経歴(学外) 【 表示 ／ 非表示 】
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2014年04月-2017年03月理化学研究所 ライフサイエンス技術基盤研究センター 特別研究員
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2017年04月-2018年03月理化学研究所 ライフサイエンス技術基盤研究センター 研究員
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2018年04月-2023年03月理化学研究所 生命機能科学研究センター 研究員
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2023年04月-2024年03月国立感染症研究所 寄生動物部 協力研究員
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2023年04月-2024年05月理化学研究所 生命医科学研究センター 研究員
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2024年06月-現在東京医科歯科大学 難治疾患研究所バイオデータ科学研究部門分子構造情報学分野 助教
研究テーマ 【 表示 ／ 非表示 】
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リシンアセチル化による後成遺伝情報の発現と継承の仕組みを理解する ，2024年04月 - 2028年03月
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治療と根治を両立する革新的マラリア制圧戦略の分子基盤に関する研究開発 ，2021年12月 - 2024年03月
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p300によるヌクレオソームアセチル化の構造基盤 ，2021年04月 - 2025年03月
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GAS41によるアセチル化ヌクレオソーム認識機構の解明，2019年04月 - 2021年03月
競争的資金等の研究課題 【 表示 ／ 非表示 】
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p300によるヌクレオソームアセチル化の構造基盤
文部科学省/日本学術振興会 : 2021年 - 2024年
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リシンアセチル化による後成遺伝情報の発現と継承の仕組みを理解する
文部科学省/日本学術振興会
論文・総説 【 表示 ／ 非表示 】
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Yuki S Tateishi, Tamasa Araki, Satoru Kawai, Shuhei Koide, Yuko Umeki, Takashi Imai, Yumiko Saito-Nakano, Masaki Kikuchi, Atsushi Iwama, Hajime Hisaeda, Cevayir Coban, Takeshi Annoura. Histone H3.3 variant plays a critical role on zygote-to-oocyst development in malaria parasites. Parasitology International. 2024.01; ( PubMed, DOI )
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Masaki Kikuchi, Shohei Takase, Tsuyoshi Konuma, Kota Noritsugu, Saaya Sekine, Takahisa Ikegami, Akihiro Ito, Takashi Umehara. GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proceedings of the National Academy of Sciences of the United States of America. 2023.10; 120 (43): e2304103120. ( PubMed, DOI )
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Masaki Kikuchi, Satoshi Morita, Masatoshi Wakamori, Shin Sato, Tomomi Uchikubo-Kamo, Takehiro Suzuki, Naoshi Dohmae, Mikako Shirouzu, Takashi Umehara. Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nature communications. 2023.07; 14 (1): 4103. ( PubMed, DOI )
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Nan Liu, Tsuyoshi Konuma, Rajal Sharma, Deyu Wang, Nan Zhao, Lingling Cao, Ying Ju, Di Liu, Shuai Wang, Almudena Bosch, Yifei Sun, Siwei Zhang, Donglei Ji, Satoru Nagatoishi, Noa Suzuki, Masaki Kikuchi, Masatoshi Wakamori, Chengcheng Zhao, Chunyan Ren, Thomas Jiachi Zhou, Yaoyao Xu, Jamel Meslamani, Shibo Fu, Takashi Umehara, Kouhei Tsumoto, Satoko Akashi, Lei Zeng, Robert G Roeder, Martin J Walsh, Qiang Zhang, Ming-Ming Zhou. Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. Molecular cell. 2023.07; 83 (13): 2206-2221. ( PubMed, DOI )
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Masaki Kikuchi, Satoshi Morita, Mie Goto, Masatoshi Wakamori, Kazushige Katsura, Kazuharu Hanada, Mikako Shirouzu, Takashi Umehara. Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. The Journal of biological chemistry. 2022.08; 298 (8): 102164. ( PubMed, DOI )
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Miyazaki Y, Kikuchi M, Umezawa K, Descamps A, Nakamura D, Furuie G, Sumida T, Saito K, Kimura N, Niwa T, Sumida Y, Umehara T, Hosoya T, Kii I. Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A. European journal of medicinal chemistry. 2022.01; 227 113948. ( PubMed, DOI )
