Joachim F. R. Van Guyse, Saed Abbasi,Kazuko Toh, Zlata Nagorna, Junjie Li, Anjaneyulu Dirisala, Sabina Quader, Satoshi Uchida, Kazunori Kataoka. Facile generation of heterotelechelic poly(2-oxazoline)s towards accelerated exploration of poly(2-oxazoline)-based nanomedicine Angewandte Chemie International Edition. 2024.04; ( DOI )

Suzuki, M; Mochida, Y; Hori, M; Hayashi, A; Toh, K; Tockary, TA; Liu, XY; Marx, V; Yokoo, H; Miyata, K; Oba, M; Uchida, S. Poly(ethylene Glycol) (PEG)-OligoRNA Hybridization to mRNA Enables Fine-Tuned Polyplex PEGylation for Spleen-Targeted mRNA Delivery SMALL SCIENCE. 2024.04; 4 (4): 2300258. ( PubMed, DOI )

Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, Makoto Oba, and Satoshi Uchida. Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine-Tuned Polyplex PEGylation for Spleen-Targeted mRNA Delivery Small Science. 2024.02; ( DOI )

Masahiro Ohara, Tetsuya Nagata, Rintaro Iwata Hara, Kie Yoshida-Tanaka, Nozomi Toide, Kazunori Takagi, Kazuki Sato, Tomoya Takenaka, Masanori Nakakariya, Kenichi Miyata, Yusuke Maeda, Kazuko Toh, Takeshi Wada, Takanori Yokota. DNA/RNA heteroduplex technology with cationic oligopeptide reduces class-related adverse effects of nucleic acid drugs Molecular Therapy: Nucleic Acid. 2024; ( DOI )

Wen P, Ke W, Dirisala A, Toh K, Tanaka M, Li J. Stealth and pseudo-stealth nanocarriers. Advanced drug delivery reviews. 2023.07; 198 114895. ( PubMed, DOI )

Garcia-Chica J, Paraiso WKD, Zagmutt S, Fosch A, Reguera AC, Alzina S, Sánchez-García L, Fukushima S, Toh K, Casals N, Serra D, Herrero L, Garcia J, Kataoka K, Ariza X, Quader S, Rodríguez-Rodríguez R. Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance. Biomaterials science. 2023.03; 11 (7): 2336-2347. ( PubMed, DOI )

Naito M, Watanuki Y, Toh K, Yum J, Kim BS, Taniwaki K, Ogura S, Ishida H, Cho M, Chaya H, Miyajima K, Yamasaki Y, Osada K, Minegishi K, Aoki Y, Miyata K. Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues. Journal of controlled release : official journal of the Controlled Release Society. 2022.07; 347 607-614. ( PubMed, DOI )

Chaya H, Naito M, Cho M, Toh K, Hayashi K, Fukushima S, Yamasaki Y, Kataoka K, Miyata K. Dynamic Stabilization of Unit Polyion Complexes Incorporating Small Interfering RNA by Fine-Tuning of Cationic Block Length in Two-Branched Poly(ethylene glycol)-b-poly(l-lysine). Biomacromolecules. 2022.01; 23 (1): 388-397. ( PubMed, DOI )

Li J, Ge Z, Toh K, Liu X, Dirisala A, Ke W, Wen P, Zhou H, Wang Z, Xiao S, Van Guyse JFR, Tockary TA, Xie J, Gonzalez-Carter D, Kinoh H, Uchida S, Anraku Y, Kataoka K. Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer. Advanced materials (Deerfield Beach, Fla.). 2021.12; 33 (49): e2105254. ( PubMed, DOI )

Abbasi S, Uchida S, Toh K, Tockary TA, Dirisala A, Hayashi K, Fukushima S, Kataoka K. Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain. Journal of controlled release : official journal of the Controlled Release Society. 2021.04; 332 260-268. ( PubMed, DOI )

Shibasaki H, Kinoh H, Cabral H, Quader S, Mochida Y, Liu X, Toh K, Miyano K, Matsumoto Y, Yamasoba T, Kataoka K. Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile. ACS nano. 2021.03; 15 (3): 5545-5559. ( PubMed, DOI )

