Personnel Information

写真a

NASHIMOTO YUJI


Job title

Associate Professor
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Graduating School 【 display / non-display 】

  • Tohoku University, Graduate school of environmental studies, 2015.03, Graduated

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Campus Career 【 display / non-display 】

  • 2022.04
    -
    2023.03
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biofunctional Restoration， Biomechanics， Associate Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， -， -， Associate Professor
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External Career 【 display / non-display 】

  • 2007.04
    -
    2012.03
    Terumo Corporation,
  • 2013.04
    -
    2015.03
    Tohoku University, Graduate School of Environmental Study, JSPS fellow
  • 2015.04
    -
    2016.03
    Kyoto University, Department of Microengineering, Program Specific Researcher
  • 2016.04
    -
    2018.02
    Kyoto University, Department of Microengineering, Project Assistant Professor
  • 2018.03
    -
    2022.03
    Tohoku University, Frontier Research Institute for Interdisciplinary Sciences, Assistant Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University, Associate Professor
  • 2022.06
    -
    Now
    RIKEN, Riken Microfluidic Lab, Visiting Researcher

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Academic Society Affiliations 【 display / non-display 】

  • THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN

  • THE ELECTROCHEMICAL SOCIETY OF JAPAN

  • THE CHEMICAL SOCIETY OF JAPAN

  • THE JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY

  • THE JAPANESE SOCIETY FOR BIOMATERIALS

  • Biomedical Engineering Society

  • The Japanese Society for Alternatives to Animal Experiments

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Academic Activity 【 display / non-display 】

  • 2019.04
    -
    2022.03
    a member of a delegation
  • 2022.11
    -
    2023.12
    Frontiers in Bioengineering and Biotechnology Topic Editor
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Research Areas 【 display / non-display 】

  • Biomaterials

  • Biomedical engineering

  • Nanobioscience

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Research Theme 【 display / non-display 】

  • Porous membrane devices with biosensors for microphysiological systems, 2022.09 - 2025.03

  • Hybrid electrochemical bioimaging with multiscale, 2016.04 - 2019.03

  • Hybrid electrochemical bioimaging with multiscale, 2016.04 - 2019.03

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Published Papers & Misc 【 display / non-display 】

  1. Hiramoto, K; Konno, A; Nashimoto, Y; Hirano-Iwata, A; Ino, K; Shiku, H. Osteogenic differentiation of mesenchymal stem cell spheroids: A microfluidic device and electrochemiluminescence imaging study ELECTROCHIMICA ACTA. 2024.07; 491 ( DOI )

  2. Shibata S, Endo S, Nagai LAE, H Kobayashi E, Oike A, Kobayashi N, Kitamura A, Hori T, Nashimoto Y, Nakato R, Hamada H, Kaji H, Kikutake C, Suyama M, Saito M, Yaegashi N, Okae H, Arima T. Modeling embryo-endometrial interface recapitulating human embryo implantation. Science advances. 2024.02; 10 (8): eadi4819. ( PubMed, DOI )

  3. Nashimoto Y, Kanno Y, Ito H, Şen M. Editorial: Modelling and sensing platform for cancer and tumour microenvironment. Frontiers in bioengineering and biotechnology. 2024; 12 1432352. ( PubMed, DOI )

  4. Nashimoto, Y; Konno, A; Imaizumi, T; Nishikawa, K; Ino, K; Hori, T; Kaji, H; Shintaku, H; Goto, M; Shiku, H. Microfluidic vascular formation model for assessing angiogenic capacities of single islets BIOTECHNOLOGY AND BIOENGINEERING. 2023.12; 121 (3): 1050-1059. ( PubMed, DOI )

  5. Utagawa, Y; Ino, K; Hiramoto, K; Iwase, K; Nashimoto, Y; Honma, I; Shiku, H. Vasculature-on-a-Chip with a Porous Membrane Electrode for In Situ Electrochemical Detection of Nitric Oxide Released from Endothelial Cells ANALYTICAL CHEMISTRY. 2023.11; 95 (49): 18158-18165. ( PubMed, DOI )

  6. Hiramoto Kaoru, Iwase Kazuyuki, Utagawa Yoshinobu, Nashimoto Yuji, Honma Itaru, Ino Kosuke, Shiku Hitoshi. Electrochemical microwell sensor with Fe-N co-doped carbon catalyst to monitor nitric oxide release from endothelial cell spheroids(タイトル和訳中) Analytical Sciences. 2022.10; 38 (10): 1297-1304. ( ichushi )

  7. Kaoru Hiramoto, Kazuyuki Iwase, Yoshinobu Utagawa, Yuji Nashimoto, Itaru Honma, Kosuke Ino, Hitoshi Shiku. Electrochemical microwell sensor with Fe–N co-doped carbon catalyst to monitor nitric oxide release from endothelial cell spheroids Analytical Sciences. 2022.07; - (-): -. ( DOI )

