基本情報

写真a

馬 悦(マ ユエ)

MA YUE


職名

助教

経歴(学内) 【 表示 / 非表示

  • 2022年09月
    -
    現在
    東京医科歯科大学 統合研究機構 研究基盤クラスター リサーチコアセンター 助教

研究分野 【 表示 / 非表示

  • 生物有機化学

 

研究テーマ 【 表示 / 非表示

  • 核酸高次構造を標的としたリピート伸長病の創薬研究,2023年07月 - 2025年03月

  • グアニン四重鎖テンプレート合成による機能性リガンドの開発,2020年04月 - 2021年03月

  • 生細胞内における核酸高次構造の可視化と生物機能との関連,2019年09月 - 2021年03月

  • 生細胞内における核酸高次構造の可視化と生物機能との関連,2019年09月 - 2021年03月

  • 生細胞内における核酸高次構造の可視化と生物機能との関連,2019年09月 - 2021年03月

  • 機能性グアニン四重鎖を選択的に安定化するリガンドの創製研究,2016年04月 - 2019年03月

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論文・総説 【 表示 / 非表示

  1. Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration. 2023.03; 24 (5): ( PubMed, DOI )

  2. Effects of G-Quadruplex Ligands on the Topology, Stability, and Immunostimulatory Properties of G-Quadruplex-Based CpG Oligodeoxynucleotides. 2022.07; 17 (7): 1703-1713. ( PubMed, DOI )

  3. Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex. 2022.07; 649 114693. ( PubMed, DOI )

  4. Detection of CpG Methylation in G-Quadruplex Forming Sequences Using G-Quadruplex Ligands. 2021.12; 22 (23): ( PubMed, DOI )

  5. Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand. 2021.09; ( PubMed, DOI )

  6. Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease. 2021.07; 57 (59): 7236-7239. ( PubMed, DOI )

  7. Selective alkylation of parallel G-quadruplex structure. 2021.02; ( PubMed, DOI )

  8. Linear consecutive hexaoxazoles as G4 ligands inducing chair-type anti-parallel topology of a telomeric G-quadruplex 2020.12; 10 (71): 43319-43323. ( DOI )

  9. Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization. 2020.11; 56 (85): 12905-12908. ( PubMed, DOI )

  10. Topologies of G-quadruplex: Biological functions and regulation by ligands. 2020.01; ( PubMed, DOI )

  11. Masai H, Fukatsu R, Kakusho N, Kanoh Y, Moriyama K, Ma Y, Iida K, Nagasawa K. Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities. Scientific reports. 2019.06; 9 (1): 8618. ( PubMed, DOI )

  12. Iida K, Tsushima Y, Ma Y, Sedghi Masoud S, Sakuma M, Yokoyama T, Yoshida W, Ikebukuro K, Nagasawa K. Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole. Bioorganic & medicinal chemistry. 2019.04; 27 (8): 1742-1746. ( PubMed, DOI )

  13. Ma Y, Iida K, Sasaki S, Hirokawa T, Heddi B, Phan AT, Nagasawa K. Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains. Molecules (Basel, Switzerland). 2019.01; 24 (2): ( PubMed, DOI )

  14. Masai H, Kakusho N, Fukatsu R, Ma Y, Iida K, Kanoh Y, Nagasawa K. Molecular architecture of G-quadruplex structures generated on duplex Rif1-binding sequences. The Journal of biological chemistry. 2018.11; 293 (44): 17033-17049. ( PubMed, DOI )

  15. Masoud, S. S, Yamaoki, Y, Ma, Y, Marchand, A, Winnerdy, F. R, Gabelica, V, Phan, A. T, Katahira, M, Nagasawa, K. The interaction analysis of a cyclic tetraoxazole with telomeric i-motif DNA Japan Society of Nucleic Acids Chemistry. 2018.11;

  16. Ma Y, Tsushima Y, Sakuma M, Sasaki S, Iida K, Okabe S, Seimiya H, Hirokawa T, Nagasawa K. Development of G-quadruplex ligands for selective induction of a parallel-type topology. Organic & biomolecular chemistry. 2018.10; 16 (40): 7375-7382. ( PubMed, DOI )

