Personnel Information

写真a

OKABE MOTOHITO


Job title

Project Assistant Professor
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Campus Career 【 display / non-display 】

  • 2022.04
    -
    2022.06
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， ， Project Researcher
  • 2022.07
    -
    2023.04
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， ， Stem Cell Therapy Laboratory， Project Researcher
  • 2023.05
    -
    2024.03
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， ， Stem Cell Therapy Laboratory， Project Researcher
  • 2024.04
    -
    Now
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Internal Medicine， Hematology， Project Assistant Professor
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External Career 【 display / non-display 】

  • 2020.04
    -
    2021.07
    , Senior Resident
  • 2021.08
    -
    2022.03
    , Project Researcher
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Qualification Acquired 【 display / non-display 】

  • Doctor

  • Medical Technologist

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Published Papers & Misc 【 display / non-display 】

  1. Fumiya Wada, Mizuki Watanabe, Takaaki Konuma, Motohito Okabe, Shinichi Kobayashi, Naoyuki Uchida, Kazuhiro Ikegame, Masatsugu Tanaka, Yasuhiro Sugio, Junichi Mukae, Makoto Onizuka, Toshiro Kawakita, Takuro Kuriyama, Satoshi Takahashi, Takahiro Fukuda, Nobuaki Nakano, Masashi Sawa, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta, Junya Kanda, . HLA 1-3 antigen-mismatched related peripheral blood stem cells transplantation using low-dose antithymocyte globulin versus unrelated cord blood transplantation. Am J Hematol. 2022.03; 97 (3): 311-321. ( PubMed, DOI )

  2. Yuta Kaito, Takaaki Konuma, Maki Monna-Oiwa, Seiko Kato, Masamichi Isobe, Motohito Okabe, Yoichi Imai, Satoshi Takahashi, Arinobu Tojo. Prognostic impacts of peripheral blood erythroblasts after single-unit cord blood transplantation. Int J Lab Hematol. 2021.12; 43 (6): 1437-1442. ( PubMed, DOI )

  3. Masamichi Isobe, Takaaki Konuma, Maki Monna-Oiwa, Motohito Okabe, Seiko Kato, Satoshi Takahashi, Arinobu Tojo. Momentum of neutrophil recovery using an exponential growth model predicts the prognosis of single cord blood transplantation. Int J Lab Hematol. 2021.12; 43 (6): 1465-1471. ( PubMed, DOI )

  4. Takaaki Konuma, Maki Monna-Oiwa, Masamichi Isobe, Motohito Okabe, Satoshi Takahashi, Arinobu Tojo. Radiation-free myeloablative conditioning consisting of fludarabine added to full-dose busulfan and cyclophosphamide in single-unit cord blood transplantation for adults. Eur J Haematol. 2021.09; 107 (3): 374-376. ( PubMed, DOI )

  5. Motohito Okabe, Takanobu Morishita, Takahiko Yasuda, Hirotoshi Sakaguchi, Masashi Sanada, Keisuke Kataoka, Seishi Ogawa, Yuichi Shiraishi, Tomoe Ichiki, Yuka Kawaguchi, Marie Ohbiki, Rena Matsumoto, Masahide Osaki, Tatsunori Goto, Yukiyasu Ozawa, Koichi Miyamura. Targeted deep next generation sequencing identifies potential somatic and germline variants for predisposition to familial Burkitt lymphoma. Eur J Haematol. 2021.07; 107 (1): 166-169. ( PubMed, DOI )

  6. Motohito Okabe, Takaaki Konuma, Maki Oiwa-Monna, Seiko Kato, Masamichi Isobe, Satoshi Takahashi, Arinobu Tojo. Impact of a prior history of cancer on prognosis after myeloablative single-unit cord blood transplantation. Jpn J Clin Oncol. 2021.04; 51 (4): 657-660. ( PubMed, DOI )

  7. Takaaki Konuma, Maki Monna-Oiwa, Yuta Kaito, Masamichi Isobe, Motohito Okabe, Seiko Kato, Satoshi Takahashi, Arinobu Tojo. Early-Phase Peripheral Blood Eosinophilia Predicts Lower Overall and Non-Relapse Mortality After Single-Unit Cord Blood Transplantation. Transplant Cell Ther. 2021.04; 27 (4): 336.e1-336.e9. ( PubMed, DOI )

  8. Okabe Motohito, Konuma Takaaki, Oiwa-Monna Maki, Kato Seiko, Isobe Masamichi, Takahashi Satoshi, Tojo Arinobu. 骨髄破壊的1単位臍帯血移植後の予後に対する癌の既往歴の影響(Impact of a prior history of cancer on prognosis after myeloablative single-unit cord blood transplantation) Japanese Journal of Clinical Oncology. 2021.04; 51 (4): 657-660. ( ichushi )