Naito, M; Chaya, H; Toh, K; Kim, BS; Hayashi, K; Fukushima, S; Nagata, T; Yokota, T; Kataoka, K; Miyata, K. Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly (ethylene glycol)-<i>block</i>-poly(L-lysine) JOURNAL OF CONTROLLED RELEASE. 2021.02; 330 812-820. ( PubMed, DOI )

Inoue Y, Matsumoto Y, Toh K, Miyano K, Cabral H, Igarashi K, Iwasaki S, Kataoka K, Yamasoba T. Manipulating dynamic tumor vessel permeability to enhance polymeric micelle accumulation. Journal of controlled release : official journal of the Controlled Release Society. 2021.01; 329 63-75. ( PubMed, DOI )

Quader S, Liu X, Toh K, Su YL, Maity AR, Tao A, Paraiso WKD, Mochida Y, Kinoh H, Cabral H, Kataoka K. Supramolecularly enabled pH- triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma. Biomaterials. 2021.01; 267 120463. ( PubMed, DOI )

Nakamura N, Mochida Y, Toh K, Fukushima S, Anraku Y, Cabral H. Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application. Polymers. 2020.12; 13 (1): ( PubMed, DOI )

Gonzalez-Carter D, Liu X, Tockary TA, Dirisala A, Toh K, Anraku Y, Kataoka K. Targeting nanoparticles to the brain by exploiting the blood-brain barrier impermeability to selectively label the brain endothelium. Proceedings of the National Academy of Sciences of the United States of America. 2020.08; 117 (32): 19141-19150. ( PubMed, DOI )

Xie, JB; Gonzalez-Carter, D; Tockary, TA; Nakamura, N; Xue, YE; Nakakido, M; Akiba, H; Dirisala, A; Liu, XY; Toh, K; Yang, T; Wang, ZT; Fukushima, S; Li, JJ; Quader, S; Tsumoto, K; Yokota, T; Anraku, Y; Kataoka, K. Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain ACS NANO. 2020.06; 14 (6): 6729-6742. ( PubMed, DOI )

Dirisala A, Uchida S, Toh K, Li J, Osawa S, Tockary TA, Liu X, Abbasi S, Hayashi K, Mochida Y, Fukushima S, Kinoh H, Osada K, Kataoka K. Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. Science advances. 2020.06; 6 (26): eabb8133. ( PubMed, DOI )

Min HS, Kim HJ, Naito M, Ogura S, Toh K, Hayashi K, Kim BS, Fukushima S, Anraku Y, Miyata K, Kataoka K. Systemic Brain Delivery of Antisense Oligonucleotides across the Blood-Brain Barrier with a Glucose-Coated Polymeric Nanocarrier. Angewandte Chemie (International ed. in English). 2020.05; 59 (21): 8173-8180. ( PubMed, DOI )

Ueki R, Uchida S, Kanda N, Yamada N, Ueki A, Akiyama M, Toh K, Cabral H, Sando S. A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application. Science advances. 2020.04; 6 (14): eaay2801. ( PubMed, DOI )

Kim BS, Kim HJ, Osawa S, Hayashi K, Toh K, Naito M, Min HS, Yi Y, Kwon IC, Kataoka K, Miyata K. Dually Stabilized Triblock Copolymer Micelles with Hydrophilic Shell and Hydrophobic Interlayer for Systemic Antisense Oligonucleotide Delivery to Solid Tumor. ACS biomaterials science & engineering. 2019.11; 5 (11): 5770-5780. ( PubMed, DOI )

Martin JD, Panagi M, Wang C, Khan TT, Martin MR, Voutouri C, Toh K, Papageorgis P, Mpekris F, Polydorou C, Ishii G, Takahashi S, Gotohda N, Suzuki T, Wilhelm ME, Melo VA, Quader S, Norimatsu J, Lanning RM, Kojima M, Stuber MD, Stylianopoulos T, Kataoka K, Cabral H. Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment. ACS nano. 2019.06; 13 (6): 6396-6408. ( PubMed, DOI )

