Personnel Information

写真a

IWATA Takanori


Job title

Professor

Homepage URL

http://www.tmd.ac.jp/dent/peri/peri-J.htm

Research Areas, Keywords

periodontal regeneration, stem cells, periodontal ligament cells, cell sheet, cytotherapy

Field Introduction URL

https://tmdu-periodontology.com/

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Dentistry, 1998.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Doctor's Course, 2002.03, Completed

Campus Career 【 display / non-display

  • 2002.04
    -
    2004.03
    Tokyo Medical and Dental University, (Old Organization)Dental Hospital, Hospital Departments, Clinics for Conservation of Oral and Maxillofacial Function, Periodontics, Dental Resident
  • 2006.04
    -
    2007.03
    Tokyo Medical and Dental University, (Old Organization)Dental Hospital, Hospital Departments, Clinics for Conservation of Oral and Maxillofacial Function, Periodontics, Dental Resident
  • 2017.06
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Periodontology, Visiting Lecturer
  • 2018.05
    -
    2019.01
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Bio-Matrix, Department of Periodontology, Visiting Lecturer
  • 2019.02
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Periodontology, Professor

External Career 【 display / non-display

  • 2007.04
    -
    2009.12
    , Project Assistant Professor
  • 2010.01
    -
    2014.06
    , Project Junior Associate Professor
  • 2014.07
    -
    2019.01
    , Associate Professor
  • 2019.02
    -
    Now
    , Visiting Lecturer

Research Areas 【 display / non-display

  • Regenerative dentistry and dental engineering

  • Oral pathobiological science

Qualification Acquired 【 display / non-display

  • Dentist

 

Published Papers & Misc 【 display / non-display

  1. Aoki A, Mizutani K, Taniguchi Y, Lin T, Ohsugi Y, Mikami R, Katagiri S, Meinzer W, Iwata T. Current status of Er:YAG laser in periodontal surgery. The Japanese dental science review. 2024.12; 60 1-14. ( PubMed, DOI )

  2. Lisa Yagasaki, Tomoki Chiba, Ryota Kurimoto, Mitsuyo Nakajima, Takanori Iwata, Hiroshi Asahara. in periodontal ligament on the metabolism of alveolar bone and cementum. Regen Ther. 2024.03; 25 186-193. ( PubMed, DOI )

  3. Shiba T, Komatsu K, Takeuchi Y, Koyanagi T, Taniguchi Y, Takagi T, Maekawa S, Nagai T, Kobayashi R, Matsumura S, Katagiri S, Izumi Y, Aoki A, Iwata T. Novel flowchart guiding the non-surgical and surgical management of peri-implant complications: a narrative review Bioenginnering. 2024.01; 11 (2): 118.

  4. Lin P, Liu A, Tsuchiya Y, Noritake K, Ohsugi Y, Toyoshima K, Tsukahara Y, Shiba T, Nitta H, Aoki A, Iwata T, Katagiri S. Association between periodontal disease and chronic obstructive pulmonary disease Japanese Dental Science Review. 2023.12; 59 389-402. ( PubMed, DOI )

  5. Takeuchi Y, Aoki A, Hiratsuka K, Chui C, Ichinose A, Aung N, Kitanaka Y, Hayashi S, Toyoshima K, Iwata T, Arakawa S. Application of different wavelengths of LED lights in antimicrobial photodynamic therapy for the treatment of periodontal disease. Antibiotics (Basel, Switzerland). 2023.11; 12 (12): ( PubMed, DOI )

  6. Lin P, Niimi H, Hirota T, Ohsugi Y, Shimohira T, Toyoshima K, Katagiri S, Iwata T, Aoki A. Effects of low-level Er:YAG laser irradiation on proliferation and gene expression in primary gingival fibroblasts isolated from mouse maxilla J Biophotonics. 2023.11; e202300166. ( PubMed, DOI )

  7. Shu Takemura, Koji Mizutani, Risako Mikami, Keita Nakagawa, Masahiro Hakariya, Eri Sakaniwa, Natsumi Saito, Hiromi Kominato, Daisuke Kido, Kohei Takeda, Akira Aoki, Takanori Iwata. Enhanced periodontal tissue healing via vascular endothelial growth factor expression following low-level erbium-doped: yttrium, aluminum, and garnet laser irradiation: In vitro and in vivo studies. J Periodontol. 2023.11; ( PubMed, DOI )

  8. Hayashi S, Takeuchi Y, Hiratsuka K, Kitanaka Y, Toyoshima K, Nemoto T, Aung N, Hakariya M, Ikeda Y, Iwata T, Aoki A. Effects of various light-emitting diode wavelengths on periodontopathic bacteria and gingival fibroblasts: An in vitro study. Photodiagnosis and Photodynamic Therapy. 2023.10; 44 ( PubMed, DOI )

  9. Mikami R, Komagamine Y, Aoyama N, Mizutani K, Sasaki Y, Iwata T, Minakuchi S, Kanazawa M. Association between occlusal supports and nutritional status in older adults: A systematic review Journal of Dental Sciences. 2023.09;

  10. Prima Buranasin, Hiromi Kominato, Koji Mizutani, Risako Mikami, Natsumi Saito, Kohei Takeda, Takanori Iwata. Influence of Reactive Oxygen Species on Wound Healing and Tissue Regeneration in Periodontal and Peri-Implant Tissues in Diabetic Patients. Antioxidants (Basel). 2023.09; 12 (9): ( PubMed, DOI )

  11. Takeuchi Y, Nemoto T, Kitanaka Y, Aoki A, Izumi Y, Iwata T, Arakawa S. Antibacterial activity of lysozyme-chitosan oligosaccharide conjugates on two periodontal bacteria. Oral diseases. 2023.08; ( PubMed, DOI )

  12. Katagiri S, Ohsugi Y, Shiba T, Yoshimi K, Nakagawa K, Nagasawa Y, Uchida A, Liu A, Lin P, Tsukahara Y, Iwata T, Tohara H. Homemade blenderized tube feeding improves gut microbiome communities in children with enteral nutrition Frontiers in Microbiology. 2023.08; 14 1215236.

  13. Mikami R, Mizutani K, Gohda T, Matsuyama Y, Gotoh H, Nakagawa K, Takemura S, Aoyama N, Matsuura T, Kido D, Takeda K, Saito N, Izumi Y, Iwata T. Malnutrition- inflammation- atherosclerosis (MIA) syndrome associates with periodontitis in end-stage renal disease patients undergoing hemodialysis: a cross-sectional study. Scientific reports. 2023.07; 13 (1): 11805. ( PubMed, DOI )

  14. Kohei Takeda, Koji Mizutani, Risako Mikami, Aiko Fujino, Yuri Ito, Shunsuke Takeuchi, Natsumi Saito, Takanori Iwata. Morphological analysis of the impact of diabetes on gingival capillaries with non-invasive blood flow scope - A preliminary study. J Dent Sci. 2023.07; 18 (3): 1134-1140. ( PubMed, DOI )

  15. Shiba T, Komatsu K, Watanabe T, Takeuchi Y, Nemoto T, Ohsugi Y, Katagiri S, Shimogishi M, Marukawa E, Iwata T. Peri-implantitis management by resective surgery combined with implantoplasty and Er:YAG laser irradiation, accompanied by free gingival graft: a case report. Therapeutic advances in chronic disease. 2023.06; 14 20406223231174816. ( PubMed, DOI )

  16. Kataoka A, Shiba T, Katagiri S, Koyama S, Kito K, Ota T, Katayama T, Ohsugi Y, Nagai T, Kobayashi R, Komatsu K, Urata M, Imazuru T, Iwata T, Kozuma K. Novel and Efficient Method for Diagnosing Infective Endocarditis Using 16S Ribosomal RNA Gene Amplicon Sequence JACC Case Reports. 2023.04; 11 101793. ( PubMed, DOI )

  17. Masuda H, Arisaka Y, Hakariya M, Iwata T, Yoda T, Yui N. Molecular mobility of polyrotaxane surfaces alleviates oxidative stress-induced senescence in mesenchymal stem cells. Macromolecular bioscience. 2023.03; e2300053. ( PubMed, DOI )

