Personnel Information

写真a

SHINZAWA Naoaki


Job title

Junior Associate Professor

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Pharmaceutical Science, 2005.03, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Master's Course, 2007.03, Completed

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 2010.03, Completed

Campus Career 【 display / non-display

  • 2017.07
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Public Health, Environmental Parasitology, Assistant Professor
  • 2018.04
    -
    2021.11
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Public Health, Environmental Parasitology, Assistant Professor
  • 2021.12
    -
    2022.12
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Public Health, Department of Parasitology & Tropical Medicine, Assistant Professor
  • 2023.01
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Public Health, Department of Parasitology & Tropical Medicine, Junior Associate Professor

External Career 【 display / non-display

  • 2010.04
    -
    2013.03
    , Assistant Professor
  • 2013.04
    -
    2013.05
    , Assistant Professor
  • 2013.06
    -
    2017.06
    , Assistant Professor
 

Published Papers & Misc 【 display / non-display

  1. Naoaki Shinzawa, Chisako Kashima, Hiroka Aonuma, Kei Takahashi, Masayuki Shimojima, Shinya Fukumoto, Erisha Saiki, Daisuke S. Yamamoto, Shigeto Yoshida, Hiroyiki Matsuoka, Yoshihiro Kawaoka, Hirotaka Kanuka. Generation of Transgenic Mosquitoes Harboring a Replication-Restricted Virus Frontiers in Tropical Diseases. 2022.05; 3 850111. ( DOI )

  2. Daniel Addo-Gyan, Haruka Matsushita, Enya Sora, Tsubasa Nishi, Masao Yuda, Naoaki Shinzawa, Shiroh Iwanaga. Chromosome splitting of Plasmodium berghei using the CRISPR/Cas9 system. PLoS One. 2022; 17 (2): e0260176. ( PubMed, DOI )

  3. Masayuki Morita, Bernard N Kanoi, Naoaki Shinzawa, Rie Kubota, Hiroyuki Takeda, Tatsuya Sawasaki, Takafumi Tsuboi, Eizo Takashima. AGIA Tag System for Ultrastructural Protein Localization Analysis in Blood-Stage Plasmodium falciparum. Front Cell Infect Microbiol. 2021.12; 11 777291. ( PubMed, DOI )

  4. Nishi Tsubasa, Shinzawa Naoaki, Yuda Masao, Iwanaga Shiroh. Highly efficient CRISPR/Cas9 system in Plasmodium falciparum using Cas9-expressing parasites and a linear donor template SCIENTIFIC REPORTS. 2021.09; 11 (1): 18501. ( PubMed, DOI )

  5. Taku Izumi, Hirai Tomohiro, Makiuchi Takashi, Shinzawa Naoaki, Iwanaga Shiroh, Annoura Takeshi, Nagamune Kisaburo, Nozaki Tomoyoshi, Saito-Nakano Yumiko. Rab5b-Associated Arf1 GTPase Regulates Export of N-Myristoylated Adenylate Kinase 2 From the Endoplasmic Reticulum in Plasmodium falciparum FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021.02; 10 610200. ( PubMed, DOI )

  6. Shinzawa N, Nishi T, Hiyoshi F, Motooka D, Yuda M, Iwanaga S. Improvement of CRISPR/Cas9 system by transfecting Cas9-expressing Plasmodium berghei with linear donor template. Communications biology. 2020.08; 3 (1): 426. ( PubMed, DOI )

  7. Tsukamoto Kentaro, Shinzawa Naoaki, Kawai Akito, Suzuki Masahiro, Kidoya Hiroyasu, Takakura Nobuyuki, Yamaguchi Hisateru, Kameyama Toshiki, Inagaki Hidehito, Kurahashi Hiroki, Horiguchi Yasuhiko, Doi Yohei. The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis NATURE COMMUNICATIONS. 2020.07; 11 (1): 3571. ( PubMed, DOI )

  8. Teruya Shihono, Hiramatsu Yukihiro, Nakamura Keiji, Fukui-Miyazaki Aya, Tsukamoto Kentaro, Shinoda Noriko, Motooka Daisuke, Nakamura Shota, Ishigaki Keisuke, Shinzawa Naoaki, Nishida Takashi, Sugihara Fuminori, Maeda Yusuke, Horiguchi Yasuhiko. Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses Ca(v)3.1 as the Cell Surface Receptor MBIO. 2020; 11 (2): ( PubMed, DOI )

  9. Aya Fukui-Miyazaki, Hirono Toshima, Yukihiro Hiramatsu, Keisuke Okada, Keiji Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Hiroyuki Abe, Yasuhiko Horiguchi. The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis. MBio. 2018.08; 9 (4): ( PubMed, DOI )

  10. Tongchai Payungwoung, Naoaki Shinzawa, Akina Hino, Tubasa Nishi, Yuho Murata, Masao Yuda, Shiroh Iwanaga. CRISPR/Cas9 system in Plasmodium falciparum using the centromere plasmid. Parasitology International. 2018.06; 67 (5): 605-608. ( PubMed, DOI )