  8. Yoshinobu Utagawa, Kosuke Ino, Tatsuki Kumagai, Kaoru Hiramoto, Masahiro Takinoue, Yuji Nashimoto, Hitoshi Shiku. Electrochemical glue for binding chitosan/alginate hydrogel fibers for cell culture Micromachines. 2022.03; 13 (3): 420. ( PubMed, DOI )

  9. Kosuke Ino, Keika Komatsu, Kaoru Hiramoto, Yoshinobu Utagawa, Yuji Nashimoto, Hitoshi Shiku. Electrochemiluminescence imaging of cellular adhesion in vascular endothelial cells during tube formation on hydrogel scaffolds Electrochimica Acta. 2022.03; 415 140240. ( DOI )

  10. Ino K, Pai HJ, Hiramoto K, Utagawa Y, Nashimoto Y, Shiku H. Electrochemical Imaging of Endothelial Permeability Using a Large-Scale Integration-Based Device. ACS omega. 2021.12; 6 (51): 35476-35483. ( PubMed, DOI )

  11. Akasaka R, Ozawa M, Nashimoto Y, Ino K, Shiku H. Ion Conductance-Based Perfusability Assay of Vascular Vessel Models in Microfluidic Devices. Micromachines. 2021.11; 12 (12): ( PubMed, DOI )

  12. Yoshinobu Utagawa, Kaoru Hiramoto, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. In vitro electrochemical assays for vascular cells and organs Electrochemical Science Advances. 2021.10; e2100089. ( DOI )

  13. Nashimoto Y, Abe M, Fujii R, Taira N, Ida H, Takahashi Y, Ino K, Ramon-Azcon J, Shiku H. Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies. Advanced healthcare materials. 2021.08; 10 (21): e2101186. ( PubMed, DOI )

  14. Hiramoto K, Ino K, Komatsu K, Nashimoto Y, Shiku H. Electrochemiluminescence imaging of respiratory activity of cellular spheroids using sequential potential steps. Biosensors & bioelectronics. 2021.03; 181 113123. ( PubMed, DOI )

  15. Taira N, Nashimoto Y, Ino K, Ida H, Imaizumi T, Kumatani A, Takahashi Y, Shiku H. Micropipet-Based Navigation in a Microvascular Model for Imaging Endothelial Cell Topography Using Scanning Ion Conductance Microscopy. Analytical chemistry. 2021.03; 93 (11): 4902-4908. ( PubMed, DOI )

  16. Kei Sugihara, Yoshimi Yamaguchi, Shiori Usui, Yuji Nashimoto, Sanshiro Hanada, Etsuko Kiyokawa, Akiyoshi Uemura, Ryuji Yokokawa, Koichi Nishiyama, Takashi Miura. A new perfusion culture method with a self-organized capillary network PLOS ONE. 2020.10; 15 (10): e0240552. ( PubMed, DOI )

  17. Kosuke Ino, Mika T Fukuda, Kaoru Hiramoto, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku. Fabrication of three-dimensional calcium alginate hydrogels using sacrificial templates of sugar. Journal of bioscience and bioengineering. 2020.08; 130 (5): 539-544. ( PubMed, DOI )

  18. Rei Mukomoto, Yuji Nashimoto, Takato Terai, Takuto Imaizumi, Kaoru Hiramoto, Kosuke Ino, Ryuji Yokokawa, Takashi Miura, Hitoshi Shiku. Oxygen consumption rate of tumour spheroids during necrotic-like core formation. Analyst. 2020.07; 145 (19): 6342-6348. ( PubMed, DOI )

  19. Kaoru Hiramoto, Elena Villani, Tomoki Iwama, Keika Komatsu, Shinsuke Inagi, Kumi Y Inoue, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Recent Advances in Electrochemiluminescence-Based Systems for Mammalian Cell Analysis. Micromachines. 2020.05; 11 (5): 530. ( PubMed, DOI )

  20. Kaoru Hiramoto, Hao-Jen Pai, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku. Electrochemical measurement of respiratory activity for evaluation of fibroblast spheroids containing endothelial cell networks ELECTROCHIMICA ACTA. 2020.04; 340 135979. ( DOI )

  21. Kosuke Ino, Fumisato Ozawa, Ning Dang, Kaoru Hiramoto, Shodai Hino, Rise Akasaka, Yuji Nashimoto, Hitoshi Shiku. Biofabrication Using Electrochemical Devices and Systems Advanced biosystems. 2020.04; 4 (4): 1900234. ( PubMed, DOI )

  22. Kosuke Ino, Ryosuke Yaegaki, Kaoru Hiramoto, Yuji Nashimoto, Hitoshi Shiku. Closed Bipolar Electrode Array for On-Chip Analysis of Cellular Respiration by Cell Aggregates ACS sensors. 2020.03; 5 (3): 740-745. ( PubMed, DOI )

  23. Yuji Nashimoto, Ryu Okada, Sanshiro Hanada, Yuichiro Arima, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa. Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid. Biomaterials. 2020.01; 229 119547. ( PubMed, DOI )

