Personnel Information

写真a

YOSHIOKAOKA HIROMASAMASA


Job title

Assistant Professor

Homepage URL

https://www.lbb.iir.isct.ac.jp/itoh-lab/en/

Field Introduction URL

https://www.lbb.iir.isct.ac.jp/itoh-lab/en/

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Graduating School 【 display / non-display 】

  • Yokohama City University, 2015.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Master's Course, 2017.03, Completed

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 2020.03, Completed

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Campus Career 【 display / non-display 】

  • 2022.05
    -
    2023.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Biomedical Sciences and Engineering， Division of Integrative Molecular Biomedicine， Department of RIKEN Molecular and Chemical Somatology， Visiting Lecturer
  • 2023.05
    -
    2024.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Biomedical Sciences and Engineering， Division of Integrative Molecular Biomedicine， Department of RIKEN Molecular and Chemical Somatology， Visiting Lecturer
  • 2026.04
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， Division of Drug Discovery Science， Biological and Pharmaceutical Chemistry， Assistant Professor
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External Career 【 display / non-display 】

  • 2020.04
    -
    2022.03
    RIKEN, CSRS Chemical Biology research group, post-doctoral researcher
  • 2021.10
    -
    Now
    Ochanomizu University, Faculty of Science, Visiting Lecturer
  • 2022.04
    -
    2024.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Visiting Lecturer
  • 2022.04
    -
    2024.03
    RIKEN, Biofunctional Synthetic Chemistry Laboratory, Postdoctoral Researcher
  • 2024.04
    -
    2026.03
    RIKEN, Special Postdoctoral Researcher
  • 2026.04
    -
    Now
    Institute of Science Tokyo, Assistant Professor

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Academic Society Affiliations 【 display / non-display 】

  • THE PHARMACEUTICAL SOCIETY OF JAPAN

  • THE JAPANESE BIOCHEMICAL SOCIETY

  • JAPANESE SOCIETY FOR CHEMICAL BIOLOGY

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Research Areas 【 display / non-display 】

  • Pharmaceutical chemistry and drug development sciences

  • Bioorganic chemistry

  • Applied biochemistry

  • Applied molecular and cellular biology

  • Chemical biology

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Research Theme 【 display / non-display 】

  • Development of "Cancer-Free Cells"., 2025.04 - 2027.03

  • Development of robust catalysts applicable in-blood synthesis and their application to tissue-specific drug synthesis., 2022.08 - 2024.03

  • Development of small molecules that modulate cholesterol homeostasis via ligand-mediated stabilization/destabilization., 2018.04 - 2020.03

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Published Papers & Misc 【 display / non-display 】

  1. Cancer-Selective Intracellular Polymerization via Acrolein-Driven Cyclodimerization Cascade. 2026.01; 65 (4): e18290. ( PubMed, DOI )

  2. In-gel refolding allows fluorescence detection of fully denatured GFPs after SDS-PAGE 2024.10; 702 115861. ( PubMed, DOI )

  3. Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein 2024.05; ( DOI )

  4. Catalytic olefin metathesis in blood 2023.09; ( DOI )

  5. Fine-Tuning of Nitrogen-Containing Bisphosphonate Esters that Potently Induce Degradation of HMG-CoA Reductase 2022.12; 78 ( PubMed, DOI )

  6. Introducing Our Authors 2022.03; 17 (3): 493-494. ( DOI )

  7. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1) 2022.02; 17 (2): 483-491. ( DOI )

  8. Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs. 2020.12; 15 (12): e0243746. ( PubMed, DOI )

  9. Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation 2020.05; 115576. ( DOI )

  10. Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols 2020.02; 28 (3): 115298. ( DOI )

  11. Multiplexing fluorogenic esterase-based viability assay with luciferase assays 2019; 6 2013-2020. ( DOI )

  12. Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold 2017.07; 25 (13): 3461-3470. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. The physiological and metabolic impact of acrolein production in cancer cells. Carbon-based material-biology interface science (CoMBiS), The Kickoff Symposium of Itami ASPIRE Project 2026.03.13

  2. In Cell Activating Proteins in Response to Cancer Metabolites. Carbon-based material-biology interface science (CoMBiS), The Kickoff Symposium of Itami ASPIRE Project 2026.03.12 Hotel Cadenza Tokyo, Tokyo

  3. In Vivo Tandem Metathesis Synthesis of PROTAC Molecules Toward Selective Cancer Cell Targeting. Carbon-based material-biology interface science (CoMBiS), The Kickoff Symposium of Itami ASPIRE Project 2026.03.12

  4. Kenji Ohgane, Hiromasa Yoshioka, Ikuya Sagimori, Yuichi Hashimoto. Chemical biology approach to understand small molecule-mediated degradation of HMG-CoA reductase. 60th International Conference on the Bioscience of Lipids (ICBL) 2019.06.17

  5. Yoshioka Hiromasa, Hashimoto Yuichi, Ogane Kenji. Chemical genetics approach identifies squalene as a novel feedback regulator of squalene epoxidase stability. The Third A3 Young Scientist Meeting 2019.02.22

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Works 【 display / non-display 】

  • Quantification of Gel Bands by an Image J Macro, Band/Peak Quantification Tool，Software，2019.09

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Campus class subject 【 display / non-display 】

  • Development of Functional Molecules，2026 - Now

  • Advanced Biofunctional Molecules，2026 - Now

  • Advanced Chemical Biology，2026 - Now

  • 生体分子制御学特論，2022 - 2024

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External class subject 【 display / non-display 】

  • Fundamental Experiment of Chemistry，Ochanomizu University

  • General Chemistry Ａ，Ochanomizu University

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