Personnel Information

写真a

YONEYAMA Yosuke


Job title

Assistant Professor
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Graduating School 【 display / non-display 】

  • The University of Tokyo, 2007.03, Graduated

  • The University of Tokyo, Faculty of Agriculture, 2009.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Master's Course, 2011.03, Completed

  • The University of Tokyo, Doctor's Course, 2014.03, Completed

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Campus Career 【 display / non-display 】

  • 2018.06
    -
    2021.01
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Assistant Professor
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， ， Assistant Professor
  • 2021.02
    -
    2022.02
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Assistant Professor
  • 2022.03
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， a， Assistant Professor
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External Career 【 display / non-display 】

  • 2014.04
    -
    2018.05
    , Project Researcher
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Research Areas 【 display / non-display 】

  • Metabolism and endocrinology

  • Cell biology

  • Molecular biology

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Research Theme 【 display / non-display 】

  • Enteral ventilation, 2021.04 - Now

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Published Papers & Misc 【 display / non-display 】

  1. Matsuzaki T, Kawano Y, Horikiri M, Shimokawa Y, Yamazaki T, Okuma N, Koike H, Kimura M, Kawamura R, Yoneyama Y, Furuichi Y, Hakuno F, Takahashi SI, Nakabayashi S, Okamoto S, Nakauchi H, Taniguchi H, Takebe T, Yoshikawa HY. Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells. STAR protocols. 2023.07; 4 (3): 102471. ( PubMed, DOI )

  2. Fujii T, Yoneyama Y, Kinebuchi A, Ozeki N, Maeda S, Saiki N, Chen-Yoshikawa TF, Date H, Nishiwaki K, Takebe T. Enteral liquid ventilation oxygenates a hypoxic pig model. iScience. 2023.03; 26 (3): 106142. ( PubMed, DOI )

  3. Kobayashi S, Ogasawara N, Watanabe S, Yoneyama Y, Kirino S, Hiraguri Y, Inoue M, Nagata S, Okamoto-Uchida Y, Kofuji S, Shimizu H, Ito G, Mizutani T, Yamauchi S, Kinugasa Y, Kano Y, Nemoto Y, Watanabe M, Tsuchiya K, Nishina H, Okamoto R, Yui S. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflammation and regeneration. 2022.11; 42 (1): 49. ( PubMed, DOI )

  4. Kimura M, Iguchi T, Iwasawa K, Dunn A, Thompson WL, Yoneyama Y, Chaturvedi P, Zorn AM, Wintzinger M, Quattrocelli M, Watanabe-Chailland M, Zhu G, Fujimoto M, Kumbaji M, Kodaka A, Gindin Y, Chung C, Myers RP, Subramanian GM, Hwa V, Takebe T. En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH. Cell. 2022.10; 185 (22): 4216-4232.e16. ( PubMed, DOI )

  5. Matsuzaki T, Shimokawa Y, Koike H, Kimura M, Kawano Y, Okuma N, Kawamura R, Yoneyama Y, Furuichi Y, Hakuno F, Takahashi SI, Nakabayashi S, Okamoto S, Nakauchi H, Taniguchi H, Takebe T, Yoshikawa HY. Mechanical guidance of self-condensation patterns of differentiating progeny. iScience. 2022.10; 25 (10): 105109. ( PubMed, DOI )

  6. Zasu A, Hishima F, Thauvin M, Yoneyama Y, Kitani Y, Hakuno F, Volovitch M, Takahashi SI, Vriz S, Rampon C, Kamei H. NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 2022; 13 929668. ( PubMed, DOI )

  7. Yosuke YONEYAMA, Ryo OKABE, Takanori TAKEBE. Enteral ventilation technology to combat severe respiratory failure Translational and Regulatory Sciences. 2021.12; 3 (3): 93-97.