  18. Tashiro A, Yonetsu T, Aoyama N, Shiheido-Watanabe Y, Niida T, Miyazaki S, Maejima Y, Goya M, Isobe M, Iwata T, Sasano T. Periodontitis was associated with worse clinical outcomes after catheter ablation for paroxysmal atrial fibrillation Frontiers in Cardiovascular Medicine. 2023.01; 9 1061243. ( DOI )

  19. Hirasawa I, Odagiri H, Park G, Sanghavi R, Oshita T, Togi A, Yoshikawa K, Mizutani K, Takeuchi Y, Kobayashi H, Katagiri S, Iwata T, Aoki A. Anti-inflammatory effects of cold atmospheric plasma irradiation on the THP-1 human acute monocytic leukemia cell line. PloS one. 2023; 18 (10): e0292267. ( PubMed, DOI )

  20. Hakariya M, Arisaka Y, Masuda H, Yoda T, Iwata T, Yui N. Suppressed migration and enhanced cisplatin chemosensitivity in human cancer cell lines by tuning the molecular mobility of supramolecular biomaterials. Macromolecular Bioscience. 2022.12; 23 (2): 2200438. ( PubMed, DOI )

  21. Morita K, Nakamura A, Machida M, Kawasaki T, Nakanishi R, Ichida J, Iwata T, Umezawa A, Akutsu H. Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions Regeneration Therapy. 2022.12; 21 389-397. ( PubMed, DOI )

  22. Tamura A, Kang TW, Tonegawa A, Arisaka Y, Masuda H, Mikami R, Iwata T, Yoda T, Yui N. Supramolecular Surface Coatings with Acetylated Polyrotaxane-Based Triblock Copolymers for Thermal Regulation of Cell Adhesion and Fabrication of Cell Sheets. Biomacromolecules. 2022.11; 23 (11): 4860-4871.

  23. Nagasawa Y, Katagiri S, Nakagawa K, Hirota T, Yoshimi K, Uchida A, Hatasa M, Komatsu K, Shiba T, Ohsugi Y, Uesaka N, Iwata T, Tohara H. Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome Journal of Functional Foods. 2022.11; e-pub

  24. Tanaka-Takemura Y, Arisaka Y, Hakariya M, Masuda H, Mikami R, Sekiya-Aoyama R, Iwata T, Yoda T, Ono T, Yui N. Independent roles of molecular mobility and zeta potential on supramolecular surfaces in the sequence of RAW264.7 macrophage responses. Macromolecular bioscience. 2022.09; 22 (11): 2200282. ( PubMed, DOI )

  25. Ohsugi Y, Hatasa M, Katagiri S, Hirota T, Shimohira T, Shiba T, Komatsu K, Tsuchiya Y, Fukuba S, Lin P, Toyoshima K, Maekawa S, Niimi H, Iwata T, Aoki A. High-frequency pulsed diode laser irradiation inhibits bone resorption in mice with ligature-induced periodontitis Journal of Clinical Periodontology. 2022.07; e-pub (12): 1275-1288. ( PubMed, DOI )

  26. Mikami R, Mizutani K, Matsuyama Y, Gohda T, Gotoh H, Aoyama N, Matsuura T, Kido D, Takeda K, Saito N, Fujiwara T, Izumi Y, Iwata T. Association of type 2 diabetes with periodontitis and tooth loss in patients undergoing hemodialysis. PLoS One. 2022.05; 17 (5): e0267494. ( PubMed, DOI )

  27. Mizutani K, Mikami R, Tsukui A, Nagai S, Pavlic V, Komada W, Iwata T, Aoki A. Novel flapless esthetic procedure for the elimination of extended gingival metal tattoos adjacent to prosthetic teeth: Er:YAG laser micro-keyhole surgery. Journal of prosthodontic research. 2022.04; 66 (2): 346-352. ( PubMed, DOI )

  28. Takada K, Chiba T, Miyazaki T, Yagasaki L, Nakamichi R, Iwata T, Moriyama K, Harada H, Asahara H. Single cell RNA sequencing reveals critical functions of Mkx in periodontal ligament homeostasis Frontiers in cell and developmental biology. 2022.02; 10 795441. ( PubMed, DOI )

  29. Shiba T, Katagiri S, Komatsu K, Nemoto T, Takeuchi Y, Chen B, Zhou YS, Iwata T. Treatment of peri-implantitis caused by malpositioning and an extra implant: a case report Int J Periodontics Restorative Dent. 2022.01; 42 (1): e15-e20. ( PubMed, DOI )

  30. Yoshida S, Hatasa M, Ohsugi Y, Tsuchiya Y, Liu A, Niimi H, Morita K, Shimohira T, Sasaki N, Maekawa S, Shiba T, Hirota T, Okano T, Hirose A, Ibi R, Noritake K, Tomiga Y, Nitta H, Suzuki T, Takahashi H, Miyasaka N, Iwata T, Katagiri S. Porphyromonas gingivalis administration induces gestational obesity, alters gene expression in the liver and brown adipose tissue in pregnant mice, and causes underweight in fetuses Frontiers in Cellular and Infection Microbiology. 2022.01; 11 745117. ( PubMed, DOI )

  31. Kaibuchi N, Iwata T, Koga YK, Okamoto T.. Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw. Frontiers in Bioengineering and Biotechnology. 2022; 10 902349. ( PubMed, DOI )

  32. Mikami Risako, Mizutani Koji, Shioyama Hidehiro, Matsuura Takanori, Aoyama Norio, Suda Tomonari, Kusunoki Yukako, Takeda Kohei, Izumi Yuichi, Aida Jun, Aoki Akira, Iwata Takanori. Influence of aging on periodontal regenerative therapy using enamel matrix derivative: A 3-year prospective cohort study JOURNAL OF CLINICAL PERIODONTOLOGY. 2021.10; 49 (2): 123-133. ( DOI )

  33. Mikami R, Arisaka Y, Hakariya M, Iwata T, Yui N. Improved epithelial cell-cell adhesion using molecular mobility of supramolecular surfaces Biomaterials science. 2021.10; 9 (21): 7151-7158. ( DOI )

  34. Tanaka D, Ikeda Y, Ikeda E, Yokose M, Ganss B, Iwata T. Effect of Amelotin on Bone Growth in the Murine Calvarial Defect Model. Annals of Biomedical Engineering. 2021.10; ( PubMed, DOI )

  35. Shimogishi M, Watanabe T, Shibasaki M, Shiba T, Komatsu K, Nemoto T, Ishihara K, Nakano Y, Iwata T, Kasugai S, Nakagawa I. Patient-specific establishment of bacterial composition within the peri-implant microbiota during the earliest weeks after implant uncovering. Journal of Periodontal Research. 2021.10; 56 (5): 964-971. ( PubMed, DOI )

  36. Nemoto T, Shiba T, Komatsu K, Watanabe T, Shimogishi M, Shibasaki M, Koyanagi T, Nagai T, Katagiri S, Takeuchi Y, Iwata T. Discrimination of bacterial community structures among healthy, gingivitis, and periodontitis statuses through integrated metatranscriptomic and network analyses. mSystems. 2021.10; 6 (6): e0088621. ( PubMed, DOI )

  37. Kominato Hiromi, Takeda Kohei, Mizutani Koji, Mikami Risako, Kido Daisuke, Buranasin Prima, Saito Natsumi, Takemura Shu, Nakagawa Keita, Nagasawa Toshiyuki, Iwata Takanori. Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin-resistant prediabetes mice JOURNAL OF PERIODONTOLOGY. 2021.09; 93 (2): 256-268. ( DOI )

  38. Shiba Takahiko, Komatsu Keiji, Sudo Takeaki, Sawafuji Rikai, Saso Aiko, Ueda Shintaroh, Watanabe Takayasu, Nemoto Takashi, Kano Chihiro, Nagai Takahiko, Ohsugi Yujin, Katagiri Sayaka, Takeuchi Yasuo, Kobayashi Hiroaki, Iwata Takanori. Comparison of Periodontal Bacteria of Edo and Modern Periods Using Novel Diagnostic Approach for Periodontitis With Micro-CT FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021.09; 11 ( DOI )