  9. Takanobu Morishita, Rena Matsumoto, Tomoki Naito, Yosuke Domon, Kenichiro Takeda, Kohei Ishigiwa, Tomoe Ichiki, Motohito Okabe, Motoki Eguchi, Yuka Kawaguchi, Marie Ohbiki, Tatsunori Goto, Yukiyasu Ozawa, Koichi Miyamura. Pretransplant increasing rate of lactate dehydrogenase as a predictor of transplant outcomes for patients with myeloid hematological malignancies. Bone Marrow Transplant. 2021.03; 56 (7): 1732-1736. ( PubMed, DOI )

  10. Takaaki Konuma, Chisato Kohara, Eri Watanabe, Shunsuke Takahashi, Genki Ozawa, Kentaro Inomata, Kei Suzuki, Motoko Mizukami, Etsuko Nagai, Motohito Okabe, Masamichi Isobe, Seiko Kato, Maki Oiwa-Monna, Satoshi Takahashi, Arinobu Tojo. Impact of Intestinal Microbiota on Reconstitution of Circulating Monocyte, Dendritic Cell, and Natural Killer Cell Subsets in Adults Undergoing Single-Unit Cord Blood Transplantation. Biol Blood Marrow Transplant. 2020.11; 26 (11): e292-e297. ( PubMed, DOI )

  11. Takaaki Konuma, Susumu Tanoue, Mai Mizusawa, Motohito Okabe, Masamichi Isobe, Seiko Kato, Satoshi Takahashi, Arinobu Tojo. Tuberculous pleurisy in an adult patient after cord blood transplantation. EJHaem. 2020.11; 1 (2): 424-425. ( PubMed, DOI )

  12. Motohito Okabe, Takanobu Morishita, Tomoe Ichiki, Yuka Kawaguchi, Yoonha Lee, Marie Ohbiki, Miyo Goto, Masahide Osaki, Hiroaki Araie, Tatsunori Goto, Yukiyasu Ozawa, Koichi Miyamura. The stability of initial tacrolimus concentration following allogeneic hematopoietic stem cell transplantation reduces the risk of acute GVHD. Clin Transplant. 2020.08; 34 (10): e14052. ( PubMed, DOI )

  13. Hiroaki Araie, Yuka Kawaguchi, Motohito Okabe, Yoonha Lee, Marie Ohbiki, Masahide Osaki, Miyo Goto, Tatsunori Goto, Takanobu Morishita, Yukiyasu Ozawa, Koichi Miyamura. Prediction of clinical outcome by controlling nutritional status (CONUT) before allogeneic hematopoietic stem cell transplantation in myeloid malignancies. Int J Hematol. 2019.11; 110 (5): 599-605. ( PubMed, DOI )

  14. Araie Hiroaki, Kawaguchi Yuka, Okabe Motohito, Lee Yoonha, Ohbiki Marie, Osaki Masahide, Goto Miyo, Goto Tatsunori, Morishita Takanobu, Ozawa Yukiyasu, Miyamura Koichi. 骨髄性悪性腫瘍における同種造血幹細胞移植前のcontrolling nutritional status(CONUT)による臨床成績の予測(Prediction of clinical outcome by controlling nutritional status(CONUT) before allogeneic hematopoietic stem cell transplantation in myeloid malignancies) International Journal of Hematology. 2019.11; 110 (5): 599-605. ( ichushi )

  15. Takanobu Morishita, Motohito Okabe, Yuuka Kawaguchi, Yoonha Lee, Marie Ohbiki, Masahide Osaki, Miyo Goto, Hiroaki Araie, Takahiko Sato, Tatsunori Goto, Yukiyasu Ozawa, Koichi Miyamura. Higher Peak Tacrolimus Concentrations after Allogeneic Hematopoietic Stem Cell Transplantation Increase the Risk of Endothelial Cell Damage Complications. Biol Blood Marrow Transplant. 2018.12; 24 (12): 2509-2516. ( PubMed, DOI )

  16. Hong-Nian Liu, Hiroaki Hirata, Yusuke Okuno, Motohito Okabe, Koichi Furukawa. Dopamine and Serotonin Receptors Cooperatively Modulate Pacemaker Activity of Intestinal Cells of Cajal. Chin J Physiol. 2018.10; 61 (5): 302-312. ( PubMed, DOI )