  8. Naraoka Y, Mabuchi Y, Yoneyama Y, Suto EG, Hisamatsu D, Ikeda M, Ito R, Nakamura T, Takebe T, Akazawa C. Isolation and Characterization of Tissue Resident CD29-Positive Progenitor Cells in Livestock to Generate a Three-Dimensional Meat Bud. Cells. 2021.09; 10 (9): ( PubMed, DOI )

  9. Miyamoto T, Uosaki H, Mizunoe Y, Han SI, Goto S, Yamanaka D, Masuda M, Yoneyama Y, Nakamura H, Hattori N, Takeuchi Y, Ohno H, Sekiya M, Matsuzaka T, Hakuno F, Takahashi SI, Yahagi N, Ito K, Shimano H. Rapid manipulation of mitochondrial morphology in a living cell with iCMM. Cell reports methods. 2021.08; 1 (4): 100052. ( PubMed, DOI )

  10. Ryo Okabe, Toyofumi F. Chen-Yoshikawa, Yosuke Yoneyama, Yuhei Yokohama, Satona Tanaka, Akihiko Yoshizawa, Wendy L. Thompson, Gokul Kannan, Eiji Kobayashi, Hiroshi Date, Takanori Takebe. Mammalian enteral ventilation ameliorates respiratory failure Med. 2021.06;

  11. Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, Koike H, Maezawa M, Zhang RR, Dunn A, Ferguson A, Togo S, Lewis K, Thompson WL, Asai A, Takebe T. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids. Gastroenterology. 2021.02; 160 (3): 831-846.e10. ( PubMed, DOI )

  12. Kobayashi Naritaka, Togo Shodai, Matsuzaki Takahisa, Hashiseko Kaede, Kawamura Ryuzo, Suganuma Masami, Nakabayashi Seiichiro, Yoneyama Yosuke, Ouchi Rie, Takebe Takanori, Yoshikawa Hiroshi Y.. Stiffness distribution analysis in indentation depth direction reveals clear mechanical features of cells and organoids by using AFM APPLIED PHYSICS EXPRESS. 2020.09; 13 (9):

  13. Okino R, Usui A, Yoneyama Y, Takahashi SI, Hakuno F. Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation. Frontiers in endocrinology. 2020; 11 96. ( PubMed, DOI )

  14. Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell metabolism. 2019.08; 30 (2): 374-384.e6. ( PubMed, DOI )

  15. Furuta H, Yoshihara H, Fukushima T, Yoneyama Y, Ito A, Worrall C, Girnita A, Girnita L, Yoshida M, Asano T, Komada M, Kataoka N, Chida K, Hakuno F, Takahashi SI. IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line. Oncotarget. 2018.09; 9 (74): 33871-33883. ( PubMed, DOI )

  16. Yoneyama Y, Inamitsu T, Chida K, Iemura SI, Natsume T, Maeda T, Hakuno F, Takahashi SI. Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase. iScience. 2018.07; 5 1-18. ( PubMed, DOI )

  17. Kamei H, Yoneyama Y, Hakuno F, Sawada R, Shimizu T, Duan C, Takahashi SI. Catch-Up Growth in Zebrafish Embryo Requires Neural Crest Cells Sustained by Irs1 Signaling. Endocrinology. 2018.04; 159 (4): 1547-1560. ( PubMed, DOI )

  18. Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI. IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling. eLife. 2018.04; 7 ( PubMed, DOI )

  19. Ng Kwokhoi, Takeshige Takuya, Kawamura Ryuzo, Nakabayashi Seiichiro, Yoneyama Yosuke, Hakuno Fumihiko, Takahashi Shin-ichiro, Yoshikawa Hiroshi. フェムト秒レーザーアブレーションにより誘導されるアクチン細胞骨格リモデリングのダイナミクス(Dynamics of Actin Cytoskeleton Remodeling Induced by Femtosecond Laser Ablation) 生物物理. 2017.08; 57 (Suppl.1-2): S253. ( ichushi )

