Personnel Information

写真a

IWAMOTO Tsutomu


Job title

Professor

Laboratory Address

1-5-45 Yushima, Bunkyou-ku, Tokyo

Laboratory Phone number

+81-3-5803-5540

Laboratory Fax number

+81-3-5803-0204

Research Areas, Keywords

Pediatric Dentistry, Tooth Development, Cell Differentiation and Extracellular Environment

Graduating School 【 display / non-display

  • Nagasaki University, Faculty of Dentistry, 1999.03, Graduated

Graduate School 【 display / non-display

  • Nagasaki University, Graduate School, Division of Dental Research, Doctor's Course, 2002.03, Completed

Campus Career 【 display / non-display

  • 2020.05
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Oral Health Sciences, Department of Pediatric Dentistry / Special Needs Dentistry, Professor

External Career 【 display / non-display

  • 2015.04
    -
    2020.05
    , Professor
  • 2013.04
    -
    2015.03
    , Professor
  • 2012.07
    -
    2013.03
    , Junior Associate Professor
  • 2009.03
    -
    2012.06
    , Assistant Professor
  • 2006.12
    -
    2009.02
    , Assistant Professor
  • 2004.12
    -
    2006.11
    National Institutes of Health, National Institute of Dental and Craniofacial Research, Visiting Fellow

▼display all

Research Areas 【 display / non-display

  • Developmental dentistry

Qualification Acquired 【 display / non-display

  • Dentist

 

Published Papers & Misc 【 display / non-display

  1. Junichiro Wada, Paulina Heponiemi, Kanae Wada, Sufyan Garoushi, Noriyuki Wakabayashi, Tsutomu Iwamoto, Pekka K. Vallittu, Lippo Lassila. Effect of ethylene oxide unit number in bis-EMA on the physical properties of additive-manufactured occlusal splint material Journal of Prosthodontic Research. 2024.01;

  2. Sugimoto A, Iwata K, Kurogoushi R, Tanaka M, Nakashima Y, Yamakawa Y, Oishi A, Yoshizaki K, Fukumoto S, Yamamoto A, Ishimaru N, Iwamoto T. C-terminus of PIEZO1 governs Ca(2+) influx and intracellular ERK1/2 signaling pathway in mechanotransduction. Biochemical and biophysical research communications. 2023.11; 682 39-45. ( PubMed, DOI )

  3. Wada J, Wada K, Uctasli S, Wakabayashi N, Iwamoto T, Vallittu PK, Lassila L. Effect of splinting material type and location on resistance against deflection force of splinted periodontally compromised teeth with hypermobility. Journal of the mechanical behavior of biomedical materials. 2023.04; 142 105873. ( PubMed, DOI )

  4. Yuta Chiba, Keigo Yoshizaki, Hiroshi Sato, Tomoko Ikeuchi, Craig Rhodes, Mitsuki Chiba, Kan Saito, Takashi Nakamura, Tsutomu Iwamoto, Aya Yamada, Yoshihiko Yamada, Satoshi Fukumoto. Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process. FASEB J. 2023.04; 37 (4): e22861. ( PubMed, DOI )

  5. Junichiro Wada, Kanae Wada, Sufyan Garoushi, Akikazu Shinya, Noriyuki Wakabayashi, Tsutomu Iwamoto, Pekka K. Vallittu, Lippo Lassila. Effect of 3D printing system and post-curing atmosphere on micro- and nano-wear of additive-manufactured occlusal splint materials Journal of the Mechanical Behavior of Biomedical Materials. 2023.03; 142 105799.

  6. Yao Fu, Kanako Miyazaki, Yuta Chiba, Keita Funada, Tomomi Yuta, Tian Tian, Kanji Mizuta, Jumpei Kawahara, Ling Zhang, Daniel Martin, Tsutomu Iwamoto, Ichiro Takahashi, Satoshi Fukumoto, Keigo Yoshizaki. Identification of GPI-anchored protein LYPD1 as an essential factor for odontoblast differentiation in tooth development. J Biol Chem. 2023.03; 104638. ( PubMed, DOI )

  7. Tomomi Yuta, Tian Tian, Yuta Chiba, Kanako Miyazaki, Keita Funada, Kanji Mizuta, Yao Fu, Jumpei Kawahara, Tsutomu Iwamoto, Ichiro Takahashi, Satoshi Fukumoto, Keigo Yoshizaki. Development of a novel ex vivo organ culture system to improve preservation methods of regenerative tissues. Sci Rep. 2023.02; 13 (1): 3354. ( PubMed, DOI )

  8. Anrizandy Narwidina, Aya Miyazaki, Kokoro Iwata, Rika Kurogoushi, Asuna Sugimoto, Yasusei Kudo, Keita Kawarabayashi, Yoshihito Yamakawa, Yuki Akazawa, Takamasa Kitamura, Hiroshi Nakagawa, Kimiko Yamaguchi-Ueda, Tomokazu Hasegawa, Keigo Yoshizaki, Satoshi Fukumoto, Akihito Yamamoto, Naozumi Ishimaru, Tomonori Iwasaki, Tsutomu Iwamoto. Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression. Biochem Biophys Res Commun. 2023.02; 650 47-54. ( PubMed, DOI )