  17. Motohito Okabe, Sachiko Ito, Naomi Nishio, Yuriko Tanaka, Ken-Ichi Isobe. Thymic Epithelial Cells Induced from Pluripotent Stem Cells by a Three-Dimensional Spheroid Culture System Regenerates Functional T Cells in Nude Mice. Cell Reprogram. 2015.10; 17 (5): 368-375. ( PubMed, DOI )

  18. Chen-Yi Lai, Satoshi Yamazaki, Motohito Okabe, Sachie Suzuki, Yoshihiro Maeyama, Yasuaki Iimura, Masafumi Onodera, Shigeru Kakuta, Yoichiro Iwakura, Masanori Nojima, Makoto Otsu, Hiromitsu Nakauchi. Stage-specific roles for CXCR4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation. Stem Cells. 2014.07; 32 (7): 1929-1942. ( PubMed, DOI )

  19. Koji Eshima, Motohito Okabe, Satoshi Kajiura, Haruka Noma, Nobukata Shinohara, Kazuya Iwabuchi. Significant involvement of nuclear factor-κB-inducing kinase in proper differentiation of αβ and γδ T cells. Immunology. 2014.02; 141 (2): 222-232. ( PubMed, DOI )

  20. Nao Suzuki, Satoshi Yamazaki, Tomoyuki Yamaguchi, Motohito Okabe, Hideki Masaki, Satoshi Takaki, Makoto Otsu, Hiromitsu Nakauchi. Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation. Mol Ther. 2013.07; 21 (7): 1424-1431. ( PubMed, DOI )

  21. Tomoyuki Yamaguchi, Sanae Hamanaka, Akihide Kamiya, Motohito Okabe, Mami Kawarai, Yukiko Wakiyama, Ayumi Umino, Tomonari Hayama, Hideyuki Sato, Youn-Su Lee, Megumi Kato-Itoh, Hideki Masaki, Toshihiro Kobayashi, Satoshi Yamazaki, Hiromitsu Nakauchi. Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming. PLoS One. 2012; 7 (7): e41007. ( PubMed, DOI )

  22. Motohito Okabe, Makoto Otsu, Dong Hyuck Ahn, Toshihiro Kobayashi, Yohei Morita, Yukiko Wakiyama, Masafumi Onodera, Koji Eto, Hideo Ema, Hiromitsu Nakauchi. Definitive proof for direct reprogramming of hematopoietic cells to pluripotency. Blood. 2009.08; 114 (9): 1764-1767. ( PubMed, DOI )

  23. Atsuhiko Oikawa, Koichi Ito, Hirotoshi Seguchi, Motohito Okabe, Fujio Migishima, Koji Eshima, Sadahiro Azuma, Si-Young Song, Takehisa Kaneko, Nobukata Shinohara. Development of immunocompetent lymphocytes in vivo from murine umbilical cord blood cells. Transplantation. 2007.07; 84 (1): 23-30. ( PubMed, DOI )

  24. Motohito Okabe, Masato Enomoto, Haruki Maeda, Kazuyuki Kuroki, Kenzo Ohtsuki. Biochemical characterization of suramin as a selective inhibitor for the PKA-mediated phosphorylation of HBV core protein in vitro. Biol Pharm Bull. 2006.09; 29 (9): 1810-1814. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 梨本 淳一郎, 佐藤 亜紀, 櫻井 健一, 岡部 基人, 磯部 優理, 川俣 豊隆, 小沼 貴晶, 横山 和明, 安井 寛, 大田 泰徳, 高橋 聡, 今井 陽一, 東條 有伸. KIT D816V変異陰性侵襲性全身性肥満細胞症の一例(A case of KIT D816V mutation negative aggressive systemic mastocytosis). 日本血液学会学術集会 2021.09.01

  2. 小川 弥穂, 横山 和明, 高橋 華, 伊藤 美香, 遊佐 希, 清水 英悟, 片山 琴絵, 岡部 基人, 磯部 優理, 小沼 貴晶, 今井 陽一, 井元 清哉, 高橋 聡. 急性リンパ性白血病移植後における腫瘍由来循環DNAの有用性(Prognostic impact of circulating tumor DNA status post-allogeneic HSCT in ALL). 日本血液学会学術集会 2021.09.01

  3. 和田 典也, 渡邊 瑞希, 小沼 貴晶, 岡部 基人, 小林 真一, 内田 直之, 池亀 和博, 田中 正嗣, 太田 貴徳, 土岐 典子, 鬼塚 真仁, 河北 敏郎, 衛藤 徹也, 高橋 聡, 木村 貴文, 一戸 辰夫, 熱田 由子, 諫田 淳也. 単一臍帯血と低用量サイモグロブリンを用いたHLA不適合血縁からの移植成績の比較(Comparison of cord blood and HLA mismatched related transplantation using antithymocyte globulin). 日本血液学会学術集会 2021.09.01

