Personnel Information

写真a

KAJI Hirokazu


Job title

Professor

Homepage URL

https://www.tmd.ac.jp/bmc

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Graduating School 【 display / non-display 】

  • Tohoku University, Faculty of Engineering, Department of Molecular Chemistry and Engineering, 2001.03, Graduated

  • Tohoku University, Graduate School of Engineering, Department of Biomolecular Engineering, 2003.03, Graduated

  • Tohoku University, Graduate School of Engineering, Department of Bioengineering and Robotics, 2005.09, Graduated

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Campus Career 【 display / non-display 】

  • 2021.10
    -
    2023.03
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biofunctional Restoration， Biomechanics， Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， -， -， Professor
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External Career 【 display / non-display 】

  • 2003.04
    -
    2006.03
    Tohoku University, Graduate School of Engineering, JSPS Research Fellow
  • 2006.04
    -
    2010.12
    Tohoku University, Graduate School of Engineering, Assistant Professor
  • 2009.09
    -
    2011.08
    Harvard-MIT Division of Health Sciences and Technology, JSPS Fellow for Research Abroad
  • 2011.01
    -
    2021.09
    Tohoku University, Graduate School of Engineering, Associate Professor
  • 2017.10
    -
    2021.09
    Tohoku University, Graduate School of Biomedical Engineering, Associate Professor
  • 2021.10
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor
  • 2023.04
    -
    Now
    Keio University, Faculty of Pharmacy, Graduate School of Pharmaceutical Sciences, Visiting Professor

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Academic Society Affiliations 【 display / non-display 】

  • The Electrochemical Society of Japan

  • Japanese Society for Medical and Biological Engineering

  • The Japan Society of Mechanical Engieers

  • 日本動物実験代替法学会

  • Japanese Society of Biorheology

  • Japanese Society for Biomaterials

  • The Japan Society of Drug Delivery System

  • Society for Chemistry and Micro-Nano Systems

  • The Association for Research in Vision and Ophthalmology

  • Society For Biomaterials

  • Biomedical Engineering Society

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Academic Activity 【 display / non-display 】

  • 2006.01
    -
    2021.09
    電気化学会東北支部 幹事
  • 2017
    　
    　
    The Netherlands Organisation for Scientific Research (NWO, the Dutch Research Council) External Reviewer,
  • 2018
    -
    Now
    MicroTAS Technical Programme Committee
  • 2018.04
    -
    Now
    The Japanese Society for Biomaterials Councillor
  • 2018.07
    　
    　
    IEEE EMBC'18 Conference Editorial Board Reviewer
  • 2019
    　
    　
    Research Committee of the University “Foro Italico" of Rome External Reviewer
  • 2019.07
    　
    　
    IEEE EMBC'19 Conference Editorial Board Reviewer
  • 2020.07
    　
    　
    IEEE EMBC'20 Conference Editorial Board Reviewer
  • 2021.07
    　
    　
    IEEE EMBC'21 Conference Editorial Board Reviewer
  • 2022
    　
    　
    WCB 2022 Session Moderator
  • 2022.05
    -
    Now
    Society for Chemistry and Micro-Nano Systems Director
  • 2022.07
    　
    　
    IEEE EMBC'22 Conference Editorial Board Reviewer
  • 2023.07
    　
    　
    IEEE EMBC'23 Conference Editorial Board Reviewer

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Research Areas 【 display / non-display 】

  • Biomaterials

  • Biomedical engineering

  • Nanomaterials

  • Nanomaterials

  • Nano/micro-systems

  • Nanobioscience

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Published Papers & Misc 【 display / non-display 】

  1. Carvalho V, Gonçalves IM, Rodrigues N, Sousa P, Pinto V, Minas G, Kaji H, Shin SR, Rodrigues RO, Teixeira SFCF, Lima RA. Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model. Computer methods and programs in biomedicine. 2024.01; 243 107883. ( PubMed, DOI )

  2. Nashimoto Y, Konno A, Imaizumi T, Nishikawa K, Ino K, Hori T, Kaji H, Shintaku H, Goto M, Shiku H. Microfluidic vascular formation model for assessing angiogenic capacities of single islets. Biotechnology and bioengineering. 2023.12; ( PubMed, DOI )

  3. Ramalingam M, Jaisankar A, Cheng L, Krishnan S, Lan L, Hassan A, Sasmazel HT, Kaji H, Deigner HP, Pedraz JL, Kim HW, Shi Z, Marrazza G. Impact of nanotechnology on conventional and artificial intelligence-based biosensing strategies for the detection of viruses. Discover nano. 2023.12; 18 (1): 58. ( PubMed, DOI )

  4. Hashikawa Y, Kato Y, Kaji H, Abe T, Nagai N. A comparative study between a transscleral sustained-release device and eyedrops on intraocular distribution of carteolol hydrochloride. Heliyon. 2023.03; 9 (3): e14392. ( PubMed, DOI )

  5. Liu S, Cheng L, Liu Y, Zhang H, Song Y, Park JH, Dashnyam K, Lee JH, Khalak FA, Riester O, Shi Z, Ostrovidov S, Kaji H, Deigner HP, Pedraz JL, Knowles JC, Hu Q, Kim HW, Ramalingam M. 3D Bioprinting tissue analogs: Current development and translational implications. Journal of tissue engineering. 2023.01; 14 20417314231187113. ( PubMed, DOI )

  6. Ostrovidov S, Ramalingam M, Bae H, Orive G, Fujie T, Shi X, Kaji H. Latest developments in engineered skeletal muscle tissues for drug discovery and development. Expert opinion on drug discovery. 2023.01; 18 (1): 47-63. ( PubMed, DOI )

  7. Ostrovidov S, Ramalingam M, Bae H, Orive G, Fujie T, Shi X, Kaji H. Bioprinting and biomaterials for dental alveolar tissue regeneration. Frontiers in bioengineering and biotechnology. 2023; 11 991821. ( PubMed, DOI )

  8. Yamashita K, Ostrovidov S, Raut B, Hori T, Nashimoto Y, Nagai N, Abe T, Kaji H. Minimally Invasive Sub-Retinal Transplantation of RPE-J Cells on a Biodegradable Composite PCL/Collagen Nanosheet. Cell transplantation. 2023; 32 9636897231165117. ( PubMed, DOI )

  9. Nagai N, Daigaku R, Motoyama R, Kaji H, Abe T. Release of ranibizumab using a porous poly(dimethylsiloxane) capsule suppressed laser-induced choroidal neovascularization via the transscleral route. Journal of materials science. Materials in medicine. 2022.12; 34 (1): 5. ( PubMed, DOI )

  10. Violeta Carvalho, Inês Gonçalves, Teresa Lage, Raquel O. Rodrigues, Graça Minas, Senhorinha F.C.F Teixeira, Ana S. Moita, Takeshi Hori, Hirokazu Kaji, Rui A. Lima. 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review Sensors. 2021.05; 21 (9): 3304. ( PubMed, DOI )

  11. Bibek Raut, Li Jiun Chen, Takeshi Hori, Hirokazu Kaji. An open-source add-on evom® device for real-time transepithelial/endothelial electrical resistance measurements in multiple transwell samples Micromachines. 2021.03; 12 (3): 1-13. ( PubMed, DOI )

