Personnel Information

写真a

KARIGANE Daiki


Job title

Associate Professor
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Graduating School 【 display / non-display 】

  • Keio University, Faculty of Medicine, 2008.03, Graduated

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Graduate School 【 display / non-display 】

  • Keio University, Graduate School, Division of Medical Sciences, Doctor's Course, 2016.03, Accomplished credits for doctoral program

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Campus Career 【 display / non-display 】

  • 2024.04
    -
    2024.07
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Hematology， Project Associate Professor
  • 2024.08
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Hematology， Associate Professor
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External Career 【 display / non-display 】

  • 2016.04
    -
    2017.12
    , Assistant Professor
  • 2018.01
    -
    2022.10
    Stanford University, Cancer Institute, Postdoctoral fellow
  • 2022.11
    -
    2024.03
    Stanford University, Institute for Stem Cell Biology and Regenerative Medicine, Instructor
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Research Areas 【 display / non-display 】

  • Hematology and medical oncology

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Qualification Acquired 【 display / non-display 】

  • Doctor

  • ECFMG certification

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Published Papers & Misc 【 display / non-display 】

  1. Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Takayuki Morikawa, Shinya Fujita, Kotaro Shide, Miho Haraguchi, Shinpei Tamaki, Takumi Mikawa, Hiroshi Kondoh, Hiroyasu Nakano, Kenta Sumiyama, Go Nagamatsu, Nobuhito Goda, Shinichiro Okamoto, Ayako Nakamura-Ishizu, Kazuya Shimoda, Makoto Suematsu, Toshio Suda, Keiyo Takubo. SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production. Cell Stem Cell. 2024.08; 31 (8): 1145-1161.e15. ( PubMed, DOI )

  2. Jonas L Fowler, Sherry Li Zheng, Alana Nguyen, Angela Chen, Xiaochen Xiong, Timothy Chai, Julie Y Chen, Daiki Karigane, Allison M Banuelos, Kouta Niizuma, Kensuke Kayamori, Toshinobu Nishimura, M Kyle Cromer, David Gonzalez-Perez, Charlotte Mason, Daniel Dan Liu, Leyla Yilmaz, Lucile Miquerol, Matthew H Porteus, Vincent C Luca, Ravindra Majeti, Hiromitsu Nakauchi, Kristy Red-Horse, Irving L Weissman, Lay Teng Ang, Kyle M Loh. Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells. Developmental Cell. 2024.05; 59 (9): 1110-1131.e22. ( PubMed, DOI )

  3. Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shinya Fujita, Takayuki Morikawa, Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Miho Haraguchi, Shinpei Tamaki, Takehiro Yamamoto, Tomohiro Yabushita, Yosuke Tanaka, Go Nagamatsu, Hiroaki Honda, Shinichiro Okamoto, Nobuhito Goda, Tomohiko Tamura, Ayako Nakamura-Ishizu, Makoto Suematsu, Atsushi Iwama, Toshio Suda, Keiyo Takubo. Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis. Elife. 2024.04; 12 ( PubMed, DOI )

  4. Fabian P Suchy, Daiki Karigane, Yusuke Nakauchi, Maimi Higuchi, Jinyu Zhang, Katja Pekrun, Ian Hsu, Amy C Fan, Toshinobu Nishimura, Carsten T Charlesworth, Joydeep Bhadury, Toshiya Nishimura, Adam C Wilkinson, Mark A Kay, Ravindra Majeti, Hiromitsu Nakauchi. Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors. Nature Biotechnology. 2024.04; ( PubMed, DOI )

  5. Niklas Landberg, Thomas Köhnke, Yang Feng, Yusuke Nakauchi, Amy C Fan, Miles H Linde, Daiki Karigane, Kelly Lim, Rahul Sinha, Luca Malcovati, Daniel Thomas, Ravindra Majeti. IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation. Blood Cancer Discovery. 2024.01; OF1-OF18. ( PubMed, DOI )

  6. Yusuke Nakauchi, Asiri Ediriwickrema, Daniel Martinez-Krams, Feifei Zhao, Athreya Rangavajhula, Daiki Karigane, Ravindra Majeti. Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis. Journal of Visualized Experiments. 2023.11; (201): ( PubMed, DOI )

  7. Amy C Fan, Yusuke Nakauchi, Lawrence Bai, Armon Azizi, Kevin A Nuno, Feifei Zhao, Thomas Köhnke, Daiki Karigane, David Cruz-Hernandez, Andreas Reinisch, Purvesh Khatri, Ravindra Majeti. RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition. Journal of Clinical Investigation. 2023.10; 133 (19): ( PubMed, DOI )