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Hiroki Kitagawa, Masaki Kikuchi, Shin Sato, Hisami Watanabe, Naoki Umezawa, Maiko Kato, Yosuke Hisamatsu, Takashi Umehara, Tsunehiko Higuchi. Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity. Journal of medicinal chemistry. 2021.03; 64 (7): 3707-3719. ( PubMed, DOI )
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Erna Davydova, Tadahiro Shimazu, Maren Kirstin Schuhmacher, Magnus E Jakobsson, Hanneke L D M Willemen, Tongri Liu, Anders Moen, Angela Y Y Ho, Jędrzej Małecki, Lisa Schroer, Rita Pinto, Takehiro Suzuki, Ida A Grønsberg, Yoshihiro Sohtome, Mai Akakabe, Sara Weirich, Masaki Kikuchi, Jesper V Olsen, Naoshi Dohmae, Takashi Umehara, Mikiko Sodeoka, Valentina Siino, Michael A McDonough, Niels Eijkelkamp, Christopher J Schofield, Albert Jeltsch, Yoichi Shinkai, Pål Ø Falnes. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nature communications. 2021.02; 12 (1): 891. ( PubMed, DOI )
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Helen D Wu, Masaki Kikuchi, Onur Dagliyan, Adam K Aragaki, Hideki Nakamura, Nikolay V Dokholyan, Takashi Umehara, Takanari Inoue. Rational design and implementation of a chemically inducible heterotrimerization system. Nature methods. 2020.09; 17 (9): 928-936. ( PubMed, DOI )
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Naoki Umezawa, Kasumi Tsuji, Shin Sato, Masaki Kikuchi, Hisami Watanabe, Yuhei Horai, Masashi Yamaguchi, Yosuke Hisamatsu, Takashi Umehara, Tsunehiko Higuchi. Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues. RSC Advances. 2018; 8 (64): 36895. ( DOI )
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Tsusaka T, Kikuchi M, Shimazu T, Suzuki T, Sohtome Y, Akakabe M, Sodeoka M, Dohmae N, Umehara T, Shinkai Y. Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8. Epigenetics Chromatin. 2018; 11 (1): 56. ( PubMed, DOI )
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Yuta Shinohara, Yohei M. Koyama, Maki Ukai-Tadenuma, Takatsugu Hirokawa, Masaki Kikuchi, Rikuhiro G. Yamada, Hideki Ukai, Hiroshi Fujishima, Takashi Umehara, Kazuki Tainaka, Hiroki R. Ueda. Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock. Molecular cell. 2017.09; 67 (5): 783-798. ( DOI )
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Yuichi Amano, Masaki Kikuchi, Shin Sato, Shigeyuki Yokoyama, Takashi Umehara, Naoki Umezawa, Tsunehiko Higuchi. Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. Bioorganic & Medicinal Chemistry. 2017.05; 25 (9): 2617-2624. ( DOI )
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Nagano-Shoji M, Hamamoto Y, Mizuno Y, Yamada A, Kikuchi M, Shirouzu M, Umehara T, Yoshida M, Nishiyama M, Kosono S. Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum. Molecular Microbiology. 2017.05;
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Masaki Kikuchi, Shinichiro Iwabuchi, Tatsuhiko Kikkou, Keiichi Noguchi, Masafumi Odaka, Masafumi Yohda, Masaaki Kawata, Chikara Sato, Osamu Matsumoto. Expression, purification, crystallization and preliminary crystallographic analysis of hepatitis B virus core protein dimerized via a peptide linker containing an EGFP insertion. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013.08; 69 (Pt 8): 942-945. ( PubMed, DOI )
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Masaki Kikuchi, Shinichiro Iwabuchi, Tatsuhiko Kikkou, Keiichi Noguchi, Masafumi Odaka, Masafumi Yohda, Masaaki Kawata, Chikara Sato, Osamu Matsumoto. Expression, purification, crystallization and preliminary X-ray crystallographic studies of hepatitis B virus core fusion protein corresponding to octahedral particles. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013.02; 69 (Pt 2): 165-169. ( PubMed, DOI )