  20. Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi SI. Glucose deprivation attenuates sortilin levels in skeletal muscle cells. Endocrine journal. 2017.03; 64 (3): 255-268. ( PubMed, DOI )

  21. Hakuno F, Fukushima T, Yoneyama Y, Kamei H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu BC, Chida K, Takahashi S. The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins. Frontiers in endocrinology. 2015.05; 6 73. ( PubMed, DOI )

  22. Lanzerstorfer P, Yoneyama Y, Hakuno F, Müller U, Höglinger O, Takahashi S, Weghuber J. Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces. The FEBS journal. 2015.03; 282 (6): 987-1005. ( PubMed, DOI )

  23. Yoneyama Y, Matsuo M, Take K, Kabuta T, Chida K, Hakuno F, Takahashi S. The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation. Molecular and cellular biology. 2013.05; 33 (10): 1991-2003. ( PubMed, DOI )

  24. Fumihiko Hakuno, Yoko Yamauchi, Gen Kaneko, Yosuke Yoneyama, Jun Nakae, Kazuhiro Chida, Tatsuhiko Kadowaki, Keitaro Yamanouchi, Masugi Nishihara, Shin-Ichiro Takahashi. Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts. PLoS ONE. 2011.10; 6 (10): e25655. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Yosuke Yoneyama. Modeling human fatty liver diseases with iPSC-derived organoid. Global Regenerative Medicine Trainee Speaker Series 2023.07.27

  2. Yosuke Yoneyama. IGFALS regulates non-alcoholic steatohepatits progression in mouse, organoid, and human. Gordon Research Conference “IGF and Insulin System in Physiology and Disease” 2023.03.16

  3. Yosuke Yoneyama. Genotype-Phenotype Association Strategy for Fatty Liver Diseases Using Human iPSC-Derived Organoids. EVIDENT ORGANOID CONFERENCE 2023 2023.02.08

  4. 渡邉史朗1、杉浦広峻1、武部貴則2、米山鷹介2、新井史人1. 高剛性センサプローブを用いたオルガノイドの粘弾性評価. 化学とマイクロ・ナノシステム学会第４５回研究会 2022.05.22

  5. Yosuke Yoneyama, Ran-Ran Zhang, Takanori Takebe. INTERCELLULAR RNA TRANSFER-DRIVEN REPROGRAMMING OF HUMAN PLURIPOTENT STEM CELLS INTO NAÏVE-LIKE STATE. ISSCR Tokyo 2021 International Symposium Stem Cells: From Basic Science to Clinical translation 2021.10.27

  6. Yosuke Yoneyama. Human Pluripotent Stem Cell-Derived Liver Organoid Manufacturing. Olympus Discovery Summit: Advanced Your Imaging 2021.10.26

  7. Yosuke Yoneyama. Live-cell incubation monitoring and human organoid manufacturing for modeling liver diseases. 2021 ZISCTI-CSCT Annual Meeting 2021.06.04

  8. Sakurako Kobayashi, Satoshi Watanabe, Yosuke Yoneyama, Kousuke Tanimoto, Ryu Nishimura, Sayaka Nagata, Masami Inoue, Kouhei Suzuki, Sei Kakinuma, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Takanori Takebe, Shiro Yui. Conceptual basis of lineage shift between intestinal epithelium and hepatocytes. Keystone Symposia, Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease 2020.01.22 Vancouver（Canada）

  9. Yosuke Yoneyama. IRS-1 is a negative feedback regulator of IGF-I receptor internalization via interaction with AP-2 clathrin adaptor complex. Gordon Research Conference IGF & Insulin System in Physiology & Disease 2015.03.12

  10. Yosuke Yoneyama. AP-1 complex regulates intracellular localization of insulin receptor substrate-1 required for insulin-like growth factor-I-dependent proliferation. The 6th International Congress of the GRS and IGF Society 2012.10.18

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