  9. Shin Yujeong, Wada Kanae, Tsuchida Yumi, Ijbara Manhal, Ikeda Masaomi, Takahashi Hidekazu, Iwamoto Tsutomu. Wear behavior of materials for additive manufacturing after simulated occlusion of deciduous dentition JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS. 2023.02; 138 105627. ( PubMed, DOI )

  10. Fumiya Kano, Noboru Hashimoto, Yao Liu, Linze Xia, Takaaki Nishihara, Wakana Oki, Keita Kawarabayashi, Noriko Mizusawa, Keiko Aota, Takayoshi Sakai, Masayuki Azuma, Hideharu Hibi, Tomonori Iwasaki, Tsutomu Iwamoto, Nobuyasu Horimai, Akihito Yamamoto. Therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for radiation-induced mouse xerostomia. Sci Rep. 2023.02; 13 (1): 2706. ( PubMed, DOI )

  11. Zhao LI, Satoko KAKINO, Tsutomu IWAMOTO. A Characteristic Analysis of the Pulse Transit Time to Dental Pulp: An Attempt at a New Approach to Dental Pulp Diagnoses Based on the Microcirculatory System Journal of Oral Health and Biosciences. 2023.01; 35 (2): 33-42.

  12. Junichiro Wada, Kanae Wada, Mona Gibreel, Noriyuki Wakabayashi, Tsutomu Iwamoto, Pekka K Vallittu, Lippo Lassila. Effect of Surface Polishing on Physical Properties of an Occlusal Splint Material for Additive Manufacturing under Protection Gas Post-Curing Condition. Polymers (Basel). 2023.01; 15 (3): ( PubMed, DOI )

  13. Kanae Wada, Manhal Ijbara, Nesreen A Salim, Junichiro Wada, Tsutomu Iwamoto. Three-dimensional microscopic comparison of wear behavior between immature and mature enamel: an in vitro study. BMC Oral Health. 2023.01; 23 (1): 40. ( PubMed, DOI )

  14. Aya Yamada, Keigo Yoshizaki, Kan Saito, Masaki Ishikawa, Yuta Chiba, Seira Hoshikawa, Mitsuki Chiba, Ryoko Hino, Yuriko Maruya, Hiroshi Sato, Keiji Masuda, Haruyoshi Yamaza, Takashi Nakamura, Tsutomu Iwamoto, Satoshi Fukumoto. GSK3beta inhibitor-induced dental mesenchymal stem cells regulate ameloblast differentiation. J Oral Biosci. 2022.12; 64 (4): 400-409. ( PubMed, DOI )

  15. Junichiro Wada, Kanae Wada, Mona Gibreel, Noriyuki Wakabayashi, Tsutomu Iwamoto, Pekka K Vallittu, Lippo Lassila. Effect of 3D Printer Type and Use of Protection Gas during Post-Curing on Some Physical Properties of Soft Occlusal Splint Material. Polymers (Basel). 2022.10; 14 (21): ( PubMed, DOI )

  16. Junichiro Wada, Kanae Wada, Mona Gibreel, Noriyuki Wakabayashi, Tsutomu Iwamoto, Pekka K Vallittu, Lippo Lassila. Effect of Nitrogen Gas Post-Curing and Printer Type on the Mechanical Properties of 3D-Printed Hard Occlusal Splint Material. Polymers (Basel). 2022.09; 14 (19): ( PubMed, DOI )

  17. Tomoka Matsumura, Susumu Hosokawa, Miho Hanaoka, Yushi Abe, Tsutomu Iwamoto, Shigeru Maeda. Transient ventricular bigeminy during emergence from general anesthesia in a pediatric patient with catecholaminergic polymorphic ventricular tachycardia. J Electrocardiol. 2022.05; 73 38-41. ( PubMed, DOI )

  18. Kokoro Iwata, Keita Kawarabayashi, Keigo Yoshizaki, Tian Tian, Kan Saito, Asuna Sugimoto, Rika Kurogoushi, Aya Yamada, Akihito Yamamoto, Yasuei Kudo, Naozumi Ishimaru, Satoshi Fukumoto, Tsutomu Iwamoto. von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation. J Cell Physiol. 2022.03; 237 (3): 1964-1979. ( PubMed, DOI )

  19. Yao Liu, Fumiya Kano, Noboru Hashimoto, Linze Xia, Qiao Zhou, Xingmei Feng, Hideharu Hibi, Aya Miyazaki, Tsutomu Iwamoto, Yoshizo Matsuka, Zhijun Zhang, Eiji Tanaka, Akihito Yamamoto. Conditioned Medium From the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Neuropathic Pain in a Partial Sciatic Nerve Ligation Model. Front Pharmacol. 2022.03; 13 745020. ( PubMed, DOI )

  20. Tian Tian, Kanako Miyazaki, Yuta Chiba, Keita Funada, Tomomi Yuta, Kanji Mizuta, Yao Fu, Jumpei Kawahara, Xue Han, Yuna Ando, Ami Funada, Aya Yamada, Tsutomu Iwamoto, Seiji Nakamura, Ichiro Takahashi, Satoshi Fukumoto, Keigo Yoshizaki. An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs. Sci Rep. 2022.02; 12 (1): 3093. ( PubMed, DOI )

