulation (TRTS)). The Journal of Physiological Sciences 2020.03.01

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