Eizo Takashima, Hikaru Nagaoka, Ricardo Correia, Paula M Alves, António Roldão, Dennis Christensen, Jeffrey A Guderian, Akihisa Fukushima, Nicola K Viebig, Hilde Depraetere, Takafumi Tsuboi. A novel asexual blood-stage malaria vaccine candidate: PfRipr5 formulated with human-use adjuvants induces potent growth inhibitory antibodies. Front Immunol. 2022; 13 1002430. ( PubMed, DOI )

Hiroshi Yamada, Tadashi Abe, Hikaru Nagaoka, Eizo Takashima, Ryo Nitta, Masahiro Yamamoto, Kohji Takei. Recruitment of Irgb6 to the membrane is a direct trigger for membrane deformation. Front Cell Infect Microbiol. 2022; 12 992198. ( PubMed, DOI )

Ricardo Correia, Bárbara Fernandes, Rute Castro, Hikaru Nagaoka, Eizo Takashima, Takafumi Tsuboi, Akihisa Fukushima, Nicola K Viebig, Hilde Depraetere, Paula M Alves, António Roldão. Asexual Blood-Stage Malaria Vaccine Candidate PfRipr5: Enhanced Production in Insect Cells. Front Bioeng Biotechnol. 2022; 10 908509. ( PubMed, DOI )

Eizo Takashima, Bernard N Kanoi, Hikaru Nagaoka, Masayuki Morita, Ifra Hassan, Nirianne M Q Palacpac, Thomas G Egwang, Toshihiro Horii, Jesse Gitaka, Takafumi Tsuboi. Meta-Analysis of Human Antibodies Against Plasmodium falciparum Variable Surface and Merozoite Stage Antigens. Front Immunol. 2022; 13 887219. ( PubMed, DOI )

Eriko Hamasaki, Natsuki Wakita, Hiroki Yasuoka, Hikaru Nagaoka, Masayuki Morita, Eizo Takashima, Takayuki Uchihashi, Tetsuya Takeda, Tadashi Abe, Ji-Won Lee, Tadahiro Iimura, Moin A Saleem, Naohisa Ogo, Akira Asai, Akihiro Narita, Kohji Takei, Hiroshi Yamada. The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes. Front Cell Dev Biol. 2022; 10 884509. ( PubMed, DOI )

Miwa Sasai, Ji Su Ma, Masaaki Okamoto, Kohei Nishino, Hikaru Nagaoka, Eizo Takashima, Ariel Pradipta, Youngae Lee, Hidetaka Kosako, Pann-Ghill Suh, Masahiro Yamamoto. Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells. J Exp Med. 2021.07; 218 (7): ( PubMed, DOI )

Bernard N Kanoi, Hikaru Nagaoka, Masayuki Morita, Takafumi Tsuboi, Eizo Takashima. Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development. Parasitol Int. 2021.02; 80 102224. ( PubMed, DOI )

Hikaru Nagaoka, Bernard N Kanoi, Masayuki Morita, Takahiro Nakata, Nirianne M Q Palacpac, Thomas G Egwang, Toshihiro Horii, Takafumi Tsuboi, Eizo Takashima. Characterization of a Plasmodium falciparum PHISTc protein, PF3D7_0801000, in blood- stage malaria parasites. Parasitol Int. 2021.02; 80 102240. ( PubMed, DOI )

Takaaki Yuguchi, Bernard N Kanoi, Hikaru Nagaoka, Toyokazu Miura, Daisuke Ito, Hiroyuki Takeda, Takafumi Tsuboi, Eizo Takashima, Hitoshi Otsuki. Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein. Front Cell Infect Microbiol. 2021; 11 656620. ( PubMed, DOI )

Eizo Takashima, Mayumi Tachibana, Masayuki Morita, Hikaru Nagaoka, Bernard N Kanoi, Takafumi Tsuboi. Identification of Novel Malaria Transmission-Blocking Vaccine Candidates. Front Cell Infect Microbiol. 2021; 11 805482. ( PubMed, DOI )

Michelle K Muthui, Eizo Takashima, Brian R Omondi, Christine Kinya, William I Muasya, Hikaru Nagaoka, Kennedy W Mwai, Benedict Orindi, Juliana Wambua, Teun Bousema, Chris Drakeley, Andrew M Blagborough, Kevin Marsh, Philip Bejon, Melissa C Kapulu. Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature P. falciparum Gametocytes. Front Cell Infect Microbiol. 2021; 11 774537. ( PubMed, DOI )

The Mon La, Hiromi Tachibana, Shun-Ai Li, Tadashi Abe, Sayaka Seiriki, Hikaru Nagaoka, Eizo Takashima, Tetsuya Takeda, Daisuke Ogawa, Shin-Ichi Makino, Katsuhiko Asanuma, Masami Watanabe, Xuefei Tian, Shuta Ishibe, Ayuko Sakane, Takuya Sasaki, Jun Wada, Kohji Takei, Hiroshi Yamada. Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes. FASEB J. 2020.12; 34 (12): 16449-16463. ( PubMed, DOI )

Kazuaki Hakamada, Manami Nakamura, Rio Midorikawa, Kyosuke Shinohara, Keiichi Noguchi, Hikaru Nagaoka, Eizo Takashima, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Akihiro Kawamoto, Masafumi Yohda. PV1 Protein from Plasmodium falciparum Exhibits Chaperone-Like Functions and Cooperates with Hsp100s. Int J Mol Sci. 2020.11; 21 (22): ( PubMed, DOI )