  12. Ayako Hoshi, Nobuhiro Nagai, Reiko Daigaku, Remi Motoyama, Saaya Saijo, Hirokazu Kaji, Toshiaki Abe. Effect of sustained insulin-releasing device made of poly(ethylene glycol) dimethacrylates on retinal function in streptozotocin-induced diabetic rats. Journal of materials science. Materials in medicine. 2020.05; 31 (6): 52. ( PubMed, DOI )

  13. Hideto Kojima, Bibek Raut, Li-Jiun Chen, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji. A 3D Printed Self-Sustainable Cell-Encapsulation Drug Delivery Device for Periocular Transplant-Based Treatment of Retinal Degenerative Diseases. Micromachines. 2020.04; 11 (4): ( PubMed, DOI )

  14. Li-Jiun Chen, Bibek Raut, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji. Prototyping a Versatile Two-Layer Multi-Channel Microfluidic Device for Direct-Contact Cell-Vessel Co-Culture. Micromachines. 2020.01; 11 (1): ( PubMed, DOI )

  15. Nobuhiro Nagai, Zhaleh Kashkouli Nezhad, Reiko Daigaku, Saaya Saijo, Yuanhui Song, Keiko Terata, Ayako Hoshi, Matsuhiko Nishizawa, Toru Nakazawa, Hirokazu Kaji, Toshiaki Abe. Transscleral sustained ranibizumab delivery using an episcleral implantable device: Suppression of laser-induced choroidal neovascularization in rats. International journal of pharmaceutics. 2019.08; 567 118458. ( PubMed, DOI )

  16. Yuto Sato, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji. A multilayered sheet-type device capable of sustained drug release and deployment control. Biomedical microdevices. 2019.07; 21 (3): 60. ( PubMed, DOI )

  17. Kuniaki Nagamine, Hirotaka Sato, Hiroyuki Kai, Hirokazu Kaji, Makoto Kanzaki, Matsuhiko Nishizawa. Contractile Skeletal Muscle Cells Cultured with a Conducting Soft Wire for Effective, Selective Stimulation Scientific Reports. 2018.12; 8 (1): ( PubMed, DOI )

  18. Yuanhui Song, Nobuhiro Nagai, Saaya Saijo, Hirokazu Kaji, Matsuhiko Nishizawa, Toshiaki Abe. In situ formation of injectable chitosan-gelatin hydrogels through double crosslinking for sustained intraocular drug delivery Materials Science and Engineering C. 2018.07; 88 1-12. ( PubMed, DOI )

  19. Hirokazu Kaji, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe. Drug delivery devices for retinal diseases Advanced Drug Delivery Reviews. 2018.03; 128 148-157. ( PubMed, DOI )

  20. Taro Kondo, Zhaleh Kashkouli Nezhad, Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. A self-deploying drug release device using polymeric films Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2018.02; 106 (2): 780-786. ( PubMed, DOI )

  21. Nobuhiro Nagai, Shinji Yamada, Junichi Kawasaki, Eri Koyanagi, Saaya Saijo, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe. Pharmacokinetic and safety evaluation of a transscleral sustained unoprostone release device in monkey eyes Investigative Ophthalmology and Visual Science. 2018.02; 59 (2): 644-652. ( PubMed, DOI )

  22. Li-Jiun Chen, Hirokazu Kaji. Modeling angiogenesis with micro- and nanotechnology LAB ON A CHIP. 2017.12; 17 (24): 4186-4219. ( PubMed, DOI )

  23. Shinji Yamada, Nobuhiro Nagai, Saaya Saijo, Hirokazu Kaji, Matsuhiko Nishizawa, Kozue Imura, Masafumi Goto, Toshiaki Abe. Controlled basic fibroblast growth factor release device made of poly(ethyleneglycol) dimethacrylates for creating a subcutaneous neovascular bed for cell transplantation JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 2017.11; 105 (11): 3017-3024. ( PubMed, DOI )

  24. Nobuhiro Nagai, Yasuko Izumida, Yoshimasa Yamazaki, Hirokazu Kaji, Junichi Kawasaki, Matsuhiko Nishizawa, Toshiaki Abe. Physicochemical and biological characterization of sustained isopropyl unoprostone-release device made of poly(ethyleneglycol) dimethacrylates JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 2017.07; 28 (7): ( PubMed, DOI )

  25. Li-Jiun Chen, Shuntaro Ito, Hiroyuki Kai, Kuniaki Nagamine, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. Microfluidic co-cultures of retinal pigment epithelial cells and vascular endothelial cells to investigate choroidal angiogenesis SCIENTIFIC REPORTS. 2017.06; 7 (1): ( PubMed, DOI )

  26. Serge Ostrovidov, Samad Ahadian, Javier Ramon-Azcon, Vahid Hosseini, Toshinori Fujie, S. Prakash Parthiban, Hitoshi Shiku, Tomokazu Matsue, Hirokazu Kaji, Murugan Ramalingam, Hojae Bae, Ali Khademhosseini. Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2017.02; 11 (2): 582-595. ( PubMed, DOI )

  27. Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. Electrochemical manipulation of cell populations supported by biodegradable polymeric nanosheets for cell transplantation therapy BIOMATERIALS SCIENCE. 2017.02; 5 (2): 216-222. ( PubMed, DOI )

  28. Kuniaki Nagamine, Shun Chihara, Hiroyuki Kai, Hirokazu Kaji, Matsuhiko Nishizawa. Totally shape-conformable electrode/hydrogel composite for on-skin electrophysiological measurements SENSORS AND ACTUATORS B-CHEMICAL. 2016.12; 237 49-53. ( DOI )

  29. Nobuhiro Nagai, Eri Koyanagi, Yasuko Izumida, Junjun Liu, Aya Katsuyama, Hirokazu Kaji, Matsuhiko Nishizawa, Noriko Osumi, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toru Nakazawa, Toshiaki Abe. Long-Term Protection of Genetically Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016.12; 57 (15): 6527-6538. ( PubMed, DOI )

  30. Nobuhiro Nagai, Satoru Iwata, Hirokazu Kaji, Kaori Sampei, Yuki Katsukura, Hideyuki Onami, Matsuhiko Nishizawa, Toru Nakazawa, Yukihiko Mashima, Toshiaki Abe. Protective effects of sustained transscleral unoprostone delivery against retinal degeneration in S334ter rhodopsin mutant rats JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 2016.11; 104 (8): 1730-1737. ( PubMed, DOI )

  31. Yuina Abe, Kuniaki Nagamine, Mayu Nakabayashi, Hiroyuki Kai, Hirokazu Kaji, Takeshi Yamauchi, Kenshi Yamasaki, Matsuhiko Nishizawa. Minimally-invasive transepidermal potentiometry with microneedle salt bridge BIOMEDICAL MICRODEVICES. 2016.08; 18 (4): ( PubMed, DOI )

  32. Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe. Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY. 2016; 854 471-477. ( PubMed, DOI )

  33. Kuniaki Nagamine, Hirotaka Sato, Hiroyuki Kai, Hirokazu Kaji, Matsuhiko Nishizawa. Hydrogel-based electrical stimulation culture system to control the engineered cellular activities driven by nano biomolecules 2016 IEEE 16TH INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO). 2016; 232-233. ( DOI )

  34. Hirokazu Kaji, Jin Suzuki, Matsuhiko Nishizawa, Nobuhiro Nagai, Toshiaki Abe. Injectable Polymeric Nanosheets for Subretinal Cell Delivery 2016 IEEE 16TH INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO). 2016; 267-269. ( DOI )

  35. Nezhad Zhaleh Kashkouli, 近藤 太郎, 梶 弘和, 永井 展裕, 西澤 松彦, 阿部 俊明. 網膜疾患に対する有望な薬剤送達システムとしての注入可能ナノシート(Injectable Nanosheets as Promising Drug Delivery Systems for Retinal Disorders) 日本バイオマテリアル学会大会予稿集. 2015.11; 37回 348.

