基本情報

写真a

大西 哲生(オオニシ テツオ)

OHNISHI Tetsuo


職名

助教

生年

1966年

メールアドレス

メールによる問い合わせは《こちら》から

出身学校 【 表示 / 非表示

  • 神戸大学  理学部  生物学科  1991年03月  卒業

出身大学院 【 表示 / 非表示

  • 神戸大学  理学系研究科  生物学  修士課程  1993年03月  修了

  • 徳島大学  医学研究科  博士課程  1998年03月  修了

取得学位 【 表示 / 非表示

  • 理学修士  

  • 博士(医学)  

経歴(学内) 【 表示 / 非表示

  • 2021年04月
    -
    現在
    東京医科歯科大学 難治疾患研究所 先端分子医学研究部門 分子神経科学 助教

所属学協会 【 表示 / 非表示

  • 北米神経科学会(Society for Neuroscience)

  • 日本生物学的精神医学会

  • 日本統合失調症学会

  • 日本神経科学会

  • 日本分子生物学会

委員歴 【 表示 / 非表示

  • 2021年08月
    -
    現在
    日本生物学的精神医学会 評議員

研究分野 【 表示 / 非表示

  • 神経科学一般

  • 分子生物学

  • 細胞生物学

  • 精神神経科学

 

競争的資金等の研究課題 【 表示 / 非表示

  • 新規遺伝子発現調節メカニズムLDB2-EGR/ARC系と精神疾患

    文部科学省/日本学術振興会 : 2020年 - 2022年

論文・総説 【 表示 / 非表示

  1. Tetsuo Ohnishi, Yuji Kiyama, Fumiko Arima-Yoshida, Mitsutaka Kadota, Tomoe Ichikawa, Kazuyuki Yamada, Akiko Watanabe, Hisako Ohba, Kaori Tanaka, Akihiro Nakaya, Yasue Horiuchi, Yoshimi Iwayama, Manabu Toyoshima, Itone Ogawa, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shabeesh Balan, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Yayoi Nozaki, Rumi Kurokawa, Kazuhiro Suzuki, Akane Yoshikawa, Tomoko Toyota, Toshihiko Hosoya, Hiroyuki Okuno, Haruhiko Bito, Masanari Itokawa, Shigehiro Kuraku, Toshiya Manabe, Takeo Yoshikawa. Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia. EMBO Mol Med. 2021.04; 13 (4): e12574. ( PubMed, DOI )

  2. Masayuki Ide, Tetsuo Ohnishi, Manabu Toyoshima, Shabeesh Balan, Motoko Maekawa, Chie Shimamoto-Mitsuyama, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Takashi Ishii, Norihiro Shibuya, Yuka Kimura, Yasuko Hisano, Yui Murata, Tomonori Hara, Momo Morikawa, Kenji Hashimoto, Yayoi Nozaki, Tomoko Toyota, Yuina Wada, Yosuke Tanaka, Tadafumi Kato, Akinori Nishi, Shigeyoshi Fujisawa, Hideyuki Okano, Masanari Itokawa, Nobutaka Hirokawa, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Kazuya Iwamoto, Kohji Meno, Takuya Katagiri, Brian Dean, Kazuhiko Uchida, Hideo Kimura, Takeo Yoshikawa. Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology. EMBO Mol Med. 2019.12; 11 (12): e10695. ( PubMed, DOI )

  3. Tetsuo Ohnishi, Shabeesh Balan, Manabu Toyoshima, Motoko Maekawa, Hisako Ohba, Akiko Watanabe, Yoshimi Iwayama, Yuko Fujita, Yunfei Tan, Yasuko Hisano, Chie Shimamoto-Mitsuyama, Yayoi Nozaki, Kayoko Esaki, Atsuko Nagaoka, Junya Matsumoto, Mizuki Hino, Nobuko Mataga, Akiko Hayashi-Takagi, Kenji Hashimoto, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Takeo Yoshikawa. Investigation of betaine as a novel psychotherapeutic for schizophrenia. EBioMedicine. 2019.07; 45 432-446. ( PubMed, DOI )