Hikaru Nagaoka, Bernard N Kanoi, Edward H Ntege, Masamitsu Aoki, Akihisa Fukushima, Takafumi Tsuboi, Eizo Takashima. Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A. Sci Rep. 2020.04; 10 (1): 6573. ( PubMed, DOI )

Youngae Lee, Hiroshi Yamada, Ariel Pradipta, Ji Su Ma, Masaaki Okamoto, Hikaru Nagaoka, Eizo Takashima, Daron M Standley, Miwa Sasai, Kohji Takei, Masahiro Yamamoto. Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense. Life Sci Alliance. 2020.01; 3 (1): ( PubMed, DOI )

Bernard N Kanoi, Hikaru Nagaoka, Michael T White, Masayuki Morita, Nirianne M Q Palacpac, Edward H Ntege, Betty Balikagala, Adoke Yeka, Thomas G Egwang, Toshihiro Horii, Takafumi Tsuboi, Eizo Takashima. Global Repertoire of Human Antibodies Against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a Malaria Exposed Population. Front Immunol. 2020; 11 893. ( PubMed, DOI )

Kazutoyo Miura, Mayumi Tachibana, Eizo Takashima, Masayuki Morita, Bernard N Kanoi, Hikaru Nagaoka, Minami Baba, Motomi Torii, Tomoko Ishino, Takafumi Tsuboi. Malaria transmission-blocking vaccines: wheat germ cell-free technology can accelerate vaccine development. Expert Rev Vaccines. 2019.10; 18 (10): 1017-1027. ( PubMed, DOI )

Tatsuhiro Tohmoto, Eizo Takashima, Satoru Takeo, Masayuki Morita, Hikaru Nagaoka, Rachanee Udomsangpetch, Jetsumon Sattabongkot, Tomoko Ishino, Motomi Torii, Takafumi Tsuboi. Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion into erythrocytes in vitro. Parasitol Int. 2019.04; 69 25-29. ( PubMed, DOI )

Hikaru Nagaoka, Chisa Sasaoka, Takaaki Yuguchi, Bernard N Kanoi, Daisuke Ito, Masayuki Morita, Rachanee Udomsangpetch, Jetsumon Sattabongkot, Tomoko Ishino, Takafumi Tsuboi, Eizo Takashima. PfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47). Sci Rep. 2019.04; 9 (1): 5923. ( PubMed, DOI )

Mayumi Tachibana, Kazutoyo Miura, Eizo Takashima, Masayuki Morita, Hikaru Nagaoka, Luwen Zhou, Carole A Long, C Richter King, Motomi Torii, Takafumi Tsuboi, Tomoko Ishino. Identification of domains within Pfs230 that elicit transmission blocking antibody responses. Vaccine. 2019.03; 37 (13): 1799-1806. ( PubMed, DOI )

Hikaru Nagaoka, Bernard N Kanoi, Kana Jinoka, Masayuki Morita, Thangavelu U Arumugam, Nirianne M Q Palacpac, Thomas G Egwang, Toshihiro Horii, Takafumi Tsuboi, Eizo Takashima. The N-Terminal Region of Plasmodium falciparum MSP10 Is a Target of Protective Antibodies in Malaria and Is Important for PfGAMA/PfMSP10 Interaction. Front Immunol. 2019; 10 2669. ( PubMed, DOI )

Bernard N Kanoi, Hikaru Nagaoka, Masayuki Morita, Michael T White, Nirianne M Q Palacpac, Edward H Ntege, Betty Balikagala, Adoke Yeka, Thomas G Egwang, Toshihiro Horii, Takafumi Tsuboi, Eizo Takashima. Comprehensive analysis of antibody responses to Plasmodium falciparum erythrocyte membrane protein 1 domains. Vaccine. 2018.10; 36 (45): 6826-6833. ( PubMed, DOI )

Masayuki Morita, Hikaru Nagaoka, Edward H Ntege, Bernard N Kanoi, Daisuke Ito, Takahiro Nakata, Ji-Won Lee, Kazuaki Tokunaga, Tadahiro Iimura, Motomi Torii, Takafumi Tsuboi, Eizo Takashima. PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes. Sci Rep. 2018.02; 8 (1): 3696. ( PubMed, DOI )

Edward H Ntege, Eizo Takashima, Masayuki Morita, Hikaru Nagaoka, Tomoko Ishino, Takafumi Tsuboi. Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates. Expert Rev Vaccines. 2017.08; 16 (8): 769-779. ( PubMed, DOI )

Hikaru Nagaoka, Hisashi Nishiwaki, Takuya Kubo, Miki Akamatsu, Satoshi Yamauchi, Yoshihiro Shuto. Docking model of the nicotinic acetylcholine receptor and nitromethylene neonicotinoid derivatives with a longer chiral substituent and their biological activities. Bioorg Med Chem. 2015.02; 23 (4): 759-769. ( PubMed, DOI )

Hisashi Nishiwaki, Mituhiro Kuriyama, Hikaru Nagaoka, Akira Kato, Miki Akamatsu, Satoshi Yamauchi, Yoshihiro Shuto. Synthesis of imidacloprid derivatives with a chiral alkylated imidazolidine ring and evaluation of their insecticidal activity and affinity to the nicotinic acetylcholine receptor. Bioorg Med Chem. 2012.11; 20 (21): 6305-6312. ( PubMed, DOI )

Hisashi Nishiwaki, Hikaru Nagaoka, Mituhiro Kuriyama, Satoshi Yamauchi, Yoshihiro Shuto. Affinity to the nicotinic acetylcholine receptor and insecticidal activity of chiral imidacloprid derivatives with a methylated imidazolidine ring. Biosci Biotechnol Biochem. 2011; 75 (4): 780-782. ( PubMed, DOI )