Personnel Information

写真a

ENDO Kentaro


Job title

Assistant Professor

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Liberal Arts, 2011.03, Graduated

  • The University of Tokyo, Faculty of Agriculture, 2015.03, Graduated

Campus Career 【 display / non-display

  • 2019.04
    -
    2020.09
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Center for Stem Cell and Regenerative Medicine, Project Researcher
  • 2020.10
    -
    2021.05
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Center for Stem Cell and Regenerative Medicine, Project Researcher
  • 2021.06
    -
    2022.02
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Center for Stem Cell and Regenerative Medicine, Assistant Professor
  • 2021.06
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Applied Regenerative Medicine, Assistant Professor
  • 2022.03
    -
    Now
    Tokyo Medical and Dental University, Institute of Research, a, Center for Stem Cell and Regenerative Medicine, Assistant Professor

Academic Society Affiliations 【 display / non-display

  • THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE

  • THE JAPANESE SOCIETY OF VETERINARY SCIENCE

Research Areas 【 display / non-display

  • Veterinary medical science

  • Orthopedics

 

Published Papers & Misc 【 display / non-display

  1. Yusuke Fuchioka, Kentaro Endo, Yuriko Sakamaki, Takahiro Tanimoto, Nobutake Ozeki,Yusuke Nakagawa, Hideyuki Koga, Makoto Tomita, Ichiro Sekiya.. Scanning electron microscopy analysis of synovial and adipose mesenchymal stem cells adhering to cartilage Regenerative Therapy. 2024.12; 27 488-495. ( DOI )

  2. Yugo Miura, Kentaro Endo, Ichiro Sekiya. Histological and biochemical changes in a rat rotator cuff tear model with or without the subacromial bursa. Tissue Cell. 2024.03; 88 102370. ( PubMed, DOI )

  3. Hisako Katano, Nobutake Ozeki, Mitsuru Mizuno, Kentaro Endo, Noriya Okanouchi 1,2, Jo Fujita, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Morphological analysis of three-dimensional MR images of patellofemoral joints in asymptomatic subjects Sci Rep. 2023.12;

  4. Hideto Furuoka, Kentaro Endo, Ichiro Sekiya. Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis. Stem Cell Res Ther. 2023.09; 14 (1): 244. ( PubMed, DOI )

  5. Misaki Yagi, Kentaro Endo, Keiichiro Komori, Ichiro Sekiya. Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence. Sci Rep. 2023.05; 13 (1): 7697. ( PubMed, DOI )

  6. Nobutake Ozeki, Mitsuru Mizuno, Shinobu Yanada, Takuya Okada, Rei Kubota, Yoshihisa Kushida, Hideto Furuoka, Kentaro Endo, Hisako Katano, Kentaro Nakamura, Shoji Ohya, Hideyuki Koga, Ichiro Sekiya. Autologous Synovial Mesenchymal Stem Cell Transplantation Suppresses Inflammation Caused by Synovial Harvesting and Promotes Healing in a Micro Minipig Repaired Meniscus Model. Transplant Proc. 2023.03; 55 (2): 470-480. ( PubMed, DOI )

  7. Shunichi Fujii, Kentaro Endo, Seiya Matsuta, Keiichiro Komori, Ichiro Sekiya. Comparison of the yields and properties of dedifferentiated fat cells and mesenchymal stem cells derived from infrapatellar fat pads. Regen Ther. 2022.12; 21 611-619. ( PubMed, DOI )

  8. Shunichi Fujii, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspikes. BMC Mol Cell Biol. 2022.12; 23 (1): 53. ( PubMed, DOI )

  9. Takahiro Tanimoto, Kentaro Endo, Yuriko Sakamaki, Nobutake Ozeki, Hisako Katano, Mitsuru Mizuno, Hideyuki Koga, Ichiro Sekiya. Human synovial mesenchymal stem cells show time-dependent morphological changes and increased adhesion to degenerated porcine cartilage. Sci Rep. 2022.10; 12 (1): 16619. ( PubMed, DOI )

