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長谷川 純矢(ハセガワ ジュンヤ) HASEGAWA Junya
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経歴(学内) 【 表示 ／ 非表示 】
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2018年07月-2022年04月東京医科歯科大学 難治疾患研究所 難治病態研究部門 病態生理化学分野 助教
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2018年07月-現在東京医科歯科大学 大学院医歯学総合研究科 医歯学専攻 生体環境応答学講座 脂質生物学分野 助教
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2018年07月-現在東京医科歯科大学 大学院医歯学総合研究科 医歯学専攻 生体環境応答学講座 脂質生物学分野 助教
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2018年07月-現在東京医科歯科大学 大学院医歯学総合研究科 医歯理工保健学専攻 脂質生物学分野 助教
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2022年05月-現在東京医科歯科大学 難治疾患研究所 未来生命科学研究部門 病態生理化学分野 助教
競争的資金等の研究課題 【 表示 ／ 非表示 】
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新規リン脂質の網羅的な探索とその分子基盤の解明
文部科学省/日本学術振興会 : 2022年 - 2023年
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リソソーム膜のタンパク質、脂質成分の統合的な解析とリソソームの分子基盤の解明
文部科学省/日本学術振興会 : 2019年 - 2020年
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新規リゾリン脂質の機能解明とその作用標的の探索
文部科学省/日本学術振興会
論文・総説 【 表示 ／ 非表示 】
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Oe Y, Kakuda K, Yoshimura SI, Hara N, Hasegawa J, Terawaki S, Kimura Y, Ikenaka K, Suetsugu S, Mochizuki H, Yoshimori T, Nakamura S. PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy. PLoS genetics. 2022.06; 18 (6): e1010264. ( PubMed, DOI )
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Kanemaru K, Shimozawa M, Kitamata M, Furuishi R, Kayano H, Sukawa Y, Chiba Y, Fukuyama T, Hasegawa J, Nakanishi H, Kishimoto T, Tsujita K, Tanaka K, Itoh T, Sasaki J, Sasaki T, Fukami K, Nakamura Y. Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics. Nature communications. 2022.05; 13 (1): 2347. ( PubMed, DOI )
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Hasegawa J, Tokuda E, Yao Y, Sasaki T, Inoki K, Weisman LS. PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity. Molecular biology of the cell. 2022.03; 33 (3): ar26. ( PubMed, DOI )
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Kawasaki A, Sakai A, Nakanishi H, Hasegawa J, Taguchi T, Sasaki J, Arai H, Sasaki T, Igarashi M, Nakatsu F. PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission. The Journal of cell biology. 2022.01; 221 (1): ( PubMed, DOI )
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Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Kugii Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T. A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation. Nature communications. 2022.01; 13 (1): 83. ( PubMed, DOI )
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Hasegawa J, Uchida Y, Mukai K, Lee S, Matsudaira T, Taguchi T. A Role of Phosphatidylserine in the Function of Recycling Endosomes. Frontiers in cell and developmental biology. 2021; 9 783857. ( PubMed, DOI )
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Hasegawa J, Imen J, Yamamoto H, Tsujita K, Tokuda E, Shibata H, Maki M, Itoh T. SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor. Journal of cell science. 2019.09; ( PubMed, DOI )
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Fei Yang, Lingli Yang, Mari Wataya-Kaneda, Junya Hasegawa, Tamotsu Yoshimori, Atsushi Tanemura, Daisuke Tsuruta, Ichiro Katayama. Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex. J. Dermatol. Sci.. 2018.02; 89 (2): 155-164. ( PubMed, DOI )
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Ismael Al-Ramahi, Sai Srinivas Panapakkam Giridharan, Yu-Chi Chen, Samarjit Patnaik, Nathaniel Safren, Junya Hasegawa, Maria de Haro, Amanda K Wagner Gee, Steven A Titus, Hyunkyung Jeong, Jonathan Clarke, Dimitri Krainc, Wei Zheng, Robin F Irvine, Sami Barmada, Marc Ferrer, Noel Southall, Lois S Weisman, Juan Botas, Juan Jose Marugan. Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. Elife. 2017.12; 6 ( PubMed, DOI )
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Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-Ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro Semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai, Tomohiko Taguchi. Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells. Nat Commun. 2017.11; 8 (1): 1246. ( PubMed, DOI )
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Junya Hasegawa, Bethany S Strunk, Lois S Weisman. PI5P and PI(3,5)P2; Minor, but Essential Phosphoinositides. Cell Struct. Funct.. 2017.05; 42 (1): 49-60. ( PubMed, DOI )
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Shuhei Nakamura, Junya Hasegawa, Tamotsu Yoshimori. Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome-lysosome fusion. Autophagy. 2016.12; 12 (12): 2500-2501. ( PubMed, DOI )