  4. Tetsuo Ohnishi, Yoshinori Tanizawa, Akiko Watanabe, Takemichi Nakamura, Hisako Ohba, Haruna Hirata, Chizu Kaneda, Yoshimi Iwayama, Takafumi Arimoto, Kazutada Watanabe, Ikue Mori, Takeo Yoshikawa. Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. J Neurochem. 2013.03; 124 (5): 685-694. ( PubMed, DOI )

  5. Tetsuo Ohnishi, Takuya Murata, Akiko Watanabe, Akiko Hida, Hisako Ohba, Yoshimi Iwayama, Kazuo Mishima, Yoichi Gondo, Takeo Yoshikawa. Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis. J Biol Chem. 2014.04; 289 (15): 10785-10796. ( PubMed, DOI )

  6. Tetsuo Ohnishi, Kazuo Yamada, Hisako Ohba, Yoshimi Iwayama, Tomoko Toyota, Eiji Hattori, Toshiya Inada, Hiroshi Kunugi, Masahiko Tatsumi, Norio Ozaki, Nakao Iwata, Kaoru Sakamoto, Yoshimi Iijima, Yasuhide Iwata, Kenji J Tsuchiya, Genichi Sugihara, Shinichiro Nanko, Noriko Osumi, Sevilla D Detera-Wadleigh, Tadafumi Kato, Takeo Yoshikawa. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. Neuropsychopharmacology. 2007.08; 32 (8): 1727-1737. ( PubMed, DOI )

  7. Tetsuo Ohnishi, Hisako Ohba, Kyung-Chang Seo, Jungkyun Im, Yumi Sato, Yoshimi Iwayama, Teiichi Furuichi, Sung-Kee Chung, Takeo Yoshikawa. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 2007.01; 282 (1): 637-646. ( PubMed, DOI )

  8. Tetsuo Ohnishi, Akio Yamashita, Isao Kashima, Thomas Schell, Kirk R Anders, Andrew Grimson, Takahisa Hachiya, Matthias W Hentze, Philip Anderson, Shigeo Ohno. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell. 2003.11; 12 (5): 1187-1200. ( PubMed, DOI )

  9. A Yamashita, T Ohnishi, I Kashima, Y Taya, S Ohno. Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev. 2001.09; 15 (17): 2215-2228. ( PubMed, DOI )

  10. Shabeesh Balan, Yoshimi Iwayama, Tetsuo Ohnishi, Mikiko Fukuda, Atsuko Shirai, Ayumi Yamada, Sara Weirich, Maren Kirstin Schuhmacher, Kalarickal Vijayan Dileep, Toshihiro Endo, Yasuko Hisano, Kaoru Kotoshiba, Tomoko Toyota, Takeshi Otowa, Hitoshi Kuwabara, Mamoru Tochigi, Akiko Watanabe, Hisako Ohba, Motoko Maekawa, Manabu Toyoshima, Tsukasa Sasaki, Kazuhiko Nakamura, Masatsugu Tsujii, Hideo Matsuzaki, Kam Y J Zhang, Albert Jeltsch, Yoichi Shinkai, Takeo Yoshikawa. A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain. Mol Psychiatry. 2021.07; ( PubMed, DOI )

  11. Shabeesh Balan, Tetsuo Ohnishi, Akiko Watanabe, Hisako Ohba, Yoshimi Iwayama, Manabu Toyoshima, Tomonori Hara, Yasuko Hisano, Yuki Miyasaka, Tomoko Toyota, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shusuke Numata, Tetsuro Ohmori, Tomomi Shimogori, Yoshiaki Kikkawa, Takeshi Hayashi, Takeo Yoshikawa. Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia. Schizophr Bull. 2021.07; 47 (4): 1190-1200. ( PubMed, DOI )

  12. Chie Shimamoto-Mitsuyama, Akihiro Nakaya, Kayoko Esaki, Shabeesh Balan, Yoshimi Iwayama, Tetsuo Ohnishi, Motoko Maekawa, Tomoko Toyota, Brian Dean, Takeo Yoshikawa. Lipid Pathology of the Corpus Callosum in Schizophrenia and the Potential Role of Abnormal Gene Regulatory Networks with Reduced Microglial Marker Expression. Cereb Cortex. 2021.01; 31 (1): 448-462. ( PubMed, DOI )

