Graduating School 【 display / non-display 】
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The University of Tokyo, Faculty of Pharmaceutical Science, 1999.03, Graduated
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The University of Tokyo, Graduate School of Pharmaceutical Sciences, Department of Pharmaceutical Biology, 2004.03, Graduated
Graduate School 【 display / non-display 】
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The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 2004.03, Completed
Campus Career 【 display / non-display 】
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2024.07-2024.09Tokyo Medical and Dental University, Medical Research Institute, Division of Visionary Life Science, Department of Biochemical Pathophysiology, Assistant Professor
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2024.10-NowInstitute of Science Tokyo, -, Institute of Integrated Research, -, Biochemical Pathophysiology, Assistant Professor
External Career 【 display / non-display 】
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2004.04-2005.02, Administrative Staff
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2005.03-2012.05, Assistant Professor
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2012.06-2016.02IFOM, Institute of Molecular Oncology of AIRC, Postdoctoral fellow
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2016.03-2024.06Kobe University, Junior Associate Professor
Research Areas 【 display / non-display 】
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Tumor biology
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Cell biology
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Pathological biochemistry
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Molecular biology
Qualification Acquired 【 display / non-display 】
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Chief Person of Radiation Handling (first and second kind)
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Pharmacist
Published Papers & Misc 【 display / non-display 】
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Kajiho H, Sakisaka T. Degradation of STIM1 through FAM134B-mediated ER-phagy is potentially involved in cell proliferation. The Journal of biological chemistry. 2024.09; 300 (9): 107674. ( PubMed, DOI )
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Anggrandariyanny PC, Kajiho H, Yamamoto Y, Sakisaka T. Lunapark ubiquitinates atlastin-2 for the tubular network formation of the endoplasmic reticulum. Journal of biochemistry. 2022.09; 172 (4): 245-257. ( PubMed, DOI )
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Kajiho H, Yamamoto Y, Sakisaka T. CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum Scientific Reports. 2019.09; 9 13152.
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Kajiho H, Kajiho Y, Scita G. Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A Small GTPases. 2018.07; 9 (4): 304-309. ( PubMed, DOI )
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Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A, Vecchi M, Chavrier P, Perez F, Scita G. RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs. EMBO reports. 2016.07; 17 (7): 1061-80. ( PubMed, DOI )
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Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G. The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination. Developmental cell. 2014.09; 30 (5): 553-68. ( PubMed, DOI )
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Palamidessi A, Frittoli E, Ducano N, Offenhauser N, Sigismund S, Kajiho H, Parazzoli D, Oldani A, Gobbi M, Serini G, Di Fiore PP, Scita G, Lanzetti L. The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration. Current biology : CB. 2013.12; 23 (23): 2355-64. ( PubMed, DOI )
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Fukuyama M, Sakuma K, Park R, Kasuga H, Nagaya R, Atsumi Y, Shimomura Y, Takahashi S, Kajiho H, Rougvie A, Kontani K, Katada T. C. elegans AMPKs promote survival and arrest germline development during nutrient stress. Biology open. 2012.10; 1 (10): 929-36. ( PubMed, DOI )
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Hata S, Hirayama J, Kajiho H, Nakagawa K, Hata Y, Katada T, Furutani-Seiki M, Nishina H. A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents. The Journal of biological chemistry. 2012.06; 287 (26): 22089-98. ( PubMed, DOI )
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Kajiho H, Fukushima S, Kontani K, Katada T. RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin. PloS one. 2012; 7 (1): e30575. ( PubMed, DOI )
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Kajiho H, Sakurai K, Minoda T, Yoshikawa M, Nakagawa S, Fukushima S, Kontani K, Katada T. Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31. The Journal of biological chemistry. 2011.07; 286 (27): 24364-73. ( PubMed, DOI )
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Takahashi S, Ebihara A, Kajiho H, Kontani K, Nishina H, Katada T. RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. Cell death and differentiation. 2011.04; 18 (4): 645-55. ( PubMed, DOI )
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Takahashi S, Sakurai K, Ebihara A, Kajiho H, Saito K, Kontani K, Nishina H, Katada T. RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs. Nucleic acids research. 2011.04; 39 (8): 3446-57. ( PubMed, DOI )
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Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, Nishina H. p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription. Stem cells and development. 2010.11; 19 (11): 1723-34. ( PubMed, DOI )
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Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, Nishina H. Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. The Biochemical journal. 2010.03; 427 (2): 237-45. ( PubMed, DOI )
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Saito R, Yamasaki T, Nagai Y, Wu J, Kajiho H, Yokoi T, Noda E, Nishina S, Niwa H, Azuma N, Katada T, Nishina H. CrxOS maintains the self-renewal capacity of murine embryonic stem cells. Biochemical and biophysical research communications. 2009.12; 390 (4): 1129-35. ( PubMed, DOI )
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Kobayashi T, Hori Y, Ueda N, Kajiho H, Muraoka S, Shima F, Kataoka T, Kontani K, Katada T. Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome. Biochemical and biophysical research communications. 2009.04; 381 (3): 439-42. ( PubMed, DOI )
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Tanemura S, Momose H, Shimizu N, Kitagawa D, Seo J, Yamasaki T, Nakagawa K, Kajiho H, Penninger JM, Katada T, Nishina H. Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. Journal of biochemistry. 2009.03; 145 (3): 345-54. ( PubMed, DOI )
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Yoshikawa M, Kajiho H, Sakurai K, Minoda T, Nakagawa S, Kontani K, Katada T. Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles. Biochemical and biophysical research communications. 2008.07; 372 (1): 168-72. ( PubMed, DOI )
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Shintani M, Tada M, Kobayashi T, Kajiho H, Kontani K, Katada T. Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase. Biochemical and biophysical research communications. 2007.06; 357 (3): 661-7. ( PubMed, DOI )
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Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, Ichijo H, Katada T, Nishina H. Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. The EMBO journal. 2006.07; 25 (14): 3286-97. ( PubMed, DOI )
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Kajiho H, Saito K, Tsujita K, Kontani K, Araki Y, Kurosu H, Katada T. RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. Journal of cell science. 2003.10; 116 (Pt 20): 4159-68. ( PubMed, DOI )
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Saito K, Murai J, Kajiho H, Kontani K, Kurosu H, Katada T. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. The Journal of biological chemistry. 2002.02; 277 (5): 3412-8. ( PubMed, DOI )
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Araki Y, Takahashi S, Kobayashi T, Kajiho H, Hoshino S, Katada T. Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. The EMBO journal. 2001.09; 20 (17): 4684-93. ( PubMed, DOI )
Conference Activities & Talks 【 display / non-display 】
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Hiroaki Kajiho,Yasunori Yamamoto, and Toshiaki Sakisaka. CAND1 regulates Lunapark for the proper tubular network of the endoplasmic reticulum. 第3回神戸大学・理研BDR合同シンポジウム 2020.03.22