Personnel Information

写真a

KATO KAZUKI


Job title

Associate Professor

Field Introduction URL

https://kato-lab.org

　

https://www.tmd.ac.jp/cmn/yisc/tenuretrack.html

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Graduating School 【 display / non-display 】

  • Tokyo Institute of Technology, Faculty of Life Science and Engineering, 2010.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Science, Master's Course, 2012.03, Completed

  • The University of Tokyo, Graduate School, Division of Science, Doctor's Course, 2015.03, Completed

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Campus Career 【 display / non-display 】

  • 2023.06
    -
    2024.09
    Tokyo Medical and Dental University， Institute of Research， Associate Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， Mechanistic Immunology Research Unit， Associate Professor
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External Career 【 display / non-display 】

  • 2018.04
    -
    2020.12
    Harvard Medical School, Biological Chemistry and Molecular Pharmacology, Postdoctoral Fellow
  • 2018.04
    -
    2020.12
    Boston Children's Hospital, Program in Cellular and Molecular Medicine, Project Researcher
  • 2021.01
    -
    2022.05
    , Project Assistant Professor
  • 2022.06
    -
    2023.04
    , Project Junior Associate Professor
  • 2023.05
    　
    　
    , Junior Associate Professor
  • 2023.06
    -
    2024.09
    Tokyo Medical and Dental University, Molecular and Mechanistic Immunology, Institute of Research, Associate Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo, Mechanistic Immunology Research Unit, Institute of Integrated Research, Associate Professor

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Research Areas 【 display / non-display 】

  • Structural biochemistry

  • Applied biochemistry

  • Applied microbiology

  • Immunology

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Research Theme 【 display / non-display 】

  • Role of ubiquitination in antiviral immune response, 2021.08 - 2023.03

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Published Papers & Misc 【 display / non-display 】

  1. Kazuki Kato, Sae Okazaki, Soumya Kannan, Han Altae-Tran, F. Esra Demircioglu, Yukari Isayama, Junichiro Ishikawa, Masahiro Fukuda, Rhiannon K. Macrae, Tomohiro Nishizawa, Kira S. Makarova, Eugene V. Koonin, Feng Zhang, Hiroshi Nishimasu. Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9 Nature communications. 2022.11; 13 (1): 6719. ( PubMed, DOI )

  2. Programmable RNA writing with trans-splicing. 2024.02; ( PubMed, DOI )

  3. A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a nonhemophilic state. 2023.11; ( PubMed, DOI )

  4. KAIYI JIANG, JUSTIN LIM, SAMANTHA SGRIZZI, MICHAEL TRINH, ALISAN KAYABOLEN, NATALYA YUTIN, WEIDONG BAO, KAZUKI KATO, EUGENE V. KOONIN, JONATHAN S. GOOTENBERG, OMAR O. ABUDAYYEH. Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses Science Advance. 2023.09; 9 (39):

  5. Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses. 2023.09; 9 (39): eadk0171. ( PubMed, DOI )

  6. Kato K, Okazaki S, Schmitt-Ulms C, Jiang K, Zhou W, Ishikawa J, Isayama Y, Adachi S, Nishizawa T, Makarova KS, Koonin EV, Abudayyeh OO, Gootenberg JS, Nishimasu H. RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease. Science (New York, N.Y.). 2022.11; 378 (6622): 882-889. ( PubMed, DOI )

  7. Kato K, Zhou W, Okazaki S, Isayama Y, Nishizawa T, Gootenberg JS, Abudayyeh OO, Nishimasu H. Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex. Cell. 2022.06; 185 (13): 2324-2337.e16. ( PubMed, DOI )

  8. Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. 2021.02; 81 (3): 599-613. ( PubMed, DOI )

  9. Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O. Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nature communications. 2018.10; 9 (1): 4424. ( PubMed, DOI )

  10. Kato Kazuki, Omura Hiroki, Ishitani Ryuichiro, Nureki Osamu. Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA. Annu Rev Biochem. 2017.06; 86 541-566. ( PubMed, DOI )

  11. Palazzo Luca, Daniels Casey M, Nettleship Joanne E, Rahman Nahid, McPherson Robert Lyle, Ong Shao-En, Kato Kazuki, Nureki Osamu, Leung Anthony K L, Ahel Ivan. ENPP1 processes protein ADP-ribosylation in vitro. FEBS J. 2016.09; 283 (18): 3371-3388. ( PubMed, DOI )