Suzuki K, Miura Y, Mochida Y, Miyazaki T, Toh K, Anraku Y, Melo V, Liu X, Ishii T, Nagano O, Saya H, Cabral H, Kataoka K. Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. Journal of controlled release : official journal of the Controlled Release Society. 2019.05; 301 28-41. ( PubMed, DOI )

Watanabe S, Hayashi K, Toh K, Kim HJ, Liu X, Chaya H, Fukushima S, Katsushima K, Kondo Y, Uchida S, Ogura S, Nomoto T, Takemoto H, Cabral H, Kinoh H, Tanaka HY, Kano MR, Matsumoto Y, Fukuhara H, Uchida S, Nangaku M, Osada K, Nishiyama N, Miyata K, Kataoka K. In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers. Nature communications. 2019.04; 10 (1): 1894. ( PubMed, DOI )

Yi Y, Kim HJ, Zheng M, Mi P, Naito M, Kim BS, Min HS, Hayashi K, Perche F, Toh K, Liu X, Mochida Y, Kinoh H, Cabral H, Miyata K, Kataoka K. Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. Journal of controlled release : official journal of the Controlled Release Society. 2019.02; 295 268-277. ( PubMed, DOI )

Hori M, Cabral H, Toh K, Kishimura A, Kataoka K. Robust Polyion Complex Vesicles (PICsomes) under Physiological Conditions Reinforced by Multiple Hydrogen Bond Formation Derived by Guanidinium Groups. Biomacromolecules. 2018.10; 19 (10): 4113-4121. ( PubMed, DOI )

Min HS, Kim HJ, Ahn J, Naito M, Hayashi K, Toh K, Kim BS, Matsumura Y, Kwon IC, Miyata K, Kataoka K. Tuned Density of Anti-Tissue Factor Antibody Fragment onto siRNA-Loaded Polyion Complex Micelles for Optimizing Targetability into Pancreatic Cancer Cells. Biomacromolecules. 2018.06; 19 (6): 2320-2329. ( PubMed, DOI )

Li J, Dirisala A, Ge Z, Wang Y, Yin W, Ke W, Toh K, Xie J, Matsumoto Y, Anraku Y, Osada K, Kataoka K. Therapeutic Vesicular Nanoreactors with Tumor-Specific Activation and Self-Destruction for Synergistic Tumor Ablation. Angewandte Chemie (International ed. in English). 2017.11; 56 (45): 14025-14030. ( PubMed, DOI )

Anraku, Y; Kuwahara, H; Fukusato, Y; Mizoguchi, A; Ishii, T; Nitta, K; Matsumoto, Y; Toh, K; Miyata, K; Uchida, S; Nishina, K; Osada, K; Itaka, K; Nishiyama, N; Mizusawa, H; Yamasoba, T; Yokota, T; Kataoka, K. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain NATURE COMMUNICATIONS. 2017.10; 8 (1): 1001. ( PubMed, DOI )

Takeuchi T, Kitayama Y, Sasao R, Yamada T, Toh K, Matsumoto Y, Kataoka K. Molecularly Imprinted Nanogels Acquire Stealth In Situ by Cloaking Themselves with Native Dysopsonic Proteins. Angewandte Chemie (International ed. in English). 2017.06; 56 (25): 7088-7092. ( PubMed, DOI )

Takeda KM, Yamasaki Y, Dirisala A, Ikeda S, Tockary TA, Toh K, Osada K, Kataoka K. Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly(l-lysine) block copolymers as systemic gene delivery carrier. Biomaterials. 2017.05; 126 31-38. ( PubMed, DOI )

Chen Q, Osada K, Ge Z, Uchida S, Tockary TA, Dirisala A, Matsui A, Toh K, Takeda KM, Liu X, Nomoto T, Ishii T, Oba M, Matsumoto Y, Kataoka K. Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials. 2017.01; 113 253-265. ( PubMed, DOI )