経歴(学内) 【 表示 ／ 非表示 】
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2022年04月東京医科歯科大学 高等研究院 卓越研究部門 特任研究員
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2022年05月-2022年06月東京医科歯科大学 高等研究院 卓越研究部門 特任研究員
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2022年07月-2023年04月東京医科歯科大学 高等研究院 卓越研究部門 幹細胞治療研究室 特任研究員
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2023年05月-2023年08月東京医科歯科大学 高等研究院 卓越研究部門 幹細胞治療研究室 特任研究員
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2023年09月-現在東京医科歯科大学 統合研究機構 研究基盤クラスター 実験動物センター 助教
競争的資金等の研究課題 【 表示 ／ 非表示 】
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多細胞期着床前胚ゲノム編集法の確立
文部科学省/日本学術振興会 : 2021年 - 2024年
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造血幹細胞体外増幅系を用いた幹細胞性・加齢・発癌機構の解析
文部科学省/日本学術振興会 : 2020年 - 2024年
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新規カニクイザル発生工学技術を用いた栄養膜特異的ノックアウト法の開発
文部科学省/日本学術振興会
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ヒト多能性幹細胞由来ブラストイド を用いた、試験管内ヒト着床後胚発生モデルの構築
文部科学省/日本学術振興会
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染色体移植によるヒトトリソミーモデルマウスの開発
文部科学省/日本学術振興会
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造血幹細胞体外増幅系を用いた幹細胞性・加齢・発癌機構の解析
文部科学省/日本学術振興会
論文・総説 【 表示 ／ 非表示 】
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Mayuko Kano, Naoaki Mizuno, Hideyuki Sato, Takaharu Kimura, Rei Hirochika, Yasumasa Iwasaki, Naoko Inoshita, Hisato Nagano, Mariko Kasai, Hiromi Yamamoto, Tomoyuki Yamaguchi, Hidetaka Suga, Hideki Masaki, Eiji Mizutani, Hiromitsu Nakauchi. Functional calcium-responsive parathyroid glands generated using single-step blastocyst complementation. Proc Natl Acad Sci U S A. 2023.07; 120 (28): e2216564120. ( PubMed, DOI )
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Mami Oikawa, Hisato Kobayashi, Makoto Sanbo, Naoaki Mizuno, Kenyu Iwatsuki, Tomoya Takashima, Keiko Yamauchi, Fumika Yoshida, Takuya Yamamoto, Takashi Shinohara, Hiromitsu Nakauchi, Kazuki Kurimoto, Masumi Hirabayashi, Toshihiro Kobayashi. Functional primordial germ cell-like cells from pluripotent stem cells in rats. Science. 2022.04; 376 (6589): 176-179. ( PubMed, DOI )
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Mami Oikawa, Mayuko Nagae, Naoaki Mizuno, Kenyu Iwatsuki, Fumika Yoshida, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Hiromitsu Nakauchi, Masumi Hirabayashi, Toshihiro Kobayashi. Generation of Tfap2c-T2A-tdTomato knock-in reporter rats via adeno-associated virus-mediated efficient gene targeting. Mol Reprod Dev. 2022.03; 89 (3): 129-132. ( PubMed, DOI )
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Kazuto Yamazaki, Kenji Kubara, Satoko Ishii, Peng Li, Ryo Dairiki, Taro Hihara, Yuta Ishizuka, Yukina Izumi, Minoru Kumai, Tsutomu Kamisako, Hiroyoshi Ishizaki, Hideyuki Sato, Hideki Masaki, Naoaki Mizuno, Kaoru Mitsuhashi, Masashi Ito, Sanae Hamanaka, Tomoyuki Yamaguchi, Motoo Watanabe, Fumihiro Sugiyama, Hiromitsu Nakauchi. In vitro and in vivo functions of T cells produced in complemented thymi of chimeric mice generated by blastocyst complementation. Sci Rep. 2022.02; 12 (1): 3242. ( PubMed, DOI )
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Toshihiro Kobayashi, Aracely Castillo-Venzor, Chris A Penfold, Michael Morgan, Naoaki Mizuno, Walfred W C Tang, Yasuyuki Osada, Masao Hirao, Fumika Yoshida, Hideyuki Sato, Hiromitsu Nakauchi, Masumi Hirabayashi, M Azim Surani. Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells. Cell Rep. 2021.10; 37 (2): 109812. ( PubMed, DOI )
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Arata Honda, Ryoma Tachibana, Kazuya Hamada, Kohtaro Morita, Naoaki Mizuno, Kento Morita, Masahide Asano. Efficient derivation of knock-out and knock-in rats using embryos obtained by in vitro fertilization. Sci Rep. 2019.08; 9 (1): 11571. ( PubMed, DOI )
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Naoaki Mizuno, Eiji Mizutani, Hideyuki Sato, Mariko Kasai, Hiromitsu Nakauchi, Tomoyuki Yamaguchi. CRISPR/Cas9 + AAV-mediated Intra-embryonic Gene Knocking in Mice. Bio Protoc. 2019.07; 9 (13): e3295. ( PubMed, DOI )