  8. Kohei Shiroshita, Hiroshi Kobayashi, Shintaro Watanuki, Daiki Karigane, Yuriko Sorimachi, Shinpei Tamaki, Miho Haraguchi, Masamichi Yamamoto, Ayako Nakamura-Ishizu, Shinichiro Okamoto, Keisuke Kataoka, Keiyo Takubo. Distinct roles of the preparatory and payoff phases of glycolysis in hematopoietic stem cells. Experimental Hematology. 2023.08; 124 56-67. ( PubMed, DOI )

  9. Kohei Shiroshita, Hiroshi Kobayashi, Shintaro Watanuki, Daiki Karigane, Yuriko Sorimachi, Shinya Fujita, Shinpei Tamaki, Miho Haraguchi, Naoki Itokawa, Kazumasa Aoyoama, Shuhei Koide, Yosuke Masamoto, Kenta Kobayashi, Ayako Nakamura-Ishizu, Mineo Kurokawa, Atsushi Iwama, Shinichiro Okamoto, Keisuke Kataoka, Keiyo Takubo. A culture platform to study quiescent hematopoietic stem cells following genome editing. Cell Reports Methods. 2022.12; 2 (12): 100354. ( PubMed, DOI )

  10. Yusuke Nakauchi, Armon Azizi, Daniel Thomas, M Ryan Corces, Andreas Reinisch, Rajiv Sharma, David Cruz Hernandez, Thomas Köhnke, Daiki Karigane, Amy Fan, Daniel Martinez-Krams, Melissa Stafford, Satinder Kaur, Ritika Dutta, Paul Phan, Asiri Ediriwickrema, Erin McCarthy, Yuhong Ning, Tierney Phillips, Christopher K Ellison, Gulfem D Guler, Anna Bergamaschi, Chin-Jen Ku, Samuel Levy, Ravindra Majeti. The Cell Type-Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia. Blood Cancer Discovery. 2022.07; 3 (4): 346-367. ( PubMed, DOI )

  11. Karigane D, Haraguchi M, Toyama-Sorimachi N, Nishimura EK, Takubo K. Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus. Biochemical and biophysical research communications. 2022.03; 596 29-35. ( PubMed, DOI )

  12. Daiki Karigane, Hidenori Kasahara, Kouhei Shiroshita, Shinya Fujita, Hiroshi Kobayashi, Shinpei Tamaki, Rie Yamazaki, Kaori Yahagi, Yoko Yatabe, Naomi Kondoh, Tomoko Arai, Hisako Katagiri, Nobuko Shimizu, Masatoshi Sakurai, Taku Kikuchi, Jun Kato, Takayuki Shimizu, Taeko Hayakawa, Tomonori Yaguchi, Maiko Matsushita, Hideaki Nakajima, Yutaka Kawakami, Mitsuru Murata, Takehiko Mori, Takashi Sasaki, Shinichiro Okamoto, Keiyo Takubo. B cells but not bone marrow stem/progenitors. Leukemia & Lymphoma. 2021.03; 62 (3): 679-687. ( PubMed, DOI )

  13. Yuriko Sorimachi, Daiki Karigane, Yukako Ootomo, Hiroshi Kobayashi, Takayuki Morikawa, Kinya Otsu, Yoshiaki Kubota, Shinichiro Okamoto, Nobuhito Goda, Keiyo Takubo. p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts. Journal of Biological Chemistry. 2021; 296 100563. ( PubMed, DOI )

  14. Toshinobu Nishimura, Haojun Xu, Masayuki Iwasaki, Daiki Karigane, Brandon Saavedra, Yusuke Takahashi, Fabian P Suchy, Shinichiro Monobe, Renata M Martin, Manami Ohtaka, Mahito Nakanishi, Scott R Burrows, Michael L Cleary, Ravindra Majeti, Akira Shibuya, Hiromitsu Nakauchi. Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells. Gene Therapy. 2019.11; 27 (10-11): 525-534. ( PubMed, DOI )

  15. M Matsushita, K Ozawa, T Suzuki, M Nakamura, N Nakano, S Kanchi, D Ichikawa, E Matsuki, M Sakurai, D Karigane, H Kasahara, N Tsukamoto, T Shimizu, T Mori, H Nakajima, S Okamoto, Y Kawakami, Y Hattori. CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients. Blood Cancer Journal. 2017.09; 7 (9): e601. ( PubMed, DOI )

  16. Daiki Karigane, Keiyo Takubo. Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions. International Journal of Hematology. 2017.07; 106 (1): 18-26. ( PubMed, DOI )

  17. Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K. p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress. Cell stem cell. 2016.08; 19 (2): 192-204. ( PubMed, DOI )

  18. Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, Takubo K. Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell reports. 2015.04; 11 (1): 71-84. ( PubMed, DOI )

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