  11. Keisuke Ishigaki, Naoaki Shinzawa, Sayaka Nishikawa, Koichiro Suzuki, Aya Fukui-Miyazaki, Yasuhiko Horiguchi. Ectopic Expression of O Antigen in Bordetella pertussis by a Novel Genomic Integration System. mSphere. 2018.01; 3 (1): ( PubMed, DOI )

  12. Koichiro Suzuki, Naoaki Shinzawa, Keisuke Ishigaki, Keiji Nakamura, Hiroyuki Abe, Aya Fukui-Miyazaki, Kazuyoshi Ikuta, Yasuhiko Horiguchi. Protective effects of in vivo-expressed autotransporters against Bordetella pertussis infection. Microbiol. Immunol.. 2017.09; 61 (9): 371-379. ( PubMed, DOI )

  13. Sayaka Nishikawa, Naoaki Shinzawa, Keiji Nakamura, Keisuke Ishigaki, Hiroyuki Abe, Yasuhiko Horiguchi. The bvg-repressed gene brtA, encoding biofilm-associated surface adhesin, is expressed during host infection by Bordetella bronchiseptica. Microbiol. Immunol.. 2016.02; 60 (2): 93-105. ( PubMed, DOI )

  14. Hiroyuki Abe, Shigeki Kamitani, Aya Fukui-Miyazaki, Naoaki Shinzawa, Keiji Nakamura, Yasuhiko Horiguchi. Detection of genes expressed in Bordetella bronchiseptica colonizing rat trachea by in vivo expressed-tag immunoprecipitation method. Microbiol. Immunol.. 2015.05; 59 (5): 249-261. ( PubMed, DOI )

  15. Keisuke Okada, Hiroyuki Abe, Fumio Ike, Yoshitoshi Ogura, Tetsuya Hayashi, Aya Fukui-Miyazaki, Keiji Nakamura, Naoaki Shinzawa, Yasuhiko Horiguchi. Polymorphisms influencing expression of dermonecrotic toxin in Bordetella bronchiseptica. PLoS ONE. 2015.02; 10 (2): e0116604. ( PubMed, DOI )

  16. Naoaki Shinzawa, Tomoko Ishino, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii. Phenotypic dissection of a Plasmodium-refractory strain of malaria vector Anopheles stephensi: the reduced susceptibility to P. berghei and P. yoelii. PLoS ONE. 2013.05; 8 (5): e63753. ( PubMed, DOI )

  17. Bryce Nelson, Tina Freisinger, Kenichi Ishii, Kiyoshi Okado, Naoaki Shinzawa, Shinya Fukumoto, Hirotaka Kanuka. Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila. Biochem. Biophys. Res. Commun.. 2013.01; 430 (3): 1120-1125. ( PubMed, DOI )

  18. Yuko Doi, Naoaki Shinzawa, Shinya Fukumoto, Hideyuki Okano, Hirotaka Kanuka. Calcium signal regulates temperature-dependent transformation of sporozoites in malaria parasite development. Exp. Parasitol.. 2011.06; 128 (2): 176-180. ( PubMed, DOI )

  19. Tomoko Kubori, Naoaki Shinzawa, Hirotaka Kanuka, Hiroki Nagai. Legionella metaeffector exploits host proteasome to temporally regulate cognate effector. PLoS Pathog.. 2010.12; 6 (12): e1001216. ( PubMed, DOI )

  20. Yuko Doi, Naoaki Shinzawa, Shinya Fukumoto, Hideyuki Okano, Hirotaka Kanuka. ADF2 is required for transformation of the ookinete and sporozoite in malaria parasite development. Biochem. Biophys. Res. Commun.. 2010.07; 397 (4): 668-672. ( PubMed, DOI )

  21. Naoaki Shinzawa, Bryce Nelson, Hiroka Aonuma, Kiyoshi Okado, Shinya Fukumoto, Masayuki Miura, Hirotaka Kanuka. p38 MAPK-dependent phagocytic encapsulation confers infection tolerance in Drosophila. Cell Host Microbe. 2009.09; 6 (3): 244-252. ( PubMed, DOI )

  22. Hiroka Aonuma, Aya Yoshimura, Namal Perera, Naoaki Shinzawa, Hironori Bando, Sugao Oshiro, Bryce Nelson, Shinya Fukumoto, Hirotaka Kanuka. Loop-mediated isothermal amplification applied to filarial parasites detection in the mosquito vectors: Dirofilaria immitis as a study model. Parasit Vectors. 2009.03; 2 (1): 15. ( PubMed, DOI )

  23. Kiyoshi Okado, Naoaki Shinzawa, Hiroka Aonuma, Bryce Nelson, Shinya Fukumoto, Kozo Fujisaki, Shin-ichiro Kawazu, Hirotaka Kanuka. Rapid recruitment of innate immunity regulates variation of intracellular pathogen resistance in Drosophila. Biochem. Biophys. Res. Commun.. 2009.01; 379 (1): 6-10. ( PubMed, DOI )

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