経歴(学内) 【 表示 ／ 非表示 】
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2019年08月-2022年06月東京医科歯科大学 高等研究院 卓越研究部門 助教
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2022年07月-現在東京医科歯科大学 高等研究院 卓越研究部門 細胞構造生理学研究室 助教
競争的資金等の研究課題 【 表示 ／ 非表示 】
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クライオ電子顕微鏡法の開発によるチャネルの構造生理学研究
文部科学省/日本学術振興会
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アクアポリンナノディスク法による水チャネル直接阻害薬の開発
文部科学省/日本学術振興会
論文・総説 【 表示 ／ 非表示 】
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Akiko Kamegawa, Shota Suzuki, Hiroshi Suzuki, Kouki Nishikawa, Nobutaka Numoto, Yoshinori Fujiyoshi. Structural analysis of the water channel AQP2 by single-particle cryo-EM. J Struct Biol. 2023.06; 215 (3): 107984. ( PubMed, DOI )
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Daisuke Kozai, Nobutaka Numoto, Kouki Nishikawa, Akiko Kamegawa, Shohei Kawasaki, Yoko Hiroaki, Katsumasa Irie, Atsunori Oshima, Hiroyuki Hanzawa, Kousei Shimada, Yutaka Kitano, Yoshinori Fujiyoshi. Recognition mechanism of a novel gabapentinoid drug, mirogabalin, for recombinant human α2δ1, a voltage-gated calcium channel subunit. J Mol Biol. 2023.05; 435 (10): 168049. ( PubMed, DOI )
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Katerina Naydenova, Akiko Kamegawa, Mathew J Peet, Richard Henderson, Yoshinori Fujiyoshi, Christopher J Russo. On the reduction in the effects of radiation damage to two-dimensional crystals of organic and biological molecules at liquid-helium temperature. Ultramicroscopy. 2022.07; 237 113512. ( PubMed, DOI )
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Hiroki Yamaguchi, Akiko Kamegawa, Kunio Nakata, Tatsuki Kashiwagi, Yoshinori Fujiyoshi, Kazutoshi Tani, Toshimi Mizukoshi. Leucine Dehydrogenase: Structure and Thermostability. Subcell Biochem. 2021; 96 355-372. ( PubMed, DOI )
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Yamaguchi Hiroki, Kamegawa Akiko, Nakata Kunio, Kashiwagi Tatsuki, Mizukoshi Toshimi, Fujiyoshi Yoshinori, Tani Kazutoshi. Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy JOURNAL OF STRUCTURAL BIOLOGY. 2019.01; 205 (1): 11-21. ( PubMed, DOI )
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Akiko Kamegawa, Yoko Hiroaki, Kazutoshi Tani, Yoshinori Fujiyoshi. Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide. Microscopy (Oxf). 2016.04; 65 (2): 177-184. ( PubMed, DOI )
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Mitsuma Tadanori, Tani Kazutoshi, Hiroaki Yoko, Kamegawa Akiko, Suzuki Hiroshi, Hibino Hiroshi, Kurachi Yoshihisa, Fujiyoshi Yoshinori. Influence of the Cytoplasmic Domains of Aquaporin-4 on Water Conduction and Array Formation JOURNAL OF MOLECULAR BIOLOGY. 2010.10; 402 (4): 669-681. ( PubMed, DOI )
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Hara-Chikuma M., Chikuma S., Kabashima K., Nakahigashi K., Kamegawa A., Fujiyoshi Y., Verkman A. S., Sugiyama Y., Inoue S., Miyachi Y.. A controlled aquaporin-3 expression in T lymphocytes regulate their migration and trafficking in cutaneous immune reaction JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010.04; 130 S116.
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Tani Kazutoshi, Mitsuma Tadanori, Hiroaki Yoko, Kamegawa Akiko, Nishikawa Kouki, Tanimura Yukihiro, Fujiyoshi Yoshinori. Mechanism of Aquaporin-4's Fast and Highly Selective Water Conduction and Proton Exclusion JOURNAL OF MOLECULAR BIOLOGY. 2009.06; 389 (4): 694-706. ( PubMed, DOI )
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Hayakawa Sei, Mori Masahiro, Okuta Akiko, Kamegawa Akiko, Fujiyoshi Yoshinori, Yoshiyama Yasumasa, Mitsuoka Kaoru, Ishibashi Kenichi, Sasaki Sei, Hattori Takamichi, Kuwabara Satoshi. Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay JOURNAL OF NEUROIMMUNOLOGY. 2008.05; 196 (1-2): 181-187. ( PubMed, DOI )
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Hiroaki Y, Tani K, Kamegawa A, Gyobu N, Nishikawa K, Suzuki H, Walz T, Sasaki S, Mitsuoka K, Kimura K, Mizoguchi A, Fujiyoshi Y. Implications of the aquaporin-4 structure on array formation and cell adhesion JOURNAL OF MOLECULAR BIOLOGY. 2006.01; 355 (4): 628-639. ( PubMed, DOI )
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Gyobu N, Tani K, Hiroaki Y, Kamegawa A, Mitsuoka K, Fujiyoshi Y. Improved specimen preparation for cryo-electron microscopy using a symmetric carbon sandwich technique JOURNAL OF STRUCTURAL BIOLOGY. 2004.06; 146 (3): 325-333. ( PubMed, DOI )
書籍等出版物 【 表示 ／ 非表示 】
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Y. Tanimura, K. Tani, H. Suzuki, K. Nishikawa, A. Kamegawa, Y. Hiroaki, Y. Fujiyoshi.. Structure and Inhibitor of water channel in brain.. Jenny Stanford Publishing, 2011 Water; The forgotten biological molecule. Chapter 10 (ISBN : 9789814267526)