  39. Saida H, Fukuba S, Shiba T, Komatsu K, Iwata T, Nitta H. Two-stage approach for class II mandibular furcation defect with insufficient keratinized mucosa: a case report with 3 years' follow-up. The Journal of international medical research. 2021.09; 49 (9): 3000605211044595. ( PubMed, DOI )

  40. Mizutani Koji, Buranasin Prima, Mikami Risako, Takeda Kohei, Kido Daisuke, Watanabe Kazuki, Takemura Shu, Nakagawa Keita, Kominato Hiromi, Saito Natsumi, Hattori Atsuhiko, Iwata Takanori. Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis ANTIOXIDANTS. 2021.08; 10 (8): ( DOI )

  41. Lin P, Niimi H, Ohsugi Y, Tsuchiya Y, Shimohira T, Komatsu K, Liu A, Shiba T, Aoki A, Iwata T, Katagiri S. Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease International Journal of Molecular Sciences. 2021.08; 22 (16): 8900. ( PubMed, DOI )

  42. Aoki Akira, Mizutani Koji, Mikami Risako, Taniguchi Yoichi, Ohsugi Yujin, Meinzer Walter, Izumi Yuichi, Iwata Takanori. Residual periodontal pocket treatment with Er:YAG laser-assisted comprehensive periodontal pocket therapy: a retrospective study CLINICAL ORAL INVESTIGATIONS. 2021.07; 26 (1): 761-771. ( DOI )

  43. Shiba T, Watanabe T, Komatsu K, Koyanagi T, Nemoto T, Ohsugi Y, Michi Y, Katagiri S, Takeuchi Y, Ishihara K, Iwata T. Non-surgical treatment for periodontitis and peri-implantitis: longitudinal clinical and bacteriological findings-A case report with a 7-year follow-up evaluation. SAGE open medical case reports. 2021.07; 9 2050313X211029154. ( PubMed, DOI )

  44. Taniguchi Y, Sawada K, Yamada A, Mizutani K, Meinzer W, Iwata T, Izumi Y, Aoki A. Er:YAG Laser-Assisted Bone Regenerative Therapy for Implant Placement: A Case Series. The International journal of periodontics & restorative dentistry. 2021.07; 41 (4): e137-e175. ( PubMed, DOI )

  45. Shimohira T, Niimi H, Ohsugi Y, Tsuchiya Y, Morita K, Yoshida S, Hatasa M, Shiba T, Kadokura H, Yokose S, Katagiri S, Iwata T, Aoki A. Low-Level Erbium-Doped Yttrium Aluminum Garnet Laser Irradiation Induced Alteration of Gene Expression in Osteogenic Cells from Rat Calvariae Photobiomodulation, Photobiomedicine, and Laser Surgery. 2021.07; ( DOI )

  46. Mikami Risako, Mizutani Koji, Matsuyama Yusuke, Matsuura Takanori, Kido Daisuke, Takeda Kohei, Takemura Shu, Nakagawa Keita, Mukaiyama Yuto, Suda Tomonari, Yasuda Takako, Ohta Syujiro, Takaya Norihide, Fujiwara Takeo, Izumi Yuichi, Iwata Takanori. Association between periodontal inflammation and serum lipid profile in a healthy population: A cross-sectional study JOURNAL OF PERIODONTAL RESEARCH. 2021.07; 56 (6): 1037-1045. ( DOI )

  47. Masuda Hiroki, Arisaka Yoshinori, Hakariya Masahiro, Iwata Takanori, Yoda Tetsuya, Yui Nobuhiko. Synergy of molecularly mobile polyrotaxane surfaces with endothelial cell co-culture for mesenchymal stem cell mineralization RSC ADVANCES. 2021.06; 11 (30): 18685-18692. ( DOI )

  48. Arisaka Y, Hakariya M, Iwata T, Masuda H, Yoda T, Tamura A, Yui N. Surface-tethering of methylated polyrotaxanes with 4-vinylbenzyl groups onto poly(ether ether ketone) substrates for improving osteoblast compatibility. Dental materials journal. 2021.05; 40 (3): 813-819. ( PubMed, DOI )

  49. 大杉 勇人, 新見 ひろみ, 下平 剛, 片桐さやか, 岩田 隆紀, 青木 章. 特集 レーザー再起動! 6. ErYAGレーザーの骨組織への効果のエビデンス 日本歯科評論. 2021.04; 81 (4): 68-71.

  50. Kataoka A, Katagiri S, Kawashima H, Nagura F, Nara Y, Hioki H, Nakashima M, Sasaki N, Hatasa M, Maekawa S, Ohsugi Y, Shiba T, Watanabe Y, Shimokawa T, Iwata T, Kozuma K. Association between Periodontal Bacteria and Degenerative Aortic Stenosis: A Pilot Study Journal of Periodontal and Implant Science. 2021.04; 51 (e9): 1-24.

  51. Hatasa M, Yoshida S, Takahashi H, Tanaka K, Kubotsu Y, Ohsugi Y, Katagiri T, Iwata T, Katagiri S. Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response International Journal of Molecular Sciences. 2021.04; 22 (7): 3728.

  52. Terasawa Kazue, Kato Yuji, Ikami Yuta, Sakamoto Kensaku, Ohtake Kazumasa, Kusano Seisuke, Tomabechi Yuri, Kukimoto-Niino Mutsuko, Shirouzu Mikako, Guan Jun-Lin, Kobayashi Toshihide, Iwata Takanori, Watabe Tetsuro, Yokoyama Shigeyuki, Hara-Yokoyama Miki. Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells AUTOPHAGY. 2021.04; 17 (12): 4286-4304. ( DOI )

  53. Chigasaki Otofumi, Aoyama Norio, Sasaki Yoshiyuki, Takeuchi Yasuo, Mizutani Koji, Ikeda Yuichi, Gokyu Misa, Umeda Makoto, Izumi Yuichi, Iwata Takanori, Aoki Akira. Porphyromonas gingivalis, the most influential pathogen in red-complex bacteria: A cross-sectional study on the relationship between bacterial count and clinical periodontal status in Japan JOURNAL OF PERIODONTOLOGY. 2021.04; 92 (12): 1719-1729. ( DOI )

  54. Fukuba Shunsuke, Akizuki Tatsuya, Matsuura Takanori, Okada Munehiro, Nohara Kohei, Hoshi Shu, Addin Ammar Shujaa, Iwata Takanori, Izumi Yuichi. Effects of combined use of recombinant human fibroblast growth factor-2 and beta-tricalcium phosphate on ridge preservation in dehiscence bone defects after tooth extraction: A split-mouth study in dogs JOURNAL OF PERIODONTAL RESEARCH. 2021.04; 56 (2): 298-305. ( PubMed, DOI )

  55. Fukuba Shunsuke, Okada Munehiro, Nohara Kohei, Iwata Takanori. Alloplastic Bone Substitutes for Periodontal and Bone Regeneration in Dentistry: Current Status and Prospects MATERIALS. 2021.03; 14 (5): ( DOI )

  56. Mikami R, Mizutani K, Nagai S, Pavlic V, Iwata T, Aoki A. A novel minimally-invasive approach for metal tattoo removal with Er:YAG laser. Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]. 2021.02; ( PubMed, DOI )

  57. Iwakawa Hidehiro, Takigawa Masateru, Goya Masahiko, Iwata Toyoto, Martin Claire A., Anzai Tatsuhiko, Takahashi Kunihiko, Amemiya Miki, Yamamoto Tasuku, Sekigawa Masahiro, Shirai Yasuhiro, Tao Susumu, Hayashi Tatsuya, Takahashi Yoshihide, Watanabe Hiroyuki, Sasano Tetsuo. Clinical implications of local impedance measurement using the IntellaNav MiFi OI ablation catheter: an ex vivo study JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY. 2021.02; ( DOI )

  58. Sekiya-Aoyama Ruriko, Arisaka Yoshinori, Hakariya Masahiro, Masuda Hiroki, Iwata Takanori, Yoda Tetsuya, Yui Nobuhiko. Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells BIOMATERIALS SCIENCE. 2021.02; 9 (3): 675-684. ( DOI )

  59. Harada Y, Sunaga M, Takeuchi Y, Mizutani K, Katagiri S, Ikeda Y, Aoki A, Iwata T, Kinoshita A. Standardization of examiners using a dental model for pocket probe training: Adequacy of evaluation with model and standard accuracy rate of skilled examiners Journal of medical and dental sciences. 2021.02; 68 49-54.