  21. Hoshiai Aiko, Kusumoto Yasuka, Hoshiai Taiji, Kimura Naoki, Ito Yukiko, Yoshida Naomi, Shinozuka Osamu, Iwamoto Tsutomu. Factors Influencing Oral Hygiene Management in Patients with Rheumatoid Arthritis 障害者歯科. 2022.02; 43 (1): 7-16. ( ichushi )

  22. Rika Kurogoushi, Tomokazu Hasegawa, Yuki Akazawa, Kokoro Iwata, Asuna Sugimoto, Kimiko Yamaguchi-Ueda, Aya Miyazaki, Anrizandy Narwidina, Keita Kawarabayashi, Takamasa Kitamura, Hiroshi Nakagawa, Tomonori Iwasaki, Tsutomu Iwamoto. Fibroblast growth factor 2 suppresses the expression of C-C motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells. Exp Ther Med. 2021.12; 22 (6): 1356. ( PubMed, DOI )

  23. Yusuke Iwabuchi, Tomoyo Nakamura, Yasuka Kusumoto, Ryoma Nakao, Tsutomu Iwamoto, Osamu Shinozuka, Hidenobu Senpuku. Effects of pH on the Properties of Membrane Vesicles Including Glucosyltransferase in Streptococcus mutans Microorganisms. 2021.11; 9 (11): 2308. ( PubMed, DOI )

  24. Aya Yamada, Keigo Yoshizaki, Masaki Ishikawa, Kan Saito, Yuta Chiba, Emiko Fukumoto, Ryoko Hino, Seira Hoshikawa, Mitsuki Chiba, Takashi Nakamura, Tsutomu Iwamoto, Satoshi Fukumoto. Connexin 43-Mediated Gap Junction Communication Regulates Ameloblast Differentiation via ERK1/2 Phosphorylation Front Physiol. 2021.09; 12 748574. ( PubMed, DOI )

  25. Manami Takenoshita, Masaki Takechi, Tri Vu Hoang, Toshiko Furutera, Chisaki Akagawa, Worachat Namangkalakul, Kazushi Aoto, Tsutomu Kume, Michiyo Miyashin, Tsutomu Iwamoto, Sachiko Iseki. Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development. Dev Dyn. 2021.08; 250 (8): 1125-1139. ( PubMed, DOI )

  26. Tamura Yukihiko, Fuangtharnthip Pornpoj, Uehara Tomoki, Iwamoto Tsutomu, Waki Yoshihiro. Metallothionein expression in zinc-treated cartilage precursor ATDC5 cells(和訳中) Biomedical Research on Trace Elements. 2021.06; 32 (1): 23-29. ( ichushi )

  27. Hino Ryoko, Yamada Aya, Chiba Yuta, Yoshizaki Keigo, Fukumoto Emiko, Iwamoto Tsutomu, Maruya Yuriko, Otsu Keishi, Harada Hidemistu, Saito Kan, Fukumoto Satoshi. Melnick-Needles syndrome associated molecule, Filamin-A regulates dental epithelial cell migration and root formation Pediatric Dental Journal. 2020.12; 30 (3): 208-214. ( ichushi )

  28. Chiba Y, Yoshizaki K, Saito K, Ikeuchi T, Iwamoto T, Rhodes C, Nakamura T, de Vega S, Morell RJ, Boger ET, Martin D, Hino R, Inuzuka H, Bleck CKE, Yamada A, Yamada Y, Fukumoto S. G-protein coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts. The Journal of biological chemistry. 2020.08; 295 (45): 15328-15341. ( PubMed, DOI )

  29. N Ogasawara, F Kano, N Hashimoto, H Mori, Y Liu, L Xia, T Sakamaki, H Hibi, T Iwamoto, E Tanaka, A Yamamoto. Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental temporomandibular joint osteoarthritis. Osteoarthritis Cartilage. 2020.06; 28 (6): 831-841. ( PubMed, DOI )

  30. Kawarabayashi Keita, Kano Fumiya, Hashimoto Noboru, Hibi Hideharu, Iwamoto Tsutomu, Yamamoto Akihito. Conditioned Media from Human Dental Pulp Stem Cells Prevent Radiation-induced Skin Injury Journal of Oral Health and Biosciences. 2020.06; 33 (1): 1-7. ( ichushi )

  31. Nakamura T, Iwamoto T, Nakamura HM, Shindo Y, Saito K, Yamada A, Yamada Y, Fukumoto S, Nakamura T. Regulation of miR-1-Mediated Connexin 43 Expression and Cell Proliferation in Dental Epithelial Cells. Frontiers in cell and developmental biology. 2020.03; 8 156. ( PubMed, DOI )

  32. Funada K, Yoshizaki K, MIyazaki K, Han X, Yuta T, Tian T, Mizuta K, Fu Y, Iwamoto T, Yamada A, Takahashi I, Fukumoto S. microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth development. Scientific reports. 2020.03; 10 (1): 4918. ( PubMed, DOI )

  33. Miyazaki A, Sugimoto A, Yoshizaki K, Kawarabayashi K, Iwata K, Kurogoushi R, Kitamura T, Otsuka K, Hasegawa T, Akazawa Y, Fukumoto S, Ishimaru N, Iwamoto T. Coordination of WNT signaling and ciliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1. Scientific reports. 2019.10; 9 (1): 14762. ( PubMed, DOI )