  10. Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi, Shinsuke Yasuda. CD34+THY1+ synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro. Arthritis Res Ther. 2022.09; 24 (1): 224. ( PubMed, DOI )

  11. Yugo Miura, Kentaro Endo, Keiichiro Komori, Ichiro Sekiya. Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients. Stem Cell Res Ther. 2022.06; 13 (1): 222. ( PubMed, DOI )

  12. Yuji Kohno, Mitsuru Mizuno, Kentaro Endo, Nobutake Ozeki, Hisako Katano, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Hideyuki Koga, Ichiro Sekiya. Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis Tissue and Cell. 2022.04; 75 101727. ( PubMed, DOI )

  13. Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Naoki Amano, Masaki Nomura, Yoshinori Hasegawa, Nobutake Ozeki, Hideyuki Koga, Naoko Takasu, Osamu Ohara, Tomohiro Morio, Ichiro Sekiya. Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow-up. Stem Cells Transl Med. 2021.11; 10 (11): 1530-1543. ( PubMed, DOI )

  14. Kentaro Endo, Kiyotaka Horiuchi, Hisako Katano, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya. Intra-articular Injection of PDGF-BB Explored in a Novel in Vitro Model Mobilizes Mesenchymal Stem Cells From the Synovium Into Synovial Fluid in Rats. Stem Cell Rev Rep. 2021.10; 17 (5): 1768-1779. ( PubMed, DOI )

  15. Misaki Yagi, Mitsuru Mizuno, Ryota Fujisawa, Hisako Katano, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya. Optimal Pore Size of Honeycomb Polylactic Acid Films for In Vitro Cartilage Formation by Synovial Mesenchymal Stem Cells. Stem Cells Int. 2021.08; 2021 9239728. ( PubMed, DOI )

  16. Kiyotaka Horiuchi, Nobutake Ozeki, Kentaro Endo, Mitsuru Mizuno, Hisako Katano, Masako Akiyama, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Thawed cryopreserved synovial mesenchymal stem cells show comparable effects to cultured cells in the inhibition of osteoarthritis progression in rats. Sci Rep. 2021.05; 11 (1): 9683. ( PubMed, DOI )

  17. Horiuchi Kiyotaka, Mizuno Mitsuru, Katano Hisako, Endo Kentaro, Ozeki Nobutake, Tsuji Kunikazu, Koga Hideyuki, Sekiya Ichiro.. Optimal initial cell density that yields the highest number of primary synovial mesenchymal stem cells in a clinical setting. J Med Dent Sci.. 2021.01; 68 17-26. ( DOI )

  18. Naoto Watanabe, Kentaro Endo, Keiichiro Komori, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Yuji Kohno, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Mesenchymal Stem Cells in Synovial Fluid Increase in Knees with Degenerative Meniscus Injury after Arthroscopic Procedures through the Endogenous Effects of CGRP and HGF. Stem Cell Rev Rep. 2020.12; 16 (6): 1305-1315. ( PubMed, DOI )

  19. Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Ayako Tsuji, Naomi Kojima, Ken Watanabe, Norio Shimizu, Tomohiro Morio, Ichiro Sekiya. The environmental risk assessment of cell-processing facilities for cell therapy in a Japanese academic institution. PLoS One. 2020.08; 15 (8): e0236600. ( PubMed, DOI )

  20. So Suzuki, Mitsuru Mizuno, Yuriko Sakamaki, Ayako Mimata, Kentaro Endo, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Morphological changes in synovial mesenchymal stem cells during their adhesion to the meniscus. Lab Invest. 2020.07; 100 (7): 916-927. ( PubMed, DOI )

  21. Kentaro Endo, Naoki Fujita, Takayuki Nakagawa, Ryohei Nishimura. Comparison of the effect of growth factors on chondrogenesis of canine mesenchymal stem cells. J Vet Med Sci. 2019.08; 81 (8): 1211-1218. ( PubMed, DOI )