  60. Hatasa M, Ohsugi Y, Katagiri S, Yoshida S, Niimi H, Morita K, Tsuchiya Y, Shimohira T, Sasaki N, Maekawa S, Shiba T, Hirota T, Tohara H, Takahashi H, Nitta H, Iwata T. Endotoxemia by Porphyromonas gingivalis alters endocrine functions in brown adipose tissue Frontiers in Cellular and Infection Microbiology. 2021.01; 19 (10): 580577.

  61. Inagaki K, Kikuchi T, Noguchi T, Mitani A, Naruse K, Matsubara T, Kawanami M, Negishi J, Furuichi Y, Nemoto E, Yamada S, Yoshie H, Tabeta K, Tomita S, Saito A, Katagiri S, Izumi Y, Nitta H, Iwata T, Numabe Y, Yamamoto M, Yoshinari N, Fujita T, Kurihara H, Nishimura F, Nagata T, Yumoto H, Naito T, Noguchi K, Ito K, Murakami S, Nishimura R, Tajima N. A large-scale observational study to investigate the current status of diabetic complications and their prevention in Japan (JDCP study 6): baseline dental and oral findings. Diabetology international. 2021.01; 12 (1): 52-61. ( PubMed, DOI )

  62. Mizutani Koji, Shioyama Hidehiro, Matsuura Takanori, Mikami Risako, Takeda Kohei, Izumi Yuichi, Aoki Akira, Iwata Takanori. Periodontal regenerative therapy in patients with type 2 diabetes using minimally invasive surgical technique with enamel matrix derivative under 3-year observation: A prospective cohort study JOURNAL OF PERIODONTOLOGY. 2021.01; 92 (9): 1262-1273. ( PubMed, DOI )

  63. Nakayama Y, Mizutani K, Tsumanuma Y, Yoshino H, Aoyama N, Inagaki K, Morita M, Izumi Y, Murakami S, Yoshimura H, Matsuura T, Murakami T, Yamamoto M, Yoshinari N, Mezawa M, Ogata Y, Yoshimura A, Kono K, Maruyama K, Sato S, Sakagami R, Ito H, Numabe Y, Nikaido M, Hanioka T, Seto K, Fukuda J, Warnakulasuriya S, Nagao T. A multicenter prospective cohort study on the effect of smoking cessation on periodontal therapies in Japan Journal of Oral Science. 2021.01; 63 (1): 114-118. ( PubMed, DOI )

  64. Takeda Kohei, Mizutani Koji, Minami Isao, Kido Daisuke, Mikami Risako, Konuma Kuniha, Saito Natsumi, Kominato Hiromi, Takemura Shu, Nakagawa Keita, Izumi Yuichi, Ogawa Yoshihiro, Iwata Takanori. Association of periodontal pocket area with type 2 diabetes and obesity: a cross-sectional study BMJ OPEN DIABETES RESEARCH & CARE. 2021; 9 (1): ( DOI )

  65. Kaibuchi N, Iwata T, Okamoto T, Kawase-Koga Y, Yamato M. Cell therapy for medication-related osteonecrosis of the jaw: update on treatment strategies European Cells & Materials. 2021; 41 31-39. ( DOI )

  66. Shimohira T, Katagiri S, Ohsugi Y, Hirota T, Hatasa M, Mizutani K, Watanabe K, Niimi H, Iwata T, Aoki A. Comprehensive and Sequential Gene Expression Analysis of Bone Healing Process Following Er:YAG Laser Ablation Photobiomodulation, Photobiomedicine, and Laser Surgery. 2020.12; ( PubMed, DOI )

  67. Ikeda Yuichi, Kawada Ayako, Tanaka Daiki, Ikeda Eri, Kobayashi Hiroaki, Iwata Takanori. A comparative questionnaire study of patient complaint levels between magnetostrictive ultrasonic scaler (Cavitron(R)) and piezoelectric ultrasonic scalers INTERNATIONAL JOURNAL OF DENTAL HYGIENE. 2020.12; ( PubMed, DOI )

  68. Kitanaka Y, Takeuchi Y, Hiratsuka K, Aung N, Sakamaki Y, Nemoto T, Meinzer W, Izumi Y, Iwata T, Aoki A. The effect of antimicrobial photodynamic therapy using yellow-green LED and rose bengal on Porphyromonas gingivalis. Photodiagnosis and photodynamic therapy. 2020.12; 32 102033. ( PubMed, DOI )

  69. Komatsu K, Shiba T, Takeuchi Y, Watanabe T, Koyanagi T, Nemoto T, Shimogishi M, Shibasaki M, Katagiri S, Kasugai S, Iwata T. Discriminating Microbial Community Structure Between Peri-Implantitis and Periodontitis With Integrated Metagenomic, Metatranscriptomic, and Network Analysis Frontiers in Cellular and Infection Microbiology. 2020.12; 10 ( DOI )

  70. Sato T, Iwata T, Usui M, Kokabu S, Sugamori Y, Takaku Y, Kobayashi T, Ito K, Matsumoto M, Takeda S, Xu R, Chida D. Bone phenotype in melanocortin 2 receptor-deficient mice. Bone reports. 2020.12; 13 100713. ( PubMed, DOI )

  71. Mizutani Koji, Mikami Risako, Gohda Tomohito, Gotoh Hiromichi, Aoyama Norio, Matsuura Takanori, Kido Daisuke, Takeda Kohei, Izumi Yuichi, Sasaki Yoshiyuki, Iwata Takanori. Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study SCIENTIFIC REPORTS. 2020.12; 10 (1): 21872. ( PubMed, DOI )

  72. Ohsugi Yujin, Niimi Hiromi, Shimohira Tsuyoshi, Hatasa Masahiro, Katagiri Sayaka, Aoki Akira, Iwata Takanori. In Vitro Cytological Responses against Laser Photobiomodulation for Periodontal Regeneration INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020.12; 21 (23): ( PubMed, DOI )

  73. Ikawa Takahiro, Mizutani Koji, Sudo Takeaki, Kano Chihiro, Ikeda Yuichi, Akizuki Tatsuya, Kobayashi Hiroaki, Izumi Yuichi, Iwata Takanori. Clinical comparison of an electric-powered ionic toothbrush and a manual toothbrush in plaque reduction: A randomized clinical trial INTERNATIONAL JOURNAL OF DENTAL HYGIENE. 2020.11; ( DOI )

  74. Ohsugi Y, Niimi H, Shimohira T, Hatasa M, Katagiri S, Aoki A, Iwata T. In vitro cytological responses against laser photobiomodulation for periodontal regeneration International Journal of Molecular Sciences. 2020.11; 21 (23):

  75. Watanabe Kazuki, Katagiri Sayaka, Takahashi Hirokazu, Sasaki Naoki, Maekawa Shogo, Komazaki Rina, Hatasa Masahiro, Kitajima Yoichiro, Maruyama Yusuke, Shiba Takahiko, Komatsu Keiji, Ohsugi Yujin, Tanaka Kenichi, Matsuzawa Ayumi, Hirota Tomomitsu, Tohara Haruka, Eguchi Yuichiro, Anzai Keizo, Hattori Atsuhiko, Iwata Takanori. Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota FASEB JOURNAL. 2020.11; 35 (2): e21171. ( PubMed, DOI )

  76. Ohsugi Y, Katagiri S, Hirota T, Niimi H, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kitazawa M, Matsuzawa A, Kadokura H, Yokose S, Iwata T, Aoki A. Laser irradiation decreases sclerostin expression in bone and osteogenic cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020.09; 34 (9): 12877-12893. ( PubMed, DOI )

  77. Ikawa T, Akizuki T, Ono W, Maruyama K, Okada M, Stavropoulos A, Izumi Y, Iwata T. Ridge reconstruction in damaged extraction sockets using tunnel beta-tricalcium phosphate blocks: A 6-month histological study in beagle dogs Journal of Periodontal Research. 2020.08; 55 (4): 496-502. ( DOI )

  78. Mikami R, Mizutani K, Gohda T, Gotoh H, Matsuyama Y, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Fujiwara T, Iwata T. Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study. Clinical and experimental nephrology. 2020.08; ( PubMed, DOI )

  79. Ohsugi Y, Katagiri S, Hirota T, Niimi N, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kitazawa M, Matsuzawa A, Kadokura H, Yokose S, Iwata T, Aoki A. Laser irradiation decreases sclerostin expression in bone and osteogenic cells. The FASEB Journal. 2020.08; 34 (9): 12877-12893.

