Personnel Information

写真a

MOROISHI TOSHIRO


Job title

Professor

Homepage URL

https://www.moroishi-lab.com/english/

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Campus Career 【 display / non-display 】

  • 2024.09
    　
    　
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， ， Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， Advanced Pathophysiological Science， Cellular Dynamics， Professor
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External Career 【 display / non-display 】

  • 2013.04
    -
    2017.08
    University of California, San Diego,, Department of Pharmacology and Moores Cancer Center,, Postdoctoral fellow
  • 2017.12
    -
    2019.12
    Kumamoto University, Faculty of Life Sciences, Associate Professor
  • 2020.01
    -
    2025.03
    Kumamoto University, Faculty of Life Sciences, Professor
  • 2024.09
    -
    Now
    Institute of Science Tokyo, Medical Research Laboratory, Institute of Integrated Research, Professor
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Academic Society Affiliations 【 display / non-display 】

  • Japanese Association of Cancer Immunology

  • The Molecular Biology Society of Japan

  • The Japanese Biochemical Society

  • The Japanese Cancer Association

  • The Japanese Pharmacological Society

  • The Japanese BioIron Society

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Academic Activity 【 display / non-display 】

  • 2020.04
    -
    Now
    Communications Biology (Springer Nature) Editorial Board Member
  • 2023.04
    -
    Now
    The Japanese Biochemical Society Councilor
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Research Areas 【 display / non-display 】

  • Developmental biology

  • Molecular biology

  • Medical biochemistry

  • Cell biology

  • Tumor biology

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Research Theme 【 display / non-display 】

  • Towards the understanding of cellular community maintained by cell competition and symbiosis, 2024.04 - 2031.03

  • 哺乳類の器官形成における[適応多様性]の解明, 2024.04 - 2027.03

  • [適応多様性]研究領域の拡大・発展に向けた総括研究, 2024.04 - 2027.03

  • DNAイベントレコーダー細胞, 2023.10 - 2029.03

  • 胎児丸ごとの体外培養法を用いた次世代オルガノイドの開発, 2023.07 - 2026.03

  • 生体における鉄動態“可視化"への挑戦, 2023.06 - 2025.03

  • F. nucleatumによる大腸癌進展と鉄代謝の関連, 2023.04 - 2026.03

  • 体外胚培養システムの構築による哺乳類器官形成期の組織自律性の解明, 2022.06 - 2024.03

  • 腫瘍微小環境における鉄代謝の役割解明, 2021.04 - 2024.03

  • A challenge to reveal and regulate multi-cellular networks that remove abnormal cells and maintain tissue homeostasis, 2020.10 - 2024.03

  • 革新的治療開発を目指した腸内細菌Fusobacteriumと腫瘍免疫の網羅的解析, 2020.04 - 2023.03

  • Towards an understanding of iron metabolism: comprehensive identification of iron-related molecules, 2018.06 - 2020.03

  • Elucidating the regulatory mechanisms and physiological functions of immunomodulation by the Hippo intracellular signaling pathway, 2018.04 - 2021.03

  • Towards an understanding of immunostimulatory extracellular vesicles in cancer, 2017.12 - 2021.03

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Published Papers & Misc 【 display / non-display 】

  1. Tatsuya Morishima, Md Fakruddin, Yohei Kanamori, Takeshi Masuda, Akiko Ogawa, Yuxin Wang, Vivien A C Schoonenberg, Falk Butter, Yuichiro Arima, Takaaki Akaike, Toshiro Moroishi, Kazuhito Tomizawa, Toshio Suda, Fan-Yan Wei, Hitoshi Takizawa. Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis. Science advances. 2025.02; 11 (8): eadu3011. ( PubMed, DOI )

  2. Pawaret Panyajai, Natsima Viriyaadhammaa, Sawitree Chiampanichayakul, Yasuhisa Sakamoto, Siriporn Okonogi, Toshiro Moroishi, Songyot Anuchapreeda. Anticancer and cancer preventive activities of shogaol and curcumin from Zingiberaceae family plants in KG-1a leukemic stem cells BMC Complementary Medicine and Therapies. 2025.02; 25 (1): ( DOI )

  3. Yumoto Shinsei, Horiguchi Haruki, Kadomatsu Tsuyoshi, Horino Taichi, Sato Michio, Terada Kazutoyo, Miyata Keishi, Moroishi Toshiro, Baba Hideo, Oike Yuichi. Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy(タイトル和訳中) Cancer Science. 2024.12; 115 (12): 3846-3858. ( ichushi )

