Personnel Information

写真a

TOYOSHIMA Fumiko


Job title

Professor

Research Areas, Keywords

stem cells, maternal organ remodeling, feto-maternal crosstalk, regenerative medicine, stress-related diseases

Field Introduction URL

https://www2.infront.kyoto-u.ac.jp/Toyoshima-HP/index-En.html

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Graduating School 【 display / non-display 】

  • Kyoto University, 2000.03, Graduated

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Graduate School 【 display / non-display 】

  • Kyoto University, Graduate School, Division of Natural Science, Doctor's Course, 2000.03, Completed

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Campus Career 【 display / non-display 】

  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Visionary Life Science， -， Professor
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External Career 【 display / non-display 】

  • 1999.04
    -
    2004.02
    Kyoto University, Graduate School of Biostudies,
  • 2004
    -
    2006
    , Assistant Professor
  • 2005.10
    -
    2009.03
    Japan Science and Technology Agency,
  • 2008
    -
    2016
    Kyoto University, Institute for Virus Research, Professor
  • 2008.03
    -
    2016.09
    Kyoto University, Institute for Virus Research, Professor
  • 2016
    -
    2022
    Kyoto University, Insittute for Fontier of Life and Medical Sciences, Professor
  • 2016.10
    -
    2022.03
    , Professor
  • 2022
    -
    Now
    Kyoto University, Institute for Life and Medical Sciences , Professor
  • 2022.04
    -
    Now
    Kyoto University, Institute for Life and Medical Sciences, Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute,

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Research Areas 【 display / non-display 】

  • Medical biochemistry

  • Developmental biology

  • Dermatology

  • Cell biology

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Published Papers & Misc 【 display / non-display 】

  1. Riki Ishibashi, Ritsuko Maki, Fumiko Toyoshima. Gene targeting in adult organs using in vivo cleavable donor plasmids for CRISPR-Cas9 and CRISPR-Cas12a Scientific Reports. 2024.03; 14 (1): 7615. ( DOI )

  2. Satoshi Kozuki, Mio Kabata, Satoko Sakurai, Keiko Iwaisako, Tomomi Nishimura, Masakazu Toi, Takuya Yamamoto, Fumiko Toyoshima. Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice Communications Biology. 2023.12; 6 (1): 1226. ( DOI )

  3. Ishibashi R, Maki R, Kitano S, Miyachi H, Toyoshima F.. Development of an in vivo cleavable donor plasmid for targeted transgene integration by CRISPR-Cas9 and CRISPR-Cas12a Scientific Reports. 2022.10; 12 (1): ( DOI )

  4. Ichijo R, Maki K, Kabata M, Murata T, Nagasaka A, Ishihara S, Haga H, Honda T, Adachi T, Yamamoto T, Toyoshima F.. Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin Nature Aging. 2022.07; 2 (7): ( DOI )

  5. Satoshi Kozuki, Satoko Sakurai, Atsushi Suzuki, Takuya Yamamoto, Fumiko Toyoshima. Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy Genes to Cells. 2022.03; 27 (3): ( DOI )

  6. Yukako Oda, Chisato Takahashi, Shota Harada, Shun Nakamura, Daxiao Sun, Kazumi Kiso, Yuko Urata, Hitoshi Miyachi, Yoshinori Fujiyoshi, Alf Honigmann, Seiichi Uchida, Yasushi Ishihama, Fumiko Toyoshima. Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation Science Advances. 2021.11; 7 (47): eabj6895. ( DOI )

  7. Ryo Ichijo, Mio Kabata, Hiroyasu Kidoya, Fumitaka Muramatsu, Riki Ishibashi, Kota Abe, Ko Tsutsui, Hirokazu Kubo, Yui Iizuka, Satsuki Kitano, Hitoshi Miyachi, Yoshiaki Kubota, Hironobu Fujiwara, Aiko Sada, Takuya Yamamoto, Fumiko Toyoshima. Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs Science Advances. 2021.02; 7 (7): eabd2575. ( PubMed, DOI )

  8. Riki Ishibashi, Kota Abe, Nanami Ido, Satsuki Kitano, Hitoshi Miyachi, Fumiko Toyoshima. Genome editing with the donor plasmid equipped with synthetic crRNA-target sequence Scientific Reports. 2020.08; 10 (1): ( DOI )

  9. Teruasa Murata, Tetsuya Honda, Gyohei Egawa, Yasuo Yamamoto, Ryo Ichijo, Fumiko Toyoshima, Teruki Dainichi, Kenji Kabashima. Transient elevation of cytoplasmic calcium ion concentration at a single cell level precedes morphological changes of epidermal keratinocytes during cornification Scientific Reports. 2018.04; 8 (1): 6610. ( PubMed, DOI )

  10. Ryo Ichijo, Hiroki Kobayashi, Saori Yoneda, Yui Iizuka, Hirokazu Kubo, Shigeru Matsumura, Satsuki Kitano, Hitoshi Miyachi, Tetsuya Honda, Fumiko Toyoshima. Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration NATURE COMMUNICATIONS. 2017.09; 8 (1): 508. ( PubMed, DOI )