  80. Tsuchiya Y, Hayashi M, Nagamatsu K, Ono T, Kamakura M, Iwata T, Nakashima T. The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-kappa B signaling downstream of FFAR4 Journal of biological chemistry, Tokyo Medical and Dental University. 2020.08; 295 (34): 12224-12232. ( DOI )

  81. Onizuka S, Yamazaki Y, Park SJ, Sugimoto T, Sone Y, Sjöqvist S, Usui M, Takeda A, Nakai K, Nakashima K, Iwata T. Correction to: RNA-sequencing reveals positional memory of multipotent mesenchymal stromal cells from oral and maxillofacial tissue transcriptomes. BMC genomics. 2020.08; 21 (1): 551. ( PubMed, DOI )

  82. Kobayashi T, Torii D, Iwata T, Izumi Y, Nasu M, Tsutsui TW. Characterization of proliferation, differentiation potential, and gene expression among clonal cultures of human dental pulp cells. Human cell. 2020.07; 33 (3): 490-501. ( PubMed, DOI )

  83. Onizuka S, Yamazaki Y, Park SJ, Sugimoto T, Sone Y, Sjöqvist S, Usui M, Takeda A, Nakai K, Nakashima K, Iwata T. RNA-sequencing reveals positional memory of multipotent mesenchymal stromal cells from oral and maxillofacial tissue transcriptomes BMC GENOMICS. 2020.06; 21 (1): 417. ( DOI )

  84. Niimi H, Ohsugi Y, Katagiri S, Watanabe K, Hatasa M, Shimohira T, Tsuchiya Y, Maekawa S, Hirota T, Kadokura H, Yokose S, Iwata T, Aoki A. Effects of Low-Level Er:YAG Laser Irradiation on Proliferation and Calcification of Primary Osteoblast-Like Cells Isolated From Rat Calvaria Frontiers in cell and developmental biology. 2020.06; 6 (459):

  85. Park JY, Park CH, Yi T, Kim SN, Iwata T, Yun JH. rhBMP-2 Pre-Treated Human Periodontal Ligament Stem Cell Sheets Regenerate a Mineralized Layer Mimicking Dental Cementum International Journal of Molecular Sciences. 2020.06; 21 (11): 3637. ( DOI )

  86. Sano K, Usui M, Moritani Y, Nakazawa K, Hanatani T, Kondo H, Nakatomi M, Onizuka S, Iwata T, Sato T, Togari A, Ariyoshi W, Nishihara T, Nakashima K. Co-cultured spheroids of human periodontal ligament mesenchymal stem cells and vascular endothelial cells enhance periodontal tissue regeneration Regenerative Therapy. 2020.06; 14 59-71. ( DOI )

  87. Kawamura Rie, Mizutani Koji, Lin Taichen, Kakizaki Sho, Mimata Ayako, Watanabe Kowashi, Saito Norihito, Meinzer Walter, Iwata Takanori, Izumi Yuichi, Aoki Akira. Ex Vivo Evaluation of Gingival Ablation with Various Laser Systems and Electroscalpel PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY. 2020.06; 38 (6): 364-373. ( DOI )

  88. Iwata T. PCR detection and new therapies for COVID-19 Journal of periodontal and implant science. 2020.06; 50 (3): 133-134. ( DOI )

  89. Kohei Nohara, Soichiro Itoh, Tatsuya Akizuki, Miho Nakamura, Shunsuke Fukuba, Takanori Matsuura, Munehiro Okada, Yuichi Izumi, Takanori Iwata, Kimihiro Yamashita. Enhanced new bone formation in canine maxilla by a graft of electrically polarized β-tricalcium phosphate. J. Biomed. Mater. Res. Part B Appl. Biomater.. 2020.04; ( PubMed, DOI )

  90. Tanaka Kenichi, Takahashi Hirokazu, Katagiri Sayaka, Sasaki Kazuyo, Ohsugi Yujin, Watanabe Kazuki, Rasadul Islam M. D., Mine Keiichiro, Nagafuchi Seiho, Iwata Takanori, Eguchi Yuichiro, Anzai Keizo. Combined effect of canagliflozin and exercise training on high-fat diet-fed mice AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2020.04; 318 (4): E492-E503. ( DOI )

  91. Kato Y, Arakawa S, Terasawa K, Inokuchi JI, Iwata T, Shimizu S, Watabe T, Hara-Yokoyama M. The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Bioorganic & medicinal chemistry letters. 2020.02; 30 (3): 126891. ( PubMed, DOI )

  92. Ogawa M, Katagiri S, Koyanagi T, Maekawa S, Shiba T, Ohsugi Y, Takeuchi Y, Ikawa T, Takeuchi S, Sekiuchi T, Arai Y, Kazama R, Wakabayashi N, Izumi Y, Iwata T. Accuracy of cone beam computed tomography in evaluation of palatal mucosa thickness. Journal of Clinical Periodontology. 2020.01; ( PubMed, DOI )

  93. Mikami R, Mizutani K, Sasaki Y, Iwata T, Aoki A. Patient-reported outcomes of laser-assisted pain control following non-surgical and surgical periodontal therapy: A systematic review and meta-analysis. PloS one. 2020; 15 (9): e0238659. ( PubMed, DOI )

  94. Hatasa M, Ohsugi Y, Katagiri S, Yoshida S, Niimi H, Morita K, Tsuchiya Y, Shimohira T, Sasaki N, Maekawa S, Shiba T, Hirota T, Tohara H, Takahashi H, Nitta H, Iwata T.. Endotoxemia by Porphyromonas gingivalis alters endocrine functions in brown adipose tissue Frontiers in Cellular and Infection Microbiology. 2020; 10 580577. ( PubMed, DOI )

  95. Niimi H, Ohsugi Y, Katagiri S, Watanabe K, Hatasa M, Shimohira T, Tsuchiya Y, Maekawa S, Hirota T, Kadokura H, Yokose S, Iwata T, Aoki A. Effects of Low-Level Er:YAG Laser Irradiation on Proliferation and Calcification of Primary Osteoblast-Like Cells Isolated From Rat Calvaria. Frontiers in cell and developmental biology. 2020; 8 459. ( PubMed, DOI )

  96. Katagiri S, Shiba T, Tohara H, Yamaguchi K, Hara K, Nakagawa K, Komatsu K, Watanabe K, Ohsugi Y, Maekawa S, Iwata T. Re-initiation of Oral Food Intake Following Enteral Nutrition Alters Oral and Gut Microbiota Communities Frontiers in Cellular and Infection Microbiology. 2019.12; 9 434. ( PubMed, DOI )

  97. Maekawa S, Onizuka S, Katagiri S, Hatasa M, Ohsugi Y, Sasaki N, Watanabe K, Ohtsu A, Komazaki R, Ogura K, Miyoshi-Akiyama T, Iwata T, Nitta H, Izumi Y. RNA sequencing for ligature induced periodontitis in mice revealed important role of S100A8 and S100A9 for periodontal destruction. Scientific reports. 2019.10; 9 (1): 14663. ( PubMed, DOI )

  98. Park Sung-Joon, Onizuka Satoru, Seki Masahide, Suzuki Yutaka, Iwata Takanori, Nakai Kenta. A systematic sequencing-based approach for microbial contaminant detection and functional inference BMC BIOLOGY. 2019.09; 17 (1): 72. ( PubMed, DOI )