  34. Yamaguchi-Ueda K, Akazawa Y, Kawarabayashi K, Sugimoto A, Nakagawa H, Miyazaki A, Kurogoushi R, Iwata K, Kitamura T, Yamada A, Hasegawa T, Fukumoto S, Iwamoto T. Combination of ions promotes cell migration via extracellular signal‑regulated kinase 1/2 signaling pathway in human gingival fibroblasts. Molecular medicine reports. 2019.06; 19 (6): 5039-5045. ( PubMed, DOI )

  35. Nakatomi C, Nakatomi M, Matsubara T, Komori T, Doi-Inoue T, Ishimaru N, Weih F, Iwamoto T, Matsuda M, Kokabu S, Jimi E. Constitutive activation of the alternative NF-κB pathway disturbs endochondral ossification. Bone. 2019.04; 121 29-41. ( PubMed, DOI )

  36. Chiba Y, He B, Yoshizaki K, Rhodes C, Ishijima M, Bleck CKE, Stempinski E, Chu EY, Nakamura T, Iwamoto T, de Vega S, Saito K, Fukumoto S, Yamada Y. The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology. The Journal of biological chemistry. 2019.03; 294 (10): 3406-3418. ( PubMed, DOI )

  37. Han X, Yoshizaki K, Miyazaki K, Arai C, Funada K, Yuta T, Tian T, Chiba Y, Saito K, Iwamoto T, Yamada A, Takahashi I, Fukumoto S. The transcription factor NKX2-3 mediates p21 expression and ectodysplasin-A signaling in the enamel knot for cusp formation in tooth development. The Journal of biological chemistry. 2018.09; 293 (38): 14572-14584. ( PubMed, DOI )

  38. Hirayama Koji, Hanada Takashi, Hino Ryoko, Saito Kan, Kobayashi Mayu, Arakaki Makiko, Chiba Yuta, Nakamura Norihiko, Sakurai Takeshi, Iwamoto Tsutomu, Fukumoto Satoshi, Yamada Aya. Material properties on enamel and fissure of surface pre-reacted glass-ionomer filler-containing dental sealant Pediatric Dental Journal. 2018.08; 28 (2): 87-95. ( ichushi )

  39. Yamaguchi-Ueda Kimiko, Kawarabayashi Keita, Miyazaki Aya, Kurogoushi Rika, Iwata Kokoro, Sugimoto Asuna, Akazawa Yuki, Hasegawa Tomokazu, Iwamoto Tsutomu. Prevention of Sports-related Dental Injuries in Children Journal of Oral Health and Biosciences. 2018.07; 31 (1): 68-72. ( ichushi )

  40. Koji Hirayama, Takashi Hanada, Ryoko Hino, Kan Saito, Mayu Kobayashi, Makiko Arakaki, Yuta Chiba, Norihiko Nakamura, Takeshi Sakurai, Tsutomu Iwamoto, Satoshi Fukumoto, Aya Yamada. Material properties on enamel and fissure of surface pre-reacted glass-ionomer filler-containing dental sealant Pediatric Dental Journal. 2018; Vol.28 (No.2): 87-95. ( DOI )

  41. Sugimoto A, Miyazaki A, Kawarabayashi K, Shono M, Akazawa Y, Hasegawa T, Ueda-Yamaguchi K, Kitamura T, Yoshizaki K, Fukumoto S, Iwamoto T. Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells. Scientific reports. 2017.12; 7 (1): 17696. ( PubMed, DOI )

  42. Arai C, Yoshizaki K, Miyazaki K, Saito K, Yamada A, Han X, Funada K, Fukumoto E, Haruyama N, Iwamoto T, Takahashi I, Fukumoto S. Nephronectin plays critical roles in Sox2 expression and proliferation in dental epithelial stem cells via EGF-like repeat domains. Scientific reports. 2017.03; 7 45181. ( PubMed, DOI )

  43. Iwamoto T, Nakamura T, Ishikawa M, Yoshizaki K, Sugimoto A, Ida-Yonemochi H, Ohshima H, Saito M, Yamada Y, Fukumoto S. Pannexin 3 regulates proliferation and differentiation of odontoblasts via its hemichannel activities. PloS one. 2017; 12 (5): e0177557. ( PubMed, DOI )

  44. Liu J, Saito K, Maruya Y, Nakamura T, Yamada A, Fukumoto E, Ishikawa M, Iwamoto T, Miyazaki K, Yoshizaki K, Ge L, Fukumoto S. Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation. Scientific reports. 2016.03; 6 23670. ( PubMed, DOI )

  45. Yuki Akazawa, Tomokazu Hasegawa, Yoshitaka Yoshimura, Naoyuki Chosa, Takeyoshi Asakawa, Kimiko Ueda, Asuna Sugimoto, Takamasa Kitamura, Hiroshi Nakagawa, Akira Ishisaki, Tsutomu Iwamoto. Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth. Int J Mol Med. 2015.08; 36 (2): 442-448. ( PubMed, DOI )

