Personnel Information

写真a

ARIMA Yoshimi


Job title

Assistant Professor

Field Introduction URL

http://www.tmd.ac.jp/cbio/

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Campus Career 【 display / non-display 】

  • 2024.11
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Bio-Matrix， Department of Cell Biology， Assistant Professor
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Research Areas 【 display / non-display 】

  • Tumor biology

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Qualification Acquired 【 display / non-display 】

  • Psychiatric Social Worker

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Research Theme 【 display / non-display 】

  • 不均一な乳がんに特異的な腫瘍抗原の同定と免疫細胞活性化メカニズムの解明, 2020.04 - 2023.03

  • Cancer cell interaction mechanisms caused by the complexity of breast cancer tissues, 2016.04 - 2019.03

  • RNA Sequencing Analysis of Distant Metastasis of Breast Cancer Cells, 2013.04 - 2016.03

  • Analysis of cancer stem cell properties andepithelial-mesenchymal transition signals in recurrence and metastasis of breast cancer cells, 2011 - 2012

  • Significance of Rb pathway in the epithelial to mesenchymal transition inducing cancer invasion and metastasis, 2009 - 2010

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Published Papers & Misc 【 display / non-display 】

  1. Yoshimi Arima, Satoko Matsueda, Hideyuki Saya. Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue. Cancers (Basel). 2023.04; 15 (9): ( PubMed, DOI )

  2. Haruki Inoue, Eriko Aimono, Akiyoshi Kasuga, Haruto Tanaka, Aika Iwasaki, Hideyuki Saya, Yoshimi Arima. Pixel-Level Clustering of Hematoxylin-Eosin-Stained Sections of Mouse and Human Biliary Tract Cancer. Biomedicines. 2022.12; 10 (12): ( PubMed, DOI )

  3. Ritsuko Harigai, Ryo Sato, Chikako Hirose, Toshiki Takenouchi, Kenjiro Kosaki, Takanori Hirose, Hideyuki Saya, Yoshimi Arima. Mutation of PTPN11 (Encoding SHP-2) Promotes MEK Activation and Malignant Progression in Neurofibromin-Deficient Cells in a Manner Sensitive to BRAP Mutation. Cancers (Basel). 2022.05; 14 (10): ( PubMed, DOI )

  4. Ryo Sato, Kosuke Imamura, Takashi Semba, Yusuke Tomita, Sho Saeki, Koei Ikeda, Yoshihiro Komohara, Makoto Suzuki, Takuro Sakagami, Hideyuki Saya, Yoshimi Arima. TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma. Cancer Res. 2021.09; 81 (18): 4751-4765. ( PubMed, DOI )

  5. Akiyoshi Kasuga, Takashi Semba, Ryo Sato, Hiroyuki Nobusue, Eiji Sugihara, Hiromasa Takaishi, Takanori Kanai, Hideyuki Saya, Yoshimi Arima. Oncogenic KRAS-expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice. Cancer Sci. 2021.05; 112 (5): 1822-1838. ( PubMed, DOI )

  6. Takashi Semba, Ryo Sato, Akiyoshi Kasuga, Kentaro Suina, Tatsuhiro Shibata, Takashi Kohno, Makoto Suzuki, Hideyuki Saya, Yoshimi Arima. Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d. Cancers (Basel). 2020.12; 12 (12): ( PubMed, DOI )

  7. Mari Hosonaga, Hideyuki Saya, Yoshimi Arima. Molecular and cellular mechanisms underlying brain metastasis of breast cancer. Cancer Metastasis Rev. 2020.09; 39 (3): 711-720. ( PubMed, DOI )

  8. Yoshimi Arima, Hiroyuki Nobusue, Hideyuki Saya. Targeting of cancer stem cells by differentiation therapy. Cancer Sci. 2020.08; 111 (8): 2689-2695. ( PubMed, DOI )

  9. Mari Hosonaga, Yoshimi Arima, Oltea Sampetrean, Daisuke Komura, Ikuko Koya, Takashi Sasaki, Eiichi Sato, Hideyuki Okano, Jun Kudoh, Shumpei Ishikawa, Hideyuki Saya, Takashi Ishikawa. HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer. Int J Mol Sci. 2018.07; 19 (8): ( PubMed, DOI )

