Personnel Information

写真a

SHINOHARA Kouki


Job title

Graduate Student
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Campus Career 【 display / non-display 】

  • 2022.04
    -
    2024.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Health Sciences and Biomedical Engineering， Department of Medicinal Chemistry， Graduate Student
  • 2024.04
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Biomedical Sciences and Engineering， Division of Biomedical Engineering， Department of Medicinal Chemistry， Graduate Student
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Biomedical Engineering， Department of Medicinal Chemistry， Graduate Student
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Published Papers & Misc 【 display / non-display 】

  1. Shinohara K, Kobayakawa T, Tsuji K, Takamatsu Y, Mitsuya H, Tamamura H. Naphthalen-1-ylethanamine-containing small molecule inhibitors of the papain-like protease of SARS-CoV-2. European journal of medicinal chemistry. 2024.12; 280 116963. ( PubMed, DOI )

  2. Kobayakawa Takuya, Yokoyama Masaru, Tsuji Kohei, Boku Sayaka, Kurakami Masaki, Fujino Masayuki, Ishii Takahiro, Miura Yutaro, Nishimura Soshi, Shinohara Kouki, Yamamoto Kenichi, Bolah Peter, Kotani Osamu, Murakami Tsutomu, Sato Hironori, Tamamura Hirokazu. HIV-1カプシド蛋白質を標的とする低分子抗HIV-1薬の開発(Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins) Chemical & Pharmaceutical Bulletin. 2024.01; 72 (1): 41-47. ( ichushi )

  3. Kobayakawa T, Yokoyama M, Tsuji K, Boku S, Kurakami M, Fujino M, Ishii T, Miura Y, Nishimura S, Shinohara K, Yamamoto K, Bolah P, Kotani O, Murakami T, Sato H, Tamamura H. Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins. Chemical & pharmaceutical bulletin. 2024; 72 (1): 41-47. ( PubMed, DOI )

  4. Tsuji Kohei, Kobayakawa Takuya, Ishii Takahiro, Higashi-Kuwata Nobuyo, Azuma Chika, Shinohara Kouki, Miura Yutaro, Yamamoto Kenichi, Nishimura Soshi, Hattori Shin-ichiro, Bulut Haydar, Mitsuya Hiroaki, Tamamura Hirokazu. ハロゲン導入およびアミド結合置換によるSARS-CoV-2のメインプロテアーゼに有効な阻害薬の探索研究(Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement) Chemical & Pharmaceutical Bulletin. 2023.12; 71 (12): 879-886. ( ichushi )

  5. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Chika Azuma, Yutaro Miura, Hiroki Nakano, Naoya Wada, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura. Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties. Journal of Medicinal Chemistry. 2023.10; 66 (19): 13516-13529. ( PubMed, DOI )

  6. Takuya Kobayakawa, Masayuki Amano, Miyuki Nakayama, Kohei Tsuji, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Kenichi Yamamoto, Masao Matsuoka, Hirokazu Tamamura. Development of anti-HBV agents targeting HBV capsid proteins. RSC Medicinal Chemistry. 2023.10; 14 (10): 1973-1980. ( PubMed, DOI )

  7. Tsuji K, Baffour-Awuah Owusu K, Miura Y, Ishii T, Shinohara K, Kobayakawa T, Emi A, Nakano T, Suzuki Y, Tamamura H. Dimerized fusion inhibitor peptides targeting the HR1-HR2 interaction of SARS-CoV-2. RSC advances. 2023.03; 13 (13): 8779-8793. ( PubMed, DOI )

  8. Kobayakawa T, Yokoyama M, Tsuji K, Fujino M, Kurakami M, Onishi T, Boku S, Ishii T, Miura Y, Shinohara K, Kishihara Y, Ohashi N, Kotani O, Murakami T, Sato H, Tamamura H. Low-molecular-weight anti-HIV-1 agents targeting HIV-1 capsid proteins. RSC advances. 2023.01; 13 (3): 2156-2167. ( PubMed, DOI )

  9. Kohei Tsuji, Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Kenichi Yamamoto, Soshi Nishimura, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura. Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement. Chemical & pharmaceutical bulletin. 2023; 71 (12): 879-886. ( PubMed, DOI )

  10. Tsuji K, Ishii T, Kobayakawa T, Higashi-Kuwata N, Azuma C, Nakayama M, Onishi T, Nakano H, Wada N, Hori M, Shinohara K, Miura Y, Kawada T, Hayashi H, Hattori SI, Bulut H, Das D, Takamune N, Kishimoto N, Saruwatari J, Okamura T, Nakano K, Misumi S, Mitsuya H, Tamamura H. Potent and biostable inhibitors of the main protease of SARS-CoV-2. iScience. 2022.11; 25 (11): 105365. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 篠原 功紀，鍬田 伸好，辻 耕平，石井 貴大，小早川 拓也，服部 真一朗，岸本 直樹，高宗 暢暁，三隅 将吾，Haydar Bulut，林 宏典，満屋 裕明，玉村 啓和. SARS-CoV-2メインプロテアーゼを標的とした高抗ウイルス活性を有する低分子阻害剤の創製. 日本薬学会第144回年会 2024.03.30 横浜

  2. Takahiro Ishii, Kohei Tsuji, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Hironori Hayashi, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura . Design and Synthesis of SARS-CoV-2 Mpro Inhibitors Containing Flurine Atoms and Amide Surrogates. 26th KPPS Annual Symposium 2023.07.03 Jeju

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