  36. 網膜疾患に対する有望な薬剤送達システムとしての注入可能ナノシート(Injectable Nanosheets as Promising Drug Delivery Systems for Retinal Disorders) 2015.11; 37回 348. ( ichushi )

  37. Kashkouli Nezhad Zhaleh, 梶 弘和, 近藤 太郎, 永井 展裕, 西澤 松彦, 阿部 俊明. 網膜疾患に対する有望な薬剤送達システムとしての注入可能なナノシートの開発(Development of Injectable Nanosheets as Promising Drug Delivery Systems for Retinal Disorders) 日本眼薬理学会プログラム・抄録集. 2015.09; 35回 48.

  38. Zhaleh Kashkouli Nezhad, Nobuhiro Nagai, Kotaro Yamamoto, Hirokazu Kaji, Matsuhiko Nishizawa, Hideyuki Saya, Toru Nakazawa, Toshiaki Abe. Application of clotrimazole via a novel controlled release device provides potent retinal protection JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 2015.09; 26 (9): ( PubMed, DOI )

  39. Injectable Polymeric Nanosheets for Subretinal Cell Delivery 2015.09; 21 S276.

  40. 網膜疾患に対する有望な薬剤送達システムとしての注入可能なナノシートの開発(Development of Injectable Nanosheets as Promising Drug Delivery Systems for Retinal Disorders) 2015.09; 35回 48. ( ichushi )

  41. Nezhad Kashkouli Zhaleh, 梶 弘和, 近藤 太郎, 永井 展裕, 西澤 松彦, 阿部 俊明. 眼疾患治療のための、注入可能で分解性だが生分解しないmicropatternedナノシート(Injectable degradable/non-biodegradable micropatterned nanosheets for the treatment of eye disease) 日本DDS学会学術集会プログラム予稿集. 2015.06; 31回 188.

  42. Nobuhiro Nagai, Yasuko Izumida, Eri Koyanagi, Hirokazu Kaji, Matsuhiko Nishizawa, Takahito Imagawa, Akiko Morikawa, Toru Nakazawa, Yukihiko Mashima, Toshiaki Abe. Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2015.06; 56 (7):

  43. Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device 2015.06; 56 (7):

  44. 眼疾患治療のための、注入可能で分解性だが生分解しないmicropatternedナノシート(Injectable degradable/non-biodegradable micropatterned nanosheets for the treatment of eye disease) 2015.06; 31回 188. ( ichushi )

  45. Kuniaki Nagamine, Takuya Hirata, Kohei Okamoto, Yuina Abe, Hirokazu Kaji, Matsuhiko Nishizawa. Portable Micropatterns of Neuronal Cells Supported by Thin Hydrogel Films ACS BIOMATERIALS SCIENCE & ENGINEERING. 2015.05; 1 (5): 329-334. ( PubMed, DOI )

  46. Kuniaki Nagamine, Yuina Abe, Hiroyuki Kai, Hirokazu Kaji, Matsuhiko Nishizawa. Highly stretchable cell-cultured hydrogel sheet RSC ADVANCES. 2015; 5 (81): 66334-66338. ( DOI )

  47. Vahid Hosseini, Philip Kollmannsberger, Samad Ahadian, Serge Ostrovidov, Hirokazu Kaji, Viola Vogel, Ali Khademhosseini. Fiber-Assisted Molding (FAM) of Surfaces with Tunable Curvature to Guide Cell Alignment and Complex Tissue Architecture SMALL. 2014.12; 10 (23): 4851-4857. ( PubMed, DOI )

  48. Samad Ahadian, Serge Ostrovidov, Toshinori Fujie, Selvakumar Prakash Parthiban, Hirokazu Kaji, Kaarunya Sampathkumar, Murugan Ramalingam, Ali Khademhosseini. Microfabrication and Nanofabrication Techniques Stem Cell Biology and Tissue Engineering in Dental Sciences. 2014.11; 207-219. ( DOI )

  49. Masato Sasaki, Bijoy Chandapillai Karikkineth, Kuniaki Nagamine, Hirokazu Kaji, Keiichi Torimitsu, Matsuhiko Nishizawa. Highly Conductive Stretchable and Biocompatible Electrode-Hydrogel Hybrids for Advanced Tissue Engineering ADVANCED HEALTHCARE MATERIALS. 2014.11; 3 (11): 1919-1927. ( PubMed, DOI )

  50. Serge Ostrovidov, Vahid Hosseini, Samad Ahadian, Toshinori Fujie, Selvakumar Prakash Parthiban, Murugan Ramalingam, Hojae Bae, Hirokazu Kaji, Ali Khademhosseini. Skeletal Muscle Tissue Engineering: Methods to Form Skeletal Myotubes and Their Applications TISSUE ENGINEERING PART B-REVIEWS. 2014.10; 20 (5): 403-436. ( PubMed, DOI )

  51. Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima, Toshiaki Abe. A Platform for Controlled Dual-Drug Delivery to the Retina: Protective Effects against Light-Induced Retinal Damage in Rats ADVANCED HEALTHCARE MATERIALS. 2014.10; 3 (10): 1555-1560. ( PubMed, DOI )

  52. Yoshihiro Mori, Toshinori Fujie, Nobuhiro Nagai, Matsuhiko Nishizawa, Ali Khademhosseini, Toshiaki Abe, Hirokazu Kaji. Cell delivery using micropatterned ultra-thin polymeric films Transactions of Japanese Society for Medical and Biological Engineering. 2014.08; 52 192-O-193. ( DOI )

  53. Toshinori Fujie, Yoshihiro Mori, Matsuhiko Nishizawa, Nobuhiro Nagai, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji. Micropatterned polymeric nanosheets for local injection of an engineered epithelial monolayer ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2014.08; 248

  54. Micropatterned polymeric nanosheets for local injection of an engineered epithelial monolayer 2014.08; 248

  55. Kuniaki Nagamine, Kohei Okamoto, Hirokazu Kaji, Matsuhiko Nishizawa. Bonding of synthetic hydrogels with fibrin as the glue to engineer hydrogel-based biodevices JOURNAL OF BIOSCIENCE AND BIOENGINEERING. 2014.07; 118 (1): 94-97. ( PubMed, DOI )

  56. Toshinori Fujie, Yoshihiro Mori, Shuntaro Ito, Matsuhiko Nishizawa, Hojae Bae, Nobuhiro Nagai, Hideyuki Onami, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji. Micropatterned Polymeric Nanosheets for Local Delivery of an Engineered Epithelial Monolayer ADVANCED MATERIALS. 2014.03; 26 (11): 1699-1705. ( PubMed, DOI )

  57. Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yumi Ishikawa, Matsuhiko Nishizawa, Noriko Osumi, Toru Nakazawa, Toshiaki Abe. A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye ACTA BIOMATERIALIA. 2014.02; 10 (2): 680-687. ( PubMed, DOI )

  58. Nagai N, Kaji H, Zhaleh K. N, Sampei K, Iwata S, Nishizawa M, Mashima Y, Abe T. Controlled Transscleral Dual-drug Delivery by a Polymeric Device Reduces Light-induced Retinal Damage Investigative Ophthalmology & Visual Science. 2014; 55 (13): 446.