  13. Yuina Wada, Motoko Maekawa, Tetsuo Ohnishi, Shabeesh Balan, Shigeru Matsuoka, Kazuya Iwamoto, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Yasuko Hisano, Yayoi Nozaki, Tomoko Toyota, Tomomi Shimogori, Masanari Itokawa, Tetsuyuki Kobayashi, Takeo Yoshikawa. Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia. EBioMedicine. 2020.12; 62 103130. ( PubMed, DOI )

  14. Usui Noriyoshi, Iwata Keiko, Miyachi Taishi, Takagai Shu, Wakusawa Keisuke, Nara Takahiro, Tsuchiya Kenji J, Matsumoto Kaori, Kurita Daisuke, Kameno Yosuke, Wakuda Tomoyasu, Takebayashi Kiyokazu, Iwata Yasuhide, Fujioka Toru, Hirai Takaharu, Toyoshima Manabu, Ohnishi Tetsuo, Toyota Tomoko, Maekawa Motoko, Yoshikawa Takeo, Maekawa Masato, Nakamura Kazuhiko, Tsujii Masatsugu, Sugiyama Toshiro, Mori Norio, Matsuzaki Hideo. VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction. EBioMedicine. 2020.08; 58 102917. ( PubMed, DOI )

  15. Qu Youge, Zhang Kai, Pu Yaoyu, Chang Lijia, Wang Siming, Tan Yunfei, Wang Xingming, Zhang Jiancheng, Ohnishi Tetsuo, Yoshikawa Takeo, Hashimoto Kenji. Betaine supplementation is associated with the resilience in mice after chronic social defeat stress: a role of brain-gut-microbiota axis. J Affect Disord. 2020.07; 272 66-76. ( PubMed, DOI )

  16. Chie Shimamoto-Mitsuyama, Tetsuo Ohnishi, Shabeesh Balan, Hisako Ohba, Akiko Watanabe, Motoko Maekawa, Yasuko Hisano, Yoshimi Iwayama, Yuji Owada, Takeo Yoshikawa. Evaluation of the role of fatty acid-binding protein 7 in controlling schizophrenia-relevant phenotypes using newly established knockout mice. Schizophr Res. 2020.03; 217 52-59. ( PubMed, DOI )

  17. Yasue Horiuchi, Tomoe Ichikawa, Tetsuo Ohnishi, Yoshimi Iwayama, Kazuya Toriumi, Mitsuhiro Miyashita, Izumi Nohara, Nanako Obata, Tomoko Toyota, Takeo Yoshikawa, Masanari Itokawa, Makoto Arai. LDB2 locus disruption on 4p16.1 as a risk factor for schizophrenia and bipolar disorder. Hum Genome Var. 2020; 7 31. ( PubMed, DOI )

  18. Motoko Maekawa, Tetsuo Ohnishi, Manabu Toyoshima, Chie Shimamoto-Mitsuyama, Kei Hamazaki, Shabeesh Balan, Yuina Wada, Kayoko Esaki, Shu Takagai, Kenji J Tsuchiya, Kazuhiko Nakamura, Yasuhide Iwata, Takahiro Nara, Yoshimi Iwayama, Tomoko Toyota, Yayoi Nozaki, Hisako Ohba, Akiko Watanabe, Yasuko Hisano, Shigeru Matsuoka, Masatsugu Tsujii, Norio Mori, Hideo Matsuzaki, Takeo Yoshikawa. A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder. Brain Commun. 2020; 2 (2): fcaa145. ( PubMed, DOI )

  19. Manabu Toyoshima, Xuguang Jiang, Tadayuki Ogawa, Tetsuo Ohnishi, Shogo Yoshihara, Shabeesh Balan, Takeo Yoshikawa, Nobutaka Hirokawa. Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis. Life Sci Alliance. 2019.10; 2 (5): ( PubMed, DOI )

