論文・総説 - 小藤　智史

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  1. Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Edinger AL, Simeonov A, Sasaki AT. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion. Biochemical and biophysical research communications. 2024.07; 718 149981. ( PubMed, DOI )

  2. Pu J, Kofuji S, Okamoto-Uchida Y, Danzaki K, Yu R, Suzuki A, Kitajima S, Nishina H. Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation. Stem cells (Dayton, Ohio). 2023.10; 41 (12): 1142-1156. ( PubMed, DOI )

  3. Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and biophysical research communications. 2023.08; 679 116-121. ( PubMed, DOI )

  4. Sakurai HT, Iwashita H, Arakawa S, Yikelamu A, Kusaba M, Kofuji S, Nishina H, Ishiyama M, Ueno Y, Shimizu S. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023.07; 26 (7): 107218. ( PubMed, DOI )

  5. Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima and Hiroshi Nishina. Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation. Stem Cells. 2023;

  6. Oda C, Kamimura K, Shibata O, Morita S, Tanaka Y, Setsu T, Abe H, Yokoo T, Sakamaki A, Kamimura H, Kofuji S, Wakai T, Nishina H, Terai S. HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. Biochemistry and biophysics reports. 2022.12; 32 101352. ( PubMed, DOI )

  7. Kobayashi S, Ogasawara N, Watanabe S, Yoneyama Y, Kirino S, Hiraguri Y, Inoue M, Nagata S, Okamoto-Uchida Y, Kofuji S, Shimizu H, Ito G, Mizutani T, Yamauchi S, Kinugasa Y, Kano Y, Nemoto Y, Watanabe M, Tsuchiya K, Nishina H, Okamoto R, Yui S. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflammation and Regeneration. 2022.11; 42 (1): 49. ( PubMed, DOI )

  8. Kobayashi Sakurako, Ogasawara Nobuhiko, Watanabe Satoshi, Yoneyama Yosuke, Kirino Sakura, Hiraguri Yui, Inoue Masami, Nagata Sayaka, Okamoto-Uchida Yoshimi, Kofuji Satoshi, Shimizu Hiromichi, Ito Go, Mizutani Tomohiro, Yamauchi Shinichi, Kinugasa Yusuke, Kano Yoshihito, Nemoto Yasuhiro, Watanabe Mamoru, Tsuchiya Kiichiro, Nishina Hiroshi, Okamoto Ryuichi, Yui Shiro. コラーゲンI型を介した機械的シグナル伝達は腸炎時の上皮細胞の運命転換を制御する(Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation) Inflammation and Regeneration. 2022.11; 42 1 of 18-18 of 18. ( 医中誌 )

  9. Shibata T, Kawana H, Nishino Y, Ito Y, Sato H, Onishi H, Kano K, Inoue A, Taketomi Y, Murakami M, Kofuji S, Nishina H, Miyazawa A, Kono N, Aoki J. Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish. Scientific reports. 2022.05; 12 (1): 7312. ( PubMed, DOI )

  10. Ikeda Yoshiki, Hirayama Akiyoshi, Kofuji Satoshi, Hirota Yoshihisa, Kamata Ryo, Osaka Natsuki, Fujii Yuki, Sasaki Mika, Ikeda Satsuki, Smith Eric P., Bachoo Robert, Soga Tomoyoshi, Sasaki Atsuo T.. SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides(和訳中) The Journal of Biochemistry. 2021.12; 170 (6): 699-711. ( 医中誌 )

  11. Sunaga S, Kofuji S, Nishina H. YAP drives cell competition by activating choline metabolism. Biochemical and biophysical research communications. 2021.08; 572 178-184. ( PubMed, DOI )

  12. Alifu Y, Kofuji S, Sunaga S, Kusaba M, Hirayama J, Nishina H. The Light-Inducible Genes Per2, Cry1a, and Cry2a Regulate Oxidative Status in Zebrafish. Biological & pharmaceutical bulletin. 2021.08; 44 (8): 1160-1165. ( PubMed, DOI )

  13. Alifu Yikelamu, Kofuji Satoshi, Sunaga Sachi, Kusaba Mizuki, Hirayama Jun, Nishina Hiroshi. The Light-Inducible Genes Per2, Cry1a, and Cry2a Regulate Oxidative Status in Zebrafish(和訳中) Biological & Pharmaceutical Bulletin. 2021.08; 44 (8): 1160-1165. ( 医中誌 )

