Personnel Information

写真a

ONO TAKEHITO


Job title

Assistant Professor

Graduating School 【 display / non-display

  • Showa University, Faculty of Dentistry, 2009.03, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, 2015.03, Completed

Campus Career 【 display / non-display

  • 2016.03
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Cell Signaling, Assistant Professor
  • 2018.04
    -
    2019.01
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Cell Signaling, Assistant Professor
  • 2019.02
     
     
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Cell Signaling, Assistant Professor
  • 2019.03
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Cell Signaling, Assistant Professor

External Career 【 display / non-display

  • 2009.04
    -
    2011.03
    , Trainee Resident of Dentistry
  • 2014.04
    -
    2016.02
    , Project Researcher
  • 2015.04
    -
    2016.02
    , Project Researcher
  • 2018.10
    -
    Now
    , Visiting Lecturer

Qualification Acquired 【 display / non-display

  • Dentist

 

Published Papers & Misc 【 display / non-display

  1. Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, Takayanagi H. IL-17-producing γδ T cells enhance bone regeneration. Nature Communications. 2016.03; 7 (1): 10928. ( PubMed, DOI )

  2. Takehito Ono, Ryosuke Denda, Yuta Tsukahara, Takashi Nakamura, Kazuo Okamoto, Hiroshi Takayanagi, Tomoki Nakashima. Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling Bone Research. 2022.08; 10 (1): 1-14. ( PubMed, DOI )

  3. Takehito Ono, Tomoki Nakashima. Recent advances in osteoclast biology Histochem. Cell Biol.. 2018.04; 149 (4): 325-341. ( PubMed, DOI )

  4. Ono T, Nakashima T. Oral bone biology Journal of oral biosciences. 2022.02; 64 (1): 8-17. ( PubMed, DOI )

  5. Takehito Ono, Mikihito Hayashi, Fumiyuki Sasaki, Tomoki Nakashima. RANKL biology: bone metabolism, the immune system, and beyond Inflammation and Regeneration. 2020.02; 40 (1): 1-16. ( DOI )

  6. Takehito Ono, Hiroshi Takayanagi. Osteoimmunology in Bone Fracture Healing. Current Osteoporosis Reports. 2017.08; 15 (4): 367-375. ( PubMed, DOI )

  7. Liu L, Koike H, Ono T, Hayashi S, Kudo F, Kaneda A, Kagechika H, Manabe I, Nakashima T, Oishi Y. Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy Proceedings of the National Academy of Sciences of the United States of America. 2021.08; 118 (35): e2102895118. ( PubMed, DOI )

  8. Sasaki Fumiyuki, Hayashi Mikihito, Ono Takehito, Nakashima Tomoki. The regulation of RANKL by mechanical force(和訳中) Journal of Bone and Mineral Metabolism. 2021.01; 39 (1): 34-44. ( ichushi )

  9. Sasaki F, Hayashi M, Ono T, Nakashima T. The regulation of RANKL by mechanical force. Journal of bone and mineral metabolism. 2020.09; 39 (1): 34-44. ( PubMed, DOI )

  10. Tsuchiya Y, Hayashi M, Nagamatsu K, Ono T, Kamakura M, Iwata T, Nakashima T. The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. The Journal of biological chemistry. 2020.08; 295 (34): 12224-12232. ( PubMed, DOI )

  11. Ono Takehito, Hayashi Mikihito, Sasaki Fumiyuki, Nakashima Tomoki. RANKLの生物学 骨代謝、免疫系、そしてその先にあるもの(RANKL biology: bone metabolism, the immune system, and beyond) Inflammation and Regeneration. 2020.02; 40 1 of 16-16 of 16. ( ichushi )

  12. Kim Yusoon, Hayashi Mikihito, Ono Takehito, Yoda Tetsuya, Takayanagi Hiroshi, Nakashima Tomoki. Suppression of hematopoietic cell kinase ameliorates the bone destruction associated with inflammation(和訳中) Modern Rheumatology. 2020.01; 30 (1): 85-92. ( ichushi )