  20. Maekawa Motoko, Ohnishi Tetsuo, Balan Shabeesh, Hisano Yasuko, Nozaki Yayoi, Ohba Hisako, Toyoshima Manabu, Shimamoto Chie, Tabata Chinatsu, Wada Yuina, Yoshikawa Takeo. Thiosulfate promotes hair growth in mouse model. Biosci Biotechnol Biochem. 2019.01; 83 (1): 114-122. ( PubMed, DOI )

  21. Nakamura Takumi, Nakajima Kazuo, Ohnishi Tetsuo, Yoshikawa Takeo, Nakanishi Moe, Takumi Toru, Tsuboi Takashi, Kato Tadafumi. Quantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system. Sci Rep. 2018.10; 8 (1): 16025. ( PubMed, DOI )

  22. Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iwamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T. Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes. Transl Psychiatry. 2017.09; 7 (9): e1229. ( PubMed, DOI )

  23. Tetsuo Ohnishi, Ikuo Miura, Hisako Ohba, Chie Shimamoto, Yoshimi Iwayama, Shigeharu Wakana, Takeo Yoshikawa. A spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defects. Gene. 2017.04; 607 16-22. ( PubMed, DOI )

  24. M Toyoshima, W Akamatsu, Y Okada, T Ohnishi, S Balan, Y Hisano, Y Iwayama, T Toyota, T Matsumoto, N Itasaka, S Sugiyama, M Tanaka, M Yano, B Dean, H Okano, T Yoshikawa. Analysis of induced pluripotent stem cells carrying 22q11.2 deletion. Transl Psychiatry. 2016.11; 6 (11): e934. ( PubMed, DOI )

  25. Andrés López-Perrote, Raquel Castaño, Roberto Melero, Teresa Zamarro, Hitomi Kurosawa, Tetsuo Ohnishi, Akiko Uchiyama, Kyoko Aoyagi, Gretel Buchwald, Naoyuki Kataoka, Akio Yamashita, Oscar Llorca. Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex. Nucleic Acids Res. 2016.02; 44 (4): 1909-1923. ( PubMed, DOI )

  26. Maekawa Motoko, Iwayama Yoshimi, Ohnishi Tetsuo, Toyoshima Manabu, Shimamoto Chie, Hisano Yasuko, Toyota Tomoko, Balan Shabeesh, Matsuzaki Hideo, Iwata Yasuhide, Takagai Shu, Yamada Kohei, Ota Motonori, Fukuchi Satoshi, Okada Yohei, Akamatsu Wado, Tsujii Masatsugu, Kojima Nobuhiko, Owada Yuji, Okano Hideyuki, Mori Norio, Yoshikawa Takeo. Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism. Sci Rep. 2015.11; 5 16239. ( PubMed, DOI )

  27. Maekawa Motoko, Yamada Kazuo, Toyoshima Manabu, Ohnishi Tetsuo, Iwayama Yoshimi, Shimamoto Chie, Toyota Tomoko, Nozaki Yayoi, Balan Shabeesh, Matsuzaki Hideo, Iwata Yasuhide, Suzuki Katsuaki, Miyashita Mitsuhiro, Kikuchi Mitsuru, Kato Motoichiro, Okada Yohei, Akamatsu Wado, Mori Norio, Owada Yuji, Itokawa Masanari, Okano Hideyuki, Yoshikawa Takeo. Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses. Biol Psychiatry. 2015.07; 78 (2): 116-125. ( PubMed, DOI )

  28. Balan Shabeesh, Iwayama Yoshimi, Yamada Kazuo, Toyota Tomoko, Ohnishi Tetsuo, Toyoshima Manabu, Shimamoto Chie, Ide Masayuki, Iwata Yasuhide, Suzuki Katsuaki, Kikuchi Mitsuru, Hashimoto Tasuku, Kanahara Nobuhisa, Yoshikawa Takeo, Maekawa Motoko. Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophrenia. J Neural Transm (Vienna). 2015.03; 122 (3): 477-485. ( PubMed, DOI )

