Published Papers & Misc - SASAKI Junko

Division display >> ／  All the affair displays  1 - 61 of about 61

  1. Yuya Ogawa, Iku Tsuchiya, Shogo Yanai, Takashi Baba, Ken-Ichirou Morohashi, Takehiko Sasaki, Junko Sasaki, Miho Terao, Atsumi Tsuji-Hosokawa, Shuji Takada. GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse. Commun Biol. 2025.01; 8 (1): 81. ( PubMed, DOI )

  2. Tsukasa Oikawa, Junya Hasegawa, Haruka Handa, Naomi Ohnishi, Yasuhito Onodera, Ari Hashimoto, Junko Sasaki, Takehiko Sasaki, Koji Ueda, Hisataka Sabe. p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleus. Life Sci Alliance. 2024.09; 7 (9): ( PubMed, DOI )

  3. Takafumi Kawai, Shin Morioka, Haruhiko Miyata, Rizki Tsari Andriani, Sharmin Akter, Gabriel Toma, Tatsuya Nakagawa, Yuki Oyama, Rie Iida-Norita, Junko Sasaki, Masahiko Watanabe, Kenji Sakimura, Masahito Ikawa, Takehiko Sasaki, Yasushi Okamura. The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase. Nat Commun. 2024.08; 15 (1): 7289. ( PubMed, DOI )

  4. Tamara A M Chessa, Piotr Jung, Arqum Anwar, Sabine Suire, Karen E Anderson, David Barneda, Anna Kielkowska, Barzan A Sadiq, Ieng Wai Lai, Sergio Felisbino, Daniel J Turnham, Helen B Pearson, Wayne A Phillips, Junko Sasaki, Takehiko Sasaki, David Oxley, Dominik Spensberger, Anne Segonds-Pichon, Michael Wilson, Simon Walker, Hanneke Okkenhaug, Sabina Cosulich, Phillip T Hawkins, Len R Stephens. PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Mol Cell. 2023.08; 83 (16): 2991-3009.e13. ( PubMed, DOI )

  5. Dang Minh Tran, Nozomu Yoshioka, Norihisa Bizen, Yukiko Mori-Ochiai, Masato Yano, Shogo Yanai, Junya Hasegawa, Satoshi Miyashita, Mikio Hoshino, Junko Sasaki, Takehiko Sasaki, Hirohide Takebayashi. Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity. Dis Model Mech. 2023.07; 16 (7): ( PubMed, DOI )

  6. Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. 2023.04; 26 (4): 106375. ( PubMed, DOI )

  7. Yusuke Kiyoki, Takayasu Kato, Sakura Kito, Takashi Matsuzaka, Shin Morioka, Junko Sasaki, Kenichi Makishima, Tatsuhiro Sakamoto, Hidekazu Nishikii, Naoshi Obara, Mamiko Sakata-Yanagimoto, Takehiko Sasaki, Hitoshi Shimano, Shigeru Chiba. The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation. Leukemia. 2023.03; ( PubMed, DOI )

  8. Takahito Miyake, Yuichi Inoue, Xinyan Shao, Takehito Seta, Yuto Aoki, Khanh Tien Nguyen Pham, Yuichi Shichino, Junko Sasaki, Takehiko Sasaki, Masahito Ikawa, Yoshiaki Yamaguchi, Hitoshi Okamura, Shintaro Iwasaki, Masao Doi. Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm. Cell Rep. 2023.02; 112157. ( PubMed, DOI )

  9. Tomonori Ayukawa, Masakazu Akiyama, Yasukazu Hozumi, Kenta Ishimoto, Junko Sasaki, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki. Tissue flow regulates planar cell polarity independently of the Frizzled core pathway. Cell Rep. 2022.09; 40 (12): 111388. ( PubMed, DOI )