  59. Toshiaki Abe, Yumi Tokita-Ishikawa, Hideyuki Onami, Yuki Katsukura, Hirokazu Kaji, Matsuhiko Nishizawa, Nobuhiro Nagai. Intrascleral Transplantation of a Collagen Sheet with Cultured Brain-Derived Neurotrophic Factor Expressing Cells Partially Rescues the Retina from Damage due to Acute High Intraocular Pressure RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY. 2014; 801 837-843. ( PubMed, DOI )

  60. Samad Ahadian, Javier Ramon-Azcon, Haixin Chang, Xiaobin Liang, Hirokazu Kaji, Hitoshi Shiku, Ken Nakajima, Murugan Ramalingam, Hongkai Wu, Tomokazu Matsue, Ali Khademhosseini. Electrically regulated differentiation of skeletal muscle cells on ultrathin graphene-based films RSC ADVANCES. 2014; 4 (19): 9534-9541. ( DOI )

  61. Kuniaki Nagamine, Kohei Okamoto, Shingo Otani, Hirokazu Kaji, Makoto Kanzaki, Matsuhiko Nishizawa. Hydrogel-based bioassay sheets for in vitro evaluation of contraction-dependent metabolic regulation in skeletal muscle cells BIOMATERIALS SCIENCE. 2014; 2 (2): 252-256. ( PubMed, DOI )

  62. Nagai N, Kaji H, Zhaleh K. N, Sampei K, Iwata S, Nishizawa M, Mashima Y, Abe T. Controlled Transscleral Dual-drug Delivery by a Polymeric Device Reduces Light-induced Retinal Damage Investigative Ophthalmology & Visual Science. 2014; 55 (13): 446.

  63. Raquel Obregón, Samad. Ahadian, Javier Ramón-Azcón, Luyang Chen, Serge Ostrovidov, Gulden Camci-Unal, Takeshi Fujita, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Mingwei Chen, Tomokazu Matsue. Non-invasive measurement of glucose uptake of skeletal muscle tissue models using a glucose nanobiosensor. Biosens. Bioelectron.. 2013.09; 50 194-201. ( DOI )

  64. Toshinori Fujie, Samad Ahadian, Hao Liu, Haixin Chang, Serge Ostrovidov, Hongkai Wu, Hojae Bae, Ken Nakajima, Hirokazu Kaji, Ali Khademhosseini. Engineered Nanomembranes for Directing Cellular Organization Toward Flexible Biodevices NANO LETTERS. 2013.07; 13 (7): 3185-3192. ( PubMed, DOI )

  65. Samad Ahadian, Serge Ostrovidov, Vahid Hosseini, Hirokazu Kaji, Murugan Ramalingam, Hojae Bae, Ali Khademhosseini. Electrical stimulation as a biomimicry tool for regulating muscle cell behavior ORGANOGENESIS. 2013.04; 9 (2): 87-92. ( PubMed, DOI )

  66. Hideyuki Onami, Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Yasufumi Sato, Noriko Osumi, Toru Nakazawa, Toshiaki Abe. Transscleral Sustained Vasohibin-1 Delivery by a Novel Device Suppressed Experimentally-Induced Choroidal Neovascularization PLoS ONE. 2013.03; 8 (3): ( PubMed, DOI )

  67. Samad Ahadian, Javier Ramón-Azcón, Serge Ostrovidov, Gulden Camci-Unal, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue. A contactless electrical stimulator: Application to fabricate functional skeletal muscle tissue Biomedical Microdevices. 2013.02; 15 (1): 109-115. ( PubMed, DOI )

  68. J. Ramón-Azcóna, S. Ahadian, M. Estili, X. Liang, S. Ostrovidov, H. Kaji, H. Shiku, M. Ramalingam, K. Nakajima, Y. Sakka, A. Khademhosseini, T. Matsue. Dielectrophoretically aligned carbon nanotubes to control electrical and mechanical properties of hydrogels for muscle tissue engineering Adv. Mater.. 2013; 25 (25): 4028-4038. ( PubMed, DOI )

  69. Seila Šelimović, Hirokazu Kaji, Hojae Bae, Ali Khademhosseini. Microfluidic Systems for Controlling Stem Cells Microenvironments Microfluidic Cell Culture Systems. 2012.12; 175-203. ( DOI )

  70. Vahid Hosseini, Samad Ahadian, Serge Ostrovidov, Gulden Camci-Unal, Song Chen, Hirokazu Kaji, Murugan Ramalingam, Ali Khademhosseini. Engineered Contractile Skeletal Muscle Tissue on a Microgrooved Methacrylated Gelatin Substrate TISSUE ENGINEERING PART A. 2012.12; 18 (23-24): 2453-2465. ( PubMed, DOI )

  71. Lamya Ghenim, Hirokazu Kaji, Matsuhiko Nishizawa, Xavier Gidrol. Impedance Sensing of Biological Processes in Mammalian Cells Integrated Biomaterials for Biomedical Technology. 2012.08; 293-308. ( DOI )

  72. Matthew J. Hancock, Fumiki Yanagawa, Yun-Ho Jang, Jiankang He, Nezamoddin N. Kachouie, Hirokazu Kaji, Ali Khademhosseini. Designer Hydrophilic Regions Regulate Droplet Shape for Controlled Surface Patterning and 3D Microgel Synthesis SMALL. 2012.02; 8 (3): 393-403. ( PubMed, DOI )

  73. Amir M. Ghaemmaghami, Matthew J. Hancock, Helen Harrington, Hirokazu Kaji, Ali Khademhosseini. Biomimetic tissues on a chip for drug discovery DRUG DISCOVERY TODAY. 2012.02; 17 (3-4): 173-181. ( PubMed, DOI )

  74. Serge Ostrovidov, Nasim Annabi, Azadeh Seidi, Murugan Ramalingam, Fariba Dehghani, Hirokazu Kaji, Ali Khademhosseini. Controlled Release of Drugs from Gradient Hydrogels for High-Throughput Analysis of Cell-Drug Interactions ANALYTICAL CHEMISTRY. 2012.02; 84 (3): 1302-1309. ( PubMed, DOI )

  75. Samad Ahadian, Javier Ramon-Azcon, Serge Ostrovidov, Gulden Camci-Unal, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue. Interdigitated array of Pt electrodes for electrical stimulation and engineering of aligned muscle tissue LAB ON A CHIP. 2012; 12 (18): 3491-3503. ( PubMed, DOI )

  76. Hirokazu Kaji. Biofabrication Techniques for Biologically Relevant Tissue Models and Drug Delivery Devices 2012 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS). 2012; 83-86. ( DOI )