  99. Onizuka S, Iwata T. Application of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets for Periodontal Regeneration. Int J Mol Sci. 2019.06; 20 (11): ( PubMed, DOI )

  100. Sebastian S, Kasai Y, Shimura D, Ishikawa T, Ali N, Iwata T, Kanai N. Oral keratinocyte-derived exosomes regulate proliferation of fibroblasts and epithelial cells. Biochem. Biophys. Res. Commun.. 2019.06; 514 (3): 706-712. ( PubMed, DOI )

  101. Kaibuchi Nobuyuki, Iwata Takanori, Onizuka Satoru, Yano Kosei, Tsumanuma Yuka, Yamato Masayuki, Okano Teruo, Ando Tomohiro. Allogeneic multipotent mesenchymal stromal cell sheet transplantation promotes healthy healing of wounds caused by zoledronate and dexamethasone in canine mandibular bones REGENERATIVE THERAPY. 2019.06; 10 77-83. ( PubMed, DOI )

  102. Sjöqvist S, Ishikawa T, Shimura D, Kasai Y, Imafuku A, Bou-Ghannam S, Iwata T, Kanai N. Exosomes derived from clinical-grade oral mucosal epithelial cell sheets promote wound healing. Journal of extracellular vesicles. 2019; 8 (1): 1565264. ( PubMed, DOI )

  103. Iwata Takanori, Yamato Masayuki, Washio Kaoru, Yoshida Toshiyuki, Tsumanuma Yuka, Yamada Azusa, Onizuka Satoru, Izumi Yuichi, Ando Tomohiro, Okano Teruo, Ishikawa Isao. Periodontal regeneration with autologous periodontal ligament-derived cell sheets - A safety and efficacy study in ten patients REGENERATIVE THERAPY. 2018.12; 9 38-44. ( PubMed, DOI )

  104. Moritani Y, Usui M, Sano K, Nakazawa K, Hanatani T, Nakatomi M, Iwata T, Sato T, Ariyoshi W, Nishihara T, Nakashima K. Spheroid culture enhances osteogenic potential of periodontal ligament mesenchymal stem cells. Journal of periodontal research. 2018.10; 53 (5): 870-882. ( PubMed, DOI )

  105. Enoki Y, Sato T, Kokabu S, Hayashi N, Iwata T, Yamato M, Usui M, Matsumoto M, Tomoda T, Ariyoshi W, Nishihara T, Yoda T. Netrin-4 Promotes Differentiation and Migration of Osteoblasts. In vivo (Athens, Greece). 2017.09; 31 (5): 793-799. ( PubMed, DOI )

  106. Kato Y, Iwata T, Washio K, Yoshida T, Kuroda H, Morikawa S, Hamada M, Ikura K, Kaibuchi N, Yamato M, Okano T, Uchigata Y. Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model. Journal of visualized experiments : JoVE. 2017.08; (126): ( PubMed, DOI )

  107. Kaibuchi N, Iwata T, Onizuka S, Yano K, Yamato M, Okano T, Ando T. Cytological character of mini pig mesenchymal stromal cells from various tissues and the attempt of cell sheet formation. Regenerative therapy. 2017.06; 6 83-89. ( PubMed, DOI )

  108. Hamada M, Iwata T, Kato Y, Washio K, Morikawa S, Sakurai H, Yamato M, Okano T, Uchigata Y. Xenogeneic transplantation of human adipose-derived stem cell sheets accelerate angiogenesis and the healing of skin wounds in a Zucker Diabetic Fatty rat model of obese diabetes. Regenerative therapy. 2017.06; 6 65-73. ( PubMed, DOI )

  109. Nagase K, Sakurada Y, Onizuka S, Iwata T, Yamato M, Takeda N, Okano T. Thermoresponsive polymer-modified microfibers for cell separations. Acta biomaterialia. 2017.04; 53 81-92. ( PubMed, DOI )

  110. Onizuka S, Iwata T, Park SJ, Nakai K, Yamato M, Okano T, Izumi Y. ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells. Journal of cellular biochemistry. 2016.10; 117 (10): 2423-34. ( PubMed, DOI )

  111. Kaibuchi N, Iwata T, Yamato M, Okano T, Ando T. Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model. Acta biomaterialia. 2016.09; 42 400-410. ( PubMed, DOI )

  112. Tsumanuma Y, Iwata T, Kinoshita A, Washio K, Yoshida T, Yamada A, Takagi R, Yamato M, Okano T, Izumi Y. Allogeneic Transplantation of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets in Canine Critical-Size Supra-Alveolar Periodontal Defect Model. BioResearch open access. 2016; 5 (1): 22-36. ( PubMed, DOI )

  113. Kato Y, Iwata T, Morikawa S, Yamato M, Okano T, Uchigata Y. Allogeneic Transplantation of an Adipose-Derived Stem Cell Sheet Combined With Artificial Skin Accelerates Wound Healing in a Rat Wound Model of Type 2 Diabetes and Obesity. Diabetes. 2015.08; 64 (8): 2723-34. ( PubMed, DOI )

  114. Iwata T, Washio K, Yoshida T, Ishikawa I, Ando T, Yamato M, Okano T. Cell sheet engineering and its application for periodontal regeneration. Journal of tissue engineering and regenerative medicine. 2015.04; 9 (4): 343-56. ( PubMed, DOI )

  115. Shimizu R, Kamei N, Adachi N, Hamanishi M, Kamei G, Mahmoud EE, Nakano T, Iwata T, Yamato M, Okano T, Ochi M. Repair mechanism of osteochondral defect promoted by bioengineered chondrocyte sheet. Tissue engineering. Part A. 2015.03; 21 (5-6): 1131-41. ( PubMed, DOI )

  116. Yoshida T, Iwata T, Takai Y, Birchmeier W, Yamato M, Okano T. Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice. Genes to cells : devoted to molecular & cellular mechanisms. 2014.11; 19 (11): 842-52. ( PubMed, DOI )

  117. Enoki Y, Sato T, Tanaka S, Iwata T, Usui M, Takeda S, Kokabu S, Matsumoto M, Okubo M, Nakashima K, Yamato M, Okano T, Fukuda T, Chida D, Imai Y, Yasuda H, Nishihara T, Akita M, Oda H, Okazaki Y, Suda T, Yoda T. Netrin-4 derived from murine vascular endothelial cells inhibits osteoclast differentiation in vitro and prevents bone loss in vivo. FEBS letters. 2014.06; 588 (14): 2262-9. ( PubMed, DOI )

  118. Pirraco RP, Iwata T, Yoshida T, Marques AP, Yamato M, Reis RL, Okano T. Endothelial cells enhance the in vivo bone-forming ability of osteogenic cell sheets. Laboratory investigation; a journal of technical methods and pathology. 2014.06; 94 (6): 663-73. ( PubMed, DOI )

  119. Suphanantachat S, Iwata T, Ishihara J, Yamato M, Okano T, Izumi Y. A role for c-Kit in the maintenance of undifferentiated human mesenchymal stromal cells. Biomaterials. 2014.04; 35 (11): 3618-26. ( PubMed, DOI )

  120. Washio K, Kuroda H, Iwata T, Yoshida T, Yamato M, Okano T. Improved enzymatic treatment for accurate cell counting from extracellular matrix-rich periodontal ligament cell sheets. The International journal of oral & maxillofacial implants. 2014.01; 29 (1): e117-21. ( PubMed, DOI )

  121. Iwata T, Yamato M, Ishikawa I, Ando T, Okano T. Tissue engineering in periodontal tissue. Anatomical record (Hoboken, N.J. : 2007). 2014.01; 297 (1): 16-25. ( PubMed, DOI )

  122. Yoshida T, Iwata T, Umemoto T, Shiratsuchi Y, Kawashima N, Sugiyama T, Yamato M, Okano T. Promotion of mouse ameloblast proliferation by Lgr5 mediated integrin signaling. Journal of cellular biochemistry. 2013.09; 114 (9): 2138-47. ( PubMed, DOI )