  46. Kan Saito, Emiko Fukumoto, Aya Yamada, Kenji Yuasa, Keigo Yoshizaki, Tsutomu Iwamoto, Masahiro Saito, Takashi Nakamura, Satoshi Fukumoto. Interaction between fibronectin and β1 integrin is essential for tooth development. PLoS One. 2015; 10 (4): e0121667. ( PubMed, DOI )

  47. Hasegawa Tomokazu, Akazawa Yuki, Kitamura Takamasa, Sugimoto Asuna, Ueda Kimiko, Iwamoto Tsutomu. Dental findings and management in a child with hypomelanosis of Ito Pediatric Dental Journal. 2014.12; 24 (3): 173-177. ( ichushi )

  48. Masaki Ishikawa, Tsutomu Iwamoto, Satoshi Fukumoto, Yoshihiko Yamada. Pannexin 3 inhibits proliferation of osteoprogenitor cells by regulating Wnt and p21 signaling. J Biol Chem. 2014.01; 289 (5): 2839-2851. ( PubMed, DOI )

  49. Tomokazu Hasegawa, Yuki Akazawa, Takamasa Kitamura, Asuna Sugimoto, Kimiko Ueda, Tsutomu Iwamoto. Dental findings and management in a child with hypomelanosis of Ito Pediatric Dental Journal. 2014; 24 (3): 173-177. ( DOI )

  50. Tsutomu Iwamoto, Asuna Sugimoto, Takamasa Kitamura, Yuki Akazawa, Tomokazu Hasegawa. The role of extracellular ATP-mediated purinergic signaling in bone, cartilage, and tooth tissue Journal of Oral Biosciences. 2014; 56 (4): 131-135. ( DOI )

  51. Hashimura Takashi, Yamada Aya, Iwamoto Tsutomu, Arakaki Makiko, Saito Kan, Fukumoto Satoshi. Application of a tooth-surface coating material to teeth with discolored crowns Pediatric Dental Journal. 2013.04; 23 (1): 44-50. ( ichushi )

  52. Takashi Hashimura, Aya Yamada, Tsutomu Iwamoto, Makiko Arakaki, Kan Saito, Satoshi Fukumoto. Application of a tooth-surface coating material to teeth with discolored crowns Pediatric Dental Journal. 2013.04; 23 (1): 44-50. ( DOI )

  53. Iwamoto Tsutomu, Ishikawa Masaki, Ono Mariko, Nakamura Takashi, Fukumoto Satoshi, Yamada Yoshihiko. Biological roles of gap junction proteins in cartilage and bone development Journal of Oral Biosciences. 2013.02; 55 (1): 29-33. ( ichushi )

  54. Makiko Arakaki, Masaki Ishikawa, Takashi Nakamura, Tsutomu Iwamoto, Aya Yamada, Emiko Fukumoto, Masahiro Saito, Keishi Otsu, Hidemitsu Harada, Yoshihiko Yamada, Satoshi Fukumoto. Role of epithelial-stem cell interactions during dental cell differentiation. J Biol Chem. 2012.03; 287 (13): 10590-10601. ( PubMed, DOI )

  55. Yamada Aya, Iwamoto Tsutomu, Fukumoto Emiko, Arakaki Makiko, Miyamoto Ryoko, Sugawara Yu, Komatsu Hideji, Nakamura Takashi, Fukumoto Satoshi. Epithelial-mesenchymal interaction reduces inhibitory effects of fluoride on proliferation and enamel matrix expression in dental epithelial cells Pediatric Dental Journal. 2012.03; 22 (1): 55-63. ( ichushi )

  56. Y Kamasaki, T Nakamura, K Yoshizaki, T Iwamoto, A Yamada, E Fukumoto, Y Maruya, K Iwabuchi, K Furukawa, T Fujiwara, S Fukumoto. Glycosphingolipids regulate ameloblastin expression in dental epithelial cells. J Dent Res. 2012.01; 91 (1): 78-83. ( PubMed, DOI )

  57. Satoshi Fukumoto, Makiko Arakaki, Tsutomu Iwamoto, Aya Yamada, Ryoko Miyamoto, Masahiro Naruse, Takashi Nakamura. Epithelial cell lines in the field of dental research: Review Interface Oral Health Science 2011. 2012.01; 327-333. ( DOI )

  58. Ishikawa M, Iwamoto T, Nakamura T, Doyle A, Fukumoto S, Yamada Y. Pannexin 3 functions as an ER Ca(2+) channel, hemichannel, and gap junction to promote osteoblast differentiation. The Journal of cell biology. 2011.06; 193 (7): 1257-74. ( PubMed, DOI )

  59. Tsutomu Iwamoto, Mariko Ono, Makiko Arakaki, Takashi Nakamura, Aya Yamada, Satoshi Fukumoto. Pannexin 3, a gap junction protein, regulates chondrocyte differentiation in part though hemichammel acivity. Interface Oral health Science. 2011.05; 346-348.

