Personnel Information

写真a

SUGIHARA Hady Yuki


Job title

Graduate Student
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Graduating School 【 display / non-display 】

  • The University of Sheffield, Faculty of Science, Department of Animal and Plant Sciences, 2016.06, Graduated

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Campus Career 【 display / non-display 】

  • 2022.04
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Systemic Organ Regulation， Department of Gastroenterology and Hepatology， Graduate Student
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Systemic Organ Regulation， Department of Gastroenterology and Hepatology， Graduate Student
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Published Papers & Misc 【 display / non-display 】

  1. Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani. Intestinal organoids: The path towards clinical application. Eur J Cell Biol. 2025.03; 104 (1): 151474. ( PubMed, DOI )

  2. Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sho Kawasaki, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani. Controlled aggregative assembly to form self-organizing macroscopic human intestine from induced pluripotent stem cells. Cell Rep Methods. 2024.12; 4 (12): 100930. ( PubMed, DOI )

  3. Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani. Protocol to generate large human intestinal organoids using a rotating bioreactor. STAR Protocols. 2023.06; 4 (3): 102374. ( PubMed, DOI )

  4. Takahashi J, Mizutani T, Sugihara HY, Nagata S, Kato S, Hiraguri Y, Takeoka S, Tsuchiya M, Kuno R, Kakinuma S, Watanabe M, Okamoto R. Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids. Cell Reports Methods. 2022.11; 2 (11): 100337. ( PubMed, DOI )

  5. Kuno R, Ito G, Kawamoto A, Hiraguri Y, Sugihara HY, Takeoka S, Nagata S, Takahashi J, Tsuchiya M, Anzai S, Mizutani T, Shimizu H, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochemistry and biophysics reports. 2021.03; 25 100906. ( PubMed, DOI )

  6. Tsuchiya M, Ito G, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Sugihara HY, Mizutani T, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Functional analysis of isoflavones using patient-derived human colonic organoids. Biochemical and biophysical research communications. 2021.01; 542 40-47. ( PubMed, DOI )

  7. Teramoto N, Sugihara H, Yamanouchi K, Nakamura K, Kimura K, Okano T, Shiga T, Shirakawa T, Matsuo M, Nagata T, Daimon M, Matsuwaki T, Nishihara M. Pathological evaluation of rats carrying in-frame mutations in the dystrophin gene: a new model of Becker muscular dystrophy. Disease models & mechanisms. 2020.09; 13 (9): ( PubMed, DOI )

  8. Anzai S, Kawamoto A, Nagata S, Takahashi J, Kawai M, Kuno R, Kobayashi S, Watanabe S, Suzuki K, Shimizu H, Hiraguri Y, Takeoka S, Sugihara HY, Yui S, Oshima S, Watanabe M, Okamoto R. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochemical and biophysical research communications. 2020.04; 524 (3): 533-541. ( PubMed, DOI )

  9. Okamoto R, Shimizu H, Suzuki K, Kawamoto A, Takahashi J, Kawai M, Nagata S, Hiraguri Y, Takeoka S, Sugihara HY, Yui S, Watanabe M. Organoid-based regenerative medicine for inflammatory bowel disease. Regenerative therapy. 2020.03; 13 1-6. ( PubMed, DOI )

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