  10. T Ouchi, S Morikawa, S Shibata, M Takahashi, M Yoshikawa, T Soma, H Miyashita, W Muraoka, K Kameyama, H Kawana, Y Arima, H Saya, H Okano, T Nakagawa, S Asoda. Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells. J Dent Res. 2018.07; 97 (7): 779-786. ( PubMed, DOI )

  11. Takashi Semba, Eiji Sugihara, Nagisa Kamoshita, Sayaka Ueno, Keitaro Fukuda, Masafumi Yoshino, Kazumasa Takao, Kazunori Yoshikawa, Kenji Izuhara, Yoshimi Arima, Makoto Suzuki, Hideyuki Saya. Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma. Cancer Sci. 2018.05; 109 (5): 1447-1454. ( PubMed, DOI )

  12. Ritsuko Harigai, Shigeki Sakai, Hiroyuki Nobusue, Chikako Hirose, Oltea Sampetrean, Noriaki Minami, Yukie Hata, Takashi Kasama, Takanori Hirose, Toshiki Takenouchi, Kenjiro Kosaki, Kazuo Kishi, Hideyuki Saya, Yoshimi Arima. Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells. Sci Rep. 2018.04; 8 (1): 6069. ( PubMed, DOI )

  13. Yuji Otsuki, Hideyuki Saya, Yoshimi Arima. Prospects for new lung cancer treatments that target EMT signaling. Dev Dyn. 2018.03; 247 (3): 462-472. ( PubMed, DOI )

  14. Noriaki Minami, Yusuke Maeda, Shunsuke Shibao, Yoshimi Arima, Fumiharu Ohka, Yutaka Kondo, Koji Maruyama, Masatoshi Kusuhara, Takashi Sasayama, Eiji Kohmura, Hideyuki Saya, Oltea Sampetrean. Organotypic brain explant culture as a drug evaluation system for malignant brain tumors. Cancer Med. 2017.11; 6 (11): 2635-2645. ( PubMed, DOI )

  15. Takashi Semba, Yoshimi Arima. Epithelial-mesenchymal transition is predetermined by the epigenetic state of the skin tumor cell of origin. Stem Cell Investig. 2017; 4 37. ( PubMed, DOI )

  16. Ryo Sato, Teppei Nakano, Mari Hosonaga, Oltea Sampetrean, Ritsuko Harigai, Takashi Sasaki, Ikuko Koya, Hideyuki Okano, Jun Kudoh, Hideyuki Saya, Yoshimi Arima. RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis. Biomed Res Int. 2017; 2017 8032910. ( PubMed, DOI )

  17. Yayoi Takamoto, Yoshimi Arima, Hideyuki Saya. Development of mouse models of malignant phyllodes tumors by transplantation of syngeneic mammary gland cells expressing mutant H-Ras. Genes Cells. 2016.11; 21 (11): 1244-1252. ( PubMed, DOI )

  18. Ryo Sato, Takashi Semba, Hideyuki Saya, Yoshimi Arima. Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets. Stem Cells. 2016.08; 34 (8): 1997-2007. ( PubMed, DOI )

  19. Kazuhiro Umeyama, Kota Watanabe, Masahito Watanabe, Keisuke Horiuchi, Kazuaki Nakano, Masateru Kitashiro, Hitomi Matsunari, Tokuhiro Kimura, Yoshimi Arima, Oltea Sampetrean, Masaki Nagaya, Masahiro Saito, Hideyuki Saya, Kenjiro Kosaki, Hiroshi Nagashima, Morio Matsumoto. Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts. Sci Rep. 2016.04; 6 24413. ( PubMed, DOI )

  20. Ryo Maruoka, Toshiki Takenouchi, Chiharu Torii, Atsushi Shimizu, Kumiko Misu, Koichiro Higasa, Fumihiko Matsuda, Arihito Ota, Katsumi Tanito, Akira Kuramochi, Yoshimi Arima, Fujio Otsuka, Yuichi Yoshida, Keiji Moriyama, Michihito Niimura, Hideyuki Saya, Kenjiro Kosaki. The use of next-generation sequencing in molecular diagnosis of neurofibromatosis type 1: a validation study. Genet Test Mol Biomarkers. 2014.11; 18 (11): 722-735. ( PubMed, DOI )