  4. 尾崎 正英, 一木 朝絵, 岡部 基人, 川口 裕佳, 李 尹河, 大引 真理恵, 後藤 実世, 新家 裕朗, 池野 世新, 佐藤 貴彦, 後藤 辰徳, 森下 喬允, 小澤 幸泰, 宮村 耕一. ダサチニブによるサイトメガロウイルス再活性化を起こしたPh+ALLでは早期に分子学的寛解に至る(Dasatinib-induced cytomegalovirus reactivation induce earlier molecular response in Ph+ALL). 臨床血液 2018.09.01

  5. 石際 康平, 尾崎 正英, 川島 直実, 一木 朝絵, 岡部 基人, 川口 裕佳, 李 尹河, 大引 真理恵, 後藤 実世, 新家 裕朗, 池野 世新, 佐藤 貴彦, 後藤 辰徳, 森下 喬允, 小澤 幸泰, 宮村 耕一. 重度の血小板減少を伴う骨髄線維症に対する低用量ルキソリチニブの使用(A myelofibrosis patient with severe thrombocytopenia treated with low dose ruxolitinib). 臨床血液 2018.09.01

  6. 佐藤 貴彦, 柳沼 莉絵, 川口 裕佳, 岡部 基人, 李 尹河, 大引 真理恵, 尾崎 正英, 後藤 実世, 池野 世新, 新家 裕朗, 森下 喬允, 小澤 幸泰, 宮村 耕一. 造血幹細胞移植後閉塞性肺疾患に対するカクテル療法の有用性(Efficacy of cocktail-therapy for obstructive disease after hematopoietic stem cell transplantation). 臨床血液 2018.09.01

  7. 川口 裕佳, 岡部 基人, 李 尹河, 大引 真理恵, 尾崎 正英, 後藤 実世, 新家 裕朗, 池野 世新, 佐藤 貴彦, 後藤 辰徳, 森下 喬允, 小澤 幸泰, 伊藤 理恵, 宮村 耕一. 眼底所見で白血病が疑われたCMLの一例(A case of chronic myeloid leukemia suspected by fundus observation). 臨床血液 2018.09.01

  8. 一木 朝絵, 尾崎 正英, 中島 麻梨絵, 岡部 基人, 川口 裕佳, 大引 真理恵, 李 尹河, 後藤 実世, 新家 裕朗, 池野 世新, 佐藤 貴彦, 倉重 真沙子, 後藤 辰徳, 森下 喬允, 小澤 幸泰, 伊藤 雅文, 宮村 耕一. 病理解剖で腸管型Behcet病が明らかになったtrisomiy 8を伴ったMDSの一例(Myelodysplastic syndrome with trisomy 8 pathologically diagnosed intestinal Behcet disease). 臨床血液 2018.09.01

  9. 池野 世新, 岡部 基人, 川口 裕佳, 大引 真理恵, 李 尹河, 尾崎 正英, 後藤 実世, 新家 裕朗, 佐藤 貴彦, 森下 喬允, 小澤 幸泰, 勝見 章, 宮村 耕一. 免疫抑制療法後に発作性夜間ヘモグロビン尿症に移行した再生不良性貧血に対するエクリズマブの有効性(Efficacy of eculizumab for aplastic anemia developed to paroximal nocturnal hemogrobinuria after IST). 臨床血液 2018.09.01

  10. 新家 裕朗, 一木 朝絵, 川口 裕佳, 岡部 基人, 李 尹河, 大引 真理恵, 尾崎 正英, 後藤 実世, 佐藤 貴彦, 後藤 辰徳, 森下 喬允, 小澤 幸泰, 宮村 耕一. 予後不良な高齢同種移植患者に対する前処置としてTBIを併用したFluBu4は予後を改善する可能性がある(Adding TBI to FluBu4 before allo HSCT may improve outcome in poor prognosis patient of elderly). 臨床血液 2018.09.01

  11. 岡部 基人, 川口 裕佳, 大引 真理恵, 李 尹河, 尾崎 正英, 後藤 実世, 新家 裕朗, 佐藤 貴彦, 後藤 辰徳, 森下 喬允, 小澤 幸泰, 宮村 耕一. 造血細胞移植後に別室患者間で同時発生したLeclercia Carboxylata感染症(Coincidence of Leclercia Carboxylata bactermia in patients after hematopoietic cell transplantation). 臨床血液 2018.09.01

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