Personnel Information

写真a

HIRAOKA Yuuichi


Job title

Visiting Lecturer
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 2007.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Master's Course, 2010.03, Completed

  • Tokyo Medical and Dental University, Doctor's Course, 2013.03, Completed

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Campus Career 【 display / non-display 】

  • 2016.05
    -
    2016.07
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Molecular Neuroscience， Project Assistant Professor
  • 2016.08
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    2020.08
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Molecular Neuroscience， Assistant Professor
  • 2016.08
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Molecular Neuroscience， Assistant Professor
  • 2020.09
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    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Molecular Neuroscience， Assistant Professor
  • 2022.05
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    2023.09
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， Department of Molecular Neuroscience， Assistant Professor
  • 2023.10
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    2024.04
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， Department of Molecular Neuroscience， Visiting Lecturer
  • 2024.05
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Visiting Lecturer

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Published Papers & Misc 【 display / non-display 】

  1. Ai Minamidate, Michio Onizawa, Chikako Saito, Rie Hikichi, Tomoaki Mochimaru, Mai Murakami, Chiharu Sakuma, Takehito Asakawa, Yuichi Hiraoka, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe. A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production. Biochem Biophys Rep. 2021.09; 27 101065. ( PubMed, DOI )

  2. Yuichi Hiraoka, Kaori Sugiyama, Daiki Nagaoka, Iku Tsutsui-Kimura, Kenji F Tanaka, Kohichi Tanaka. Mice with reduced glutamate transporter GLT1 expression exhibit behaviors related to attention-deficit/hyperactivity disorder. Biochem Biophys Res Commun. 2021.08; 567 161-165. ( PubMed, DOI )

  3. Sally Eshiba, Takeshi Namiki, Yasuaki Mohri, Tomomi Aida, Naotaka Serizawa, Takakazu Shibata, Hironobu Morinaga, Daisuke Nanba, Yuichi Hiraoka, Kohichi Tanaka, Keiko Miura, Masaru Tanaka, Hisashi Uhara, Hiroo Yokozeki, Toshiaki Saida, Emi K Nishimura. Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi. Cell Rep. 2021.08; 36 (5): 109492. ( PubMed, DOI )

  4. Mariko Onodera, Jan Meyer, Kota Furukawa, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Kenji F Tanaka, Christine R Rose, Ko Matsui. Exacerbation of Epilepsy by Astrocyte Alkalization and Gap Junction Uncoupling. J Neurosci. 2021.03; 41 (10): 2106-2118. ( PubMed, DOI )

  5. Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D Marth, Josef M Penninger, Masami Kanai-Azuma, Kohichi Tanaka, Satoshi Kofuji, Hiroshi Nishina. MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes Cells. 2021.01; 26 (1): 5-17. ( PubMed, DOI )

  6. Yoshifumi Abe, Norio Takata, Yuki Sakai, Hiro Taiyo Hamada, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Denis Le Bihan, Kenji Doya, Kenji F Tanaka. Diffusion functional MRI reveals global brain network functional abnormalities driven by targeted local activity in a neuropsychiatric disease mouse model. Neuroimage. 2020.12; 223 117318. ( PubMed, DOI )

  7. Machi Horiai, Ayano Otsuka, Shizu Hidema, Yuichi Hiraoka, Ryotaro Hayashi, Shinji Miyazaki, Tamio Furuse, Hiroaki Mizukami, Ryoichi Teruyama, Masaru Tamura, Haruhiko Bito, Yuko Maejima, Kenju Shimomura, Katsuhiko Nishimori. Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models. Sci Rep. 2020.12; 10 (1): 22173. ( PubMed, DOI )

  8. Hiromi Tsuru, Mizuko Osaka, Yuichi Hiraoka, Masayuki Yoshida. HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse. Sci Rep. 2020.10; 10 (1): 17593. ( PubMed, DOI )

  9. Kensuke Ihara, Tetsuo Sasano, Yuichi Hiraoka, Marina Togo-Ohno, Yurie Soejima, Motoji Sawabe, Megumi Tsuchiya, Hidesato Ogawa, Tetsushi Furukawa, Hidehito Kuroyanagi. A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice. Sci Rep. 2020.10; 10 (1): 17894. ( PubMed, DOI )

  10. Ihara Kensuke, Kuroyanagi Hidehito, Hiraoka Yuichi, Sasano Tetsuo, Furukawa Tetsushi. Cytoplasmic Expansion of RNA-Binding Motif Protein 20(Rbm20) is Critical for Development of Atrial Fibrillation in Mice(和訳中) 日本循環器学会学術集会抄録集. 2020.07; 84回 OE79-5. ( ichushi )

  11. Takahiko Yamada, Masaki Takechi, Norisuke Yokoyama, Yuichi Hiraoka, Harumi Ishikubo, Takako Usami, Toshiko Furutera, Yuki Taga, Yoshikazu Hirate, Masami Kanai-Azuma, Tetsuya Yoda, Kiyoko Ogawa-Goto, Sachiko Iseki. Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse. Dev Dyn. 2020.05; 249 (5): 622-635. ( PubMed, DOI )

  12. Hirayama Takashi, Hiraoka Yuichi, Kitamura Eri, Miyazaki Shinji, Horie Kengo, Fukuda Tomokazu, Hidema Shizu, Koike Masato, Itakura Atsuo, Takeda Satoru, Nishimori Katsuhiko. Oxytocin induced labor causes region and sex-specific transient oligodendrocyte cell death in neonatal mouse brain(和訳中) The Journal of Obstetrics and Gynaecology Research. 2020.01; 46 (1): 66-78. ( ichushi )