  21. Mari Hosonaga, Yoshimi Arima, Eiji Sugihara, Norio Kohno, Hideyuki Saya. Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells. Cancer Sci. 2014.07; 105 (7): 779-787. ( PubMed, DOI )

  22. K Kai, T Iwamoto, T Kobayashi, Y Arima, Y Takamoto, N Ohnishi, C Bartholomeusz, R Horii, F Akiyama, G N Hortobagyi, L Pusztai, H Saya, N T Ueno. Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells. Oncogene. 2014.01; 33 (4): 440-448. ( PubMed, DOI )

  23. Takaaki M Goto, Yoshimi Arima, Osamu Nagano, Hideyuki Saya. Lysyl oxidase is induced by cell density-mediated cell cycle suppression via RB-E2F1-HIF-1α axis. Cell Struct Funct. 2013; 38 (1): 9-14. ( PubMed, DOI )

  24. Yoshimi Arima, Naoki Hayashi, Hidemi Hayashi, Mikako Sasaki, Kazuharu Kai, Eiji Sugihara, Eriko Abe, Atsushi Yoshida, Shuji Mikami, Seigo Nakamura, Hideyuki Saya. Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer. Int J Cancer. 2012.06; 130 (11): 2568-2579. ( PubMed, DOI )

  25. Tatsuyuki Chiyoda, Naoyuki Sugiyama, Takatsune Shimizu, Hideaki Naoe, Yusuke Kobayashi, Jo Ishizawa, Yoshimi Arima, Hiroshi Tsuda, Masaaki Ito, Kozo Kaibuchi, Daisuke Aoki, Yasushi Ishihama, Hideyuki Saya, Shinji Kuninaka. LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression. J Cell Biol. 2012.05; 197 (5): 625-641. ( PubMed, DOI )

  26. Yoshimi Arima, Hidemi Hayashi, Mikako Sasaki, Mari Hosonaga, Takaaki M Goto, Tatsuyuki Chiyoda, Shinji Kuninaka, Tatsuhiro Shibata, Hirokazu Ohata, Hitoshi Nakagama, Yoichi Taya, Hideyuki Saya. Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer. J Biol Chem. 2012.03; 287 (11): 7896-7906. ( PubMed, DOI )

  27. Yoshimi Arima, Hidemi Hayashi, Kanako Kamata, Takaaki M Goto, Mikako Sasaki, Akira Kuramochi, Hideyuki Saya. Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1. Exp Dermatol. 2010.08; 19 (8): e136-e141. ( PubMed, DOI )

  28. Kazuharu Kai, Yoshimi Arima, Toshio Kamiya, Hideyuki Saya. Breast cancer stem cells. Breast Cancer. 2010.04; 17 (2): 80-85. ( PubMed, DOI )

  29. Kazuharu Kai, Osamu Nagano, Eiji Sugihara, Yoshimi Arima, Oltea Sampetrean, Takatsugu Ishimoto, Masaya Nakanishi, Naoto T Ueno, Hirotaka Iwase, Hideyuki Saya. Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model. Cancer Sci. 2009.12; 100 (12): 2275-2282. ( PubMed, DOI )

  30. Yoshimi Arima, Yasumichi Inoue, Tatsuhiro Shibata, Hidemi Hayashi, Osamu Nagano, Hideyuki Saya, Yoichi Taya. Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. Cancer Res. 2008.07; 68 (13): 5104-5112. ( PubMed, DOI )

  31. Christian Bronner, Mayada Achour, Yoshimi Arima, Thierry Chataigneau, Hideyuki Saya, Valérie B Schini-Kerth. The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future? Pharmacol Ther. 2007.09; 115 (3): 419-434. ( PubMed, DOI )

  32. S Kuninaka, S-I Iida, T Hara, M Nomura, H Naoe, T Morisaki, M Nitta, Y Arima, T Mimori, S Yonehara, H Saya. Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation. Oncogene. 2007.04; 26 (17): 2395-2406. ( PubMed, DOI )

  33. Yoshihiro Komohara, Mamoru Harada, Yoshimi Arima, Shigetaka Suekane, Masanori Noguchi, Akira Yamada, Kyogo Itoh, Kei Matsuoka. Identification of target antigens in specific immunotherapy for renal cell carcinoma. J Urol. 2007.03; 177 (3): 1157-1162. ( PubMed, DOI )