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Naoaki Mizuno, Eiji Mizutani, Hideyuki Sato, Mariko Kasai, Aki Ogawa, Fabian Suchy, Tomoyuki Yamaguchi, Hiromitsu Nakauchi. Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector. iScience. 2018.11; 9 286-297. ( PubMed, DOI )
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Tomoyuki Yamaguchi, Hideyuki Sato, Toshihiro Kobayashi, Megumi Kato-Itoh, Teppei Goto, Hiromasa Hara, Naoaki Mizuno, Ayaka Yanagida, Ayumi Umino, Sanae Hamanaka, Fabian Suchy, Hideki Masaki, Yasunori Ota, Masumi Hirabayashi, Hiromitsu Nakauchi. An interspecies barrier to tetraploid complementation and chimera formation. Sci Rep. 2018.10; 8 (1): 15289. ( PubMed, DOI )
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Sanae Hamanaka, Ayumi Umino, Hideyuki Sato, Tomonari Hayama, Ayaka Yanagida, Naoaki Mizuno, Toshihiro Kobayashi, Mariko Kasai, Fabian Patrik Suchy, Satoshi Yamazaki, Hideki Masaki, Tomoyuki Yamaguchi, Hiromitsu Nakauchi. Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. Stem Cell Reports. 2018.10; 11 (4): 988-997. ( PubMed, DOI )
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Tomoyuki Yamaguchi, Hideyuki Sato, Megumi Kato-Itoh, Teppei Goto, Hiromasa Hara, Makoto Sanbo, Naoaki Mizuno, Toshihiro Kobayashi, Ayaka Yanagida, Ayumi Umino, Yasunori Ota, Sanae Hamanaka, Hideki Masaki, Sheikh Tamir Rashid, Masumi Hirabayashi, Hiromitsu Nakauchi. Interspecies organogenesis generates autologous functional islets. Nature. 2017.02; 542 (7640): 191-196. ( PubMed, DOI )
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Ayaka Yanagida, Naoak Mizuno, Yuji Yamazaki, Megumi Kato-Itoh, Ayumi Umino, Hideyuki Sato, Keiichi Ito, Tomoyuki Yamaguchi, Hiromitsu Nakauchi, Akihide Kamiya. Investigation of bipotent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice. Hepatol Res. 2016.07; 46 (8): 816-828. ( PubMed, DOI )
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Hayama T, Yamaguchi T, Kato-Itoh M, Ishii Y, Mizuno N, Umino A, Sato H, Sanbo M, Hamanaka S, Masaki H, Hirabayashi M, Nakauchi H.. Practical selection methods for rat and mouse round spermatids without DNA staining by flow cytometric cell sorting. Mol Reprod Dev.. 2016.06;
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Tomonari Hayama, Tomoyuki Yamaguchi, Megumi Kato-Itoh, Sanae Hamanaka, Mami Kawarai, Makoto Sanbo, Chihiro Tamura, Youn-Su Lee, Ayaka Yanagida, Hideyuki Murayama, Naoaki Mizuno, Ayumi Umino, Hideyuki Sato, Satoshi Yamazaki, Hideki Masaki, Toshihiro Kobayashi, Masumi Hirabayashi, Hiromitsu Nakauchi. Generation of mouse functional oocytes in rat by xeno-ectopic transplantation of primordial germ cells. Biol Reprod. 2014.10; 91 (4): 89. ( PubMed, DOI )
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Ryota Inokuchi, Kensuke Nakamura, Naoaki Mizuno, Hajime Sato, Kazuaki Shinohara, Takehiro Matsubara, Kent Doi, Takeshi Ishii, Masataka Gunshin, Susumu Nakajima, Naoki Yahagi. Adult-onset seizures in a patient with Down syndrome and portosystemic shunt. Brain Dev. 2014.08; 36 (7): 626-629. ( PubMed, DOI )
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Ken Morita, Fumihiko Nakamura, Yasuhiko Kamikubo, Naoaki Mizuno, Masashi Miyauchi, Go Yamamoto, Yasuhito Nannya, Motoshi Ichikawa, Mineo Kurokawa. Pituitary lymphoma developing within pituitary adenoma. Int J Hematol. 2012.06; 95 (6): 721-724. ( PubMed, DOI )
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Junji Kawada, Hisashi Wada, Midori Isobe, Sacha Gnjatic, Hiroyoshi Nishikawa, Achim A Jungbluth, Nami Okazaki, Akiko Uenaka, Yurika Nakamura, Shinichi Fujiwara, Naoaki Mizuno, Takashi Saika, Erika Ritter, Makoto Yamasaki, Hiroshi Miyata, Gerd Ritter, Roger Murphy, Ralph Venhaus, Linda Pan, Lloyd J Old, Yuichiro Doki, Eiichi Nakayama. Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination. Int J Cancer. 2012.02; 130 (3): 584-592. ( PubMed, DOI )