Personnel Information

写真a

AMANO Akiko


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2017.04
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Researcher
  • 2018.04
    -
    2024.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurology and Neurological Science， Project Researcher
  • 2025.01
    -
    2025.06
    Institute of Science Tokyo， -， Institute of Integrated Research， NucleoTIDE and PepTIDE Drug Discovery Center， Assistant Professor
  • 2025.07
    -
    Now
    Institute of Science Tokyo， -， -， -， Assistant Professor
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Published Papers & Misc 【 display / non-display 】

  1. Rayle Mamuti, Sato Nozomu, Ozaki Kokoro, Higashi Miwa, Okita Michi, Yajima Reiko, Amano Akiko, Mizusawa Hidehiro, Yokota Takanori, Ishikawa Kinya. Degenerative ataxiaの日本人患者167名のコホートを対象とした、多型性を示すSCA37遺伝子座の解析(Analysis of the polymorphic SCA37 locus in a cohort of 167 Japanese patients with degenerative ataxia) Journal of Medical and Dental Sciences. 2024; 71 11-17. ( ichushi )

  2. Amano, A; Sanjo, N; Araki, W; Anraku, Y; Nakakido, M; Matsubara, E; Tomiyama, T; Nagata, T; Tsumoto, K; Kataoka, K; Yokota, T. Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain JOURNAL OF NANOBIOTECHNOLOGY. 2023.01; 21 (1): ( PubMed, DOI )

  3. Taniguchi Kaori, Yamamoto Fumiko, Amano Akiko, Tamaoka Akira, Sanjo Nobuo, Yokota Takanori, Kametani Fuyuki, Araki Wataru. 初代培養皮質神経細胞でアミロイドβオリゴマーは、GluN2Bサブユニットを含むNMDA受容体および代謝型グルタミン酸受容体1と相互作用する　Alzheimer病によるシナプス障害との関連性(Amyloid-β oligomers interact with NMDA receptors containing GluN2B subunits and metabotropic glutamate receptor 1 in primary cortical neurons: Relevance to the synapse pathology of Alzheimer's disease) Neuroscience Research. 2022.07; 180 90-98. ( ichushi )

  4. Amano A, Kondo Y, Noda Y, Ohta M, Kawanishi N, Machida S, Mitsuhashi K, Senmaru T, Fukui M, Takaoka O, Mori T, Kitawaki J, Ono M, Saibara T, Obayashi H, Ishigami A. Abnormal lipid/lipoprotein metabolism and high plasma testosterone levels in male but not female aromatase-knockout mice. Archives of biochemistry and biophysics. 2017.05; 622 47-58. ( PubMed, DOI )

  5. Ohta M, Fujinami A, Kobayashi N, Amano A, Ishigami A, Tokuda H, Suzuki N, Ito F, Mori T, Sawada M, Iwasa K, Kitawaki J, Ohnishi K, Tsujikawa M, Obayashi H. Two chalcones, 4-hydroxyderricin and xanthoangelol, stimulate GLUT4-dependent glucose uptake through the LKB1/AMP-activated protein kinase signaling pathway in 3T3-L1 adipocytes. Nutrition research (New York, N.Y.). 2015.07; 35 (7): 618-25. ( PubMed, DOI )

  6. Sato Y, Amano A, Kishimoto Y, Takahashi K, Handa S, Maruyama N, Ishigami A. Ascorbic acid prevents protein oxidation in livers of senescence marker protein-30/gluconolactonase knockout mice. Geriatrics & gerontology international. 2014.10; 14 (4): 989-95. ( PubMed, DOI )

  7. Amano A, Tsunoda M, Aigaki T, Maruyama N, Ishigami A. Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice. European journal of nutrition. 2014.02; 53 (1): 177-85. ( PubMed, DOI )

  8. Amano A, Tsunoda M, Aigaki T, Maruyama N, Ishigami A. Age-related changes of dopamine, noradrenaline and adrenaline in adrenal glands of mice. Geriatrics & gerontology international. 2013.04; 13 (2): 490-6. ( PubMed, DOI )

  9. Amano A, Sato Y, Kishimoto Y, Takahashi K, Handa S, Aigaki T, Maruyama N, Ishigami A. Effects of ascorbic acid deficiency on protein and lipid oxidation in livers from SMP30/GNL knockout mice. Journal of nutritional science and vitaminology. 2013; 59 (6): 489-95. ( PubMed, DOI )

  10. Kondo Y, Hasegawa G, Okada H, Senmaru T, Fukui M, Nakamura N, Sawada M, Kitawaki J, Okanoue T, Kishimoto Y, Amano A, Maruyama N, Obayashi H, Ishigami A. Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet. PloS one. 2013; 8 (6): e65698. ( PubMed, DOI )

  11. Iwama M, Amano A, Shimokado K, Maruyama N, Ishigami A. Ascorbic acid levels in various tissues, plasma and urine of mice during aging. Journal of nutritional science and vitaminology. 2012; 58 (3): 169-74. ( PubMed, DOI )

  12. Kondo Y, Sasaki T, Sato Y, Amano A, Aizawa S, Iwama M, Handa S, Shimada N, Fukuda M, Akita M, Lee J, Jeong KS, Maruyama N, Ishigami A. Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice. Biochemical and biophysical research communications. 2008.12; 377 (1): 291-6. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Aoki Hanako, Honda Takeru, Amano Akiko, Higashi Miwa, Nagata Tetsuya, Yokota Takanori, Ishikawa Kinya. 脊髄小脳変性症31型に対する疾患修飾薬となり得る臨床バイオマーカーの発見(Clinical biomarker discovery for potential disease-modifying drug of Spinocerebellar ataxia type 31). 臨床神経学 2024.10.01

  2. Sanjo Nobuo, Amano Akiko, Araki Wataru, Anraku Yasutaka, Nakakido Makoto, Matsubara Etsuro, Hirata Kousei, Nagata Tetsuya, Tsumoto Kouhei, Kataoka Kazunori, Yokota Takanori. ナノミセル化抗アミロイドβオリゴマー断片抗体のAD病態における有効性(Efficacy of nanomicelle-encapsulated anti-amyloid β oligomer fragment antibody in AD pathology). 臨床神経学 2022.10.01

  3. Amano Akiko, Sanjo Nobuo, Nakakido Makoto, Tsumoto Kouhei, Matsubara Etsuro, Furukawa Fumiko, Nishida Yoichiro, Saito Takashi, Saido Takaomi, Yokota Takanori. ドットブロット法を用いたマウス脳におけるAβオリゴマーの定量的評価(Quantitative evaluation of Aβ oligomer in mouse brain using dot blot method). Dementia Japan 2019.10.01

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Others 【 display / non-display 】

  • Transporting antibodies across the blood–brain barrier to treat Alzheimer's disease，2023.03

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