Personnel Information

写真a

NAKANISHI Hideyuki


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2020.02
    -
    2022.03
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biofunctional Restoration， Material Biofunctions， Assistant Professor
  • 2022.04
    -
    2023.03
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biofunctional Restoration， Material Biofunctions， Assistant Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， -， -， Assistant Professor
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Published Papers & Misc 【 display / non-display 】

  1. Yang T, Nakanishi H, Itaka K. Development of a new caged intein for multi-input conditional translation of synthetic mRNA. Scientific reports. 2024.05; 14 (1): 9988. ( PubMed, DOI )

  2. Du X, Yada E, Terai Y, Takahashi T, Nakanishi H, Tanaka H, Akita H, Itaka K. Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery. Pharmaceutics. 2023.09; 15 (9): 2291. ( PubMed, DOI )

  3. Zhang Maorui, Fukushima Yuta, Nozaki Kosuke, Nakanishi Hideyuki, Deng Jia, Wakabayashi Noriyuki, Itaka Keiji. メッセンジャーRNAを用いた血管新生因子と骨形成因子の同時投与による骨再生の増強(Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA) Inflammation and Regeneration. 2023.06; 43 1 of 16-16 of 16. ( ichushi )

  4. Deng J, Fukushima Y, Nozaki K, Nakanishi H, Yada E, Terai Y, Fueki K, Itaka K. Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist Pharmaceutics. 2022.08; 14 (9): 1785.

  5. Hideyuki Nakanishi, Tatsuyuki Yoshii, Shinya Tsukiji, Hirohide Saito. A protocol to construct RNA-protein devices for photochemical translational regulation of synthetic mRNAs in mammalian cells. STAR Protoc. 2022.06; 3 (2): 101451. ( PubMed, DOI )

  6. Hideyuki Nakanishi. Protein-Based Systems for Translational Regulation of Synthetic mRNAs in Mammalian Cells. Life (Basel). 2021.11; 11 (11): 1192. ( PubMed, DOI )

  7. Nakanishi H, Yoshii T, Kawasaki S, Hayashi K, Tsutsui K, Oki C, Tsukiji S, Saito H. Light-controllable RNA-protein devices for translational regulation of synthetic mRNAs in mammalian cells. Cell chemical biology. 2021.05; 28 (5): 662-674.e5. ( PubMed, DOI )

  8. Nakanishi H, Saito H. Purification of Specific Cell Populations Differentiated from Stem Cells Using MicroRNA-Responsive Synthetic Messenger RNAs. Methods in molecular biology (Clifton, N.J.). 2021; 2312 73-86. ( PubMed, DOI )

  9. Nakanishi H, Saito H. Caliciviral protein-based artificial translational activator for mammalian gene circuits with RNA-only delivery. Nature communications. 2020.03; 11 (1): 1297. ( PubMed, DOI )

  10. Nakanishi H, Saito H. Mammalian gene circuits with biomolecule-responsive RNA devices. Current opinion in chemical biology. 2019.10; 52 16-22. ( PubMed, DOI )

  11. Nakanishi H, Miki K, Komatsu KR, Umeda M, Mochizuki M, Inagaki A, Yoshida Y, Saito H. Monitoring and visualizing microRNA dynamics during live cell differentiation using microRNA-responsive non-viral reporter vectors. Biomaterials. 2017.06; 128 121-135. ( PubMed, DOI )

  12. Nakanishi H, Higuchi Y, Yamashita F, Hashida M. Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase. Journal of biotechnology. 2014.09; 186 139-47. ( PubMed, DOI )

  13. Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M. Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells. Journal of biotechnology. 2011.07; 154 (4): 205-8. ( PubMed, DOI )

  14. Nakanishi H, Higuchi Y, Kawakami S, Yamashita F, Hashida M. piggyBac transposon-mediated long-term gene expression in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2010.04; 18 (4): 707-14. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Hideyuki Nakanishi. Extracellular biomolecule-responsive translational regulation system for mRNA drugs. The Joint Symposium of AMED SCARDA Japan Initiative for World-leading Vaccine Research and Development Centers for Early-career Researchers 2024 2024.08.26

  2. Hideyuki Nakanishi, Keiji Itaka. Extracellular biomolecule-responsive translational regulation system for synthetic mRNAs. 第25回日本RNA学会年会 2024.06.26

  3. Hideyuki Nakanishi, Keiji Itaka. Development of extracellular signal-responsive mRNA drugs for controlled translation. 日本核酸医薬学会第8回年会 2023.07.14

  4. MAORUI‌ZHANG，福島雄大，野崎浩佑，中西秀之，若林則幸，位高啓史. Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA. 第44回日本炎症・再生医学会 2023.07.12

  5. 中西秀之, 齊藤博英, 位髙啓史. Intracellular protein-responsive translational regulation system based on the conditional reconstitution of an artificial translational regulator protein. 10th International mRNA Health Conference 2022.11.08

  6. ケンドル ・ フリー, 中西 秀之, 位髙 啓史. mRNAによる選択的細胞除去システム： 細胞内タンパクに応答した細胞除去因子再構成. 日本核酸医薬学会第7回年会 2022.08.02

  7. 中西秀之, Kendall Free, 位髙啓史. Synthetic mRNA-based selective cell elimination systems utilizing conditional reconstitution of split proteins. 第23回日本RNA学会年会 2022.07.20

  8. Free Kendall, 中西秀之, 位髙啓史. mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection. 9th International mRNA Health Conference 2021.11.08

  9. Hideyuki Nakanishi, Keiji Itaka, Hirohide Saito. Conditional translational regulation of synthetic mRNAs by caliciviral VPg protein-based translational activator (CaVT). Virtual 8th International mRNA Health Conference 2020.11.09

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Awards & Honors 【 display / non-display 】

  • The 15th encouragement award of the Japanese society of drug delivery system，The Japanese Society of Drug Delivery System，2023.07

  • innovation idea contest 2021，Tokyo Medical and Dental University (TMDU)，2021.10

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Social Contribution 【 display / non-display 】

  • Japanese Association for the Advancement of Science，2022.02.22 - Now

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