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Junya Hasegawa, Ryo Iwamoto, Takanobu Otomo, Akiko Nezu, Maho Hamasaki, Tamotsu Yoshimori. Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome. EMBO J.. 2016.09; 35 (17): 1853-1867. ( PubMed, DOI )
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Junya Hasegawa, Ikuko Maejima, Ryo Iwamoto, Tamotsu Yoshimori. Selective autophagy: lysophagy. Methods. 2015.03; 75 128-132. ( PubMed, DOI )
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Emi Tokuda, Toshiki Itoh, Junya Hasegawa, Takeshi Ijuin, Yukiko Takeuchi, Yasuhiro Irino, Miki Fukumoto, Tadaomi Takenawa. Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer. Cancer Res.. 2014.06; 74 (11): 3054-3066. ( PubMed, DOI )
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Kazuya Tsujita, Akihiro Kondo, Shusaku Kurisu, Junya Hasegawa, Toshiki Itoh, Tadaomi Takenawa. Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation. J. Cell. Sci.. 2013.05; 126 (Pt 10): 2267-2278. ( PubMed, DOI )
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Toshiki Itoh, Junya Hasegawa. Mechanistic insights into the regulation of circular dorsal ruffle formation. J. Biochem.. 2013.01; 153 (1): 21-29. ( PubMed, DOI )
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Junya Hasegawa, Kazuya Tsujita, Tadaomi Takenawa, Toshiki Itoh. ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5. Mol. Biol. Cell. 2012.07; 23 (13): 2481-2489. ( PubMed, DOI )
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Yasuhiro Irino, Emi Tokuda, Junya Hasegawa, Toshiki Itoh, Tadaomi Takenawa. Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes. J. Lipid Res.. 2012.04; 53 (4): 810-819. ( PubMed, DOI )
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Yasunori Uchida, Junya Hasegawa, Daniel Chinnapen, Takao Inoue, Seiji Okazaki, Ryuichi Kato, Soichi Wakatsuki, Ryo Misaki, Masato Koike, Yasuo Uchiyama, Shun-ichiro Iemura, Tohru Natsume, Ryusuke Kuwahara, Takatoshi Nakagawa, Kiyotaka Nishikawa, Kojiro Mukai, Eiji Miyoshi, Naoyuki Taniguchi, David Sheff, Wayne I Lencer, Tomohiko Taguchi, Hiroyuki Arai. Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc. Natl. Acad. Sci. U.S.A.. 2011.09; 108 (38): 15846-15851. ( PubMed, DOI )
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Junya Hasegawa, Emi Tokuda, Takeshi Tenno, Kazuya Tsujita, Haruko Sawai, Hidekazu Hiroaki, Tadaomi Takenawa, Toshiki Itoh. SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. J. Cell Biol.. 2011.05; 193 (5): 901-916. ( PubMed, DOI )
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Kazuya Tsujita, Toshiki Itoh, Akihiro Kondo, Masaaki Oyama, Hiroko Kozuka-Hata, Yasuhiro Irino, Junya Hasegawa, Tadaomi Takenawa. Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides. J. Biol. Chem.. 2010.02; 285 (9): 6781-6789. ( PubMed, DOI )
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Toshiki Itoh, Junya Hasegawa, Kazuya Tsujita, Yasunori Kanaho, Tadaomi Takenawa. The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. Sci Signal. 2009.09; 2 (87): ra52. ( PubMed, DOI )
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Hirotaka Imai, Makoto Saito, Nozomu Kirai, Junya Hasegawa, Kumiko Konishi, Hiroyuki Hattori, Masuhiro Nishimura, Shinsaku Naito, Yasuhito Nakagawa. Identification of the positive regulatory and distinct core regions of promoters, and transcriptional regulation in three types of mouse phospholipid hydroperoxide glutathione peroxidase. J. Biochem.. 2006.10; 140 (4): 573-590. ( PubMed, DOI )
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長谷川 純矢. 【オルガネラと脂質-基礎と臨床から-】基礎 リソソームとイノシトールリン脂質 The Lipid. 2021.10; 32 (2): 140-146. ( 医中誌 )
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高橋 恒一郎, 長谷川 純矢, 佐々木 純子, 佐々木 雄彦. 酸化ストレスによるイノシトールリン脂質の変動とその意義の解明 日本生化学会大会プログラム・講演要旨集. 2020.09; 93回 [P-072]. ( 医中誌 )
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池田 拓海, 長谷川 純矢, 佐々木 純子, 佐々木 雄彦. 膵臓がん細胞特性へのPI(3)Pの関与 日本生化学会大会プログラム・講演要旨集. 2020.09; 93回 [2Z02-02(P. ( 医中誌 )
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佐々木 雄彦, 山本 利義, 森岡 真, 徳田 恵美, 長谷川 純矢, 佐々木 純子. リン脂質の多様性が紡ぐ生命現象 イノシトールリン脂質とタンパク質の新しい相互作用様式 日本生化学会大会プログラム・講演要旨集. 2020.09; 93回 [3S05a-03]. ( 医中誌 )
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佐藤 太地, 佐々木 純子, 長谷川 純矢, 佐々木 雄彦. イノシトールリン脂質分子種の機能解析方法の開発 日本生化学会大会プログラム・講演要旨集. 2020.09; 93回 [P-078]. ( 医中誌 )
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森岡 真, 濁川 清美, 佐々木 純子, 長谷川 純矢, 佐々木 雄彦. PI(4、5)P2の脱リン酸化を介した新規マクロファージ貪食抑制メカニズム 日本生化学会大会プログラム・講演要旨集. 2020.09; 93回 [2Z02-11(P. ( 医中誌 )