  12. Morita Junko, Kato Kazuki, Nakane Takanori, Kondo Yuki, Fukuda Hiroo, Nishimasu Hiroshi, Ishitani Ryuichiro, Nureki Osamu. Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide. Nat Commun. 2016.08; 7 12383. ( PubMed, DOI )

  13. Kato Kazuki, Satouh Yuhkoh, Nishimasu Hiroshi, Kurabayashi Arisa, Morita Junko, Fujihara Yoshitaka, Oji Asami, Ishitani Ryuichiro, Ikawa Masahito, Nureki Osamu. Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization. Nat Commun. 2016.07; 7 12198. ( PubMed, DOI )

  14. Kato Kazuki, Ikeda Hisako, Miyakawa Shin, Futakawa Satoshi, Nonaka Yosuke, Fujiwara Masatoshi, Okudaira Shinichi, Kano Kuniyuki, Aoki Junken, Morita Junko, Ishitani Ryuichiro, Nishimasu Hiroshi, Nakamura Yoshikazu, Nureki Osamu. Structural basis for specific inhibition of Autotaxin by a DNA aptamer. Nat Struct Mol Biol. 2016.05; 23 (5): 395-401. ( PubMed, DOI )

  15. Morita Junko, Kano Kuniyuki, Kato Kazuki, Takita Hiroyuki, Sakagami Hideki, Yamamoto Yasuo, Mihara Emiko, Ueda Hirofumi, Sato Takanao, Tokuyama Hidetoshi, Arai Hiroyuki, Asou Hiroaki, Takagi Junichi, Ishitani Ryuichiro, Nishimasu Hiroshi, Nureki Osamu, Aoki Junken. Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase. Sci Rep. 2016.02; 6 20995. ( PubMed, DOI )

  16. Kato Kazuki, Ishii Ryohei, Hirano Seiichi, Ishitani Ryuichiro, Nureki Osamu. Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase. Structure. 2015.05; 23 (5): 843-850. ( PubMed, DOI )

  17. Morita Junko, Kato Kazuki, Mihara Emiko, Ishitani Ryuichiro, Takagi Junichi, Nishimasu Hiroshi, Aoki Junken, Nureki Osamu. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp6. Acta Crystallogr F Struct Biol Commun. 2014.06; 70 (Pt 6): 794-799. ( PubMed, DOI )

  18. Kato Kazuki, Ishii Ryohei, Goto Eiji, Ishitani Ryuichiro, Tokunaga Fuminori, Nureki Osamu. Structural and functional analyses of DNA-sensing and immune activation by human cGAS. PLoS One. 2013; 8 (10): e76983. ( PubMed, DOI )

  19. Kato Kazuki, Nishimasu Hiroshi, Okudaira Shinichi, Mihara Emiko, Ishitani Ryuichiro, Takagi Junichi, Aoki Junken, Nureki Osamu. Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. Proc Natl Acad Sci U S A. 2012.10; 109 (42): 16876-16881. ( PubMed, DOI )

  20. Kato Kazuki, Nishimasu Hiroshi, Mihara Emiko, Ishitani Ryuichiro, Takagi Junichi, Aoki Junken, Nureki Osamu. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012.07; 68 (Pt 7): 778-782. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 加藤 一希. RNA依存性プロテアーゼ、CRISPR-Cas7-11の発見と細胞操作技術への応用. 第46回日本分子生物学会年会 2023.12.01

  2. 加藤 一希, 岡崎 早恵, Zhou Wenyuan, Gootenberg Jonathan, Abudayyeh Omar, 西増 弘志. 新規CRISPR-Cas酵素、Cas7-11のクライオ電子顕微鏡構造とエンジニアリングによるRNAノックダウン技術への応用. 日本生化学会大会プログラム・講演要旨集 2022.11.01

  3. 加藤　一希. Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9. 生物物理学会年会 2022.09.30 函館

  4. 加藤 一希. Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9. 第60回日本生物物理学会年会 2022.09.30

  5. 加藤 一希. Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex, and its application for RNA knockdown tool. 第55回発生生物学会年会 2022.06.01

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Awards & Honors 【 display / non-display 】

  • JAICI Award，2023

  • 日本生化学会 奨励賞，2023

  • Young Innovator Award，2022

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