  14. Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT. SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. Journal of biochemistry. 2021.07; 170 (6): 699-711. ( PubMed, DOI )

  15. Shin T, Hiraoka Y, Yamasaki T, Marth JD, Penninger JM, Kanai-Azuma M, Tanaka K, Kofuji S, Nishina H. MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes to cells : devoted to molecular & cellular mechanisms. 2020.10; 26 (1): 5-17. ( PubMed, DOI )

  16. Kofuji Satoshi, Sasaki Atsuo T.. GTP metabolic reprogramming by IMPDH2: unlocking cancer cells' fuelling mechanism(和訳中) The Journal of Biochemistry. 2020.10; 168 (4): 319-328. ( 医中誌 )

  17. Kofuji S, Sasaki AT. GTP Metabolic Reprogramming by IMPDH2: Unlocking Cancer Cells' Fueling Mechanism. Journal of biochemistry. 2020.07; 168 (4): 319-328. ( PubMed, DOI )

  18. Ishihara E, Nagaoka Y, Okuno T, Kofuji S, Ishigami-Yuasa M, Kagechika H, Kamimura K, Terai S, Yokomizo T, Sugimoto Y, Fujita Y, Suzuki A, Nishina H. Prostaglandin E<sub>2</sub> and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes to cells : devoted to molecular & cellular mechanisms. 2020.03; 25 (3): 197-214. ( PubMed, DOI )

  19. Naffouje R, Grover P, Yu H, Sendilnathan A, Wolfe K, Majd N, Smith EP, Takeuchi K, Senda T, Kofuji S, Sasaki AT. Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story. Cancers. 2019.09; 11 (9): ( PubMed, DOI )

  20. Wolfe K, Kofuji S, Yoshino H, Sasaki M, Okumura K, Sasaki AT. Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma. Biochemical and biophysical research communications. 2019.08; 516 (1): 50-56. ( PubMed, DOI )

  21. Takemasu S, Nigorikawa K, Yamada M, Tsurumi G, Kofuji S, Takasuga S, Hazeki K. Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. Journal of biochemistry. 2019.08; 166 (2): 175-185. ( PubMed, DOI )

  22. Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT. IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Nature cell biology. 2019.08; 21 (8): 1003-1014. ( PubMed, DOI )

  23. Takemasu Shinya, Nigorikawa Kiyomi, Yamada Miho, Tsurumi Go, Kofuji Satoshi, Takasuga Shunsuke, Hazeki Kaoru. Erk/MAPKによるTMEM55Bのリン酸化はリソソームのポジショニングを制御する(Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning) The Journal of Biochemistry. 2019.08; 166 (2): 175-185. ( 医中誌 )

  24. Nigorikawa Kiyomi, Matsumura Takuma, Sakamoto Hiromi, Morioka Shin, Kofuji Satoshi, Takasuga Shunsuke, Hazeki Kaoru. Sac1ホスホイノシチドホスファターゼは、マクロファージにおけるSR-A発現を調節することにより、泡沫細胞の形成を制御する(Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages) Biological & Pharmaceutical Bulletin. 2019.06; 42 (6): 923-928. ( 医中誌 )

  25. Takemasu S, Ito M, Morioka S, Nigorikawa K, Kofuji S, Takasuga S, Eguchi S, Nakanishi H, Matsuoka I, Sasaki J, Sasaki T, Hazeki K. Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca<sup>2+</sup> oscillations in macrophages. Genes to cells : devoted to molecular & cellular mechanisms. 2019.05; 24 (5): 366-376. ( PubMed, DOI )

  26. Isobe Y, Nigorikawa K, Tsurumi G, Takemasu S, Takasuga S, Kofuji S, Hazeki K. PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel. Journal of biochemistry. 2019.01; 165 (1): 75-84. ( PubMed, DOI )

  27. Isobe Yuri, Nigorikawa Kiyomi, Tsurumi Go, Takemasu Shinya, Takasuga Shunsuke, Kofuji Satoshi, Hazeki Kaoru. PIKfyveはTRPML1活性化を介してファゴソーム酸性化を促進するが、Ca2+チャネルとは無関係に異常な空胞形成を阻止する(PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel) The Journal of Biochemistry. 2019.01; 165 (1): 75-84. ( 医中誌 )