  77. Javier Ramon-Azcon, Samad Ahadian, Raquel Obregon, Gulden Camci-Unal, Serge Ostrovidov, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue. Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells LAB ON A CHIP. 2012; 12 (16): 2959-2969. ( PubMed, DOI )

  78. Azadeh Seidi, Hirokazu Kaji, Nasim Annabi, Serge Ostrovidov, Murugan Ramalingam, Ali Khademhosseini. A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease BIOMICROFLUIDICS. 2011.06; 5 (2): ( PubMed, DOI )

  79. Fumiki Yanagawa, Hirokazu Kaji, Yun-Ho Jang, Hojae Bae, Du Yanan, Junji Fukuda, Hao Qi, Ali Khademhosseini. Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 2011.04; 97A (1): 93-102. ( PubMed, DOI )

  80. Hirokazu Kaji, Gulden Camci-Unal, Robert Langer, Ali Khademhosseini. Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2011.03; 1810 (3): 239-250. ( PubMed, DOI )

  81. Takeaki Kawashima, Nobuhiro Nagai, Hirokazu Kaji, Norihiro Kumasaka, Hideyuki Onami, Yumi Ishikawa, Noriko Osumi, Matsuhiko Nishizawa, Toshiaki Abe. A scalable controlled-release device for transscleral drug delivery to the retina BIOMATERIALS. 2011.03; 32 (7): 1950-1956. ( PubMed, DOI )

  82. Ian Wheeldon, Javier Fernandez, Hojae Bae, Hirokazu Kaji, Ali Khademhosseini. Microscale biomaterials for tissue engineering Biomaterials for Tissue Engineering Applications: A Review of the Past and Future Trends. 2011; 119-138. ( DOI )

  83. Hao Qi, Yanan Du, Lianyong Wang, Hirokazu Kaji, Hojae Bae, Ali Khademhosseini. Patterned Differentiation of Individual Embryoid Bodies in Spatially Organized 3D Hybrid Microgels ADVANCED MATERIALS. 2010.12; 22 (46): 5276-5281. ( PubMed, DOI )

  84. Hirokazu Kaji, Takeshi Ishibashi, Kuniaki Nagamine, Makoto Kanzaki, Matsuhiko Nishizawa. Electrically induced contraction of C2C12 myotubes cultured on a porous membrane-based substrate with muscle tissue-like stiffness BIOMATERIALS. 2010.09; 31 (27): 6981-6986. ( PubMed, DOI )

  85. Soichiro Sekine, Shinya Nakanishi, Takeo Miyake, Kuniaki Nagamine, Hirokazu Kaji, Matsuhiko Nishizawa. Electrodes Combined with an Agarose Stamp for Addressable Micropatterning LANGMUIR. 2010.07; 26 (13): 11526-11529. ( PubMed, DOI )

  86. Nobuhiro Nagai, Norihiro Kumasaka, Takeaki Kawashima, Hirokazu Kaji, Matsuhiko Nishizawa, Toshiaki Abe. Preparation and characterization of collagen microspheres for sustained release of VEGF JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 2010.06; 21 (6): 1891-1898. ( PubMed, DOI )

  87. Kuniaki Nagamine, Takeaki Kawashima, Takeshi Ishibashi, Hirokazu Kaji, Makoto Kanzaki, Matsuhiko Nishizawa. Micropatterning Contractile C2C12 Myotubes Embedded in a Fibrin Gel BIOTECHNOLOGY AND BIOENGINEERING. 2010.04; 105 (6): 1161-1167. ( PubMed, DOI )

  88. Takeaki Kawashima, Takeshi Yokoi, Hirokazu Kaji, Matsuhiko Nishizawa. Transfer of two-dimensional patterns of human umbilical vein endothelial cells into fibrin gels to facilitate vessel formation CHEMICAL COMMUNICATIONS. 2010; 46 (12): 2070-2072. ( PubMed, DOI )

  89. Hirokazu Kaji, Takeshi Yokoi, Takeaki Kawashima, Matsuhiko Nishizawa. Directing the flow of medium in controlled cocultures of HeLa cells and human umbilical vein endothelial cells with a microfluidic device LAB ON A CHIP. 2010; 10 (18): 2374-2379. ( PubMed, DOI )

  90. Lamya Ghenim, Hirokazu Kaji, Yu Hoshino, Takeshi Ishibashi, Vincent Haguet, Xavier Gidrol, Matsuhiko Nishizawa. Monitoring impedance changes associated with motility and mitosis of a single cell LAB ON A CHIP. 2010; 10 (19): 2546-2550. ( PubMed, DOI )

  91. Soichiro Sekine, Hirokazu Kaji, Matsuhiko Nishizawa. Spatiotemporal sub-cellular biopatterning using an AFM-assisted electrochemical system ELECTROCHEMISTRY COMMUNICATIONS. 2009.09; 11 (9): 1781-1784. ( DOI )

  92. Rui Lima, Monica S. N. Oliveira, Takuji Ishikawa, Hirokazu Kaji, Shuji Tanaka, Matsuhiko Nishizawa, Takami Yamaguchi. Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies BIOFABRICATION. 2009.09; 1 (3): ( PubMed, DOI )

  93. T. Miyake, M. Oike, S. Yoshino, Y. Yatagawa, K. Haneda, H. Kaji, M. Nishizawa. Biofuel cell anode: NAD(+)/glucose dehydrogenase-coimmobilized ketjenblack electrode CHEMICAL PHYSICS LETTERS. 2009.09; 480 (1-3): 123-126. ( DOI )

  94. H. Fujiwara, T. Ishikawa, R. Lima, N. Matsuki, Y. Imai, H. Kaji, M. Nishizawa, T. Yamaguchi. Red blood cell motions in high-hematocrit blood flowing through a stenosed microchannel JOURNAL OF BIOMECHANICS. 2009.05; 42 (7): 838-843. ( PubMed, DOI )

  95. Masahiko Hashimoto, Hirokazu Kaji, Matsuhiko Nishizawa. Selective capture of a specific cell type from mixed leucocytes in an electrode-integrated microfluidic device BIOSENSORS & BIOELECTRONICS. 2009.05; 24 (9): 2892-2897. ( PubMed, DOI )

  96. Takeshi Ishibashi, Yu Hoshino, Hirokazu Kaji, Makoto Kanzaki, Masaaki Sato, Matsuhiko Nishizawa. Localized electrical stimulation to C2C12 myotubes cultured on a porous membrane-based substrate BIOMEDICAL MICRODEVICES. 2009.04; 11 (2): 413-419. ( PubMed, DOI )

  97. M. Togo, K. Morimoto, T. Abe, H. Kaji, M. Nishizawa. Microfluidic biofuel cells: Series-connection with superhydrophobic air valves TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009; 2102-2105. ( DOI )

  98. Hirokazu Kaji, Takeshi Yokoi, Takeaki Kawashima, Matsuhiko Nishizawa. Controlled cocultures of HeLa cells and human umbilical vein endothelial cells on detachable substrates LAB ON A CHIP. 2009; 9 (3): 427-432. ( PubMed, DOI )

  99. M. Nishizawa, H. Kaji, S. Sekine. Electrochemical In-Situ Micropatterning of Cells and Polymers 13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3. 2009; 23 (1-3): 2173-2176. ( DOI )