  24. Angiogenesis derived from shear stress optimised by a microfruidic device 2020; 1072-1073.

  25. Perfusion culture through a vasculature constructed in a tumor spheroid 2020; 1029-1030.

  26. Oxygen metabolism analysis of a vascularized spheroid using a scanning electrochemical microscopy 2020; 520-521.

  27. Tamura Ayako, Hiramoto Kaoru, Ino Kosuke, Taira Noriko, Nashimoto Yuji, Shiku Hitoshi. Genipin Crosslinking of Electrodeposited Chitosan/Gelatin Hydrogels for Cell Culture CHEMISTRY LETTERS. 2019.10; 48 (10): 1178-1180. ( DOI )

  28. 腫瘍転移における血管内侵入を模したオンチップモデルの開発(On-chip model for cancer metastatic intravasation) 2019.09; 78回 E-2103. ( ichushi )

  29. Nashimoto Yuji, Echigo Masakuni, Ino Kosuke, Shiku Hitoshi. Site-Specific Cytosol Sampling from a Single Cell in an Intact Tumor Spheroid Using an Electrochemical Syringe ANALYTICAL CHEMISTRY. 2019.07; 91 (14): 8772-8776. ( PubMed, DOI )

  30. Taira Noriko, Ino Kosuke, Ida Hiroki, Nashimoto Yuji, Shiku Hitoshi. Electrodeposition-based rapid bioprinting of 3D-designed hydrogels with a pin art device BIOFABRICATION. 2019.07; 11 (3): 035018. ( PubMed, DOI )

  31. Ino Kosuke, Onodera Takehiro, Fukuda Mika T, Nashimoto Yuji, Shiku Hitoshi. Combination of Double-Mediator System with Large-Scale Integration-Based Amperometric Devices for Detecting NAD(P)H:quinone Oxidoreductase 1 Activity of Cancer Cell Aggregates ACS SENSORS. 2019.06; 4 (6): 1619-1625. ( PubMed, DOI )

  32. Kaoru Hiramoto, Kosuke Ino, Yuji Nashimoto, Kentaro Ito, Hitoshi Shiku. Electric and Electrochemical Microfluidic Devices for Cell Analysis Frontiers in Chemistry. 2019.06; 7 1-9. ( PubMed, DOI )

  33. Taira Noriko, Ino Kosuke, Kumagai Tatsuki, Nashimoto Yuji, Shiku Hitoshi. Electrochemical fabrication of fibrin gels via cascade reaction for cell culture CHEMICAL COMMUNICATIONS. 2019.05; 55 (37): 5335-5338. ( PubMed, DOI )

  34. Ino Kosuke, Yokokawa Yuki, Taira Noriko, Suda Atsushi, Kunikata Ryota, Nashimoto Yuji, Matsue Tomokazu, Shiku Hitoshi. 大規模集積回路での電流滴定器を用いた、グリッド状ポリカプロラクトンScaffoldにおける細胞活性の電気化学イメージング(Electrochemical Imaging of Cell Activity in Hydrogels Embedded in Grid-shaped Polycaprolactone Scaffolds Using a Large-scale Integration-based Amperometric Device) Analytical Sciences. 2019.01; 35 (1): 39-43. ( ichushi )

  35. Ino Kosuke, Onodera Takehiro, Nashimoto Yuji, Shiku Hitoshi. Differential Electrochemicolor Imaging Using LSI-based Device for Simultaneous Detection of Multiple Analytes SENSORS AND MATERIALS. 2019; 31 (1): 13-22. ( DOI )

  36. Electrochemical imaging using redox mediators for cell activity of three-dimensional cultured cells 2019; 11007 ( DOI )

  37. Kosuke Ino, Yuki Yokokawa, Noriko Taira, Atsushi Suda, Ryota Kunikata, Yuji Nashimoto, Tomokazu Matsue, Hitoshi Shiku. Electrochemical Imaging of Cell Activity in Hydrogels Embedded in Grid-Shaped Polycaprolactone Scaffolds Using a Large-scale Integration (LSI)-based Amperometric Device Analytical Sciences. 2018.09; 35 (1): 39-43. ( PubMed, DOI )

  38. Ino K, Matsumoto T, Taira N, Kumagai T, Nashimoto Y, Shiku H. Hydrogel electrodeposition based on bipolar electrochemistry. Lab on a chip. 2018.08; 18 (16): 2425-2432. ( PubMed, DOI )

  39. Sano E, Mori C, Nashimoto Y, Yokokawa R, Kotera H, Torisawa YS. Engineering of vascularized 3D cell constructs to model cellular interactions through a vascular network. Biomicrofluidics. 2018.07; 12 (4): 042204. ( PubMed, DOI )

  40. Ino Kosuke, Nashimoto Yuji, Taira Noriko, Azcon Javier Ramon, Shiku Hitoshi. Intracellular electrochemical sensing Electroanalysis. 2018.07; 30 (10): 2195-2209. ( DOI )