  11. Mitsuko Fukuhara, Yue Ma, Kazuo Nagasawa, Fumiko Toyoshima. A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription SCIENTIFIC REPORTS. 2017.04; 7 45815. ( DOI )

  12. Dormant Pluripotent Cells Emerge during Neural Differentiation of Embryonic Stem Cells in a FoxO3-Dependent Manner 2017.03; 37 (5): e00417-16. ( PubMed, DOI )

  13. Essential roles of Tbx3 in embryonic skin development during epidermal stratification 2017.03; 22 (3): 284-292. ( PubMed, DOI )

  14. Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1 2016.06; 7 ncomms11858. ( PubMed, DOI )

  15. c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Differentiation 2016.02; 291 (7): 3333-3345. ( PubMed, DOI )

  16. PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2 2015.08; 17 (8): 1024-U360. ( PubMed, DOI )

  17. PCTK1 Regulates Integrin-Dependent Spindle Orientation via Protein Kinase A Regulatory Subunit KAP0 and Myosin X 2015.04; 35 (7): 1197-1208. ( PubMed, DOI )

  18. Pregnenolone Functions in Centriole Cohesion during Mitosis 2014.12; 21 (12): 1707-1721. ( PubMed, DOI )

  19. Inhibition of endocytic vesicle fusion by Plk1-mediated phosphorylation of vimentin during mitosis 2014.01; 13 (1): 126-137. ( PubMed, DOI )

  20. ABL1 regulates spindle orientation in adherent cells and mammalian skin 2012.01; 3 626. ( PubMed, DOI )

  21. ABL1 Joins the Cadre of Spindle Orientation Machinery 2012; 37 (2): 81-87. ( PubMed, DOI )

  22. Revolving movement of a dynamic cluster of actin filaments during mitosis 2010.11; 191 (3): 453-462. ( PubMed, DOI )

  23. Dual Role of Cdc42 in Spindle Orientation Control of Adherent Cells 2009.05; 29 (10): 2816-2827. ( PubMed, DOI )

  24. PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells 2007.12; 13 (6): 796-811. ( PubMed, DOI )

  25. Spindle orientation in animal cell mitosis: Roles of integrin in the control of spindle axis 2007.11; 213 (2): 407-411. ( PubMed, DOI )

  26. Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1 2007.05; 282 (20): 15217-15227. ( PubMed, DOI )

  27. Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1-and myosin X-dependent manner 2007.03; 26 (6): 1487-1498. ( PubMed, DOI )

  28. Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate 2003.07; 278 (28): 25277-25280. ( PubMed, DOI )

  29. Nuclear translocation of Plk1 mediated by its bipartite nuclear localization signal 2002.12; 277 (50): 48884-48888. ( PubMed, DOI )

  30. Plk1 promotes nuclear translocation of human Cdc25C during prophase 2002.04; 3 (4): 341-348. ( PubMed, DOI )

  31. Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase 2001.03; 410 (6825): 215-220. ( PubMed, DOI )

  32. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G(2) checkpoint 1998.05; 17 (10): 2728-2735. ( PubMed, DOI )

  33. A novel SAPK/JNK kinase, MKK7, stimulated by TNF alpha and cellular stresses 1997.12; 16 (23): 7045-7053. ( PubMed, DOI )

  34. Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases 1997.11; 139 (4): 1005-1015. ( PubMed, DOI )

  35. Purification and identification of a major activator for p38 from osmotically shocked cells - Activation of mitogen-activated protein kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2 1996.10; 271 (43): 26981-26988. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Fumiko Toyoshima. Maternal Organ Remodeling and Fetal Growth. IRCMS symposium 2023.11.22

  2. Fumiko Toyoshima. Dermal stiffness regulates epidermal stem cell function. 第75回日本細胞生物学会 2023.06.28

  3. Ryo Ichijo, Fumiko Toyoshima. Skin Remodeling During Life Stages. International Symposium on Skin Stem Cell Dynamics 2023.05.14 Tokyo

  4. Fumiko Toyoshima. Stem cell dynamics in skin homeostasis.. Frontline in Developmental Biology 2018.03.22

  5. 豊島 文子. Orchestration of stem and progenitor cells drives abdominal skin expansion during pregnancy. 第１５回幹細胞シンポジウム 2017.05.26

  6. 豊島 文子. Stem and transit-amplifying cells orchestrate abdominal skin expansion during pregnancy. SPIRITS Swiss-Kyoto Joint symposium on Life Science 2016.06.13

  7. 豊島 文子. Oriented stem/progenitor cell division and skin expansion during pregnancy. iCeMSリトリート 2016.05.30

  8. 豊島 文子. Molecular mechanisms for ECM-dependent oriented cell division. 第37回日本分子生物学会大会 2014.11.25

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