  100. Hirokazu Kaji, Masahiko Hashimoto, Soichiro Sekine, Takeaki Kawashima, Matsuhiko Nishizawa. Patterning adherent cells within microchannels by combination of electrochemical biolithography technique and repulsive dielectrophoretic force ELECTROCHEMISTRY. 2008.08; 76 (8): 555-558. ( DOI )

  101. Matsuhiko Nishizawa, Takahiro Kitazume, Hirokazu Kaji. Conducting polymer-based electrodes for controlling cellular functions ELECTROCHEMISTRY. 2008.08; 76 (8): 532-534. ( DOI )

  102. Soichiro Sekine, Hirokazu Kaji, Matsuhiko Nishizawa. Integration of an electrochemical-based biolithography technique into an AFM system ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2008.08; 391 (8): 2711-2716. ( PubMed, DOI )

  103. Makoto Togo, Akimasa Takamura, Tatsuya Asai, Hirokazu Kaji, Matsuhiko Nishizawa. Structural studies of enzyme-based microfluidic biofuel cells JOURNAL OF POWER SOURCES. 2008.03; 178 (1): 53-58. ( DOI )

  104. Masahiko Hashimoto, Hirokazu Kaji, Maria E. Kemppinen, Matsuhiko Nishizawa. Localized immobilization of proteins onto microstructures within a preassembled microfluidic device SENSORS AND ACTUATORS B-CHEMICAL. 2008.01; 128 (2): 545-551. ( DOI )

  105. M. Hashimoto, H. Kaji, M. Nishizawa. Control of cellular adhesion within microfluidic device using electrochemical biolithography and dielectrophoresis for cell-based assay ECS Transactions. 2008; 16 (14): 11-20. ( DOI )

  106. H. Fujiwara, T. Ishikawa, R. Lima, Y. Imai, N. Matsuki, H. Kaji, D. Mori, M. Nishizawa, T. Yamaguchi. Tracking of red blood cells in microchannel with stenosis by confocal micro PTV system Proc. 7th Int. Symp. Adv. Fluid Info. & 4th Int. Symp. Transdisciplinary Fluid Integr.. 2007.12; 56-57.

  107. Takeshi Ishibashi, Kimiyasu Takoh, Hirokazu Kaji, Takashi Abe, Matsuhiko Nishizawa. A porous membrane-based culture substrate for localized in situ electroporation of adherent mammalian cells SENSORS AND ACTUATORS B-CHEMICAL. 2007.12; 128 (1): 5-11. ( DOI )

  108. H. Fujiwara, T. Ishikawa, R. Lima, Y. Imai, N. Matsuki, H. Kaji, D. Mori, M. Nishizawa, T. Yamaguchi. Tracking of red blood cells in microchannel with stenosis by confocal micro PTV system Proc. 7th Int. Symp. Adv. Fluid Info. & 4th Int. Symp. Transdisciplinary Fluid Integr.. 2007.12; 56-57.

  109. Hirokazu Kaji, Soichiro Sekine, Masahiko Hashimoto, Takeaki Kawashima, Matsuhiko Nishizawa. Stepwise formation of patterned cell co-cultures in silicone tubing BIOTECHNOLOGY AND BIOENGINEERING. 2007.11; 98 (4): 919-925. ( PubMed, DOI )

  110. FUJIWARA Hiroki, ISHIKAWA Takuji, LIMA Rui, KAJI Hirokazu, MATSUKI Noriaki, IMAI Yohsuke, NISHIZAWA Matsuhiko, YAMAGUCHI Takami. P-01 OBSERVATION OF THE BLOOD FLOW IN MICROCHANNEL WITH STENOSIS BY CONFOCAL-MICRO-PIV Proceedings of the ... Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics. 2007.11; 2007 (3): S89.

  111. Matsuhiko Nishizawa, Takashi Kamiya, Hyuma Nozaki, Hirokazu Kaji. Anisotropic growth of conducting polymers along heparin-modified surfaces LANGMUIR. 2007.07; 23 (16): 8304-8307. ( PubMed, DOI )

  112. Makoto Togo, Akimasa Takamura, Tatsuya Asai, Hirokazu Kaji, Matsuhiko Nishizawa. An enzyme-based microfluidic biofuel cell using vitamin K-3-mediated glucose oxidation ELECTROCHIMICA ACTA. 2007.04; 52 (14): 4669-4674. ( DOI )

  113. Matsuhiko Nishizawa, Hyuma Nozaki, Hirokazu Kaji, Takahiro Kitazume, Noriyuki Kobayashi, Takeshi Ishibashi, Takashi Abe. Electrodeposition of anchored polypyrrole film on microelectrodes and stimulation of cultured cardiac myocytes BIOMATERIALS. 2007.03; 28 (8): 1480-1485. ( PubMed, DOI )

  114. Hirokazu Kaji, Soichiro Sekine, Masahiko Hashimoto, Takeaki Kawashima, Matsuhiko Nishizawa. Generation of patterned cell Co-cultures in silicone tubing using a microelectrode technique and electrostatic assembly Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007; 5860-5863. ( DOI )

  115. Hirokazu Kaji, Soichiro Sekine, Takashi Abe, Matsuhiko Nishizawa. Generation of patterned cell co-cultures inside tubular structure using electrochemical biolithography and electrostatic assembly 2007 INTERNATIONAL SYMPOSIUM ON MICRO-NANO MECHATRONICS AND HUMAN SCIENCE, VOLS 1 AND 2. 2007; 187-192. ( DOI )

  116. Hirokazu Kaji, Takeaki Kawashima, Matsuhiko Nishizawa. Patterning cellular motility using an electrochemical technique and a geometrically confined environment LANGMUIR. 2006.12; 22 (25): 10784-10787. ( PubMed, DOI )

  117. Hirokazu Kaji, Masahiko Hashimoto, Matsuhiko Nishizawa. On-demand patterning of protein matrixes inside a microfluidic device ANALYTICAL CHEMISTRY. 2006.08; 78 (15): 5469-5473. ( PubMed, DOI )

  118. Hirokazu Kaji, Masahiko Hashimoto, Takeaki Kawashima, Takashi Abe, Matsuhiko Nishizawa. An electrochemical microsystem for manipulating living cells FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS. 2006; 3-+.

  119. Matsuhiko Nishizawa, Takashi Abe, Hirokazu Kaji. Electrochemical approach to pattern cells within three-dimensional microstructures 2006 IEEE INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE. 2006; 242-+. ( DOI )

  120. Makoto Togo, Tatsuya Asai, Fuyuki Sato, Hirokazu Kaji, Takashi Abe, Matsuhiko Nishizawa. Enzyme-based glucose biofuel cell using vitamin K-3-immobilized polymer as electron mediator FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS. 2006; 173-+.