  4. Yasuhisa Sakamoto, Akiyoshi Uezu, Koji Kikuchi, Jangmi Kang, Eiko Fujii, Toshiro Moroishi, Shiro Suetsugu, Hiroyuki Nakanishi. The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature The EMBO Journal. 2024.10; ( DOI )

  5. Chanida Thinyakul, Yasuhisa Sakamoto, Mayuko Shimoda, Yanliang Liu, Suyanee Thongcho, Omnia Reda, Akihiro Nita, Romgase Sakamula, Somponnat Sampattavanich, Ayato Maeda, Paweenapon Chunthaboon, David Nduru, Mayumi Niimura, Yohei Kanamori, Peti Thuwaji, Keiichi I. Nakayama, Kun-Liang Guan, Yorifumi Satou, Chanitra Thuwaji, Toshiro Moroishi. Hippo pathway in cancer cells induces NCAM1+αSMA+ fibroblasts to modulate tumor microenvironment Communications Biology. 2024.10; 7 (1): 1343. ( PubMed, DOI )

  6. Tomoya Yamashita, Haruki Horiguchi, Tsuyoshi Kadomatsu, Michio Sato, Toshiro Moroishi, Yuichi Oike. Immunotherapy-induced reprogramming of cancer-associated fibroblasts can promote tumor progression. Genes to cells : devoted to molecular & cellular mechanisms. 2024.10; ( PubMed, DOI )

  7. Shinsei Yumoto, Haruki Horiguchi, Tsuyoshi Kadomatsu, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Toshiro Moroishi, Hideo Baba, Yuichi Oike. Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy. Cancer science. 2024.09; ( PubMed, DOI )

  8. Hao Li, Yohei Kanamori, Toshiro Moroishi. Cell attachment defines sensitivity to cold stress via the Hippo pathway Biochemical and Biophysical Research Communications. 2024.07; 730 150373. ( DOI )

  9. Koki Murata, Kai Harayama, Mayuko Shimoda, Mayumi Niimura, Masahiro Wakao, Yasuo Suda, Toshiro Moroishi, Hiroyuki Shinchi. Improvement of the Nuclease Resistance and Immunostimulatory Activity of CpG Oligodeoxynucleotides by Conjugation to Sugar-Immobilized Gold Nanoparticles Bioconjugate Chemistry. 2024.05; 35 (6): 804-815. ( DOI )

  10. Akihiro Nita, Toshiro Moroishi. Hippo pathway in cell–cell communication: emerging roles in development and regeneration Inflammation and Regeneration. 2024.04; 44 (1): ( DOI )

  11. Nita Akihiro, Moroishi Toshiro. 細胞間情報伝達におけるHippo経路　発生と再生において判明しつつある役割(Hippo pathway in cell-cell communication: emerging roles in development and regeneration) Inflammation and Regeneration. 2024.04; 44 s41232-024. ( ichushi )

  12. Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy. 2024.03; ( PubMed, DOI )

  13. Hinokuma Hironori, Kanamori Yohei, Ikeda Koei, Hao Li, Maruno Masataka, Yamane Taishi, Maeda Ayato, Nita Akihiro, Shimoda Mayuko, Niimura Mayumi, Takeshima Yuki, Li Shuran, Suzuki Makoto, Moroishi Toshiro. 肺癌細胞増殖における第一鉄と第二鉄で異なる機能(Distinct functions between ferrous and ferric iron in lung cancer cell growth) Cancer Science. 2023.11; 114 (11): 4355-4364. ( ichushi )

  14. Hironori Hinokuma, Yohei Kanamori, Koei Ikeda, Li Hao, Masataka Maruno, Taishi Yamane, Ayato Maeda, Akihiro Nita, Mayuko Shimoda, Mayumi Niimura, Yuki Takeshima, Shuran Li, Makoto Suzuki, Toshiro Moroishi. Distinct functions between ferrous and ferric iron in lung cancer cell growth. Cancer science. 2023.09; ( PubMed, DOI )

  15. Bu Luke, Yonemura Atsuko, Yasuda-Yoshihara Noriko, Uchihara Tomoyuki, Ismagulov Galym, Takasugi Sanae, Yasuda Tadahito, Okamoto Yuya, Kitamura Fumimasa, Akiyama Takahiko, Arima Kota, Itoyama Rumi, Zhang Jun, Fu Lingfeng, Hu Xichen, Wei Feng, Arima Yuichiro, Moroishi Toshiro, Nishiyama Koichi, Sheng Guojun, Mukunoki Toshifumi, Otani Jun, Baba Hideo, Ishimoto Takatsugu. 腫瘍微小環境における15-PGDHの枯渇は膵臓癌における線維性腫瘍形成と血管新生を促進する(Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer) Cancer Science. 2022.10; 113 (10): 3579-3592. ( ichushi )