  10. Kaori Kanemaru, Makoto Shimozawa, Manabu Kitamata, Rikuto Furuishi, Hinako Kayano, Yui Sukawa, Yuuki Chiba, Takatsugu Fukuyama, Junya Hasegawa, Hiroki Nakanishi, Takuma Kishimoto, Kazuya Tsujita, Kazuma Tanaka, Toshiki Itoh, Junko Sasaki, Takehiko Sasaki, Kiyoko Fukami, Yoshikazu Nakamura. Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics. Nat Commun. 2022.05; 13 (1): 2347. ( PubMed, DOI )

  11. Asami Kawasaki, Akiko Sakai, Hiroki Nakanishi, Junya Hasegawa, Tomohiko Taguchi, Junko Sasaki, Hiroyuki Arai, Takehiko Sasaki, Michihiro Igarashi, Fubito Nakatsu. PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission. J Cell Biol. 2022.01; 221 (1): ( PubMed, DOI )

  12. Shin Morioka, Hiroki Nakanishi, Toshiyoshi Yamamoto, Junya Hasegawa, Emi Tokuda, Tomoya Hikita, Tomoko Sakihara, Yuuki Kugii, Chitose Oneyama, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki. A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation. Nat Commun. 2022.01; 13 (1): 83. ( PubMed, DOI )

  13. 1. Kawai T, Miyata H, Nakanishi H, Sakata S, Morioka S, Sasaki J, Watanabe M, Sakimura K, Fujimoto T, Sasaki T, Ikawa M & Okamura Y.. PtdIns(4,5)P2 Distribution Mediated by a Voltage-Sensing Phosphatase (VSP) Regulates Sperm Motility. Proc. Natl. Acad. Sci. USA. 2019.12; 116 (51): 26020-26028. ( DOI )

  14. Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T & Sasaki T.. Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression. Sci Rep. 2019.09; 9 (1): 13257. ( DOI )

  15. Takemasu Shinya、Ito Masaki、Morioka Shin、Nigorikawa Kiyomi、Kofuji Satoshi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Matsuoka Isao、Sasaki Junko、Sasaki Takehiko、 Hazeki Kaoru. Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages. Genes to Cells. 2019.03; 24 (5): 366-376. ( DOI )

  16. Fujioka Yoichiro、Satoh Aya O.、Horiuchi Kosui、Fujioka Mari、Tsutsumi Kaori、Sasaki Junko、 Nepal Prabha、Kashiwagi Sayaka、Paudel Sarad、Nishide Shinya、Nanbo Asuka、Sasaki Takehiko、 Ohba Yusuke. A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection Cell Structure and Function. 2019.03; 44 (1): 61-74. ( DOI )

  17. Marc C Liggins, Jessica L Flesher, Sohail Jahid, Priya Vasudeva, Victoria Eby, Shunsuke Takasuga, Junko Sasaki, Takehiko Sasaki, Raymond E Boissy, Anand K Ganesan. PIKfyve regulates melanosome biogenesis. PLoS Genet.. 2018.05; 14 (3): e1007290. ( PubMed, DOI )

  18. Hirotaka Kimura, Yasushi Matsuyama, Sachiko Araki, Atsushi Koizumi, Yumi Kariya, Shunsuke Takasuga, Satoshi Eguchi, Hiroki Nakanishi, Junko Sasaki, Takehiko Sasaki. The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis. Mod Rheumatol. 2018.05; 28 (3): 530-541. ( PubMed, DOI )

  19. Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E Anderson, David Barneda, Pınar Pir, Hiroki Nakanishi, Satoshi Eguchi, Atsushi Koizumi, Junko Sasaki, Véronique Juvin, Vladimir Y Kiselev, Izabella Niewczas, Alexander Gray, Alexandre Valayer, Dominik Spensberger, Marine Imbert, Sergio Felisbino, Tomonori Habuchi, Soren Beinke, Sabina Cosulich, Nicolas Le Novère, Takehiko Sasaki, Jonathan Clark, Phillip T Hawkins, Len R Stephens. PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Mol. Cell. 2017.11; 68 (3): 566-580.e10. ( PubMed, DOI )