  121. An electrochemical microsystem for manipulating living cells 2006; 3-+.

  122. Enzyme-based glucose biofuel cell using vitamin K-3-immobilized polymer as electron mediator 2006; 173-+.

  123. H Kaji, K Tsukidate, M Hashimoto, T Matsue, M Nishizawa. Patterning the surface cytophobicity of an albumin-physisorbed substrate by electrochemical means LANGMUIR. 2005.07; 21 (15): 6966-6969. ( PubMed, DOI )

  124. M Nishizawa, H Kaji, K Tsukidate, M Hashimoto, T Abe. Elcrochemical bio-lithography for in-situ immobilization of proteins and cells within microchannels Transducers '05, Digest of Technical Papers, Vols 1 and 2. 2005; 1 151-154. ( DOI )

  125. A Khademhosseini, J Yeh, G Eng, J Karp, H Kaji, J Borenstein, OC Farokhzad, R Langer. Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays LAB ON A CHIP. 2005; 5 (12): 1380-1386. ( PubMed, DOI )

  126. M Nishizawa, H Kaji. Electrochemical bio-lithography for in situ control of cellular adhesion and growth on a chip 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. 2005; 2005 396-397. ( DOI )

  127. Y Takii, H Kaji, T Matsue, M Nishizawa. Microstamp-based micromachining for modulation of growth of cultured neuronal cells JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING. 2004.12; 47 (4): 956-961. ( DOI )

  128. H Kaji, K Tsukidate, T Matsue, M Nishizawa. In situ control of cellular growth and migration on substrates using microelectrodes JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2004.11; 126 (46): 15026-15027. ( PubMed, DOI )

  129. H Kaji, M Kanada, D Oyamatsu, T Matsue, M Nishizawa. Microelectrochemical approach to induce local cell adhesion and growth on substrates LANGMUIR. 2004.01; 20 (1): 16-19. ( PubMed, DOI )

  130. H Kaji, Y Takii, M Nishizawa, T Matsue. Pharmacological characterization of micropatterned cardiac myocytes BIOMATERIALS. 2003.10; 24 (23): 4239-4244. ( PubMed, DOI )

  131. H Kaji, K Takoh, M Nishizawa, T Matsue. Intracellular Ca2+ imaging for micropatterned cardiac myocytes BIOTECHNOLOGY AND BIOENGINEERING. 2003.03; 81 (6): 748-751. ( PubMed, DOI )

  132. H Kaji, M Nishizawa, T Matsue. Localized chemical stimulation to micropatterned cells using multiple laminar fluid flows LAB ON A CHIP. 2003; 3 (3): 208-211. ( PubMed, DOI )

  133. M Nishizawa, A Takahashi, H Kaji, T Matsue. Micropatterned HeLa cell culture on PEG monolayer-coated glass substrates CHEMISTRY LETTERS. 2002.09; (9): 904-905. ( DOI )

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Books etc 【 display / non-display 】

  1. Tim Albrecht, Maarten P. de Boer, Frank W. DelRio, Mehmet R. Dokmeci, Cristoph Eberl, Junji Fukuda, Hirokazu Kaji, Chris Keimel, Ali Khademhosseini. MEMS, BioMEMS and Bioelectronics – Materials and Devices. Cambridge University Press， 2012

  2. MEMS, BioMEMS and Bioelectronics – Materials and Devices. 2012

  3. MEMS, BioMEMS and Bioelectronics – Materials and Devices. 2012

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Conference Activities & Talks 【 display / non-display 】

  1. Takeshi Hori, Hiroaki Akae, Norio Kobayashi, Takahiro Arima, Hirokazu Kaji. Recapitulating the human placental barrier with trophoblast stem cells and a microfluidic device. 2022 Joint Symposium – SFB + JSB 2022.01.08 Honolulu, HI & Online

  2. Takeshi Hori, Hiroaki Akae, Norio Kobayashi, Takahiro Arima, Hirokazu Kaji. A trophoblast stem cell-based model of the human placental barrier. MicroTAS 2021 2021.10.10 California, USA & Virtual

  3. Bibek Raut, Li Jiun Chen, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. Development of a human corneal model using a blinking eyelid device. EMBS Micro and Nanotechnology in Medicine Conference 2018.12.10

  4. Yuto Sato, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. Development of a multilayered drug-delivery sheet that allows minimally invasive delivery to the eye. EMBS Micro and Nanotechnology in Medicine Conference 2018.12.10

  5. Hideto Kojima, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. Development of an implantable cell culture device for retinal diseases. EMBS Micro and Nanotechnology in Medicine Conference 2018.12.10

  6. Shun Ito, Li-Jiun Chen, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. Microfluidic cell culture model of the outer-blood-retina-barrier. EMBS Micro and Nanotechnology in Medicine Conference 2018.12.10

  7. Li-Jiun Chen, Shun Ito, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji. Microfluidic model of the outer blood-retina-barrier. MicroTAS 2018 2018.11.15

  8. Bibek Raut, Li-Jiun Chen, Shun Ito, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. Development of an artificial eyelid device for corneal culture models. 5th TERMIS World Congress 2018.09.04

  9. Li-Jiun Chen, Shun Ito, Bibek Raut, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. In vitro disease model of retinal microvessels. 5th TERMIS World Congress 2018.09.04

  10. Hirokazu Kaji, Jin Suzuki, Nobuhiro Nagai, Toshiaki Abe. Electrochemical manipulation of an epithelial monolayer supported by a biodegradable polymeric nanosheet for cell transplantation therapy. 5th TERMIS World Congress 2018.09.04

  11. Hirokazu Kaji, Jin Suzuki, Nobuhiro Nagai, Toshiaki Abe. Electrochemical manipulation of a cell monolayer supported by a biodegradable polymeric nanosheet for cell transplantation therapy. 2018 Society For Biomaterials Annual Meeting & Exposition 2018.04.11

  12. Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. Electrochemical manipulation of living cells supported by biodegradable polymeric nanosheets for cell transplantation therapy. 2017 BMES Annual Meeting 2017.10.11

  13. Li-Jiun Chen, Shun Ito, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji. In vitro disease model of the retina focusing on angiogenesis. 2017 BMES Annual Meeting 2017.10.11

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Awards & Honors 【 display / non-display 】

  • テルモ生命科学芸術財団研究開発助成，公益財団法人テルモ生命科学芸術財団，2018.03

  • 化学とマイクロ・ナノシステム学会奨励賞，化学とマイクロ・ナノシステム学会，2016.04

  • 豊田理研スカラー，公益財団法人豊田理化学研究所，2014.04

  • 日本失明予防協会研究助成，財団法人日本失明予防協会，2014.02

  • 化学素材研究開発振興財団記念基金グラント研究奨励金，一般財団法人バイオインダストリー協会，2012.10

  • マンダム動物実験代替法国際研究助成，日本動物実験代替法学会，2012.04

  • 電気化学会進歩賞・佐野賞，電気化学会，2009.03

  • 新世代研究所研究助成，公益財団法人新世代研究所，2007.10

  • 服部報公会工学研究奨励援助，公益財団法人服部報公会，2007.10

  • 青葉工学振興会研究奨励賞，青葉工学振興会，2006.12

  • 東北大学総長賞，東北大学，2006.03

  • 日本バイオレオロジー学会学術奨励賞，日本バイオレオロジー学会，2005.07

  • μTAS Poster Award，μTAS 2002 organizing comittee，2002.09

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Others 【 display / non-display 】

  • Breaking through barriers，2024.02

  • ウノプロストン徐放デバイスによる網膜色素変性進行抑制の治験開始に向けた検討，2015.10

    ウノプロストンを内包したカプセル型DDSデバイスの早期治験開始に向けた検討を行う.

  • バイオ医薬品局所徐放のための展開型ナノシート創出技術開発，2014.10

    バイオ医薬品の局所徐放を可能にする微細加工ナノシート開発と,モデル動物での局所展開技術開発を行う.