  29. Shimamoto Chie, Ohnishi Tetsuo, Maekawa Motoko, Watanabe Akiko, Ohba Hisako, Arai Ryoichi, Iwayama Yoshimi, Hisano Yasuko, Toyota Tomoko, Toyoshima Manabu, Suzuki Katsuaki, Shirayama Yukihiko, Nakamura Kazuhiko, Mori Norio, Owada Yuji, Kobayashi Tetsuyuki, Yoshikawa Takeo. Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. Hum Mol Genet. 2014.12; 23 (24): 6495-6511. ( PubMed, DOI )

  30. Balan Shabeesh, Iwayama Yoshimi, Maekawa Motoko, Toyota Tomoko, Ohnishi Tetsuo, Toyoshima Manabu, Shimamoto Chie, Esaki Kayoko, Yamada Kazuo, Iwata Yasuhide, Suzuki Katsuaki, Ide Masayuki, Ota Motonori, Fukuchi Satoshi, Tsujii Masatsugu, Mori Norio, Shinkai Yoichi, Yoshikawa Takeo. Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects. Mol Autism. 2014.10; 5 (1): 49. ( PubMed, DOI )

  31. Balan Shabeesh, Yamada Kazuo, Iwayama Yoshimi, Toyota Tomoko, Ohnishi Tetsuo, Maekawa Motoko, Toyoshima Manabu, Iwata Yasuhide, Suzuki Katsuaki, Kikuchi Mitsuru, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Iwata Nakao, Nanko Shinichiro, Kato Tadafumi, Yoshikawa Takeo. Lack of association of EGR2 variants with bipolar disorder in Japanese population. Gene. 2013.09; 526 (2): 246-250. ( PubMed, DOI )

  32. Takata Atsushi, Iwayama Yoshimi, Fukuo Yasuhisa, Ikeda Masashi, Okochi Tomo, Maekawa Motoko, Toyota Tomoko, Yamada Kazuo, Hattori Eiji, Ohnishi Tetsuo, Toyoshima Manabu, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Nanko Shinichiro, Nakamura Kazuhiko, Mori Norio, Kanba Shigenobu, Iwata Nakao, Kato Tadafumi, Yoshikawa Takeo. A population-specific uncommon variant in GRIN3A associated with schizophrenia. Biol Psychiatry. 2013.03; 73 (6): 532-539. ( PubMed, DOI )

  33. Balan Shabeesh, Yamada Kazuo, Hattori Eiji, Iwayama Yoshimi, Toyota Tomoko, Ohnishi Tetsuo, Maekawa Motoko, Toyoshima Manabu, Iwata Yasuhide, Suzuki Katsuaki, Kikuchi Mitsuru, Yoshikawa Takeo. Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies. PLoS One. 2013; 8 (7): e70302. ( PubMed, DOI )

  34. Yamada Kazuo, Iwayama Yoshimi, Toyota Tomoko, Ohnishi Tetsuo, Ohba Hisako, Maekawa Motoko, Yoshikawa Takeo. Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population. Hum Genet. 2012.03; 131 (3): 443-451. ( PubMed, DOI )

  35. Fujita Seisuke, Ohnishi Tetsuo, Okuda Shujiro, Kobayashi Ryo, Fukuno Satoshi, Furuta Daisuke, Kikuchi Takeshi, Yoshikawa Takeo, Fujita Norihisa. In silico study on the substrate binding manner in human myo-inositol monophosphatase 2. J Mol Model. 2011.10; 17 (10): 2559-2567. ( PubMed, DOI )

  36. Yamada Kazuo, Iwayama Yoshimi, Hattori Eiji, Iwamoto Kazuya, Toyota Tomoko, Ohnishi Tetsuo, Ohba Hisako, Maekawa Motoko, Kato Tadafumi, Yoshikawa Takeo. Genome-wide association study of schizophrenia in Japanese population. PLoS One. 2011; 6 (6): e20468. ( PubMed, DOI )

  37. Ohnishi Tetsuo, Yamada Kazuo, Watanabe Akiko, Ohba Hisako, Sakaguchi Toru, Honma Yota, Iwayama Yoshimi, Toyota Tomoko, Maekawa Motoko, Watanabe Kazutada, Detera-Wadleigh Sevilla D, Wakana Shigeharu, Yoshikawa Takeo. Ablation of Mrds1/Ofcc1 induces hyper-gamma-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice. PLoS One. 2011; 6 (12): e29499. ( PubMed, DOI )

