基本情報

写真a

阿部　真也(アベ　シンヤ)

ABE Shinnya


職名

助教
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経歴(学内) 【 表示 ／ 非表示 】

  • 2024年04月
    -
    2024年09月
    東京医科歯科大学 難治疾患研究所 未来生命科学研究部門 恒常性医学分野 助教
  • 2024年10月
    -
    現在
    東京科学大学 教育研究組織 総合研究院 難治研・未来科学研究部門 恒常性医学分野 助教
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競争的資金等の研究課題 【 表示 ／ 非表示 】

  • 新規IL-15依存性自然免疫系リンパ球による免疫応答と組織恒常性の制御機構

    文部科学省/日本学術振興会

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論文・総説 【 表示 ／ 非表示 】

  1. Akihiro Shimba, Shizue Tani-Ichi, Kyoko Masuda, Guangwei Cui, Satoru Munakata, Shinya Abe, Satsuki Kitano, Hitoshi Miyachi, Hiroshi Kawamoto, Koichi Ikuta. A Chimeric IL-7Rα/IL-2Rβ Receptor Promotes the Differentiation of T Cell Progenitors into B Cells and Type 2 Innate Lymphoid Cells. J Immunol. 2024.10; 213 (7): 952-964. ( PubMed, DOI )

  2. Shizue Tani-Ichi, David Obwegs, Alice Yoshikawa, Hitomi Watanabe, Satsuki Kitano, Aki Ejima, Shinya Hatano, Hitoshi Miyachi, Guangwei Cui, Akihiro Shimba, Shinya Abe, Shohei Hori, Gen Kondoh, Sagar, Yasunobu Yoshikai, Koichi Ikuta. A RORE-dependent Intronic Enhancer in the IL-7 Receptor-α Locus Controls Glucose Metabolism via Vγ4+ γδT17 Cells. J Immunol. 2024.08; 213 (3): 283-295. ( PubMed, DOI )

  3. Guangwei Cui, Shinya Abe, Ryoma Kato, Koichi Ikuta. Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues. Front Immunol. 2024; 15 1349184. ( PubMed, DOI )

  4. Koichi Ikuta, Takuma Asahi, Guangwei Cui, Shinya Abe, Daichi Takami. Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment. Adv Exp Med Biol. 2024; 1444 111-127. ( PubMed, DOI )

  5. Daichi Takami, Shinya Abe, Akihiro Shimba, Takuma Asahi, Guangwei Cui, Shizue Tani-Ichi, Takahiro Hara, Keishi Miyata, Masashi Ikutani, Kiyoshi Takatsu, Yuichi Oike, Koichi Ikuta. Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation. Int Immunol. 2023.11; 35 (11): 513-530. ( PubMed, DOI )

  6. Guangwei Cui, Akihiro Shimba, Jianshi Jin, Nozomi Hojo, Takuma Asahi, Shinya Abe, Aki Ejima, Shinri Okada, Keizo Ohira, Ryoma Kato, Shizue Tani-Ichi, Ryo Yamada, Takashi Ebihara, Katsuyuki Shiroguchi, Koichi Ikuta. CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s. Proc Natl Acad Sci U S A. 2023.09; 120 (36): e2215941120. ( PubMed, DOI )

  7. Shinya Abe, Takuma Asahi, Takahiro Hara, Guangwei Cui, Akihiro Shimba, Shizue Tani-Ichi, Kohei Yamada, Kazuko Miyazaki, Hitoshi Miyachi, Satsuki Kitano, Naotoshi Nakamura, Junichi Kikuta, Alexis Vandenbon, Masaki Miyazaki, Ryo Yamada, Toshiaki Ohteki, Masaru Ishii, Veronika Sexl, Takashi Nagasawa, Koichi Ikuta. Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell Rep. 2023.09; 42 (9): 113127. ( PubMed, DOI )

  8. Takuma Asahi, Shinya Abe, Guangwei Cui, Akihiro Shimba, Tsukasa Nabekura, Hitoshi Miyachi, Satsuki Kitano, Keizo Ohira, Johannes M Dijkstra, Masaki Miyazaki, Akira Shibuya, Hiroshi Ohno, Koichi Ikuta. Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches. Elife. 2023.06; 12 ( PubMed, DOI )

  9. Takuma Asahi, Shinya Abe, Yuya Tajika, Hans-Reimer Rodewald, Veronika Sexl, Hiroshi Takeshima, Koichi Ikuta. Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells. Int Immunol. 2023.03; 35 (3): 147-155. ( PubMed, DOI )