  20. Hideo Shindou, Hideto Koso, Junko Sasaki, Hiroki Nakanishi, Hiroshi Sagara, Koh M Nakagawa, Yoshikazu Takahashi, Daisuke Hishikawa, Yoshiko Iizuka-Hishikawa, Fuyuki Tokumasu, Hiroshi Noguchi, Sumiko Watanabe, Takehiko Sasaki, Takao Shimizu. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J. Biol. Chem.. 2017.07; 292 (29): 12054-12064. ( PubMed, DOI )

  21. Yoshiko Iizuka-Hishikawa, Daisuke Hishikawa, Junko Sasaki, Keiyo Takubo, Motohito Goto, Katsuyuki Nagata, Hiroki Nakanishi, Hideo Shindou, Tadashi Okamura, Chizuru Ito, Kiyotaka Toshimori, Takehiko Sasaki, Takao Shimizu. Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J. Biol. Chem.. 2017.07; 292 (29): 12065-12076. ( PubMed, DOI )

  22. Hirotaka Kimura, Satoshi Eguchi, Junko Sasaki, Keiji Kuba, Hiroki Nakanishi, Shunsuke Takasuga, Masakazu Yamazaki, Akiteru Goto, Hiroyuki Watanabe, Hiroshi Itoh, Yumiko Imai, Akira Suzuki, Noboru Mizushima, Takehiko Sasaki. Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2017.01; 2 (1): e89462. ( PubMed, DOI )

  23. Shin Morioka, Kiyomi Nigorikawa, Junko Sasaki, Kaoru Hazeki, Yoshihiro Kasuu, Takehiko Sasaki, Osamu Hazeki. Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model. Innate Immun. 2016.08; 22 (6): 444-451. ( PubMed, DOI )

  24. Kiyomi Nigorikawa, Kaoru Hazeki, Junko Sasaki, Yumio Omori, Mikiko Miyake, Shin Morioka, Ying Guo, Takehiko Sasaki, Osamu Hazeki. Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2. PLoS ONE. 2015.11; 10 (11): e0142091. ( PubMed, DOI )

  25. Satoshi Kofuji, Hirotaka Kimura, Hiroki Nakanishi, Hiroshi Nanjo, Shunsuke Takasuga, Hui Liu, Satoshi Eguchi, Ryotaro Nakamura, Reietsu Itoh, Noriko Ueno, Ken Asanuma, Mingguo Huang, Atsushi Koizumi, Tomonori Habuchi, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki. INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov. 2015.07; 5 (7): 730-739. ( PubMed, DOI )

  26. Chen Li Chew, Andrea Lunardi, Federico Gulluni, Daniel T Ruan, Ming Chen, Leonardo Salmena, Michiya Nishino, Antonella Papa, Christopher Ng, Jacqueline Fung, John G Clohessy, Junko Sasaki, Takehiko Sasaki, Roderick T Bronson, Emilio Hirsch, Pier Paolo Pandolfi. In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov. 2015.07; 5 (7): 740-751. ( PubMed, DOI )

  27. Laura R H Ip, George Poulogiannis, Felipe Cia Viciano, Junko Sasaki, Satoshi Kofuji, Victoria J Spanswick, Daniel Hochhauser, John A Hartley, Takehiko Sasaki, Christina A Gewinner. Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget. 2015.04; 6 (12): 10548-10562. ( PubMed, DOI )

  28. Tomonori Ayukawa, Masakazu Akiyama, Jennifer L Mummery-Widmer, Thomas Stoeger, Junko Sasaki, Juergen A Knoblich, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki. Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 2014.07; 8 (2): 610-621. ( PubMed, DOI )

  29. Yoichiro Fujioka, Masumi Tsuda, Asuka Nanbo, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba. A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection. Nat Commun. 2013.11; 4 2763. ( PubMed, DOI )

  30. Hideaki Morishita, Satoshi Eguchi, Hirotaka Kimura, Junko Sasaki, Yuriko Sakamaki, Michael L Robinson, Takehiko Sasaki, Noboru Mizushima. Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J. Biol. Chem.. 2013.04; 288 (16): 11436-11447. ( PubMed, DOI )