  • 局所展開能に優れた薬剤徐放微細パターン化ナノシートの網膜疾患への応用，2014.04

    狭い空間(針など)を介して網膜で展開させる薬剤徐放システムを開発する.

  • 眼底組織を模倣するオーガンチップデバイスの開発とドラッグデリバリーシステム評価系への拡張，2014.04

    マイクロ流体デバイスや高分子ナノ薄膜などのマイクロ・ナノ技術を眼科領域に適用し,眼底を模倣したオーガンチップデバイスを開発する.特に,神経支持細胞である網膜色素上皮(RPE)細胞,血管内皮細胞,グリア細胞を3次元流路デバイス内に配置・培養して,生体を模した刺激を負荷することで,加齢黄斑変性の主要病態である脈絡膜新生血管モデルを構築する.この培養モデルを動物から採取する強膜組織とハイブリッド化させ,経強膜ドラッグデリバリーシステムによる候補薬の持続投与の理論と薬効に即した薬剤治療の可能性を追求する.

  • 高分子ナノ薄膜を用いる細胞デリバリー療法の開発，2014.02

    柔軟かつ生体拒絶反応の小さい生分解性の自己支持性高分子ナノ薄膜を利用して新しい細胞デリバリー療法を開発する.

  • Real time impedance sensing of intermediate stages of mitosis of individual cancerous prostate cells，2013.04

    The aim of this research project is to develop sensitive new electrical measurements that may define cellular "signatures" at the single cell level: observables reflecting cell properties relevant to development of cancer that were not visible by optical means. The novelty of the project is to apply single cell impedance measurements at low frequencies (< MHz) of the electrical field as a new way to analyze novel cell phenotypes. The ability to study single cells will permit a better understanding of cellular heterogeneity which is significant in growth, division, infection and more particularly in cancer.

  • 網膜変性疾患治療を目指したインプラント型薬剤徐放システム，2012.10

    本研究では,生体親和性材料であるポリエチレングリコールを駆使して,侵襲的な硝子体手術の必要がない[強膜留置型の薬剤徐放デバイス]を開発する.

  • マイクロ流体デバイスを用いる眼底組織培養モデルの開発，2012.04

    生体組織・臓器の構造や機能を模倣した新しい3次元培養モデルが最近注目されてきており,肺,肝,腸などの消化呼吸器系組織を模倣する試みが盛んに検討されている.しかしながら,眼などの感覚器系に関するオンチップの培養モデルはほとんど例がない.そこで本研究では,マイクロ流路デバイス内に眼底組織を模倣した3次元培養系を構築し,流圧や各種分子濃度等の細胞周囲環境の精密制御を行い,細胞への影響を調べる.

  • 網膜疾患動物モデルを利用した薬剤徐放システムの評価，2011.07

    我々は網膜に精密に薬剤を徐放できるデバイスを開発し特許も取得した(22年度).薬剤徐放面はコラーゲン粒子を含ませたPEGで作成し,デバイス内の薬剤はTEG/PEG比を調整して包埋し徐放させるものであるが,デバイスのサイズは自由にへ変更でき,薬剤の種類・サイズを問わず包埋・徐放できるようになった.しかもこのシステムは眼内操作は伴わず,強膜上に固定するものであり,安全で,全身投与ではなく局所投与であるために副作用も少なく,さらに点眼ができない・忘れるなど高齢者が抱える問題の1つを根底から覆すものであり,また眼科領域を超えて薬剤徐放システムの他科疾患への拡張まで考えられる有用なシステムである.
    現在直面している問題はこのシステムが実際に網膜疾患を治療可能であることを証明することである.この領域は競争が激しくできるだけ早く効果もあることを示す必要がある.過去に報告されたものは非実用的であったり,大型(人用サイズ)サイズで,適切な動物モデルが存在せず動物モデルでの評価ができないままでいた.我々のデバイスはサイズを自由に変更できるために,動物モデルが多い,あるいは疾患モデルを作成しやすい小動物(ラット等)で実際に薬剤の効果を確認できる.震災のために実験が中断していたが,動物実験はすぐにでも開始できるので臨床応用実現のために今年度はこれまで作製してきたこのデバイスで動物モデルでの効果を評価し,デバイスの最適化を行う.

  • 低侵襲で多剤動態制御可能な薬物徐放デバイスの開発と網膜疾患治療への応用，2011.05

    我々は,眼外の強膜にインプラントを置き,強膜を通して薬物を眼内に送達する低侵襲な眼内薬物徐放デバイスの開発を行ってきた.デバイスは徐放膜でシールしたカプセルであり,内部薬物を徐放形にすることで,カプセル内部と徐放膜を介した2段階徐放システムを有することが特徴である.0次徐放可能なデバイスを開発し特許化・論文化したが,本研究ではこれをさらに発展させてデバイス内に複数の薬物ペレットを充填し,徐放形をそれぞれ変えることで多剤動態制御可能な薬物徐放デバイスを開発する.網膜疾患は多因子関与が判明しており,1因子の抑制だけでは病態抑制が困難な場合がある.そのため,多剤効率投与によって相乗効果的治療を可能にするデバイスを確立する.

  • 電気化学的な異種材料ナノ集積化技術の開拓とバイオデバイス応用，2008.10

    微小電極による局所的な電気化学反応によって,固体表面の物性(親疎水性,静電極性)をナノスケールでin-situ 制御できる技術[電気化学バイオリソグラフィー]を開発し,タンパク質の吸着・配向や細胞の接着・伸展・遊走,さらには,有機高分子の異方性電析といった組織化の局所的誘発・誘導(ナノナビゲーション)を実現する.さらに,この異種融合プロセスを駆使したバイオ・有機・無機材料のハイブリッド集積によって,①半閉鎖空間であるマイクロ流路内部にタンパク質や細胞をオンデマンドに集積可能な次世代バイオチップ,②神経・筋肉細胞が集積され,導電性高分子配線を介して制御されるハイブリッド細胞チップ,および③酵素スイッチ素子の開発を進める.

  • バイオリソグラフィー技術によるナノ界面プロセシング，2007.10

    水溶液中で行えるin-situ表面改質技術(電気化学バイオリソグラフィー)を用いて,交互積層膜のナノメートルスケールでの加工を行う.

  • 細胞およびインターフェース材料のハイブリッドパターンの作製と機能評価，2007.10

    パターン培養技術により作製した細胞ネットワークを,導電性高分子による有機配線と組み合わせることで,細胞マイクロパターンへの電気的かつ生化学的情報の入出力機構を備えたバイオアッセイチップの開発に取り組む.

  • 電気化学的な新規リソグラフィー技術を搭載したバイオチップシステムの開発，2005.10

    タンパク質や細胞を“その場"で固定して計測に供するセルフメイド式バイオチップシステムを創出する.

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Social Contribution 【 display / non-display 】

  • 滲出型加齢黄斑変性の病態の一部を生体組織チップ上で再現-東北大，QLifePro医療ニュース，2017.06.20

  • 目の難病,細胞実験で再現=新薬開発に期待-東北大，時事通信，2017.06.17

  • 東北大ら,患部に細胞を大量に効率よく送り届けるナノカーペットを開発，OPTRONICS，2013.12.06

  • SPP[コスモス理科実験講座]，2007.08.07 - 2007.08.08

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