  10. Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, Hitoshi Miyachi, Shinya Abe, Takuma Asahi, Shizue Tani-Ichi, Johannes M Dijkstra, Yayoi Iwamoto, Kirill Kryukov, Yuanbo Zhu, Daichi Takami, Takahiro Hara, Satsuki Kitano, Yan Xu, Hajime Morita, Moyu Zhang, Lynn Zreka, Keishi Miyata, Takashi Kanaya, Shinya Okumura, Takashi Ito, Etsuro Hatano, Yoshimasa Takahashi, Hiroshi Watarai, Yuichi Oike, Tadashi Imanishi, Hiroshi Ohno, Toshiaki Ohteki, Nagahiro Minato, Masato Kubo, Georg A Holländer, Hideki Ueno, Takeshi Noda, Katsuyuki Shiroguchi, Koichi Ikuta. A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Sci Immunol. 2022.10; 7 (76): eabj8760. ( PubMed, DOI )

  11. Koichi Ikuta, Aki Ejima, Shinya Abe, Akihiro Shimba. Control of immunity and allergy by steroid hormones. Allergol Int. 2022.10; 71 (4): 432-436. ( PubMed, DOI )

  12. Aki Ejima, Shinya Abe, Akihiro Shimba, Susumu Sato, Takuya Uehata, Shizue Tani-Ichi, Satoru Munakata, Guangwei Cui, Osamu Takeuchi, Toyohiro Hirai, Shigeaki Kato, Koichi Ikuta. Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells. J Immunol. 2022.09; 209 (6): 1083-1094. ( PubMed, DOI )

  13. Koichi Ikuta, Takahiro Hara, Shinya Abe, Takuma Asahi, Daichi Takami, Guangwei Cui. The Roles of IL-7 and IL-15 in Niches for Lymphocyte Progenitors and Immune Cells in Lymphoid Organs. Curr Top Microbiol Immunol. 2021; 434 83-101. ( PubMed, DOI )

  14. Yuanbo Zhu, Guangwei Cui, Eiji Miyauchi, Yuki Nakanishi, Hisa Mukohira, Akihiro Shimba, Shinya Abe, Shizue Tani-Ichi, Takahiro Hara, Hiroshi Nakase, Tsutomu Chiba, Atsuko Sehara-Fujisawa, Hiroshi Seno, Hiroshi Ohno, Koichi Ikuta. Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine. Int Immunol. 2020.05; 32 (5): 307-319. ( PubMed, DOI )

  15. Shizue Tani-Ichi, Keisuke Wagatsuma, Takahiro Hara, Guangwei Cui, Shinya Abe, Hitoshi Miyachi, Satsuki Kitano, Koichi Ikuta. γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs. J Immunol. 2020.05; 204 (10): 2671-2684. ( PubMed, DOI )

  16. Hisa Mukohira, Takahiro Hara, Shinya Abe, Shizue Tani-Ichi, Atsuko Sehara-Fujisawa, Takashi Nagasawa, Kazuyuki Tobe, Koichi Ikuta. Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene. Int Immunol. 2019.10; 31 (11): 729-742. ( PubMed, DOI )

  17. Shiho Ueda, Hidemi Hayashi, Takako Miyamoto, Shinya Abe, Kana Hirai, Kanji Matsukura, Hideki Yagi, Yuta Hara, Kinji Yoshida, Shogo Okazaki, Masakazu Tamura, Yuki Abe, Toshinori Agatsuma, Shin-Ichiro Niwa, Kazue Masuko, Takashi Masuko. Anti-tumor effects of mAb against L-type amino acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes. Cancer Sci. 2019.02; 110 (2): 674-685. ( PubMed, DOI )

  18. Akihiro Shimba, Guangwei Cui, Shizue Tani-Ichi, Makoto Ogawa, Shinya Abe, Fumie Okazaki, Satsuki Kitano, Hitoshi Miyachi, Hisakata Yamada, Takahiro Hara, Yasunobu Yoshikai, Takashi Nagasawa, Günther Schütz, Koichi Ikuta. Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Immunity. 2018.02; 48 (2): 286-298.e6. ( PubMed, DOI )

  19. 阿部　真也, 旭　拓真, 生田　宏一. グループ1ILCの分化と機能 実験医学. 2024.08; 42 (12): 1834-1839.

  20. 阿部　真也, 生田　宏一. 骨髄NK細胞は造血系細胞が産生するIL-15に依存して分化する 臨床免疫・アレルギー科. 2024.05; 81 (5): 517-522.

  21. 旭　拓真, 阿部　真也, 生田　宏一. 1型自然リンパ球の多様性と生体内微小環境 医学のあゆみ. 2024.01; 288 (1):

  22. 旭　拓真, 阿部　真也, 生田　宏一. 1型自然リンパ球とNK細胞の多様性 臨床免疫・アレルギー科. 2023.07; 80 (1): 1-7.

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