  41. Nashimoto Y, Teraoka Y, Banan Sadeghian R, Nakamasu A, Arima Y, Hanada S, Kotera H, Nishiyama K, Miura T, Yokokawa R. Perfusable Vascular Network with a Tissue Model in a Microfluidic Device. Journal of visualized experiments : JoVE. 2018.04; (134): ( PubMed, DOI )

  42. 西山功一, 有馬勇一郎, 弓削進弥, 内川道江, 山口佳美, 梨本裕司, 中益朗子, 横川隆司, 三浦岳, 福原茂朋. 血管内腔圧による新生血管の伸長抑制作用 日本心血管内分泌代謝学会学術総会プログラム及び抄録集. 2018; 22nd

  43. Nashimoto Y, Hayashi T, Kunita I, Nakamasu A, Torisawa YS, Nakayama M, Takigawa-Imamura H, Kotera H, Nishiyama K, Miura T, Yokokawa R. Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device. Integrative biology : quantitative biosciences from nano to macro. 2017.06; 9 (6): 506-518. ( PubMed, DOI )

  44. Ito H, Tanaka M, Zhou Y, Nashimoto Y, Takahashi Y, Ino K, Matsue T, Shiku H. Continuous collection and simultaneous detection of picoliter volume of nucleic acid samples using a mille-feuille probe. Analytical and bioanalytical chemistry. 2017.02; 409 (4): 961-969. ( PubMed, DOI )

  45. Nashimoto Y, Takahashi Y, Zhou Y, Ito H, Ida H, Ino K, Matsue T, Shiku H. Evaluation of mRNA Localization Using Double Barrel Scanning Ion Conductance Microscopy. ACS nano. 2016.07; 10 (7): 6915-6922. ( PubMed, DOI )

  46. Ito H, Nashimoto Y, Zhou Y, Takahashi Y, Ino K, Shiku H, Matsue T. Localized Gene Expression Analysis during Sprouting Angiogenesis in Mouse Embryoid Bodies Using a Double Barrel Carbon Probe. Analytical chemistry. 2016.01; 88 (1): 610-613. ( PubMed, DOI )

  47. 國田樹, 有馬勇一郎, 梨本裕司, 中益朗子, 中山雅宗, 横川隆司, 三浦岳, 西山功一. 微小流体デバイスを用いた血管新生メカニズムの解析 化学とマイクロ・ナノシステム学会研究会講演要旨集. 2016; 34th

  48. Nashimoto Y, Takahashi Y, Ida H, Matsumae Y, Ino K, Shiku H, Matsue T. Nanoscale imaging of an unlabeled secretory protein in living cells using scanning ion conductance microscopy. Analytical chemistry. 2015.03; 87 (5): 2542-2545. ( PubMed, DOI )

  49. Ahadian S, Banan Sadeghian R, Yaginuma S, Ramón-Azcón J, Nashimoto Y, Liang X, Bae H, Nakajima K, Shiku H, Matsue T, Nakayama KS, Khademhosseini A. Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour. Biomaterials science. 2015; 3 (11): 1449-1458. ( PubMed, DOI )

  50. Nashimoto Y, Takahashi Y, Takano R, Miyashita K, Yamada S, Ino K, Shiku H, Matsue T. Isolation and quantification of messenger RNA from tissue models by using a double-barrel carbon probe. Analytical and bioanalytical chemistry. 2014.01; 406 (1): 275-282. ( PubMed, DOI )

  51. Nashimoto Yuji, Takahashi Yasufumi, Ino Kosuke, Inoue Y Kumi, Shiku Hitoshi, Matsue Tomokazu. 1P292 走査型イオンコンダクタンス顕微鏡の単一細胞ナノバイオプシーへの応用と細胞内mRNA局在性の評価(26. 計測,ポスター,第52回日本生物物理学会年会(2014年度)) 生物物理. 2014; 54 (1): S189. ( DOI )

  52. Nashimoto Yuji, Takahashi Yasufumi, Takano Ryosuke, Miyashita Kosuke, Yamada Shukuyo, Ino Kosuke, Shiku Hitoshi, Matsue Tomokazu. 1P265 ダブルバレルカーボンプローブを用いた組織モデルからのmRNA回収と定量評価(21A. ゲノム生物学:ゲノム解析,ポスター,日本生物物理学会年会第51回(2013年度)) 生物物理. 2013; 53 (1): S149. ( DOI )

  53. Nakamura K, Oyama M, Saito T, Oshiki R, Kobayashi R, Nishiwaki T, Nashimoto M, Tsuchiya Y. Nutritional and biochemical parameters associated with 6-year change in bone mineral density in community-dwelling Japanese women aged 69 years and older: The Muramatsu Study. Nutrition (Burbank, Los Angeles County, Calif.). 2012.04; 28 (4): 357-61. ( PubMed, DOI )

