経歴(学内) 【 表示 ／ 非表示 】
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2017年04月-現在東京医科歯科大学 医学部 医学科 学生
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2022年04月-現在東京医科歯科大学 大学院医歯学総合研究科 医歯学専攻 先端医療開発学講座 システム発生・再生医学分野 大学院生
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2022年06月-2023年03月東京医科歯科大学 TMDU卓越大学院生 (II)
論文・総説 【 表示 ／ 非表示 】
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Kensuke Miyake, Junya Ito, Jun Nakabayashi, Shigeyuki Shichino, Kenji Ishiwata, Hajime Karasuyama. Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils. Nat Commun. 2023.05; 14 (1): 2694. ( PubMed, DOI )
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Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Frank Brombacher, Shigeyuki Shichino, Soichiro Yoshikawa, Sachiko Miyake, Hajime Karasuyama. Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model. Nat Commun. 2024.02; 15 (1): 1666. ( PubMed, DOI )
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Kazufusa Takahashi, Kensuke Miyake, Junya Ito, Hinano Shimamura, Tadahiro Suenaga, Hajime Karasuyama, Kenichi Ohashi. Topical application of a PDE4 inhibitor ameliorates atopic dermatitis through inhibition of basophil IL-4 production. J Invest Dermatol. 2023.10; ( PubMed, DOI )
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Kensuke Miyake, Junya Ito, Hajime Karasuyama. Role of Basophils in a Broad Spectrum of Disorders. Front Immunol. 2022; 13 902494. ( PubMed, DOI )
講演・口頭発表等 【 表示 ／ 非表示 】
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Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Shigeyuki Shichino, Hajime Karasuyama. Classical monocyte-derived macrophages display high efferocytic ability and contribute to the resolution of basophil-dependent skin allergic inflammation. The 52nd Annual Meeting of the Japanese Society for Immunology 2024.01.18
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Junya Ito, Kensuke Miyake, Kazufusa Takahashi, Shigeyuki Shichino, Hajime Karasuyama. FoxO1 regulates the number of basophils in the peripheral tissues and basophil-dependent allergic inflammation. The 52nd Annual Meeting of the Japanese Society for Immunology 2024.01.17
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Junya Ito, Kensuke Miyake, Kazufusa Takahashi, Shigeyuki Shichino, Hajime Karasuyama. Transcriptomic and functional analyses uncover an immature subpopulation of basophils in the bone marrow and FoxO1 as a transcription factor involved in the regulation of basophil responsiveness. 2022.12.08
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Kazufusa Takahashi, Kensuke Miyake, Junya Ito, Hinano Shimamura, Hajime Karasuyama. Difamilast, a selective phosphodiesterase 4 inhibitor, suppresses IL-4 production by basophils and ameliorates atopic dermatitis in a murine model. 2022.12.08
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Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Shigeyuki Shichino, Hajime Karasuyama. M2 macrophages generated in the termination phase of skin allergic inflammation display high efferocytic capacity and promote resolution of inflammation.. The 51th Annual Meeting of The Japanese Society for Immunology 2022.12.07
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Miyake K, Takahashi K, Ito J, Nakabayashi J, Shichino S, Yoshikawa S, Karasuyama H.. Basophils promote the generation of highly phagocytic M2 macrophages which dampen excess inflammation at the resolution phase of allergic inflammation.. The 50th Annual Meeting of The Japanese Society for Immunology 2021.12.10
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Ito J, Miyake K, Nakabayashi J, Shichino S, Karasuyama H.. Single-cell RNA-seq analysis identified a novel subpopulation of basophils with immature phenotypes and unique functionality.. The 50th Annual Meeting of The Japanese Society for Immunology 2021.12.08
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Miyake K, Takahashi K, Ito J, Nakabayashi J, Shichino S, Yoshikawa S, Karasuyama H.. Basophil-derived IL-4 induces the generation of M2 macrophages which dampen skin chronic allergic inflammation via the efferocytic clearance of dead cells.. 第70回日本アレルギー学会学術大会 2021.10.10
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Miyake K, Ito J, Takahashi K, Yoshikawa S, Yamanishi Y, Karasuyama. H. Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation.. JSA/WAO XXVII World Allergy Congress (WAC2020) conjoint with the APAPARI 2020 Congress 2020.09.17
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Ito J, Miyake K, Shichino S, Yamanishi Y, Karasuyama H.. Identification of two distinct subpopulations among basophils in the bone marrow.. JSA/WAO XXVII World Allergy Congress (WAC2020) conjoint with the APAPARI 2020 Congress 2020.09.17
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Ito J, Miyake K, Shichino S, Yamanishi Y, Karasuyama H.. Identification of immature-type basophils that are distinguishable from mature ones in terms of surface phenotype and activation property.. The 48th Annual Meeting of The Japanese Society for Immunology 2019.12.13
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三宅 健介, 高橋 和総, 伊藤 潤哉, 島村 雛乃, 烏山 一. 新規PDE4阻害薬のジファミラストは好塩基球のIL-4産生を抑制し,アトピー性皮膚炎モデルへの治療効果を示す. 日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集 2022.12.01
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伊藤潤哉, 三宅健介, 中林潤, 七野成之, 烏山一. 成熟好塩基球とは異なる活性化能を呈する未熟好塩基球の新規同定. 第70回日本アレルギー学会学術大会 2021.10.08
その他業績 【 表示 ／ 非表示 】
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Pre-basophils: A basophil origin story，2023年06月
AAAS EurekAlert! The Global Source for Science News
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「 希少な免疫細胞である好塩基球の分化・成熟経路を解明 」 ― アレルギーや寄生虫感染への応用に期待 ―，2023年05月
Nature Communications