  31. Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Toshiaki Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi, Takehiko Sasaki. Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc. Natl. Acad. Sci. U.S.A.. 2013.01; 110 (5): 1726-1731. ( PubMed, DOI )

  32. Hyeon-Cheol Lee, Takao Inoue, Junko Sasaki, Takuya Kubo, Shinji Matsuda, Yasuko Nakasaki, Mitsuharu Hattori, Fumiharu Tanaka, Osamu Udagawa, Nozomu Kono, Toshiki Itoh, Hideo Ogiso, Ryo Taguchi, Makoto Arita, Takehiko Sasaki, Hiroyuki Arai. LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol. Biol. Cell. 2012.12; 23 (24): 4689-4700. ( PubMed, DOI )

  33. G Gregory Neely, Shuan Rao, Michael Costigan, Norbert Mair, Ildiko Racz, Giedre Milinkeviciute, Arabella Meixner, Swetha Nayanala, Robert S Griffin, Inna Belfer, Feng Dai, Shad Smith, Luda Diatchenko, Stefano Marengo, Bernhard J Haubner, Maria Novatchkova, Dustin Gibson, William Maixner, J Andrew Pospisilik, Emilio Hirsch, Ian Q Whishaw, Andreas Zimmer, Vaijayanti Gupta, Junko Sasaki, Yasunori Kanaho, Takehiko Sasaki, Michaela Kress, Clifford J Woolf, Josef M Penninger. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet.. 2012.11; 8 (12): e1003071. ( PubMed, DOI )

  34. Naoki Kobayashi, Kohjiro Ueki, Yukiko Okazaki, Aya Iwane, Naoto Kubota, Mitsuru Ohsugi, Motoharu Awazawa, Masatoshi Kobayashi, Takayoshi Sasako, Kazuma Kaneko, Miho Suzuki, Yoshitaka Nishikawa, Kazuo Hara, Kotaro Yoshimura, Isao Koshima, Susumu Goyama, Koji Murakami, Junko Sasaki, Ryozo Nagai, Mineo Kurokawa, Takehiko Sasaki, Takashi Kadowaki. Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. U.S.A.. 2011.04; 108 (14): 5753-5758. ( PubMed, DOI )

  35. Yoichiro Fujioka, Masumi Tsuda, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba. The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS ONE. 2011.01; 6 (1): e16324. ( PubMed, DOI )

  36. Nobukatsu Kinoshita, Yasuo Horie, Shigetoshi Ohshima, Yohei Hirai, Takahiro Dohmen, Mario Jin, Tamotsu Matsuhashi, Junko Sasaki, Takehiko Sasaki, Masahiro Iizuka, Hirohide Ohnishi. Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury. J. Gastroenterol. Hepatol.. 2011.01; 26 (1): 201-206. ( PubMed, DOI )

  37. Laura A Volpicelli-Daley, Louise Lucast, Liang-Wei Gong, Lijuan Liu, Junko Sasaki, Takehiko Sasaki, Charles S Abrams, Yasunori Kanaho, Pietro De Camilli. Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J. Biol. Chem.. 2010.09; 285 (37): 28708-28714. ( PubMed, DOI )

  38. Junko Sasaki, Satoshi Kofuji, Reietsu Itoh, Toshihiko Momiyama, Kiyohiko Takayama, Haruka Murakami, Shinsuke Chida, Yuko Tsuya, Shunsuke Takasuga, Satoshi Eguchi, Ken Asanuma, Yasuo Horie, Kouichi Miura, Elizabeth Michele Davies, Christina Mitchell, Masakazu Yamazaki, Hirokazu Hirai, Tadaomi Takenawa, Akira Suzuki, Takehiko Sasaki. The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature. 2010.05; 465 (7297): 497-501. ( PubMed, DOI )

  39. Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki, Akira Suzuki. Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res.. 2009.11; 48 (6): 307-343. ( PubMed, DOI )

  40. Yumiko Anezaki, Shigetoshi Ohshima, Hajime Ishii, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Masahiro Iizuka, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Akira Suzuki, Hirohide Ohnishi, Yasuo Horie. Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis. Hepatol. Res.. 2009.06; 39 (6): 609-618. ( PubMed, DOI )