  54. Shiku H, Yamakawa T, Nashimoto Y, Takahashi Y, Torisawa YS, Yasukawa T, Ito-Sasaki T, Yokoo M, Abe H, Kambara H, Matsue T. A microfluidic dual capillary probe to collect messenger RNA from adherent cells and spheroids. Analytical biochemistry. 2009.02; 385 (1): 138-142. ( PubMed, DOI )

  55. Yamaguchi K, Nakagawa S, Yabusaki H, Nashimoto A. Combination chemotherapy with 5-fluorouracil, cisplatin and paclitaxel for pretreated patients with advanced gastric cancer. Anticancer research. 2007.09; 27 (5B): 3535-9. ( PubMed )

  56. Nashimoto Y, Takahashi Y, Yamakawa T, Torisawa YS, Yasukawa T, Ito-Sasaki T, Yokoo M, Abe H, Shiku H, Kambara H, Matsue T. Measurement of gene expression from single adherent cells and spheroids collected using fast electrical lysis. Analytical chemistry. 2007.09; 79 (17): 6823-6830. ( PubMed, DOI )

  57. Torisawa YS, Nashimoto Y, Yasukawa T, Shiku H, Matsue T. Regulation and characterization of the polarity of cells embedded in a reconstructed basement matrix using a three-dimensional micro-culture system. Biotechnology and bioengineering. 2007.06; 97 (3): 615-621. ( PubMed, DOI )

  58. Torisawa YS, Takagi A, Nashimoto Y, Yasukawa T, Shiku H, Matsue T. A multicellular spheroid array to realize spheroid formation, culture, and viability assay on a chip. Biomaterials. 2007.01; 28 (3): 559-566. ( PubMed, DOI )

  59. 珠玖仁, 梨本裕司, 高橋康史, 安川智之, 阿部宏之, 末永智一. 単一細胞由来mRNA回収マイクロプローブの開発 日本化学会講演予稿集. 2007; 87th (2):

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Conference Activities & Talks 【 display / non-display 】

  1. Nashimoto Yuji. New development of alternatives to animal experiments utilizing device technologies　Manipulation and Assessment of Biological Phenomena in Three-dimensional Culture Models via Engineered Vascular Networks(タイトル和訳中). AATEX: Alternatives to Animal Testing and EXperimentation 2023.12.01

  2. Hori Takeshi, Ando Moe, Yamamoto Akane, Kitano Isamu, Ishihara Kohei, Mizuta Taro, Yoshida Shotaro, Nashimoto Yuji, Kaji Hirokazu. Development of insert column type vascular network MPS(タイトル和訳中). AATEX: Alternatives to Animal Testing and EXperimentation 2023.12.01

  3. Sato Yuki, Nashimoto Yuji, Ohsugi Yujin, Hori Takeshi, Yoshida Shotaro, Katagiri Sayaka, Kaji Hirokazu. Construction of gingival epithelium and gingival vascular network for observation of bacterial invasion into to gingival tissue(タイトル和訳中). AATEX: Alternatives to Animal Testing and EXperimentation 2023.12.01

  4. Yuji Nashimoto. Electrochemical Analysis of Vasculature-on-a-Chip and Vascularized-3D-Model-on-a-Chip. 3D-Bioprinting, Biofabrication, Organoids & Organs-on-Chips Asia 2022 2022.10.07

  5. Yuji Nashimoto, Yuki Sato, Takeshi Hori, Kosuke Ino, Hitoshi Shiku, Sayaka Katagiri, Hirokazu Kaji. Engineering and analyzing organ microenvironment with a perfusable vascular network and its application in oral pathology. Interface Summer Seminar 2022 2022.08.24

  6. Yuji Nashimoto, Rei Mukomoto, Takuto Imaizumi, Kosuke Ino, Hitoshi Shiku. Electrochemical analysis of a respiration activity for a three-dimensional cultured model with biomimetic vascular flow. 9th World Congress of Biomechanics 2022.07.10

  7. Noriko Taira, Hiroki Ida, Yuji Nashimoto, Kosuke Ino, Akichika Kumatani, Hitoshi Shiku. Visualization of Structural Changes of Cell-Cell Adhesion and Cell Surface under Epithelial-Mesenchymal Transition. Pacifichem 2021 2021.12.16

  8. Nashimoto Yuji, Abe Minori, Fujii Ryota, Taira Noriko, Ida Hiroki, Takahashi Yasufumi. 血管系チップ走査プローブ顕微鏡における細胞機能の可視化(Visualization for cell functions in a vasculature on-a-chip scanning probe microscopies). AATEX: Alternatives to Animal Testing and EXperimentation 2021.12.01

  9. Kaoru Hiramoto, Kosuke Ino, Keika Komatsu, Yuji Nashimoto, Hitoshi Shiku. HIGH RESOLUTION, ONE-SHOT IMAGING OF CELLULAR ACTIVITY OF SPHEROIDS BY OXYGEN DEPENDENT ELECTROCHEMILUMINESCENCE. MicroTAS 2021 2021.10.12

