Personnel Information

写真a

Rios Alain


Job title

Assistant Professor

Homepage URL

https://www.tmd.ac.jp/med/phy2/en/

Research Areas, Keywords

Neurosciences

Profile

The motor features of Parkinson's disease have been attributed in part to the reduction of dopamine in the basal ganglia. These features are the result of a complex neuronal disorder at different levels of the SNC, such as changes in the neuronal excitability, synchronized oscillatory activity, and abnormal sensory responses of areas of the cerebral cortex that are involved in planning and execution of movement, as well as executive, limbic and sensory functions. The adequately characterization of these changes will increase our understanding of both normal and pathological neuronal activity, and will help to develop more specific and effective treatments for parkinsonian patients.
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Graduating School 【 display / non-display 】

  • Tamagawa University, Graduate School of Brain Science, Neuroscience, Graduated

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Campus Career 【 display / non-display 】

  • 2020.01
    -
    2020.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Physiology and Cell Biology， Project Assistant Professor
  • 2020.10
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Physiology and Cell Biology， Assistant Professor
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Academic Society Affiliations 【 display / non-display 】

  • The Japanese Neuroscinece Society

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Research Theme 【 display / non-display 】

  • Differential dopamine dynamics of DMS and DLS projecting SNc neurons during reversal learning, 2021.04 - 2023.04

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Published Papers & Misc 【 display / non-display 】

  1. Alain Rios, Kyohei Fujita, Yoshikazu Isomura, Nobuya Sato. Adaptive circuits for action and value information in rodent operant learning Neuroscience Research. 2024.09; ( DOI )

  2. Rios A, Nonomura S, Kato S, Yoshida J, Matsushita N, Nambu A, Takada M, Hira R, Kobayashi K, Sakai Y, Kimura M, Isomura Y. Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways Commun Biol. 2023.09; 6 (1): 914. ( PubMed, DOI )

  3. Masanori Kawabata , Shogo Soma, Akiko Saiki-Ishikawa , Satoshi Nonomura , Junichi Yoshida , Alain Ríos , Yutaka Sakai , Yoshikazu Isomura. A spike analysis method for characterizing neurons based on phase locking and scaling to the interval between two behavioral events J Neurophysiol. 2020.10; 124 (6): 1923-1941. ( PubMed, DOI )

  4. Rios A, Soma S, Yoshida J, Nonomura S, Kawabata M, Sakai Y, *Isomura Y. Differential changes in the lateralized activity of identified projection neurons of motor cortex in hemiparkinsonian rats. eNeuro. 2019.06; 6 (4): ENEURO.0110-19. ( PubMed, DOI )

  5. *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Ríos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y. Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex. The Journal of neuroscience. 2019.01; 39 (3): 485-502. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 報酬に基づく意思決定における前頭前野ニューロンの異なる役割. 第47回日本神経科学大会 2024.07.24 福岡コンベンションセンター

  2. 報酬履歴は黒質ドーパミン作動性線条体出力経路の行動関連活動を強化する. 第 101 回日本生理学会大会 2024.03.28 北九州国際会議場

  3. Sakairi T, Kawabata M, Alain R, Kaneko S, Sakai Y, Isomura Y. Hippocampal sharp-wave ripples disappear during consummatory licking in head-fixed rodents . 第46回日本神経科学大会（仙台国際センター, 宮城県） 2023.08.03

  4. Alain Rios, Satoshi Nonomura, Shigeki Kato, Junichi Yoshida, Natsuki Matsushida, Atsushi Nambu, Masahiko Takada, Riichiro Hira, Kazuto Kobayashi, Yutaka Sakai, Minoru Kimura, Yoshikazu Isomura. Integration of Reward Expectation and Action Selection in the Nigrostriatal System. The 46th annual meeting 2023.08.01 Sendai International Center

  5. Sunahara M, Rios A, Kawabata M, Takahashi H, Isomura Y. The functional role of thalamic reticular nucleus in motor execution . 第46回日本神経科学大会（仙台国際センター, 宮城県） 2023.08.01

  6. Alain Rios, Satoshi Nonomura, Yutaka Sakai, Shigeki Kato, Kazuto Kobayashi, Masahiko Takada, Yoshikazu Isomura, Minoru Kimura. Dynamic and pathway-specific signaling in the dorsomedial striatum and dopamine neurons during behavioral adaptation . 第45回日本神経科学大会NEURO2022（沖縄コンベンションセンター, 沖縄県宜野湾市） 2022.07.02

  7. 野々村 聡, リオス アライン, 加藤 成樹, 酒井 裕, 南部 篤, 高田 昌彦, 小林 和人, 木村 實, 礒村 宜和. 黒質-線条体路ドーパミン伝達による行動関連ニューロン活動の報酬履歴への依存性 . 第45回日本神経科学大会NEURO2022（沖縄コンベンションセンター, 沖縄県宜野湾市） 2022.07.02

  8. Kawabata M, Rios AA, Sakairi T, Sakai Y, Isomura Y. 視覚性二段階応答課題を用いたげっ歯類大脳皮質における感覚・運動変換関連領域の探索. Neuroscience 2022, The 45th Annual Meeting of the Japan Neuroscience Society (Okinawa convention center, Ginowan, Okinawa) 2022.07.01 Okinawa convention center, Ginowan, Okinawa

  9. 坂入 朋美, 川端 政則, Alain Rios, 金子 聡, 酒井 裕, 礒村 宜和. 海馬 CA1細胞の発火活動と鋭波関連リップルは報酬予測と報酬応答を異なって表現する . 第45回日本神経科学大会NEURO2022（沖縄コンベンションセンター, 沖縄県宜野湾市） 2022.06.30

  10. Kawabata M, Rios AA, Sakairi T, Sakai Y, Isomura Y. Phase—Scaling analysisを用いた齧歯類大脳皮質における感覚・運動関連活動のマッピング. Neuroscience 2021, The 44th Annual Meeting of the Japan Neuroscience Society (Virtual: Kobe International Conference Center, Kobe, Hyogo) 2021.07.29 Kobe

  11. Rios A, Soma S, Nonomura S, Yoshida J, Kawabata M, Sakai Y, Isomura Y. Differential changes in the forelimb selectivity of IT and PT projection neurons of motor cortex in hemiparkinsonian rats. The Annual Meeting of Society for Neuroscience (Neuroscience 2019) 2019.10.20 McCormick Place, Chicago, IL, USA

  12. Rios AA, Satoshi N, Yoshizawa T, Kawabata M, Sakairi T, Sakai Y, Isomura Y. Modification of motor cortex forelimb lateralization preference in a hemiparkinsonian rat model. The 42nd Annual Meeting of the Japan Neuroscience Society (Neuro2019) 2019.07.27 Toki Messe, Niigata, Niigata

  13. Kawabata M, Nonomura S, Yoshizawa T, Rios AA, Sakairi T, Sakai Y, Isomura Y. Distribution of sensory/motor-related information in the rat cerebral cortex. The 42nd Annual Meeting of the Japan Neuroscience Society (Neuro2019) (Toki Messe, Niigata, Niigata) 2019.07.27

  14. Soma S, Yoshida J, Kato S, Nonomura S, Sugimura YK, Rios A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y. Rodent posterior parietal cortex controls ipsilateral as well contralateral movement. The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019) (Kobe Convention Center, Kobe, Hyogo) 2019.03.30

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