  41. Hajime Ishii, Yasuo Horie, Shigetoshi Ohshima, Yumiko Anezaki, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Sumio Watanabe, Akira Suzuki, Hirohide Ohnishi. Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J. Hepatol.. 2009.03; 50 (3): 562-571. ( PubMed, DOI )

  42. H Kuwana, Y Terada, T Kobayashi, T Okado, J M Penninger, J Irie-Sasaki, T Sasaki, S Sasaki. The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int.. 2008.02; 73 (4): 430-445. ( PubMed, DOI )

  43. Takehiko Sasaki, Junko Sasaki, Takahiro Sakai, Shunsuke Takasuga, Akira Suzuki. The physiology of phosphoinositides. Biol. Pharm. Bull.. 2007.09; 30 (9): 1599-1604. ( PubMed )

  44. T Sasaki, J Sasaki, K Watanabe, A Suzuki. Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models. Biochem. Soc. Trans.. 2007.04; 35 (Pt 2): 215-218. ( PubMed, DOI )

  45. Miki Nishio, Ken-ichi Watanabe, Junko Sasaki, Choji Taya, Shunsuke Takasuga, Ryota Iizuka, Tamas Balla, Masakazu Yamazaki, Hiroshi Watanabe, Reietsu Itoh, Shoko Kuroda, Yasuo Horie, Irmgard Förster, Tak W Mak, Hiromichi Yonekawa, Josef M Penninger, Yasunori Kanaho, Akira Suzuki, Takehiko Sasaki. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat. Cell Biol.. 2007.01; 9 (1): 36-44. ( PubMed, DOI )

  46. Teruhiko Suzuki, Yoshiakira Kanai, Takahiko Hara, Junko Sasaki, Takehiko Sasaki, Michinori Kohara, Tomohiko Maehama, Choji Taya, Hiroshi Shitara, Hiromichi Yonekawa, Michael A Frohman, Takeaki Yokozeki, Yasunori Kanaho. Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol. Cell. Biol.. 2006.08; 26 (16): 6149-6156. ( PubMed, DOI )

  47. Wataru Sato, Yasuo Horie, Ei Kataoka, Shigetoshi Ohshima, Takahiro Dohmen, Masahiro Iizuka, Junko Sasaki, Takehiko Sasaki, Koichi Hamada, Hiroyuki Kishimoto, Akira Suzuki, Sumio Watanabe. Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol. Res.. 2006.04; 34 (4): 256-265. ( PubMed, DOI )

  48. Koichi Hamada, Takehiko Sasaki, Pandelakis A Koni, Miyuki Natsui, Hiroyuki Kishimoto, Junko Sasaki, Nobuyuki Yajima, Yasuo Horie, Go Hasegawa, Makoto Naito, Jun-Ichi Miyazaki, Toshio Suda, Hiroshi Itoh, Kazuwa Nakao, Tak Wah Mak, Toru Nakano, Akira Suzuki. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev.. 2005.09; 19 (17): 2054-2065. ( PubMed, DOI )

  49. Junko Sasaki, Takehiko Sasaki, Masakazu Yamazaki, Kunie Matsuoka, Choji Taya, Hiroshi Shitara, Shunsuke Takasuga, Miki Nishio, Katsunori Mizuno, Teiji Wada, Hideyuki Miyazaki, Hiroshi Watanabe, Ryota Iizuka, Shuichi Kubo, Shigeo Murata, Tomoki Chiba, Tomohiko Maehama, Koichi Hamada, Hiroyuki Kishimoto, Michael A Frohman, Keiji Tanaka, Josef M Penninger, Hiromichi Yonekawa, Akira Suzuki, Yasunori Kanaho. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J. Exp. Med.. 2005.03; 201 (6): 859-870. ( PubMed, DOI )

