Personnel Information

写真a

ISHII Takahiro


Job title

Graduate Student
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Campus Career 【 display / non-display 】

  • 2019.04
    -
    2021.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Health Sciences and Biomedical Engineering， Department of Medicinal Chemistry， Graduate Student
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Biomedical Sciences and Engineering， Division of Biomedical Engineering， Department of Medicinal Chemistry， Graduate Student
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Published Papers & Misc 【 display / non-display 】

  1. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Chika Azuma, Yutaro Miura, Hiroki Nakano, Naoya Wada, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura. Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties. Journal of Medicinal Chemistry. 2023.10; 66 (19): 13516-13529. ( PubMed, DOI )

  2. Takuya Kobayakawa, Masayuki Amano, Miyuki Nakayama, Kohei Tsuji, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Kenichi Yamamoto, Masao Matsuoka, Hirokazu Tamamura. Development of anti-HBV agents targeting HBV capsid proteins. RSC Medicinal Chemistry. 2023.10; 14 (10): 1973-1980. ( PubMed, DOI )

  3. Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Shingo Nakahata, Airi Noborio, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura. Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity. European journal of medicinal chemistry. 2023.08; 256 115449. ( PubMed, DOI )

  4. Kohei Tsuji, Kofi Baffour-Awuah Owusu, Yutaro Miura, Takahiro Ishii, Kouki Shinohara, Takuya Kobayakawa, Akino Emi, Takashi Nakano, Youichi Suzuki, Hirokazu Tamamura . Dimerized fusion inhibitor peptides targeting the HR1–HR2 interaction of SARS-CoV-2 RSC Advances. 2023.03; 13 8779-8793.

  5. Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai, Hiromi Ogata-Aoki, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Nobutoki Takamune, Naoki Kishimoto, Shin-Ichiro Hattori, Debananda Das, Yukari Uemura, Yosuke Shimizu, Manabu Aoki, Kazuya Hasegawa, Satoshi Suzuki, Akie Nishiyama, Junji Saruwatari, Yukiko Shimizu, Yoshikazu Sukenaga, Yuki Takamatsu, Kiyoto Tsuchiya, Kenji Maeda, Kazuhisa Yoshimura, Shun Iida, Seiya Ozono, Tadaki Suzuki, Tadashi Okamura, Shogo Misumi, Yoshihiro Kawaoka, Hirokazu Tamamura, Hiroaki Mitsuya. Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nature Communications. 2023.02; 14 (1): 1076. ( PubMed, DOI )

  6. Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Takato Onishi, Sayaka Boku, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Yuki Kishihara, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato, Hirokazu Tamamura. Low-molecular-weight anti-HIV-1 agents targeting HIV-1 capsid proteins. RSC Advances. 2023.01; 13 (3): 2156-2167. ( PubMed, DOI )

  7. Kohei Tsuji, Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Kenichi Yamamoto, Soshi Nishimura, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura. Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement. Chemical & pharmaceutical bulletin. 2023; 71 (12): 879-886. ( PubMed, DOI )

  8. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Miyuki Nakayama, Takato Onishi, Hiroki Nakano, Naoya Wada, Miki Hori, Kouki Shinohara, Yutaro Miura, Takuma Kawada, Hironori Hayashi, Shin-Ichiro Hattori, Haydar Bulut, Debananda Das, Nobutoki Takamune, Naoki Kishimoto, Junji Saruwatari, Tadashi Okamura, Kenta Nakano, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura. Potent and biostable inhibitors of the main protease of SARS-CoV-2. iScience. 2022.11; 25 (11): 105365. ( PubMed, DOI )

  9. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura. Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones. Organic Biomolecular Chemistry. 2021.07; 19 (38): 8264-8271. ( PubMed, DOI )

  10. Kouki Matsuda, Takuya Kobayakawa, Ryusho Kariya, Kiyoto Tsuchiya, Shoraku Ryu, Kohei Tsuji, Takahiro Ishii, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Seiji Okada, Akinobu Hamada, Hiroaki Mitsuya, Hirokazu Tamamura, Kenji Maeda. A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Frontires in Microbiology. 2021.03; 12 636276. ( PubMed, DOI )

  11. Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta, Hirokazu Tamamura. Synthesis of hydrophilic caged DAG-lactones for chemical biology applications. Organic Biomolecular Chemistry. 2020.03; 18 (22): 4217-4223. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Kouki Shinohara, Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Yutaro Miura, Chika Azuma, Hironori Hayashi, Shin-ichiro Hattori, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura. Structure-activity relationship studies of novel SARS-CoV-2 main protease inhibitors with potent antiviral activity. The 60th Japanese Peptide Symposium 2023.11.08 Otsu

  2. Takahiro Ishii, Kohei Tsuji, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Hironori Hayashi, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura . Design and Synthesis of SARS-CoV-2 Mpro Inhibitors Containing Flurine Atoms and Amide Surrogates. 26th KPPS Annual Symposium 2023.07.03 Jeju

  3. Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura . Structure-Activity Relationship Studies of DAG-lactone Derivatives with HIV-1 Latancy Reversing Activity. 14th AFMC International Medicinal Chemistry Symposium 2023.06.27 Seoul

  4. Takahiro Ishii, Kohei Tsuji, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Yutaro Miura, Hironori Hayashi, Shin-ichiro Hattori, Haydar Bulut, Shogo Misumi, Hiroaki Mitsuya, and Hirokazu Tamamura. SYNSESIS OF INHIBITORS TARGETING THE MAIN PROTEASE OF SARS-COV-2 FOR THERAPEUTICS OF COVID-19. 第59回ペプチド討論会 2022.10.26 仙台

  5. Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura. Development of protein kinase C activators for cure of HIV infectious diseases. The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021) 2021.12.20

  6. Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura. Structure-Activity Relationship Studies of Protein Kinase C Activators Derived from Diacylglycerol for Cure of HIV Infectious Diseases. 13th AFMC International Medicinal Chemistry Symposium, Online Symposium 2021.11

  7. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Hirokazu Tamamura. A FRET-BASED ASSAY SYSTEM FOR PROTEIN KINASE C LIGAND SCREENING USING 1,2-DIACYLGLYCEROL-LACTONE DERIVATIVE. 第 58 回ペプチド討論会 2021.10.22

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Awards & Honors 【 display / non-display 】

  • 2023 Young Scientist Oral Presentation Certificate (Takahiro Ishii)，26th Korean Peptide Protein Symposium，2023.07

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Others 【 display / non-display 】

  • A new, promising weapon in the fight against HIV，2023.06

  • Expanding the arsenal of drugs against COVID-19，2022.12

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