  16. Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto, Mayuko Shimoda, Mayumi Niimura, Shingo Usuki, Noriko Yasuda-Yoshihara, Masato Niwa, Yoshifumi Baba, Takatsugu Ishimoto, Yoshihiro Komohara, Tomohiro Sawa, Tasuku Hirayama, Hideo Baba, Toshiro Moroishi. Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in macrophages and is associated with colorectal cancer progression JCI Insight. 2022.09; 7 (21): ( PubMed, DOI )

  17. Luke Bu, Atsuko Yonemura, N. Yasuda‐Yoshihara, Tomoyuki Uchihara, Galym Ismagulov, Sanae Takasugi, Tadahito Yasuda, Yuya Okamoto, Fumimasa Kitamura, Takahiko Akiyama, Kota Arima, Rumi Itoyama, Jun Zhang, Lingfeng Fu, Xichen Hu, Feng Wei, Yuichiro Arima, Toshiro Moroishi, Koichi Nishiyama, Guojun Sheng, Toshifumi Mukunoki, Jun Otani, Hideo Baba, Takatsugu Ishimoto. Tumor microenvironmental <scp>15‐PGDH</scp> depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer Cancer Science. 2022.07; 113 (10): 3579-3592. ( PubMed, DOI )

  18. Haruki Horiguchi, Tsuyoshi Kadomatsu, Shinsei Yumoto, Takeshi Masuda, Keishi Miyata, Shuji Yamamura, Michio Sato, Jun Morinaga, Sumio Ohtsuki, Hideo Baba, Toshiro Moroishi, Yuichi Oike. Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis Oncogene. 2022.07; 41 (33): 4028-4041. ( PubMed, DOI )

  19. Hiroyuki Shinchi, Fumikazu Komaki, Masaharu Yuki, Haruka Ohara, Naohiro Hayakawa, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, Yasuo Suda. Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects ACS Chemical Biology. 2022.03; 17 (4): 957-968. ( DOI )

  20. Daichi Nomoto, Yoshifumi Baba, Yang Liu, Hiroyasu Tsutsuki, Kazuo Okadome, Kazuto Harada, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Toshiro Moroishi, Yoshihiro Komohara, Tomohiro Sawa, Hideo Baba. Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway Cancer Letters. 2022.01; 530 59-67. ( PubMed, DOI )

  21. Le Yu, Dan Zhou, Guiming Zhang, Zhonglu Ren, Xin Luo, Peng Liu, Steven W. Plouffe, Zhipeng Meng, Toshiro Moroishi, Yilei Li, Yiyue Zhang, Joan Heller Brown, Shuwen Liu, Kun‐Liang Guan. Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence Molecular Oncology. 2022; ( DOI )

  22. ANXious for YAP 2021.07; ( DOI )

  23. Hiroyuki Shinchi, Masaharu Yuki, Takayoshi Yamauchi, Mayumi Niimura, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, Yasuo Suda. Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities ACS Applied Bio Materials. 2021.03; 4 (3): 2732-2741. ( DOI )

  24. Yamauchi Takayoshi, Moroishi Toshiro. 腫瘍免疫における腫瘍由来細胞外小胞の陰と陽(【Medical chemistry of extracellular vesicles】The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity) The Journal of Biochemistry. 2021.02; 169 (2): 155-161. ( ichushi )

  25. The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity 2021; ( DOI )

  26. Heat stress activates YAP/TAZ to induce the heat shock transcriptome 2020.12; 22 (12): 1447-1459. ( DOI )

  27. Haruki Horiguchi, Tsuyoshi Kadomatsu, Keishi Miyata, Kazutoyo Terada, Michio Sato, Daisuke Torigoe, Jun Morinaga, Toshiro Moroishi, Yuichi Oike. Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis Oncogene. 2020.10; ( DOI )

  28. Shimoda Mayuko, Moroishi Toshiro. Hippo pathwayとノンコーディングRNAとの新たなリンク(The Emerging Link between the Hippo Pathway and Non-coding RNA) Biological & Pharmaceutical Bulletin. 2020.01; 43 (1): 1-10. ( ichushi )