  123. Yamada A, Iwata T, Yamato M, Okano T, Izumi Y. Diverse functions of secreted frizzled-related proteins in the osteoblastogenesis of human multipotent mesenchymal stromal cells. Biomaterials. 2013.04; 34 (13): 3270-8. ( PubMed, DOI )

  124. Tatsumi K, Ohashi K, Matsubara Y, Kohori A, Ohno T, Kakidachi H, Horii A, Kanegae K, Utoh R, Iwata T, Okano T. Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism. Biochemical and biophysical research communications. 2013.02; 431 (2): 203-9. ( PubMed, DOI )

  125. Yoshida T, Kumashiro Y, Iwata T, Ishihara J, Umemoto T, Shiratsuchi Y, Kawashima N, Sugiyama T, Yamato M, Okano T. Requirement of integrin β3 for iron transportation during enamel formation. Journal of dental research. 2012.12; 91 (12): 1154-9. ( PubMed, DOI )

  126. Yoshida T, Washio K, Iwata T, Okano T, Ishikawa I. Current status and future development of cell transplantation therapy for periodontal tissue regeneration. International journal of dentistry. 2012; 2012 307024. ( PubMed, DOI )

  127. Tsumanuma Y, Iwata T, Washio K, Yoshida T, Yamada A, Takagi R, Ohno T, Lin K, Yamato M, Ishikawa I, Okano T, Izumi Y. Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model. Biomaterials. 2011.09; 32 (25): 5819-25. ( PubMed, DOI )

  128. Izumi Y, Aoki A, Yamada Y, Kobayashi H, Iwata T, Akizuki T, Suda T, Nakamura S, Wara-Aswapati N, Ueda M, Ishikawa I. Current and future periodontal tissue engineering. Periodontology 2000. 2011.06; 56 (1): 166-87. ( PubMed, DOI )

  129. Pirraco RP, Obokata H, Iwata T, Marques AP, Tsuneda S, Yamato M, Reis RL, Okano T. Development of osteogenic cell sheets for bone tissue engineering applications. Tissue engineering. Part A. 2011.06; 17 (11-12): 1507-15. ( PubMed, DOI )

  130. H G Wang, N Kawashima, T Iwata, J Xu, S Takahashi, T Sugiyama, H Suda. MEPE activated by furin promotes pulpal cell adhesion. J Dent Res. 2011.04; 90 (4): 529-534. ( PubMed, DOI )

  131. Sato T, Chida D, Iwata T, Usui M, Hatori K, Abe T, Takeda S, Yoda T. Non-neuronal regulation and repertoire of cholinergic receptors in organs. Biomolecular concepts. 2010.12; 1 (5-6): 357-66. ( PubMed, DOI )

  132. Iwata T, Yamato M, Zhang Z, Mukobata S, Washio K, Ando T, Feijen J, Okano T, Ishikawa I. Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use. Journal of clinical periodontology. 2010.12; 37 (12): 1088-99. ( PubMed, DOI )

  133. Washio K, Iwata T, Mizutani M, Ando T, Yamato M, Okano T, Ishikawa I. Assessment of cell sheets derived from human periodontal ligament cells: a pre-clinical study. Cell and tissue research. 2010.09; 341 (3): 397-404. ( PubMed, DOI )

  134. Wang H, Kawashima N, Iwata T, Xu J, Takahashi S, Sugiyama T, Suda H. Differentiation of odontoblasts is negatively regulated by MEPE via its C-terminal fragment. Biochemical and biophysical research communications. 2010.07; 398 (3): 406-12. ( PubMed, DOI )

  135. Sato T, Abe T, Chida D, Nakamoto N, Hori N, Kokabu S, Sakata Y, Tomaru Y, Iwata T, Usui M, Aiko K, Yoda T. Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts. FEBS letters. 2010.02; 584 (4): 817-24. ( PubMed, DOI )

  136. Iwata T, Yamato M, Tsuchioka H, Takagi R, Mukobata S, Washio K, Okano T, Ishikawa I. Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model. Biomaterials. 2009.05; 30 (14): 2716-23. ( PubMed, DOI )

  137. Ishikawa I, Iwata T, Washio K, Okano T, Nagasawa T, Iwasaki K, Ando T. Cell sheet engineering and other novel cell-based approaches to periodontal regeneration. Periodontology 2000. 2009; 51 220-38. ( PubMed, DOI )

  138. Yamakoshi Y, Lu Y, Hu JC, Kim JW, Iwata T, Kobayashi K, Nagano T, Yamakoshi F, Hu Y, Fukae M, Simmer JP. Porcine dentin sialophosphoprotein: length polymorphisms, glycosylation, phosphorylation, and stability. The Journal of biological chemistry. 2008.05; 283 (21): 14835-44. ( PubMed, DOI )

  139. Iwata T, Yamakoshi Y, Simmer JP, Ishikawa I, Hu JC. Establishment of porcine pulp-derived cell lines and expression of recombinant dentin sialoprotein and recombinant dentin matrix protein-1. European journal of oral sciences. 2007.02; 115 (1): 48-56. ( PubMed, DOI )

  140. T Iwata, Y Yamakoshi, J C-C Hu, I Ishikawa, J D Bartlett, P H Krebsbach, J P Simmer. Processing of ameloblastin by MMP-20. J Dent Res. 2007.02; 86 (2): 153-157. ( PubMed, DOI )

  141. Yamakoshi Y, Hu JC, Iwata T, Kobayashi K, Fukae M, Simmer JP. Dentin sialophosphoprotein is processed by MMP-2 and MMP-20 in vitro and in vivo. The Journal of biological chemistry. 2006.12; 281 (50): 38235-43. ( PubMed, DOI )

  142. Nagano T, Oida S, Suzuki S, Iwata T, Yamakoshi Y, Ogata Y, Gomi K, Arai T, Fukae M. Porcine enamel protein fractions contain transforming growth factor-beta1. Journal of periodontology. 2006.10; 77 (10): 1688-94. ( PubMed, DOI )

  143. Chun YH, Yamakoshi Y, Kim JW, Iwata T, Hu JC, Simmer JP. Porcine SPARC: isolation from dentin, cDNA sequence, and computer model. European journal of oral sciences. 2006.05; 114 Suppl 1 78-85; discussion 93. ( PubMed, DOI )

  144. Yamakoshi Y, Hu JC, Zhang H, Iwata T, Yamakoshi F, Simmer JP. Proteomic analysis of enamel matrix using a two-dimensional protein fractionation system. European journal of oral sciences. 2006.05; 114 Suppl 1 266-71; discussion 285. ( PubMed, DOI )

  145. Kim JW, Yamakoshi Y, Iwata T, Hu YY, Zhang H, Hu JC, Simmer JP. Porcine dentin matrix protein 1: gene structure, cDNA sequence, and expression in teeth. European journal of oral sciences. 2006.02; 114 (1): 33-41. ( PubMed, DOI )

  146. Yamakoshi Y, Hu JC, Fukae M, Iwata T, Kim JW, Zhang H, Simmer JP. Porcine dentin sialoprotein is a proteoglycan with glycosaminoglycan chains containing chondroitin 6-sulfate. The Journal of biological chemistry. 2005.01; 280 (2): 1552-60. ( PubMed, DOI )

  147. Nagano T, Iwata T, Ogata Y, Tanabe T, Gomi K, Fukae M, Arai T, Oida S. Effect of heat treatment on bioactivities of enamel matrix derivatives in human periodontal ligament (HPDL) cells. Journal of periodontal research. 2004.08; 39 (4): 249-56. ( PubMed, DOI )

  148. Ishikawa I, Kawashima Y, Oda S, Iwata T, Arakawa S. Three case reports of aggressive periodontitis associated with Porphyromonas gingivalis in younger patients. Journal of periodontal research. 2002.10; 37 (5): 324-32. ( PubMed )