  17. Kaori Tsukakoshi, Maui Nishio, Yuri Ikuta, Ikkei Sasaki, Yue Ma, Kazuo Nagasawa, Yoshio Kato, Chikashi Nakamura, Koji Sode, Kazunori Ikebukuro. Smart aptamers forming G-quadruplex: Structural and functional change of aptamers forming G-quadruplex in response to surrounding conditions and its regulation with the ligands Abstracts of Papers of The American Chemical Society. 2018.08; 256

  18. FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 (vol 8, 1073. 2017) 2017.12; 8 ( DOI )

  19. Masoud, S, Yamaoki, Y, Ma, Y, Katahira, M, Nagasawa, K. Interaction of a cyclic tetraoxazole with i-motif DNA and its effects on this structure The 44th International Symposium on Nucleic Acids Chemistry. 2017.11;

  20. FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 2017.10; 8 (1): 1073. ( PubMed, DOI )

  21. Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units 2017.06; 139 (22): 7476-7484. ( PubMed, DOI )

  22. Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole 2017.06; 7 (1): 3605. ( PubMed, DOI )

  23. A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription 2017.04; 7 45815. ( PubMed, DOI )

  24. A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions 2017.01; 45 (1): 288-295. ( PubMed, DOI )

  25. Design and synthesis of unsymmetric macrocyclic hexaoxazole compounds with an ability to induce distinct G-quadruplex topologies in telomeric DNA 2016.06; 14 (22): 5109-5116. ( PubMed, DOI )

  26. A Single Molecule Study of G-Quadruplex and Telomestatin Intractions 2016.02; 110 (3): 635A.

  27. DESIGN, SYNTHESIS AND EVALUATION OF AN L-DOPA-DERIVED MACROCYCLIC HEXAOXAZOLE (6OTD) AS A G-QUADRUPLEX-SELECTIVE LIGAND 2016.02; 92 (2): 305-315. ( DOI )

  28. Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers 2016; 52 (85): 12646-12649. ( PubMed, DOI )

  29. Ligand-Induced Conformational Changes with Cation Ejection upon Binding to Human Telomeric DNA G-Quadruplexes 2015.01; 137 (2): 750-756. ( PubMed, DOI )

  30. Regulation of thrombin activity by ligand-induced topological alteration in a thrombin-binding aptamer 2023; ( DOI )

  31. Maleki P, Mustafa G, Gyawali P, Budhathoki JB, Ma Y, Nagasawa K, Balci H. Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase. Nucleic acids research. 2019.09; ( PubMed, DOI )

  32. Gyawali P, Gc K, Ma Y, Abeysirigunawardena S, Nagasawa K, Balci H. Impact of Small Molecules on Intermolecular G-Quadruplex Formation. Molecules (Basel, Switzerland). 2019.04; 24 (8): ( PubMed, DOI )

  33. Mustafa G, Chuang CY, Roy WA, Farhath MM, Pokhrel N, Ma Y, Nagasawa K, Antony E, Comstock MJ, Basu S, Balci H. A force sensor that converts fluorescence signal into force measurement utilizing short looped DNA. Biosensors & bioelectronics. 2018.12; 121 34-40. ( PubMed, DOI )

  34. Sedghi Masoud S, Yamaoki Y, Ma Y, Marchand A, Winnerdy FR, Gabelica V, Phan AT, Katahira M, Nagasawa K. Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound. Chembiochem : a European journal of chemical biology. 2018.11; 19 (21): 2268-2272. ( PubMed, DOI )

  35. Abraham Punnoose J, Ma Y, Hoque ME, Cui Y, Sasaki S, Guo AH, Nagasawa K, Mao H. Random formation of G-quadruplexes in human telomere overhangs leads to a kinetic folding pattern with targetable vacant G-tracts. Biochemistry. 2018.11; ( PubMed, DOI )

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書籍等出版物 【 表示 / 非表示

  1. 月刊BIOINDUSTRY 2023年8月号 ビタミンA 誘導体:レチノイドの構造,機能,医療応用. 2023.08

  2. Handbook of Chemical Biology of Nucleic Acids. 2023 Macrocyclic G-Quadruplex Ligands of Telomestatin Analogs