  10. Shotaro Shishido, Yuji Nashimoto, Kosuke Ino, Kunishige Onuma, Masahiro Inoue, Hitoshi Shiku. Electrochemical mesurement of oxygen consumption rate for patient-derived cancer cells. 化学系学協会東北大会 2021.10.02

  11. Yoshinobu Utagawa, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku. Microfluidic device with porous electrodes for electrochemical cell analysis. 化学系学協会東北大会 2021.10.02

  12. Yoshinobu Utagawa, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku. Microfluidic device with porous electrodes for electrochemical cell analysis. INTERFINISH2020 2021.09.06

  13. Rei Mukomoto, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Analysis of vascularization effects on oxygen metabolism of a fibroblast spheroid using scanning electrochemical microscopy. 日本化学会 第101春季年会 2021.03.20

  14. Kaoru Hiramoto, Kosuke Ino, Keika Komatsu, Yuji Nashimoto, Hitoshi Shiku. Electrochemiluminescence Imaging of Cell Spheroid and its Ex Vivo Microenvironment. 第30回日本MRS年次大会 2020.12.10

  15. Yuji Nashimoto, Rei Mukomoto, Takato Terai, Kosuke Ino, Koichi Nishiyama, Ryuji Yokokawa, Takashi Miura, Hitoshi Shiku. OXYGEN METABOLISM ANALYSIS OF A VASCULARIZED SPHEROID USING A SCANNING ELECTROCHEMICAL MICROSCOPY. The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2020) 2020.10.07

  16. Rei Mukomoto, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Evaluation of oxygen consumption rate of vascularized spheroids using scanning electrochemical microscopy. 化学系学協会東北大会 2020.09.27

  17. XUYANG, Zhang, NORIKO, Taira, TAKUO, Nakamura, YUJI, Nashimoto, HIROKI, Ida, YASUFUMI,Takahashi, KOSUKE, Ino, HITOSHI, Shiku. Morphological evaluation of hMSC osteogenic differentiation using scanning ion conductance microscopy. 第14回バイオ関連化学シンポジウム 2020.09.07

  18. Pai Hao Jen, 伊野 浩介, 梨本 裕司, 珠玖 仁. LSIデバイスを用いた細胞の透過性アッセイ(Permeability assay of cells using LSI devices). 日本分析化学会講演要旨集 2020.09.01

  19. Kaoru Hiramoto, Hao-Jen Pai, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku. Effect of endothelial cell networks on respiratory activity of spheroids. 71st Annual Meeting of the International Society of Electrochemistry 2020.08.31

  20. Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Yuji Nashimoto, Tomokazu Matsue, Hitoshi Shiku. Endotoxin Sensor Using Redox Cycling in Nano-space. 71st Annual Meeting of the International Society of Electrochemistry 2020.08.31

  21. Noriko Taira, Hiroki Ida, Yuji Nashimoto, Kosuke Ino, Akichika Kumatani, Hitoshi Shiku. Nanoscale visualization of cell surface under Epithelial-Mesenchymal Transition by Scanning Ion Conductance Microscopy. 71st Annual Meeting of the International Society of Electrochemistry 2020.08.31

  22. Ida Hiroki, Takahashi Yasufumi, Kumatani Akichika, Nashimoto Yuji, Shiku Hitoshi, Yoshida Takeshi, Hanayama Rikinari. ナノピペットを用いた単一細胞からの細胞外小胞の回収(Collection of Extracellular Vesicles from Single Cell Using Nanopipette). 生物物理 2020.08.01

  23. Tatsuki Kumagai, Kosuke Ino, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku. Electrochemical reaction for hydrogel fabrication. 2019 International Symposium on Chemical-Environmental-Biomedical Technology (isCEBT 2019) 2019.12.12

  24. Noriko Taira, Yuji Nashimoto, Kosuke Ino, Hiroki Ida, Yasufumi Takahashi, Hitoshi Shiku. Micropipette navigation of microvasculature for intravascular topography imaging by SICM. 2019 International Symposium on Chemical-Environmental-Biomedical Technology (isCEBT 2019) 2019.12.12

  25. Hao-Jen Pai, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku. Real-time sensing of endothelial cell barrier function by using a large-scale integration device. 2019 International Symposium on Chemical-Environmental-Biomedical Technology (isCEBT 2019) 2019.12.12

  26. Takato Terai, Yuji Nashimoto, Kosuke Ino, Koichi Nishiyama, Ryuji Yokokawa, Takashi Miura, Hitoshi Shiku. Optimizing conditions for engineering a vascularized spheroid and its electrochemical evaluation in a microfluidic device. 2019 International Symposium on Chemical-Environmental-Biomedical Technology (isCEBT 2019) 2019.12.12

  27. Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Yuji Nashimoto, Tomokazu Matsue, Hitoshi Shiku. Easy-to-use electrochemical endotoxin sensor. The International Joint Meeting of the Polarographic Society of Japan and National Taiwan University 2019.11.06