  22. Kentaro Endo, Naoki Fujita, Takayuki Nakagawa, Ryohei Nishimura. Effect of Fibroblast Growth Factor-2 and Serum on Canine Mesenchymal Stem Cell Chondrogenesis. Tissue Eng Part A. 2019.06; 25 (11-12): 901-910. ( PubMed, DOI )

  23. Nam Eunryel, Fujita Naoki, Morita Maresuke, Lin Hsing-Yi, Endo Kentaro, Nakagawa Takayuki, Nishimura Ryohei, Tsuzuki Keiko. A pilot study of transplantation of an autologous corneal epithelial cell sheet in a canine model of corneal injury JAPANESE JOURNAL OF VETERINARY RESEARCH. 2018.05; 66 (2): 83-92. ( DOI )

  24. Hsing-Yi Lin, Naoki Fujita, Kentaro Endo, Maresuke Morita, Tae Takeda, Takayuki Nakagawa, Ryohei Nishimura. Isolation and Characterization of Multipotent Mesenchymal Stem Cells Adhering to Adipocytes in Canine Bone Marrow. Stem Cells Dev. 2017.03; 26 (6): 431-440. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Yuki Hidaka, Kentaro Endo, Ichiro Sekiya. Single-cell RNA Sequencing Analysis Of Human Synovial And Adipose Mesenchymal Stem Cells For Knee Osteoarthritis Treatment. Orthopaedic Research Society 2024 Annual Meeting 2024.02.02 California,USA

  2. Hideto Furuoka, Kentaro Endo, Ichiro Sekiya. Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis. Orthopaedic Research Society 2024 Annual Meeting 2024.02.02 California,USA

  3. Endo Kentaro, Fujita Naoki, Nakagawa Takayuki, Nishimura Ryohei. 犬間葉系幹細胞の軟骨形成に対する各成長因子の作用に関する比較(Comparison of the effect of growth factors on chondrogenesis of canine mesenchymal stem cells). The Journal of Veterinary Medical Science 2019.08.01

  4. Nam Eunryel, Fujita Naoki, Morita Maresuke, Lin Hsing-Yi, Endo Kentaro, Nakagawa Takayuki, Nishimura Ryohei, Tsuzuki Keiko. 角膜損傷犬モデルにおける自己角膜上皮細胞シート移植のパイロット研究(A pilot study of transplantation of an autologous corneal epithelial cell sheet in a canine model of corneal injury). Japanese Journal of Veterinary Research 2018.05.01

  5. Kentaro Endo, Naoki Fujita, Yoshihiro Kunitomi, Tae Takeda, Junyan Chen, Koichi Nakayama, Ryohei Nishimura. 3D Bioprinting of Cartilage Tissue Using Canine Mesenchymal Stem Cell Spheroids under the Optimal Growth Factor Condition. TERMIS-Americas 2017.12

  6. Kentaro Endo, Hsing-Yi Lin, Naoki Fujita, Kaori Harada, Yoshihiro Kunitomi, Takayuki Nakagawa, Ryohei Nishimura. Cartilage tissue fabrication with canine mesenchymal stem cells under hypoxia. The 7th Joint Symposium of Veterinary Research in East Asia 2016.02

  7. Kentaro Endo, Hsing-Yi Lin, Naoki Fujita, Kaori Harada, Yoshihiro Kunitomi, Takayuki Nakagawa, Ryohei Nishimura. Hypoxic conditions and spheroid chondrogenesis aimed at canine cartilage tissue biofabrication. The 4th Annual Congress of Asian Society of Veterinary Surgery 2014.12

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Social Contribution 【 display / non-display

  • The Senolytic ABT-263 Enhances Stem Cell Function to Improve Osteoarthritis,NAD.com,https://www.nad.com/news/senolytic-abt-263-stem-cell-function-osteoarthritis,2022.07

  • Senolytic Helps Anti-Osteoarthritis Potential in Stem Cells,Lifespan Extension Advocacy Foundation,Lifespan.io,https://www.lifespan.io/news/senolytic-helps-anti-osteoarthritis-potential-in-stem-cells/,2022.06