  50. Yasuo Horie, Akira Suzuki, Ei Kataoka, Takehiko Sasaki, Koichi Hamada, Junko Sasaki, Katsunori Mizuno, Go Hasegawa, Hiroyuki Kishimoto, Masahiro Iizuka, Makoto Naito, Katsuhiko Enomoto, Sumio Watanabe, Tak Wah Mak, Toru Nakano. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Invest.. 2004.06; 113 (12): 1774-1783. ( PubMed, DOI )

  51. Junko Irie-Sasaki, Takehiko Sasaki, Josef M Penninger. CD45 regulated signaling pathways. Curr Top Med Chem. 2003.11; 3 (7): 783-796. ( PubMed )

  52. Gavin Y Oudit, Michael A Crackower, Urs Eriksson, Renu Sarao, Ivona Kozieradzki, Takehiko Sasaki, Junko Irie-Sasaki, Dominica Gidrewicz, Vitalyi O Rybin, Teiji Wada, Susan F Steinberg, Peter H Backx, Josef M Penninger. Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 2003.10; 108 (17): 2147-2152. ( PubMed, DOI )

  53. Michael A Crackower, Gavin Y Oudit, Ivona Kozieradzki, Renu Sarao, Hui Sun, Takehiko Sasaki, Emilio Hirsch, Akira Suzuki, Tetsuo Shioi, Junko Irie-Sasaki, Rajan Sah, Hai-Ying M Cheng, Vitalyi O Rybin, Giuseppe Lembo, Luigi Fratta, Antonio J Oliveira-dos-Santos, Jeffery L Benovic, C Ronald Kahn, Seigo Izumo, Susan F Steinberg, Matthias P Wymann, Peter H Backx, Josef M Penninger. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002.09; 110 (6): 737-749. ( PubMed )

  54. Kenji Matsuno, Michio Ichimura, Takao Nakajima, Keiko Tahara, Shigeki Fujiwara, Hiroshi Kase, Junko Ushiki, Neill A Giese, Anjali Pandey, Robert M Scarborough, Nathalie A Lokker, Jin-Chen Yu, Junko Irie, Eiji Tsukuda, Shin-ichi Ide, Shoji Oda, Yuji Nomoto. Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J. Med. Chem.. 2002.07; 45 (14): 3057-3066. ( PubMed )

  55. Takehiko Sasaki, Akira Suzuki, Junko Sasaki, Josef M Penninger. Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J. Biochem.. 2002.04; 131 (4): 495-501. ( PubMed )

  56. R Hirose, H Okumura, A Yoshimatsu, J Irie, Y Onoda, Y Nomoto, H Takai, T Ohno, M Ichimura. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur. J. Pharmacol.. 2001.11; 431 (1): 17-24. ( PubMed )

  57. T Sasaki, J Sasaki-Irie, J M Penninger. New insights into the transmembrane protein tyrosine phosphatase CD45. Int. J. Biochem. Cell Biol.. 2001.11; 33 (11): 1041-1046. ( PubMed )

  58. J M Penninger, J Irie-Sasaki, T Sasaki, A J Oliveira-dos-Santos. CD45: new jobs for an old acquaintance. Nat. Immunol.. 2001.05; 2 (5): 389-396. ( PubMed, DOI )

  59. J Irie-Sasaki, T Sasaki, W Matsumoto, A Opavsky, M Cheng, G Welstead, E Griffiths, C Krawczyk, C D Richardson, K Aitken, N Iscove, G Koretzky, P Johnson, P Liu, D M Rothstein, J M Penninger. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001.01; 409 (6818): 349-354. ( PubMed, DOI )

  60. J E Fata, Y Y Kong, J Li, T Sasaki, J Irie-Sasaki, R A Moorehead, R Elliott, S Scully, E B Voura, D L Lacey, W J Boyle, R Khokha, J M Penninger. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000.09; 103 (1): 41-50. ( PubMed )

  61. T Sasaki, J Irie-Sasaki, R G Jones, A J Oliveira-dos-Santos, W L Stanford, B Bolon, A Wakeham, A Itie, D Bouchard, I Kozieradzki, N Joza, T W Mak, P S Ohashi, A Suzuki, J M Penninger. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science. 2000.02; 287 (5455): 1040-1046. ( PubMed )

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