  28. Yuji Nashimoto, Ryu Okada, Sanshiro Hanada, Yuichiro Arima, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa. Vascularization of a tumor spheroid in a microfluidic device to investigate flow-effects on growth and drug delivery. The 20th International Conference on Systems Biology 2019.11.01

  29. 梨本 裕司. Tumor-on-a-chip for studying effects of flow through a vascular network. THE 7TH INTERNATIONAL CONFERENCE ON SMART SYSTEMS ENGINEERING 2019 2019.10.10

  30. Xuyang Zhang, Takuo Nakamura, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Culture of hMSC and Observe by SICM. 2019年度化学系学協会東北大会 2019.09.21

  31. A. Tamura, K. Hiramoto, K. Ino, N. Taira, Y. Nashimoto, H. Shiku. Electrochemical patterning of biocompatible hydrogels for cell culture. 2019年度化学系学協会東北大会 2019.09.21

  32. Takuto Imaizumi, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Directional control of angiogenesis using a probe culturing fibroblast cells. 2019年度化学系学協会東北大会 2019.09.21

  33. Liana Moh, Zulkifly. Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku. Development of an electrochemical aptasensor for detection of cancerous exosomes. 2019年度化学系学協会東北大会 2019.09.21

  34. Ryota Fujii, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Measuring cell monolayer permeability using scanning electrochemical microscopy. 2019年度化学系学協会東北大会 2019.09.21

  35. Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Spatiotemporal analysis of cell function using a micro/nano electrode. 2019年度化学系学協会東北大会 2019.09.21

  36. Minori Abe, Yuji Nashimoto, Hiroki Ida, Akichika Kumatani, Yasufumi Takahashi, Kosuke Ino, Hitoshi Shiku. Nanoscale imaging of cells cultured in o rgan on a chip using scanning ion conductance microscope. 2019年度化学系学協会東北大会 2019.09.21

  37. Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Yuji Nashimoto, Tomokazu Matsue, Hitoshi Shiku. A redox-cycling-based highly sensitive endotoxin sensor. RSC Tokyo International Conference 2019 2019.09.04

  38. Noriko Taira, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Development of microcapillary guidance for microvascular access using ionic current. RSC Tokyo International Conference 2019 2019.09.04

  39. 花田 三四郎, 花田 保之, 梨本 裕司, フリードル・ピーター , 三浦 岳, 横川 隆司, 西山 功一. 腫瘍転移における血管内侵入を模したオンチップモデルの開発(On-chip model for cancer metastatic intravasation). 日本癌学会総会記事 2019.09.01

  40. Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. DEVELOPMENT OF AN ELECTROCHEMICAL SYRINGE FOR SPATIALLY RESOLVED TRANSCRIPTOME ANALYSIS. International Symposium on Analytical Electrochemistry 2019 (ISAE 2019) 2019.08.26

  41. Takato Terai, Yuji Nashimoto, Kosuke Ino, Koichi Nishiyama, Ryuji Yokokawa, Takashi Miura, Hitoshi Shiku. Engineering a vascularized spheroid in a microfluidic device and considering its electrochemical evaluation. International Symposium on Analytical Electrochemistry 2019 (ISAE 2019) 2019.08.26

  42. 梨本 裕司Ayako Tamura, Kosuke Ino, Kaoru Hiramoto, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku. Electrochemical patterning of hydrogel for cell culture. International Symposium on Analytical Electrochemistry 2019 (ISAE 2019) 2019.08.26

  43. T. Kumagai, K. Ino, N.Taira, Y. Nashimoto, H. Shiku. Electrochemical gel formation by controlling enzyme activity for cell culture. International Symposium on Analytical Electrochemistry 2019 (ISAE 2019) 2019.08.26

  44. Ryota Fujii, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Measuring cell monolayer permeability using scanning electrochemical microscopy. International Symposium on Analytical Electrochemistry 2019 (ISAE 2019) 2019.08.26

  45. Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Yuji Nashimoto, Tomokazu Matsue, Hitoshi Shiku. A redox-cycling-based electrochemical sensor for detection of endotoxin. International Symposium on Analytical Electrochemistry 2019 2019.08.25

  46. Kosuke Ino, Ryosuke Yaegaki, Yuji Nashimoto, Hitoshi Shiku. Electrochemical analysis of three-dimensional cultured cells using bipolar array devices. 70th Annual Meeting of the International Society of Electrochemistry 2019.08.04

  47. Kosuke Ino, Noriko Taira, Yuji Nashimoto, Hitoshi Shiku. Electrodeposition of 3D hydrogels using 3D electrode arrays in applications of cell culture. 70th Annual Meeting of the International Society of Electrochemistry 2019.08.04

  48. Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Yuji Nashimoto, Tomokazu Matsue, Hitoshi Shiku. A redox-cycling-based endotoxin sensor using nanogap electrode. The 3rd ECS Yamagata University Student Chapter Symposium 2019.06.14