  60. Iwamoto Tsutomu, Yamada Aya, Arakaki Makiko, Sugawara Yu, Ono Mariko, Futaki Masaharu, Yoshizaki Keigo, Fukumoto Emiko, Nakamura Takashi, Fukumoto Satoshi. Expressions and Functions of Neurotrophic Factors in Tooth Development Journal of Oral Biosciences. 2011.02; 53 (1): 13-21. ( DOI )

  61. Tsutomu Iwamoto, Takashi Nakamura, Andrew Doyle, Masaki Ishikawa, Susana de Vega, Satoshi Fukumoto, Yoshihiko Yamada. Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation. J Biol Chem. 2010.06; 285 (24): 18948-18958. ( PubMed, DOI )

  62. Nan Wu, Tsutomu Iwamoto, Yu Sugawara, Masaharu Futaki, Keigo Yoshizaki, Shinya Yamamoto, Aya Yamada, Takashi Nakamura, Kazuaki Nonaka, Satoshi Fukumoto. PDGFs regulate tooth germ proliferation and ameloblast differentiation. Arch Oral Biol. 2010.06; 55 (6): 426-434. ( PubMed, DOI )

  63. Satoshi Fukumoto, Aya Yamada, Tsutomu Iwamoto, Takashi Nakamura. Dental epithelium proliferation and differentiation regulated by ameloblastin INTERFACE ORAL HEALTH SCIENCE 2009. 2010; 33-38. ( DOI )

  64. Akira Sonoda, Tsutomu Iwamoto, Takashi Nakamura, Emiko Fukumoto, Keigo Yoshizaki, Aya Yamada, Makiko Arakaki, Hidemitsu Harada, Kazuaki Nonaka, Seiji Nakamura, Yoshihiko Yamada, Satoshi Fukumoto. Critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation. J Biol Chem. 2009.10; 284 (40): 27176-27184. ( PubMed, DOI )

  65. Tsutomu Iwamoto, Aya Yamada, Kenji Yuasa, Emiko Fukumoto, Takashi Nakamura, Taku Fujiwara, Satoshi Fukumoto. Influences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts. Arch Oral Biol. 2009.10; 54 (10): 963-969. ( PubMed, DOI )

  66. S de Vega, T Iwamoto, Y Yamada. Fibulins: multiple roles in matrix structures and tissue functions. Cell Mol Life Sci. 2009.06; 66 (11-12): 1890-1902. ( PubMed, DOI )

  67. Iwamoto Tsutomu, Yoshizaki Keigo, Sonoda Akira, Nakamura Yuki, Matsuishi Yumiko, Yamaguchi Noboru, Nonaka Kazuaki. Prevalence of natal/neonatal teeth in cleft lip and palate infants Pediatric Dental Journal. 2009.03; 19 (1): 46-51. ( ichushi )

  68. Iwamoto Tsutomu, Yoshizaki Keigo, Nakamura Yuki, Sonoda Akira, Nakamoto Yuki, Okuma Yukiko, Tamiya Rei, Nonaka Kazuaki. Dens evaginatus and dens invaginatus in a mandibular central incisor Pediatric Dental Journal. 2009.03; 19 (1): 145-149. ( ichushi )

  69. Nakamura Norihiko, Yamada Aya, Iwamoto Tsutomu, Arakaki Makiko, Tanaka Kojiro, Aizawa Shizuko, Nonaka Kazuaki, Fukumoto Satoshi. Two-year clinical evaluation of flowable composite resin containing pre-reacted glass-ionomer Pediatric Dental Journal. 2009.03; 19 (1): 89-97. ( ichushi )

  70. Fukumoto S, Nakamura T, Iwamoto T, Yamada A Fukumoto, E, Yamada Y. Identification of tooth specific genes Proceeding of 3rd Hiroshima Conference on Education and Science in Dentistry. 2009; 35-37.

  71. Iwamoto Tsutomu, Fukumoto Satoshi, Yamada Aya, Arakaki Makiko, Nonaka Kazuaki. Presurgical treatment of cleft lip and palate in Aicardi syndrome: A case report Pediatric Dental Journal. 2008.09; 18 (2): 204-209. ( ichushi )

  72. Shinya Yamamoto, Emiko Fukumoto, Keigo Yoshizaki, Tsutomu Iwamoto, Aya Yamada, Kojiro Tanaka, Hiroharu Suzuki, Shizuko Aizawa, Makiko Arakaki, Kenji Yuasa, Kyoko Oka, Yang Chai, Kazuaki Nonaka, Satoshi Fukumoto. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008.08; 283 (34): 23139-23149. ( PubMed, DOI )

  73. Keigo Yoshizaki, Shinya Yamamoto, Aya Yamada, Kenji Yuasa, Tsutomu Iwamoto, Emiko Fukumoto, Hidemitsu Harada, Masahiro Saito, Akihiko Nakasima, Kazuaki Nonaka, Yoshihiko Yamada, Satoshi Fukumoto. Neurotrophic factor neurotrophin-4 regulates ameloblastin expression via full-length TrkB. J Biol Chem. 2008.02; 283 (6): 3385-3391. ( PubMed, DOI )

  74. Souichi Yanamoto, Goro Kawasaki, Izumi Yoshitomi, Tsutomu Iwamoto, Kazunari Hirata, Akio Mizuno. Clinicopathologic significance of EpCAM expression in squamous cell carcinoma of the tongue and its possibility as a potential target for tongue cancer gene therapy. Oral Oncol. 2007.10; 43 (9): 869-877. ( PubMed, DOI )