  28. Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT. Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan. PloS one. 2019; 14 (10): e0224443. ( PubMed, DOI )

  29. Nigorikawa K, Matsumura T, Sakamoto H, Morioka S, Kofuji S, Takasuga S, Hazeki K. Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages. Biological & pharmaceutical bulletin. 2019; 42 (6): 923-928. ( PubMed, DOI )

  30. Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT. Identification of lysine methylation in the core GTPase domain by GoMADScan. PloS one. 2019; 14 (8): e0219436. ( PubMed, DOI )

  31. 劉 瀟瀟, 合山 進, 四方 紫織, 林 康貴, 岩村 浩幸, 齊藤 基輝, 杉浦 悠毅, 滝澤 仁, 小藤 智史, 壽美田 一貴, 佐々木 敦朗, Schibler Janet, Mulloy James C., 北村 俊雄. IMPDH阻害剤による新規白血病治療法の開発 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-0963]. ( 医中誌 )

  32. 小藤 智史, 岡本 好海[内田], 仁科 博史. 【細胞死のすべて-そのメカニズムと,生命現象・疾患との関わり】さまざまな細胞機能と細胞死　生死を制御するJNKシグナル伝達経路 医学のあゆみ. 2022.10; 283 (5): 420-424. ( 医中誌 )

  33. 小藤 智史. がんにおける代謝変化 臨床免疫・アレルギー科. 2021.08; 76 (2): 190-195. ( 医中誌 )

  34. 小藤 智史, 進 匡, 仁科 博史. 育仔行動におけるMKK7-JNKシグナル伝達経路の役割の解明 日本薬学会年会要旨集. 2021.03; 141年会 29V05-pm16. ( 医中誌 )

  35. 森川 みなみ, 小藤 智史, 濁川 清美, 野村 渉. 細胞内グアニンヌクレオチド維持機構の解析 日本薬学会年会要旨集. 2021.03; 141年会 29V05-am06. ( 医中誌 )

  36. 小藤　智史. 核小体の活性と腫瘍形成を制御するGTP代謝リプログラミング 生化学. 2020.11; 92 (5): 722-725. ( DOI )

  37. 小藤 智史. 核小体の活性と腫瘍形成を制御するGTP代謝リプログラミング 生化学. 2020.10; 92 (5): 722-725. ( 医中誌 )

  38. 小藤 智史. 細胞の特性と多様性を制御する代謝システム:生理的役割とその破綻による疾患発症　グアニンヌクレオチド代謝リプログラミングが制御する腫瘍形成のメカニズム 日本生化学会大会プログラム・講演要旨集. 2020.09; 93回 [3S01m-04]. ( 医中誌 )

  39. 小藤 智史, 佐々木 敦朗. 脳腫瘍における核小体の活性化制御とGTP代謝リプログラミング 日本薬学会年会要旨集. 2020.03; 140年会 27I-pm14. ( 医中誌 )

  40. 高橋 宏隆, 壽美田 一貴, 河口 理紗, 小藤 智史, 笠原 亜希子, 井上 竜也, 櫻井 秀敬, 和田 直也, 久保田 一石, 佐々木 敦朗, 澤崎 達也. 多角的解析からみえてくるGTPの新たな機能と人疾患への治療戦略　GTP結合タンパク質PIP4Kβによって制御される、PI(5)Pの標的タンパク質の網羅的探索系の構築 生命科学系学会合同年次大会. 2017.12; 2017年度 [4PW07-7]. ( 医中誌 )

  41. 河口 理紗, デホーン・ミヒル , 池田 幸樹, 小藤 智史, 平山 明由, 森 大, 曽我 朋義, 竹内 恒, 千田 俊哉, 佐々木 敦朗, 木立 尚孝. 多角的解析からみえてくるGTPの新たな機能と人疾患への治療戦略　時系列マルチオミクス解析によるGTP代謝とがん化をつなぐ制御メカニズムの解明 生命科学系学会合同年次大会. 2017.12; 2017年度 [4PW07-2]. ( 医中誌 )

  42. 小藤 智史, 佐々木 敦朗. 多角的解析からみえてくるGTPの新たな機能と人疾患への治療戦略　グリオブラストーマにおける同化的増殖のためのGTP代謝変換 生命科学系学会合同年次大会. 2017.12; 2017年度 [4PW07-8]. ( 医中誌 )

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