  49. Kentaro Ito, Kumi Y. Inoue, Kosuke Ino, Yuji Nashimoto, Tomokazu Matsue, Hitoshi Shiku. A highly sensitive and rapid endotoxin sensor using redox cycling with nanogap electrode. 11th International Symposium on Microchemistry and Microsystem 2019.05.17

  50. Noriko Taira, Kosuke Ino, Yuji Nashimoto, Hitoshi Shiku. Rapid electrodeposition-based hydrogel printing system. 11th International Symposium on Microchemistry and Microsystem 2019.05.17

  51. Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku. Electrochemical Evaluation of a Three-dimensional tissue model Leveraging a Scanning Probe Microscopy. State-of-the-Art 3D Tissue Culture & Organoids 2019 2019.04.18

  52. Yuji Nashimoto, Ryu Okada, Sanshiro Hanada, Yuichiro Arima, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa. Spheroid on a chip model integrated with a perusable vascular network for investigating flow effects on tumor activities. State-of-the-Art 3D Tissue Culture & Organoids 2019 2019.04.18

  53. 伊野浩介, 熊谷明哉, 梨本裕司, 甲斐洋行. Electrochemical detection in micro/nano-systems: from cell analysis to characterization of energy materials. The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018.11.11

  54. 熊谷樹, 伊野浩介, 松本知明, 平典子, 梨本裕司, 珠玖仁. Electrochemical formation of biocompatible hydrogels for cell culture. 化学系学協会東北大会 2018.09.15

  55. 寺井崇人, 梨本裕司, 伊野浩介, 西山功一, 横川隆司, 三浦岳, 珠玖仁. Optimizing conditions for electrochemical evaluation of vascularized spheroid in a microfluidic device. 化学系学協会東北大会 2018.09.15

  56. 日野翔太, 伊野浩介, 梨本裕司, 珠玖仁. Vascular network formation on electrochemical devices. 化学系学協会東北大会 2018.09.15

  57. 越後雅邦, 梨本裕司, 伊野浩介, 末永智一, 珠玖仁. Electrochemical attosyringe for local gene analysis of cell aggregations. International Symposium on Chemical-Enviromental-Biomedical Technology (isCEBT2018) 2018.09.06

  58. 八重垣稜佑, 伊野浩介, 梨本裕司, 珠玖仁. Electrochemiluminescence detection for cellular respiratory activity using closed bipolar electrodes. International Symposium on Chemical-Enviromental-Biomedical Technology (isCEBT2018) 2018.09.06

  59. 中村拓生, 熊谷明哉, 梨本裕司, 伊野浩介, 高橋康史, 末永智一, 珠玖仁. SECM-SICM Analysis for Investigation of Enzyme Activities. International Symposium on Chemical-Enviromental-Biomedical Technology (isCEBT2018) 2018.09.06

  60. 小野寺岳大, 伊野浩介, 梨本裕司, 珠玖仁. Simultaneous imaging of enzyme and respiration activities of cell aggregates using an electrode array device. International Symposium on Chemical-Enviromental-Biomedical Technology (isCEBT2018) 2018.09.06

  61. 梨本 裕司. Regulation and evaluation of multi-cellular functions by integrating a scanning probe microscopy with microfluidic devices. The 3rd FRIS/DIARE Joint Workshop 2018.07.30

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Awards & Honors 【 display / non-display 】

  • The Young Scientists' Award，The Minister of Education, Culture, Sports, Science and Technology，2022.04

  • Young Researcher Award，CHEMINAS，2018.05

  • Paper Award 2017，The Institute of Electrical Engineers of Japan，2018.04

  • Short Presentation Award，2016.02

  • Poster Award，CHEMINAS，2015.11

  • Best Paper Award，Japan-China-Korea MEMS/NEMS，2015.09

  • Best Presentation Award，Sendai Symposium on Analytical Sciences，2012.11

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Campus class subject 【 display / non-display 】

  • Research internship in department of dental sciences，2022 - Now

  • Research internship in department of medical sciences，2022 - Now

  • Research drill in Biomechanics，2022 - Now

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External class subject 【 display / non-display 】

  • Collaborative Biomedical Engineering seminar，Queen's University

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Social Contribution 【 display / non-display 】

  • Study utilizes scanning probe microscopy to analyze organ-on-a-chip，AZoLifeSciences，AZoLifeSciences，https://www.azolifesciences.com/news/20210824/Study-utilizes-scanning-probe-microscopy-to-analyze-organ-on-a-chip.aspx，2021.08.24

  • Imaging Tool Visualizes Cell Functions in Organ-on-a-Chip，Technology Network，Technology Network，https://www.technologynetworks.com/tn/news/imaging-tool-visualizes-cell-functions-in-organ-on-a-chip-352917，2021.08.23

  • Japan invents organ-on-a-chip imaging tool to visualize cell functions，BioSpectrum，BioSpectrum Asia Edition Edition，https://www.biospectrumasia.com/news/101/18877/japan-invents-organ-on-a-chip-imaging-tool-to-visualize-cell-functions.html，2021.08.23

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