  38. Maekawa Motoko, Ohnishi Tetsuo, Hashimoto Kenji, Watanabe Akiko, Iwayama Yoshimi, Ohba Hisako, Hattori Eiji, Yamada Kazuo, Yoshikawa Takeo. Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia. J Neurochem. 2010.12; 115 (6): 1374-1385. ( PubMed, DOI )

  39. Maekawa Motoko, Iwayama Yoshimi, Watanabe Akiko, Nozaki Yayoi, Ohnishi Tetsuo, Ohba Hisako, Toyoshima Manabu, Hamazaki Kei, Osumi Noriko, Aruga Jun, Yoshikawa Takeo. Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice. Biochem Biophys Res Commun. 2010.11; 402 (2): 431-437. ( PubMed, DOI )

  40. Iwata Yasuhide, Yamada Kazuo, Iwayama Yoshimi, Anitha Ayyappan, Thanseem Ismail, Toyota Tomoko, Hattori Eiji, Ohnishi Tetsuo, Maekawa Motoko, Nakamura Kazuhiko, Suzuki Katsuaki, Matsuzaki Hideo, Tsuchiya Kenji J, Suda Shiro, Sugihara Genichi, Takebayashi Kiyokazu, Yamamoto Shigeyuki, Iwata Keiko, Mori Norio, Yoshikawa Takeo. Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2010.09; 153B (6): 1221-1227. ( PubMed, DOI )

  41. Makoto Arai, Hiroko Yuzawa, Izumi Nohara, Tetsuo Ohnishi, Nanako Obata, Yoshimi Iwayama, Seiichi Haga, Tomoko Toyota, Hiroshi Ujike, Mayumi Arai, Tomoe Ichikawa, Atsushi Nishida, Yoko Tanaka, Aizo Furukawa, Yuuzou Aikawa, Osamu Kuroda, Kazuhiro Niizato, Ryosuke Izawa, Kazuhiko Nakamura, Norio Mori, Daisuke Matsuzawa, Kenji Hashimoto, Masaomi Iyo, Ichiro Sora, Masaaki Matsushita, Yuji Okazaki, Takeo Yoshikawa, Toshio Miyata, Masanari Itokawa. Enhanced carbonyl stress in a subpopulation of schizophrenia. Arch Gen Psychiatry. 2010.06; 67 (6): 589-597. ( PubMed, DOI )

  42. Tetsuo Ohnishi, Akiko Watanabe, Hisako Ohba, Yoshimi Iwayama, Motoko Maekawa, Takeo Yoshikawa. Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2. Neurosci Res. 2010.05; 67 (1): 86-94. ( PubMed, DOI )

  43. Iwayama Yoshimi, Hattori Eiji, Maekawa Motoko, Yamada Kazuo, Toyota Tomoko, Ohnishi Tetsuo, Iwata Yasuhide, Tsuchiya Kenji J, Sugihara Genichi, Kikuchi Mitsuru, Hashimoto Kenji, Iyo Masaomi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Iwata Nakao, Nanko Shinichiro, Iwamoto Kazuya, Okazaki Yuji, Kato Tadafumi, Yoshikawa Takeo. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2010.03; 153B (2): 484-493. ( PubMed, DOI )

  44. Maekawa Motoko, Iwayama Yoshimi, Arai Ryoichi, Nakamura Kazuhiko, Ohnishi Tetsuo, Toyota Tomoko, Tsujii Masatsugu, Okazaki Yuji, Osumi Noriko, Owada Yuji, Mori Norio, Yoshikawa Takeo. Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. J Hum Genet. 2010.02; 55 (2): 127-130. ( PubMed, DOI )

  45. Maekawa Motoko, Iwayama Yoshimi, Nakamura Kazuhiko, Sato Miho, Toyota Tomoko, Ohnishi Tetsuo, Yamada Kazuo, Miyachi Taishi, Tsujii Masatsugu, Hattori Eiji, Maekawa Nobuo, Osumi Noriko, Mori Norio, Yoshikawa Takeo. A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient. Neurosci Lett. 2009.10; 462 (3): 267-271. ( PubMed, DOI )

