Personnel Information

写真a

YONEYAMA Yosuke


Job title

Assistant Professor

Graduating School 【 display / non-display

  • The University of Tokyo, 2007.03, Graduated

  • The University of Tokyo, Faculty of Agriculture, 2009.03, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Master's Course, 2011.03, Completed

  • The University of Tokyo, Doctor's Course, 2014.03, Completed

Campus Career 【 display / non-display

  • 2018.06
    -
    2021.01
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Assistant Professor
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, -, , Assistant Professor
  • 2021.02
    -
    Now
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Assistant Professor

External Career 【 display / non-display

  • 2014.04
    -
    2018.05
    , Project Researcher

Research Areas 【 display / non-display

  • Metabolism and endocrinology

  • Cell biology

  • Molecular biology

 

Published Papers & Misc 【 display / non-display

  1. Ryo Okabe, Toyofumi F. Chen-Yoshikawa, Yosuke Yoneyama, Yuhei Yokohama, Satona Tanaka, Akihiko Yoshizawa, Wendy L. Thompson, Gokul Kannan, Eiji Kobayashi, Hiroshi Date, Takanori Takebe. Mammalian enteral ventilation ameliorates respiratory failure Med. 2021.06;

  2. Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, Koike H, Maezawa M, Zhang RR, Dunn A, Ferguson A, Togo S, Lewis K, Thompson WL, Asai A, Takebe T. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids. Gastroenterology. 2021.02; 160 (3): 831-846.e10. ( PubMed, DOI )

  3. Kobayashi Naritaka, Togo Shodai, Matsuzaki Takahisa, Hashiseko Kaede, Kawamura Ryuzo, Suganuma Masami, Nakabayashi Seiichiro, Yoneyama Yosuke, Ouchi Rie, Takebe Takanori, Yoshikawa Hiroshi Y.. Stiffness distribution analysis in indentation depth direction reveals clear mechanical features of cells and organoids by using AFM APPLIED PHYSICS EXPRESS. 2020.09; 13 (9):

  4. Okino R, Usui A, Yoneyama Y, Takahashi SI, Hakuno F. Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation. Frontiers in endocrinology. 2020; 11 96. ( PubMed, DOI )

  5. Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell metabolism. 2019.08; 30 (2): 374-384.e6. ( PubMed, DOI )

  6. Furuta H, Yoshihara H, Fukushima T, Yoneyama Y, Ito A, Worrall C, Girnita A, Girnita L, Yoshida M, Asano T, Komada M, Kataoka N, Chida K, Hakuno F, Takahashi SI. IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line. Oncotarget. 2018.09; 9 (74): 33871-33883. ( PubMed, DOI )

  7. Yoneyama Y, Inamitsu T, Chida K, Iemura SI, Natsume T, Maeda T, Hakuno F, Takahashi SI. Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase. iScience. 2018.07; 5 1-18. ( PubMed, DOI )

  8. Kamei H, Yoneyama Y, Hakuno F, Sawada R, Shimizu T, Duan C, Takahashi SI. Catch-Up Growth in Zebrafish Embryo Requires Neural Crest Cells Sustained by Irs1 Signaling. Endocrinology. 2018.04; 159 (4): 1547-1560. ( PubMed, DOI )

  9. Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI. IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling. eLife. 2018.04; 7 ( PubMed, DOI )

  10. Ng Kwokhoi, Takeshige Takuya, Kawamura Ryuzo, Nakabayashi Seiichiro, Yoneyama Yosuke, Hakuno Fumihiko, Takahashi Shin-ichiro, Yoshikawa Hiroshi. フェムト秒レーザーアブレーションにより誘導されるアクチン細胞骨格リモデリングのダイナミクス(Dynamics of Actin Cytoskeleton Remodeling Induced by Femtosecond Laser Ablation) 生物物理. 2017.08; 57 (Suppl.1-2): S253. ( ichushi )

  11. Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi SI. Glucose deprivation attenuates sortilin levels in skeletal muscle cells. Endocrine journal. 2017.03; 64 (3): 255-268. ( PubMed, DOI )

  12. Ariga Miyako, Yoneyama Yosuke, Fukushima Toshiaki, Ishiuchi Yuri, Ishii Takayuki, Sato Hitoshi, Hakuno Fumihiko, Nedachi Taku, Takahashi Shin-ichiro. グルコース除去は骨格筋細胞におけるsortilinを減少させる(Glucose deprivation attenuates sortilin levels in skeletal muscle cells) Endocrine Journal. 2017.03; 64 (3): 255-268. ( ichushi )

  13. Hakuno F, Fukushima T, Yoneyama Y, Kamei H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu BC, Chida K, Takahashi S. The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins. Frontiers in endocrinology. 2015.05; 6 73. ( PubMed, DOI )

  14. Lanzerstorfer P, Yoneyama Y, Hakuno F, Müller U, Höglinger O, Takahashi S, Weghuber J. Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces. The FEBS journal. 2015.03; 282 (6): 987-1005. ( PubMed, DOI )

  15. Yoneyama Y, Matsuo M, Take K, Kabuta T, Chida K, Hakuno F, Takahashi S. The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation. Molecular and cellular biology. 2013.05; 33 (10): 1991-2003. ( PubMed, DOI )

  16. Fumihiko Hakuno, Yoko Yamauchi, Gen Kaneko, Yosuke Yoneyama, Jun Nakae, Kazuhiro Chida, Tatsuhiko Kadowaki, Keitaro Yamanouchi, Masugi Nishihara, Shin-Ichiro Takahashi. Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts. PLoS ONE. 2011.10; 6 (10): e25655. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Yosuke Yoneyama. Live-cell incubation monitoring and human organoid manufacturing for modeling liver diseases. 2021 ZISCTI-CSCT Annual Meeting 2021.06.04

  2. Sakurako Kobayashi, Satoshi Watanabe, Yosuke Yoneyama, Kousuke Tanimoto, Ryu Nishimura, Sayaka Nagata, Masami Inoue, Kouhei Suzuki, Sei Kakinuma, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Takanori Takebe, Shiro Yui. Conceptual basis of lineage shift between intestinal epithelium and hepatocytes. Keystone Symposia, Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease 2020.01.22 Vancouver(Canada)

  3. Yosuke Yoneyama. IRS-1 is a negative feedback regulator of IGF-I receptor internalization via interaction with AP-2 clathrin adaptor complex. Gordon Research Conference IGF & Insulin System in Physiology & Disease 2015.03.12

  4. Yosuke Yoneyama. AP-1 complex regulates intracellular localization of insulin receptor substrate-1 required for insulin-like growth factor-I-dependent proliferation. The 6th International Congress of the GRS and IGF Society 2012.10.18