  75. Susana de Vega, Tsutomu Iwamoto, Takashi Nakamura, Kentaro Hozumi, Dianalee A McKnight, Larry W Fisher, Satoshi Fukumoto, Yoshihiko Yamada. TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding. J Biol Chem. 2007.10; 282 (42): 30878-30888. ( PubMed, DOI )

  76. Souichi Yanamoto, Goro Kawasaki, Hajime Yoshida, Izumi Yoshitomi, Tsutomu Iwamoto, Akio Mizuno, Shuichi Fujita. Rapidly growing mass of the anterior maxillary gingiva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007.08; 104 (2): 153-159. ( PubMed, DOI )

  77. Fukumoto Satoshi, Yamada Aya, Fukumoto Emiko, Yuasa Kenji, Yoshizaki Keigo, Iwamoto Tsutomu, Nonaka Kazuaki. A New Era for Young Dental Scientists: Glycolipids Regulate Ameloblast Differentiation Journal of Oral Biosciences. 2007.05; 49 (2): 113-119. ( ichushi )

  78. Fukumoto S, Iwamoto T, Sakai E, Yuasa K, Fukumoto E, Yamada A, Hasegawa T, Nonaka K, Kato Y. Current topics in pharmacological research on bone metabolism: osteoclast differentiation regulated by glycosphingolipids. Journal of pharmacological sciences. 2006.03; 100 (3): 195-200. ( PubMed, DOI )

  79. Hajime Yoshida, Kuniaki Okamoto, Tsutomu Iwamoto, Eiko Sakai, Kazuhiro Kanaoka, Jin-Ping Hu, Mitsue Shibata, Hitoshi Hotokezaka, Kazuhisa Nishishita, Akio Mizuno, Yuzo Kato. Pepstatin A, an aspartic proteinase inhibitor, suppresses RANKL-induced osteoclast differentiation. J Biochem. 2006.03; 139 (3): 583-590. ( PubMed, DOI )

  80. Souichi Yanamoto, Tsutomu Iwamoto, Goro Kawasaki, Izumi Yoshitomi, Nobuyuki Baba, Akio Mizuno. Silencing of the p53R2 gene by RNA interference inhibits growth and enhances 5-fluorouracil sensitivity of oral cancer cells. Cancer Lett. 2005.06; 223 (1): 67-76. ( PubMed, DOI )

  81. Masahiko Okada, Michi-ichiro Itoh Mi, Masashi Haraguchi, Tetsuya Okajima, Masahiro Inoue, Hideto Oishi, Yoichi Matsuda, Tsutomu Iwamoto, Toshihiro Kawano, Satoshi Fukumoto, Hiroshi Miyazaki, Keiko Furukawa, Shinichi Aizawa, Koichi Furukawa. b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. J Biol Chem. 2002.01; 277 (3): 1633-1636. ( PubMed, DOI )

  82. T Iwamoto, S Fukumoto, K Kanaoka, E Sakai, M Shibata, E Fukumoto, J Inokuchi Ji, K Takamiya, K Furukawa, K Furukawa, Y Kato, A Mizuno. Lactosylceramide is essential for the osteoclastogenesis mediated by macrophage-colony-stimulating factor and receptor activator of nuclear factor-kappa B ligand. J Biol Chem. 2001.12; 276 (49): 46031-46038. ( PubMed, DOI )

  83. M Itoh, S Fukumoto, T Iwamoto, A Mizuno, A Rokutanda, H K Ishida, M Kiso, K Furukawa. Specificity of carbohydrate structures of gangliosides in the activity to regenerate the rat axotomized hypoglossal nerve. Glycobiology. 2001.02; 11 (2): 125-130. ( PubMed, DOI )

▼display all

Conference Activities & Talks 【 display / non-display

  1. 岩田こころ, 岩本 勉. 歯の硬組織形成における細胞外マトリックス分子の機能. 小児歯科学会第38回関東地方会大会 2023.10.01 川口総合文化センター・リリア

  2. Rika Kurogoushi, Kokoro Iwata, Tsutomu Iwamoto. Regulation of cytokine expression by FGF2 in dental pulp-derived mesenchymal stem cells and a consideration on relevance to inflammation and regeneration. 国際小児歯科学会2023 2023.06.16 Maastricht, The Netherlands

  3. 岩田こころ, 岩本 勉. エナメル芽細胞の分化初期に発現するVwdeによる細胞-細胞間,細胞-細胞外基質間接着の発現制御機構の解析. 第61回日本小児歯科学会大会 2023.05.19 出島メッセ長崎

  4. 田中 眞実,杉本 明日菜,中島 結美子,武永 嶺,岩本 勉. 乳歯の根尖性歯周炎が歯性上顎洞炎を引き起こした1例. 2023.05.18

  5. Kanae Wada, Junichiro Wada, Hanae Kanazawa, Janna Waltimo-Siren, Tsutomu Iwamoto, Pekka K. Vallittu, Lippo Lassila. Nano-mechanical Properties of Primary Molar Enamel with Enamel Hypoplasia, Early Enamel Demineralized, and Sound Enamel. International Association of Pediatric Dentistry (IAPD) 2nd Global Summit 2022.11.12 Roma, Italy

  6. Kanae Wada, Junichiro Wada, Hanae Kanazawa, Janna Waltimo-Siren, Tsutomu Iwamoto, Pekka K. Vallittu, Lippo Lassila. Kiillevaurioalentaa merkittävästi maitohampaan pintakovuutta. Finnish Dental Journal 2022.11.10 Helsinki, Finland