  13. Inoue M, Ono T, Kameo Y, Sasaki F, Ono T, Adachi T, Nakashima T. Forceful mastication activates osteocytes and builds a stout jawbone. Scientific reports. 2019.03; 9 (1): 4404. ( PubMed, DOI )

  14. Kim Y, Hayashi M, Ono T, Yoda T, Takayanagi H, Nakashima T. Suppression of hematopoietic cell kinase ameliorates the bone destruction associated with inflammation. Modern rheumatology. 2019.01; 30 (1): 85-92. ( PubMed, DOI )

  15. Takehito Ono. Why and how do teeth come off? –New insights into the tooth loss during periodontitis– Dental, Oral and Craniofacial Research. 2018.04; 4 (4): 1-2. ( DOI )

  16. Fukushima-Nakayama Y, Ono T, Hayashi M, Inoue M, Wake H, Ono T, Nakashima T. Reduced Mastication Impairs Memory Function. Journal of Dental Research. 2017.08; 96 (9): 1058-1066. ( PubMed, DOI )

  17. Shoji-MatsunagaA, Ono T, Hayashi M, Takayanagi H, Moriyama K, Nakashima T. Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression. Scientific Reports. 2017.08; 7 (1): 8753. ( PubMed, DOI )

  18. Masanobu Abe, Takehito Ono et. al.. The efficacy of dental therapy for an adult case of Henoch-Schönlein Purpura Oral Science International. 2012.05; 9 (2): 59-62. ( DOI )

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Books etc 【 display / non-display

  1. MIkihito Hayashi, Takehito Ono, Tomoki Nakashima. Encyclopedia of Bone Biology 1st Edition. Elsevier, 2020.06 Signaling in Osteoblast Differentiation (ISBN : 9780128140819)

Conference Activities & Talks 【 display / non-display

  1. Ayumi Shoji-Matsunaga, Takehito Ono, Keiji Moriyama, Tomoki Nakashima. Osteocyte-derived RANKL Is A Key Regulator of Orthodontic Tooth Movement. International Association for Dental Research 2018.07.20

  2. Takehito Ono, Kazuo Okamoto, Tomoki Nakashima, Takeshi NItta, Hiroshi Takayanagi. The role of T cells in the process of bone fracture healing. Japanese Association for Dental Research 2017.11.19

  3. Ayumi Shoji-Matsunaga, Takehito Ono, Keiji Moriyama, Tomoki Nakashima. Osteocyte-derived RANKL is a key regulator of orthodontic tooth movement. Japanese Association for Dental Research 2017.11.18

  4. Takehito Ono. IL-17-producing γδ T cells enhance bone regeneration. 13th Bone biology Forum 2016.08.19

  5. Takeshi Nitta, Takehito Ono, Kazuo Okamoto, Hiroshi Takayanagi. IL-17-producing Vγ6+ γδT cells enhance bone fracture healing. 7th International gamma/delta T Cell Conference 2016.06.16

  6. Takehito Ono, Kazuo Okamoto, Hiroshi Takayanagi. T lymphocytes facilitate bone fracture healing. 15th Life Science Symposium in the University of Tokyo 2015.06.27

  7. Takehito Ono, Kazuo Okamoto, Hiroshi Takayanagi. Interleukin-17 contributes to bone regeneration after drill-hole injury. 7th GCOE International Symposium 2012.11.12 Tokyo

  8. Takehito Ono, Kazuo Okamoto, Hiroshi Takayanagi. Effects of the immune system on bone regeneration after drill-hole injury. Research Day 2012.02.14 The University of Toronto

  9. Takehito Ono, Kazuo Okamoto, Hiroshi Takayanagi. Effects of the immune system on bone regeneration after drill-hole injury. 6th GCOE International symposium 2012.01.24 Tokyo

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