  46. Yamada Kazuo, Hattori Eiji, Iwayama Yoshimi, Toyota Tomoko, Ohnishi Tetsuo, Iwata Yasuhide, Tsuchiya Kenji J, Sugihara Genichi, Kikuchi Mitsuru, Okazaki Yuji, Yoshikawa Takeo. Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations. Am J Med Genet B Neuropsychiatr Genet. 2009.06; 150B (4): 508-514. ( PubMed, DOI )

  47. Akio Yamashita, Natsuko Izumi, Isao Kashima, Tetsuo Ohnishi, Bonnie Saari, Yukiko Katsuhata, Reiko Muramatsu, Tomoko Morita, Akihiro Iwamatsu, Takahisa Hachiya, Rie Kurata, Hisashi Hirano, Philip Anderson, Shigeo Ohno. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 2009.05; 23 (9): 1091-1105. ( PubMed, DOI )

  48. Watanabe Akiko, Toyota Tomoko, Owada Yuji, Hayashi Takeshi, Iwayama Yoshimi, Matsumata Miho, Ishitsuka Yuichi, Nakaya Akihiro, Maekawa Motoko, Ohnishi Tetsuo, Arai Ryoichi, Sakurai Katsuyasu, Yamada Kazuo, Kondo Hisatake, Hashimoto Kenji, Osumi Noriko, Yoshikawa Takeo. Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. PLoS Biol. 2007.11; 5 (11): e297. ( PubMed, DOI )

  49. Ryoichi Arai, Kaori Ito, Tetsuo Ohnishi, Hisako Ohba, Ryogo Akasaka, Yoshitaka Bessho, Kyoko Hanawa-Suetsugu, Takeo Yoshikawa, Mikako Shirouzu, Shigeyuki Yokoyama. Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. Proteins. 2007.05; 67 (3): 732-742. ( PubMed, DOI )

  50. Kazuo Yamada, David J Gerber, Yoshimi Iwayama, Tetsuo Ohnishi, Hisako Ohba, Tomoko Toyota, Jun Aruga, Yoshio Minabe, Susumu Tonegawa, Takeo Yoshikawa. Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc Natl Acad Sci U S A. 2007.02; 104 (8): 2815-2820. ( PubMed, DOI )

  51. Nakatani Noriaki, Ohnishi Tetsuo, Iwamoto Kazuya, Watanabe Akiko, Iwayama Yoshimi, Yamashita Shunji, Ishitsuka Yuichi, Moriyama Kenji, Nakajima Mizuho, Tatebayashi Yoshitaka, Akiyama Haruhiko, Higuchi Teruhiko, Kato Tadafumi, Yoshikawa Takeo. Expression analysis of actin-related genes as an underlying mechanism for mood disorders. Biochem Biophys Res Commun. 2007.01; 352 (3): 780-786. ( PubMed, DOI )

  52. Masayuki Ide, Tetsuo Ohnishi, Miyuki Murayama, Izuru Matsumoto, Kazuo Yamada, Yoshimi Iwayama, Irina Dedova, Tomoko Toyota, Takashi Asada, Akihiko Takashima, Takeo Yoshikawa. Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia. J Neurochem. 2006.10; 99 (1): 277-287. ( PubMed, DOI )

  53. Kazuo Yamada, Eiji Hattori, Yoshimi Iwayama, Tetsuo Ohnishi, Hisako Ohba, Tomoko Toyota, Hitomi Takao, Yoshio Minabe, Noriaki Nakatani, Teruhiko Higuchi, Sevilla D Detera-Wadleigh, Takeo Yoshikawa. Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. Biol Psychiatry. 2006.07; 60 (2): 192-201. ( PubMed, DOI )

  54. Noriaki Nakatani, Eiji Hattori, Tetsuo Ohnishi, Brian Dean, Yoshimi Iwayama, Izuru Matsumoto, Tadafumi Kato, Noriko Osumi, Teruhiko Higuchi, Shin-ichi Niwa, Takeo Yoshikawa. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. Hum Mol Genet. 2006.06; 15 (12): 1949-1962. ( PubMed, DOI )