  7. Kanae Wada, Junichiro Wada, Hanae Kanazawa, Janna Waltimo-Siren, Tsutomu Iwamoto, Pekka K. Vallittu, Lippo Lassila.. Mechanical and Histological Properties of Primary Molar Enamel with Enamel Hypoplasia. Biomaterials and Medical Devices Research Program of BioCity Turku, Turku Biomaterials Days 2022.10.27 Turku, Finland

  8. Junichiro Wada, Kanae Wada, Mona Gibreel, Noriyuki Wakabayashi, Tsutomu Iwamoto, Pekka K. Vallittu, Lippo Lassila. Effect of Nitrogen Post-Curing on Surface Conditions of 3D-Printed Splint. The Academy of Dental Materials 2022 Meeting 2022.10.01 Athens, Greece

  9. Junichiro Wada, Kanae Wada, Mona Gibreel, Noriyuki Wakabayashi, Tsutomu Iwamoto, Pekka K. Vallittu, Lippo Lassila. Effect of printer types on mechanical properties of 3D-printed splint. The PAN EUROPEAN REGION of the International Association for Dental Research (PER-IADR Oral Health Research Congress) 2022.09.16 Marseille, France

  10. Kanae Wada, Junichiro Wada, Mona Gibreel, Noriyuki Wakabayashi, Tsutomu Iwamoto, Pekka K. Vallittu, Lippo Lassila. Effect of nitrogen gas on mechanical properties of 3D-printed splint. The PAN EUROPEAN REGION of the International Association for Dental Research (PER-IADR Oral Health Research Congress 2022.09.16 Marseille, France

  11. Junichiro Wada, Kanae Wada, Mona Gibreel, Noriyuki Wakabayashi, Tsutomu Iwamoto, Pekka K. Vallittu, Lippo Lassila. Effect of Post-curing at Nitrogen Gas on Mechanical Properties of Water-stored 3D-printed Soft Occlusal Splint. Scandinavian Society for Prosthodontic Dentistry 2022.08.19 Aarhus, Denmark

  12. Yujeong Shin, Kanae Wada, Tsutomu Iwamoto. Wear of 3D-printing resin materials against primary enamel: applicability to artificial tooth of removable space maintainers for child. 第59回日本小児歯科学会大会 2021.06.06 Web開催

  13. Akazawa Yuki, Hasegawa Tomokazu, Yoshimura Yoshitaka, Chosa Naoyuki, Asakawa Takeyoshi, Sugimoto Asuna, Kitamura Takamasa, Ueda Kimiko, Kawarabayashi Keita, Ishisaki Akira, Takahashi Riku, Suehiro Yoto, Iwamoto Tsutomu. 歯髄細胞におけるFGF2によるSDF-1αの抑制の分子機序(Molecular Mechanisms of SDF-1α Suppression by FGF2 in Dental Pulp Cells). 小児歯科学雑誌 2016.04.01

  14. 中村 卓史, 吉冨 康夫, 岩本 勉, 山田 吉彦, 福本 敏. 歯および皮膚の発生におけるエピプロフィンの役割(Roles of Epiprofin in tooth and skin development). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2010.12.01

  15. 菅原 優, 岩本 勉, 二木 正晴, 山田 亜矢, 新垣 真紀子, 小野 真理子, 中村 卓史, 福本 敏. 歯発生における血小板由来増殖因子の機能的役割(Functional roles of platelet-derived growth factors in tooth development). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2010.12.01

  16. Wu Nan, Yamamoto Shinya, Iwamoto Tsutomu, Yoshizaki Keigo, Sonoda Akira, Yamada Aya, Nonaka Kazuaki, Fukumoto Satoshi. 早期歯胚形成における血小板由来成長因子の重要な役割(Platelet-derived growth factors play an important role in early tooth germ development). 小児歯科学雑誌 2009.04.01

  17. Sakai Eiko, Fukumoto Satoshi, Kanaoka Kazuhiro, Shibata Mitsue, Iwamoto Tsutomu, Fukumoto Emiko, Okamoto Kuniaki, Kato Yuzo. 破骨細胞におけるカベオリンの発現とSrc kinaseおよびRANKとの細胞内局在(Expression and subcellular localization of caveolin with Src kinase and RANK in osteoclasts). Journal of Pharmacological Sciences 2003.03.01

  18. Iwamoto Tsutomu, Fukumoto Satoshi, Kanaoka Kazuhiro, Sakai Eiko, Shibata Mitsue, Fukumoto Emiko, Mizuno Akio, Kato Yuzo. 破骨細胞形成におけるGlycosphingolipidの機能的役割(Functional role of glycoshingolipids on osteoclastogenesis). The Japanese Journal of Pharmacology 2002.03.01

▼display all

 

Campus class subject 【 display / non-display

  • Pediatric Dentistry,2020 - Now

  • Laboratory practice of Pediatric Dentistry / Special Needs Dentistry,2020 - Now

  • Lecture of Pediatric Dentistry / Special Needs Dentistry,2020 - Now

  • Practice of Pediatric Dentistry / Special Needs Dentistry,2020 - Now