  149. Iwata T, Morotome Y, Tanabe T, Fukae M, Ishikawa I, Oida S. Noggin blocks osteoinductive activity of porcine enamel extracts. Journal of dental research. 2002.06; 81 (6): 387-91. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Wang B, Inokoshi M, Katagiri S, Ohsugi Y, Lin P, Nakai H, Iwata T, Minakuchi S, Kanazawa M. Determination of the optimal cell density for immunofluorescence observation of MC3T3-E1 cells on zirconia. The 89th annual meeting and scientific session of the Pacific Coast Society for Prosthodontics 2024.06.21 Monterey

  2. Lin P, Niimi H, Hirota T, Ohsugi Y, Shimohira T, Toyoshima K, Katagiri K, Iwata T, Aoki A. Effect of low-level Er:YAG laser irradiation on proliferation and gene expression changes of primary gingival fibroblasts isolated from mouse maxilla. The 17th Congress of WFLD, Faculty of Pharmacy 2023.04.16 Wrocław Medical University, Wroclaw

  3. Iwata T. Bacterial Analysis between Periodontitis and Peri- implantitis. The 14th Asian Pacific Society of Periodontology Meeting 2022 2022.08.30 Bangkok

  4. Iwata T. Periodontal Regeneration with Cell Sheet Engineering. The 14th Asian Pacific Society of Periodontology Meeting 2022 2022.08.29 Bangkok

  5. Yoshida S, Hatasa M, Ohsugi Y, Tsuchiya Y, Liu A, Niimi H, Morita K, Shimohira T, Sasaki N, Maekawa S, Shiba T, Hirota T, Noritake K, Nitta H, Katagiri S, Iwata T. Porphyromonas gingivalis administration induces obesity, modifies gene expression in the liver and brown adipose tissue in pregnant mice, and causes underweight in fetuses. Europerio 10 2022.06.15 Copenhagen

  6. Ohsugi Y, Katagiri S, Niimi H, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kadokura H, Yokose S, Iwata T, Aoki A. Sequential microarray analysis of Er:YAG laser ablated bone tissue. The 99th General Session of the IADR 2021.07.21 Virtual

  7. Shimohira T, Niimi H, Ohsugi Y, Tsuchiya Y, Morita K, Yoshida S, Hatasa M, Shiba T, Kadokura H, Yokose S, Katagiri S, Iwata T, Aoki A. . Low-level Er:YAG laser irradiation induced alteration of gene expression in rat calvarial osteogenic cells. Dental Laser Virtual Scientific Conference 2021 2021.07.16

  8. Er:YAGレーザーによるラット頭蓋骨由来初代培養骨芽細胞様細胞の増殖と石灰化に対する効果. 第32回日本レーザー歯学会総会・学術大会 2020.11.28 誌上開催

  9. Hatasa M, Ohsugi Y, Katagiri S, Hirota T, Yoshida S, Morita K, Niimi H, Shimohira T, Watanabe K, Sasaki N, Maekawa S, Nitta H, Iwata T. Endotoxemia by Porphyromonas gingivalis aggravates inflammation in brown adipose tissue. AAP 106th Annual Meeting 2020.11.06

  10. Niimi H, Ohsugi Y, Katagiri S, Watanabe K, Hatasa M, Shimohira T, Tsuchiya Y, Maekawa S, Hirota T, Kadokura H, Yokose S, Iwata T, Aoki A. The effects of Er:YAG laser irradiation on primary osteoblast-like cells. AAP 106th Annual Meeting 2020.11.06 Virtual

  11. Ohsugi Y, Katagiri S, Hirota T, Niimi H, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kitazawa M, Matsuzawa A, Kadokura H, Yokose S, Iwata T, Aoki A. Laser irradiation decreases Sost expression in bone and osteogenic cells. The 106th Annual meeting American Academy of Periodontology 2020.11 Web開催

  12. Shimohira T, Katagiri S, Ohsugi Y, Hirota T, Hatasa M, Mizutani K, Watanabe K, Niimi H, Iwata T, Aoki A. Comprehensive and sequential gene expression analysis during bone healing process following Er:YAG laser ablation. 第63回春季日本歯周病学会 2020.07.13

  13. Shimohira T, Katagiri S, Ohsugi Y, Hirota T, Mizutani K, Watanabe K, Niimi H, Hatasa M, Meinzer W, Iwata T, Aoki A . Comprehensive and Sequential Gene expression analysis of bone healing process following Er:YAG laser ablation. World Federation of Laser Dentistry Dubai Congress 2020 2020.02.05

  14. Ohsugi Y, Katagiri S, Mizutani K, Takagi T, Kakizaki S, Kitanaka Y, Watanabe K, Niimi H, Hatasa M, Shimohira T, Meinzer W, Hirota T, Iwata T, Aoki A. Microarray analysis of comprehensive gene expression in rat calvarial bone after Er:YAG laser ablation. The first asian pacific division of the World Federation for Laser Dentistry 2019.11.10 Grand Hyatt Beijing, Beijing, Chaina

  15. Ohsugi Y, Katagiri S, Mizutani K, Takagi T, Kakizaki S, Kitanaka Y, Watanabe K, Niimi H, Meinzer W, Hirota T, Iwata T, Aoki A. Comprehensive gene expression analysis in rat calvarial bone after ablation with Er:YAG laser and the effects of Er:YAG laser on osteocytes. The 105th Annual meeting American Academy of Periodontology 2019.11.03 McCormick Place, Chicago, US

  16. Risako Mikami, Koji Mizutani, Takanori Matsuura, Daisuke Kido, Yoshiyuki Sasaki, Takanori Iwata 他. The impact of diabetes on periodontal parameters in Japanese hemodialysis patients: A cross-sectional study. 105th Annual Meeting of the American Academy of Periodontology 2019.11.03

  17. 坪川正樹, 柿﨑 翔, 大杉勇人, 北中祐太郎, 水谷幸嗣, 角 保徳, 岩田隆紀, 青木 章.. OCTによるプラークの検出および定量. 第62回秋季日本歯周病学会学術大会 2019.10.25 小倉

  18. Periodontal regenerative effect of enamel matrix derivative in diabetes. IADR/AADR/CADR General Session & Exhibition 2019.06.20

  19. Iwata T. Periodontal regeneration with periodontal ligament derived multipotent mesenchymal stromal cell sheets. The 41st Asia-Pacific Dental Congress 2019.05.10 Seoul

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  • Wisdom tooth periodontal treatment,2019.07

    Research to treat periodontal disease using unnecessary teeth such as"wisdom wisdom"that will be thrown away after removal is progressing. The idea of cultivating healthy stem cells at the base of teeth into a sheet and pasting them on the lesion to restore the work of bones and gums that support the teeth is attracting attention as a new method for regenerative medicine that effectively uses biomaterials.

  • Tissue regeneration with cell sheet,2019.07

    Research to treat periodontal disease using unnecessary teeth such as"wisdom wisdom"that is thrown away after removal. The idea of cultivating healthy stem cells at the base of teeth into a sheet and pasting them on the lesion to restore the work of bones and gums that support the teeth is attracting attention as a new method for regenerative medicine that effectively uses biomaterials.

  • Removed teeth for regenerative medicine,2019.07

    Research to treat periodontal disease using unnecessary teeth such as"wisdom wisdom"that is thrown away after removal. The idea of cultivating healthy stem cells at the base of teeth into a sheet and pasting them on the lesion to restore the work of bones and gums that support the teeth is attracting attention as a new method for regenerative medicine that effectively uses biomaterials.

  • Periodontal disease treatment without wisdom,2019.07

    Research to treat periodontal disease using unnecessary teeth such as"wisdom wisdom"that will be thrown away after removal is progressing. The idea of cultivating healthy stem cells at the base of teeth into a sheet and pasting them on the lesion to restore the work of bones and gums that support the teeth is attracting attention as a new method for regenerative medicine that effectively uses biomaterials.

  • Healthy capsule! Genki time,2019.06

    "Periodontal disease" is said to affect 80% of people over 40 years old. Because there is no noticeable subjective symptom, it may be too late when you notice it. If you leave it alone, not only your teeth will fall out, but there is also a risk of life-threatening problems such as myocardial infarction and cerebral infarction. This time, I elucidate the fear of periodontal disease which creeps up quietly. We introduce periodontal disease prevention method that we can do at home.