  55. Kazuo Yamada, Tetsuo Ohnishi, Kenji Hashimoto, Hisako Ohba, Yoshimi Iwayama-Shigeno, Manabu Toyoshima, Akira Okuno, Hitomi Takao, Tomoko Toyota, Yoshio Minabe, Kazuhiko Nakamura, Eiji Shimizu, Masanari Itokawa, Norio Mori, Masaomi Iyo, Takeo Yoshikawa. Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels. Biol Psychiatry. 2005.06; 57 (12): 1493-1503. ( PubMed, DOI )

  56. Fusako Usuki, Akio Yamashita, Itsuro Higuchi, Tetsuo Ohnishi, Tadafumi Shiraishi, Mitsuhiro Osame, Shigeo Ohno. Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease. Ann Neurol. 2004.05; 55 (5): 740-744. ( PubMed, DOI )

  57. Syu-ichi Hirai, Atsumi Kawaguchi, Ryutaro Hirasawa, Masaya Baba, Tetsuo Ohnishi, Shigeo Ohno. MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Development. 2002.10; 129 (19): 4483-4495. ( PubMed )

  58. Aki Mishima, Atsushi Suzuki, Makiko Enaka, Tomonori Hirose, Keiko Mizuno, Tetsuo Ohnishi, Hiroshi Mohri, Yoshiaki Ishigatsubo, Shigeo Ohno. Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells. Genes Cells. 2002.06; 7 (6): 581-596. ( PubMed, DOI )

  59. A Suzuki, T Yamanaka, T Hirose, N Manabe, K Mizuno, M Shimizu, K Akimoto, Y Izumi, T Ohnishi, S Ohno. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol. 2001.03; 152 (6): 1183-1196. ( PubMed, DOI )

  60. K Kotani, W Ogawa, M Hashiramoto, T Onishi, S Ohno, M Kasuga. Inhibition of insulin-induced glucose uptake by atypical protein kinase C isotype-specific interacting protein in 3T3-L1 adipocytes. J Biol Chem. 2000.08; 275 (34): 26390-26395. ( PubMed, DOI )

  61. S Noda, K Kishi, T Yuasa, H Hayashi, T Ohnishi, I Miyata, H Nishitani, Y Ebina. Overexpression of wild-type Akt1 promoted insulin-stimulated p70S6 kinase (p70S6K) activity and affected GSK3 beta regulation, but did not promote insulin-stimulated GLUT4 translocation or glucose transport in L6 myotubes. J Med Invest. 2000.02; 47 (1-2): 47-55. ( PubMed )

  62. L Wang, H Hayashi, Y Mitani, K Ishii, T Ohnishi, Y Niwa, H Kido, Y Ebina. Cloning of a cDNA encoding a 190-kDa insulin receptor substrate-1-like protein of simian COS cells. Biochem Biophys Res Commun. 1995.11; 216 (1): 321-328. ( PubMed, DOI )

  63. M Kan, F Kanai, M Iida, H Jinnouchi, M Todaka, T Imanaka, K Ito, Y Nishioka, T Ohnishi, S Kamohara. Frequency of mutations of insulin receptor gene in Japanese patients with NIDDM. Diabetes. 1995.09; 44 (9): 1081-1086. ( PubMed, DOI )

  64. S Sahara, K Sato, M Aoto, T Ohnishi, H Kaise, H Koide, K Ogita, Y Fukami. Characterization of protein kinase C in Xenopus oocytes. Biochem Biophys Res Commun. 1992.01; 182 (1): 105-114. ( PubMed, DOI )

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  1. 大西哲生、吉川武男. 統合失調症. 医学書院, 2013.05 第20章「動物モデル」

  2. 大西哲生、吉川武男. 疾患モデルマウスと表現型解析. 中山書店, 2011.11 精神疾患

  3. 『専門医のための精神科臨床リュミエール』 16巻 脳科学エッセンシャル〜精神疾患の生物学的理解のために〜. 中山書店, 2010.06 イノシトールリン脂質系と双極性障害