  13. Mieradili Mulati, Yutaka Kobayashi, Akira Takahashi, Hoashi Numata, Masanori Saito, Yuichi Hiraoka, Hiroki Ochi, Shingo Sato, Yoichi Ezura, Masato Yuasa, Takashi Hirai, Toshitaka Yoshii, Atsushi Okawa, Hiroyuki Inose. The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice. Bone. 2020.01; 130 115076. ( PubMed, DOI )

  14. Uchida Mizuki, Hida Hirotake, Mori Kentaro, Yoshimi Akira, Kitagaki Shinji, Yamada Kiyofumi, Hiraoka Yuichi, Aida Tomomi, Tanaka Kohichi, Ozaki Norio, Noda Yukihiro. Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019.08; 29 (8): 914-924. ( PubMed, DOI )

  15. Yang-Yang Feng, Miao Tang, Mitsuhiro Suzuki, Chinthika Gunasekara, Yuki Anbe, Yuichi Hiraoka, Jun Liu, Helmut Grasberger, Mamoru Ohkita, Yasuo Matsumura, Ji-Yang Wang and Takeshi Tsubata. Essential Role of NADPH Oxidase–Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation J Immunol. 2019.03;

  16. Murayama R, Kimura-Asami M, Togo-Ohno M, Yamasaki-Kato Y, Naruse TK, Yamamoto T, Hayashi T, Ai T, Spoonamore KG, Kovacs RJ, Vatta M, Iizuka M, Saito M, Wani S, Hiraoka Y, Kimura A, Kuroyanagi H. Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization. Scientific reports. 2018.06; 8 (1): 8970. ( PubMed, DOI )

  17. Miyasaka Y, Uno Y, Yoshimi K, Kunihiro Y, Yoshimura T, Tanaka T, Ishikubo H, Hiraoka Y, Takemoto N, Tanaka T, Ooguchi Y, Skehel P, Aida T, Takeda J, Mashimo T. CLICK: one-step generation of conditional knockout mice. BMC genomics. 2018.05; 19 (1): 318. ( PubMed, DOI )

  18. Zhao Z, Hiraoka Y, Ogawa H, Tanaka K. Region-specific deletions of the glutamate transporter GLT1 differentially affect nerve injury-induced neuropathic pain in mice. Glia. 2018.05; ( PubMed, DOI )

  19. Menon R, Grund T, Zoicas I, Althammer F, Fiedler D, Biermeier V, Bosch OJ, Hiraoka Y, Nishimori K, Eliava M, Grinevich V, Neumann ID. Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation. Current biology : CB. 2018.04; 28 (7): 1066-1078.e6. ( PubMed, DOI )

  20. Shizu Hidema, Tomokazu Fukuda, Yuichi Hiraoka, Hiroaki Mizukami, Ryotaro Hayashi, Ayano Otsuka, Shingo Suzuki, Shinji Miyazaki, and Katsuhiko Nishimori. Generation of Oxtr cDNA(HA) -Ires-Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner. Journal of Cellular Biochemistry. 2016.05; Volume 117, (Number 5 ): 1099-1111.

  21. Hidema S, Fukuda T, Hiraoka Y, Mizukami H, Hayashi R, Otsuka A, Suzuki S, Miyazaki S, Nishimori K. Generation of Oxtr cDNA(HA)-Ires-Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner. Journal of cellular biochemistry. 2016.05; 117 (5): 1099-111. ( PubMed, DOI )

  22. Miyazaki S, Hiraoka Y, Hidema S, Nishimori K. Prenatal minocycline treatment alters synaptic protein expression, and rescues reduced mother call rate in oxytocin receptor-knockout mice. Biochemical and biophysical research communications. 2016.04; 472 (2): 319-23. ( PubMed, DOI )

  23. Benjamin Jurek, David A Slattery, Yuichi Hiraoka, Ying Liu, Katsuhiko Nishimori, Greti Aguilera, Inga D Neumann, Erwin H van den Burg. Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3. J. Neurosci.. 2015.09; 35 (35): 12248-12260. ( PubMed, DOI )

  24. Yuko Maejima, Rauza Sukma Rita, Putra Santoso, Masato Aoyama, Yuichi Hiraoka, Katsuhiko Nishimori, Darambazar Gantulga, Kenju Shimomura, Toshihiko Yada. Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology. 2015; 101 (1): 35-44. ( PubMed, DOI )

  25. Yoshiyuki Kasahara, Yuko Tateishi, Yuichi Hiraoka, Ayano Otsuka, Hiroaki Mizukami, Keiya Ozawa, Keisuke Sato, Shizu Hidema, Katsuhiko Nishimori. Role of the Oxytocin Receptor Expressed in the Rostral Medullary Raphe in Thermoregulation During Cold Conditions. Front Endocrinol (Lausanne). 2015; 6 180. ( PubMed, DOI )

  26. Yuko Maejima, Kazuya Sakuma, Putra Santoso, Darambazar Gantulga, Kenichi Katsurada, Yoichi Ueta, Yuichi Hiraoka, Katsuhiko Nishimori, Shigeyasu Tanaka, Kenju Shimomura, Toshihiko Yada. Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS Lett.. 2014.11; 588 (23): 4404-4412. ( PubMed, DOI )

  27. Yuichi Hiraoka, Okiru Komine, Mai Nagaoka, Ning Bai, Katsuto Hozumi, Kohichi Tanaka. Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development. Mol Brain. 2013.05; 6 25. ( PubMed, DOI )

  28. Okiru Komine, Mai Nagaoka, Yuichi Hiraoka, Mikio Hoshino, Yoshiya Kawaguchi, Warren S Pear, Kohichi Tanaka. RBP-J promotes the maturation of neuronal progenitors. Dev. Biol.. 2011.06; 354 (1): 44-54. ( PubMed, DOI )

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