  34. Yoshihiro Komohara, Mamoru Harada, Yoshimi Arima, Shigetaka Suekane, Masanori Noguchi, Akira Yamada, Kyogo Itoh, Kei Matsuoka. Anti-cancer vaccine candidates in specific immunotherapy for bladder carcinoma. Int J Oncol. 2006.12; 29 (6): 1555-1560. ( PubMed )

  35. Yoshimi Arima, Satoko Matsueda, Hirohisa Yano, Mamoru Harada, Kyogo Itoh. Parathyroid hormone-related protein as a common target molecule in specific immunotherapy for a wide variety of tumor types. Int J Oncol. 2005.10; 27 (4): 981-988. ( PubMed )

  36. Naoki Yajima, Ryuya Yamanaka, Takashi Mine, Naoto Tsuchiya, Jumpei Homma, Masakazu Sano, Terukazu Kuramoto, Yayoi Obata, Nobukazu Komatsu, Yoshimi Arima, Akira Yamada, Minoru Shigemori, Kyogo Itoh, Ryuichi Tanaka. Immunologic evaluation of personalized peptide vaccination for patients with advanced malignant glioma. Clin Cancer Res. 2005.08; 11 (16): 5900-5911. ( PubMed, DOI )

  37. Shinji Kuninaka, Masanobu Nomura, Toru Hirota, Shin-Ichi Iida, Toshihiro Hara, Shinobu Honda, Naoko Kunitoku, Takashi Sasayama, Yoshimi Arima, Tomotoshi Marumoto, Kageharu Koja, Shin Yonehara, Hideyuki Saya. The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death. Oncogene. 2005.08; 24 (34): 5287-5298. ( PubMed, DOI )

  38. Yoshimi Arima, Masayuki Nitta, Shinji Kuninaka, Dongwei Zhang, Toshiyoshi Fujiwara, Yoichi Taya, Mitsuyoshi Nakao, Hideyuki Saya. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem. 2005.05; 280 (19): 19166-19176. ( PubMed, DOI )

  39. Yi Wang, Mamoru Harada, Hirohisa Yano, Sachiko Ogasawara, Hiroko Takedatsu, Yoshimi Arima, Satoko Matsueda, Akira Yamada, Kyogo Itoh. Prostatic acid phosphatase as a target molecule in specific immunotherapy for patients with nonprostate adenocarcinoma. J Immunother. 2005; 28 (6): 535-541. ( PubMed, DOI )

  40. Dongwei Zhang, Toru Hirota, Tomotoshi Marumoto, Michio Shimizu, Naoko Kunitoku, Takashi Sasayama, Yoshimi Arima, Liping Feng, Misao Suzuki, Motohiro Takeya, Hideyuki Saya. Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene. 2004.11; 23 (54): 8720-8730. ( PubMed, DOI )

  41. Shinobu Honda, Tomotoshi Marumoto, Toru Hirota, Masayuki Nitta, Yoshimi Arima, Michio Ogawa, Hideyuki Saya. Activation of m-calpain is required for chromosome alignment on the metaphase plate during mitosis. J Biol Chem. 2004.03; 279 (11): 10615-10623. ( PubMed, DOI )

  42. Yoshimi Arima, Toru Hirota, Christian Bronner, Marc Mousli, Toshiyoshi Fujiwara, Shin-ichiro Niwa, Hiroyuki Ishikawa, Hideyuki Saya. Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition. Genes Cells. 2004.02; 9 (2): 131-142. ( PubMed, DOI )

  43. Masayuki Nitta, Hiromasa Tsuiki, Yoshimi Arima, Kei Harada, Takahumi Nishizaki, Kousuke Sasaki, Tatsuyuki Mimori, Yukitaka Ushio, Hideyuki Saya. Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability. Genes Cells. 2002.02; 7 (2): 151-162. ( PubMed, DOI )

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Awards & Honors 【 display / non-display 】

  • 第45回(2016年度)内藤記念特定研究助成金(第41回内藤コンファレンス ポスター発表者)，2017.03

  • 2013年度 日本がん分子標的治療学会研究奨励賞，2014.06

  • 第1回日本レックリングハウゼン病学会賞(Riccardi賞)，2010.11

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