  29. Spotlight on early-career researchers: an interview with Toshiro Moroishi 2019.12; 2 (1): ( DOI )

  30. Haruki Horiguchi, Tsuyoshi Kadomatsu, Ryoma Kurahashi, Chiaki Hara, Keishi Miyata, Masaya Baba, Hironobu Osumi, Kazutoyo Terada, Kimi Araki, Toshiyuki Takai, Tomomi Kamba, W Marston Linehan, Toshiro Moroishi, Yuichi Oike. Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity. Genes & development. 2019.12; 33 (23-24): 1641-1656. ( PubMed, DOI )

  31. Shinchi, H, Yamaguchi, T, Moroishi, T, Yuki, M, Wakao, M, Hayashi, T, Cottam, H.B, Carson, D.A, Suda, Y. Gold nanoparticles co-immobilized with small molecule toll-like receptor 7 ligand and α-mannose as adjuvants Bioconjugate Chem.. 2019.10; 30 2811-2821. ( DOI )

  32. Hippo Pathway in Mammalian Adaptive Immune System 2019.04; 8 (5): 398. ( DOI )

  33. BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling 2019.04; 116 (15): 7363-7370. ( DOI )

  34. Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. 2019.04; 216 (4): 950-965. ( PubMed, DOI )

  35. Ei Ei Mon , Wei Fan-Yan, Ahmad Raja Norazireen Raja, Yamamoto Takahiro, Moroishi Toshiro, Tomizawa Kazuhito. sideroflexin 2によるミトコンドリアでの鉄恒常性の制御(Regulation of mitochondrial iron homeostasis by sideroflexin 2) The Journal of Physiological Sciences. 2019.03; 69 (2): 359-373. ( ichushi )

  36. Mon, E.E, Wei, F.Y, Ahmad, R.N.R, Yamamoto, T, Moroishi, T, Tomizawa, K. Regulation of mitochondrial iron homeostasis by sideroflexin 2. J. Physiol. Sci.. 2019.03; 69 (2): 359-373. ( PubMed, DOI )

  37. RAP2 mediates mechanoresponses of the Hippo pathway 2018.08; 560 (7720): 655-660. ( DOI )

  38. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor 2018.07; 9 (1): 2372. ( DOI )

  39. Cell type-dependent function of LATS1/2 in cancer cell growth 2018; 38 (14): 2595-2610. ( DOI )

  40. Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma 2017.12; 32 (6): 856-868.e5. ( DOI )

  41. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation 2017.08; 19 (8): 996-1002. ( DOI )

  42. Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells 2017.07; 8 1-13. ( DOI )

  43. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis 2017.02; 114 (7): 1643-1648. ( DOI )

  44. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells 2017.01; 37 ( DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 諸石 寿朗, Thinyakul Chanida, 柳 彦良, 森田 康之. Hippo経路は力学シグナルを介して免疫抑制性の腫瘍微小環境を構築する(The Hippo pathway constructs an immunosuppressive tumor microenvironment through mechanical signaling). 日本癌学会総会記事 2024.09.01

  2. Shimoda Mayuko, Niimura Mayumi, Takeshima Yuki, Thinyakul Chanida, Harada Narumi, Liu Saisai, Moroishi Toshiro. 抗SARS-CoV-2免疫反応および抗体産生株　鉄代謝がB細胞の抗体産生に及ぼす影響(Anti SARS-CoV-2 immune responses and Antibody producers　The effect of iron metabolism on antibody production of B cell). 日本免疫学会総会・学術集会記録 2022.11.01

  3. 諸石 寿朗. Hippoシグナル経路の新展開　がんと免疫におけるHippo経路の新たな理解(An emerging understanding of the Hippo pathway in cancer and immunity). 日本細胞生物学会大会講演要旨集 2021.06.01

  4. 諸石 寿朗. 細胞外小胞の医化学　細胞外小胞とHippo経路による抗腫瘍免疫の調節(Regulation of anti-tumor immunity by extracellular vesicles and the Hippo pathway). 日本生化学会大会プログラム・講演要旨集 2020.09.01

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Awards & Honors 【 display / non-display 】

  • 科学技術分野の文部科学大臣表彰 若手科学者賞(令和3年度)，Ministry of Education, Culture, Sports, Science and Technology (MEXT)，2021.04

  • 花王科学奨励賞(平成31年度)，The Kao Foundation for Arts and Sciences，2019.06

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External class subject 【 display / non-display 】

  • Special Lecture I/II on CMHA，Graduate School of Medical Sciences, Kumamoto University

  • Practice I/II on CMHA，Graduate School of Medical Sciences, Kumamoto University

  • Special Practice，Graduate School of Medical Sciences, Kumamoto University

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